JP2020125323A5 - - Google Patents
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- Publication number
- JP2020125323A5 JP2020125323A5 JP2020073065A JP2020073065A JP2020125323A5 JP 2020125323 A5 JP2020125323 A5 JP 2020125323A5 JP 2020073065 A JP2020073065 A JP 2020073065A JP 2020073065 A JP2020073065 A JP 2020073065A JP 2020125323 A5 JP2020125323 A5 JP 2020125323A5
- Authority
- JP
- Japan
- Prior art keywords
- viral
- coat protein
- protein
- viral coat
- protein complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000565 Capsid Proteins Proteins 0.000 claims 44
- 108010067390 Viral Proteins Proteins 0.000 claims 30
- 241001465754 Metazoa Species 0.000 claims 24
- 238000000034 method Methods 0.000 claims 22
- 230000003472 neutralizing effect Effects 0.000 claims 20
- 238000004519 manufacturing process Methods 0.000 claims 16
- OQALFHMKVSJFRR-UHFFFAOYSA-N dityrosine Chemical compound OC(=O)C(N)CC1=CC=C(O)C(C=2C(=CC=C(CC(N)C(O)=O)C=2)O)=C1 OQALFHMKVSJFRR-UHFFFAOYSA-N 0.000 claims 14
- 108090000623 proteins and genes Proteins 0.000 claims 12
- 102000004169 proteins and genes Human genes 0.000 claims 11
- 230000003612 virological effect Effects 0.000 claims 11
- 230000001681 protective effect Effects 0.000 claims 10
- 230000005875 antibody response Effects 0.000 claims 8
- 230000002163 immunogen Effects 0.000 claims 6
- 108091008875 B cell receptors Proteins 0.000 claims 4
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 4
- 241000711513 Mononegavirales Species 0.000 claims 4
- 230000028993 immune response Effects 0.000 claims 4
- 230000035772 mutation Effects 0.000 claims 4
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 4
- 229960005486 vaccine Drugs 0.000 claims 4
- 241000700605 Viruses Species 0.000 claims 3
- 238000004132 cross linking Methods 0.000 claims 3
- 241000711573 Coronaviridae Species 0.000 claims 2
- 241000710831 Flavivirus Species 0.000 claims 2
- 241000725303 Human immunodeficiency virus Species 0.000 claims 2
- 241000709664 Picornaviridae Species 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000002708 enhancing effect Effects 0.000 claims 2
- 208000006454 hepatitis Diseases 0.000 claims 2
- 231100000283 hepatitis Toxicity 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000004044 response Effects 0.000 claims 2
- 241001529453 unidentified herpesvirus Species 0.000 claims 2
- 241000712461 unidentified influenza virus Species 0.000 claims 2
- 241001430294 unidentified retrovirus Species 0.000 claims 2
- 101710132601 Capsid protein Proteins 0.000 claims 1
- 101710094648 Coat protein Proteins 0.000 claims 1
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 claims 1
- 101710125418 Major capsid protein Proteins 0.000 claims 1
- 102000007474 Multiprotein Complexes Human genes 0.000 claims 1
- 101710141454 Nucleoprotein Proteins 0.000 claims 1
- 101710083689 Probable capsid protein Proteins 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022128985A JP7472209B2 (ja) | 2012-05-09 | 2022-08-12 | 立体構造的に特異的なウイルス免疫原 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261644830P | 2012-05-09 | 2012-05-09 | |
| US61/644,830 | 2012-05-09 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018088600A Division JP6692853B2 (ja) | 2012-05-09 | 2018-05-02 | 立体構造的に特異的なウイルス免疫原 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022128985A Division JP7472209B2 (ja) | 2012-05-09 | 2022-08-12 | 立体構造的に特異的なウイルス免疫原 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020125323A JP2020125323A (ja) | 2020-08-20 |
| JP2020125323A5 true JP2020125323A5 (https=) | 2021-05-20 |
Family
ID=49548782
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015511675A Pending JP2015518819A (ja) | 2012-05-09 | 2013-05-09 | 立体構造的に特異的なウイルス免疫原 |
| JP2018088600A Expired - Fee Related JP6692853B2 (ja) | 2012-05-09 | 2018-05-02 | 立体構造的に特異的なウイルス免疫原 |
| JP2020073065A Pending JP2020125323A (ja) | 2012-05-09 | 2020-04-15 | 立体構造的に特異的なウイルス免疫原 |
| JP2022128985A Active JP7472209B2 (ja) | 2012-05-09 | 2022-08-12 | 立体構造的に特異的なウイルス免疫原 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015511675A Pending JP2015518819A (ja) | 2012-05-09 | 2013-05-09 | 立体構造的に特異的なウイルス免疫原 |
| JP2018088600A Expired - Fee Related JP6692853B2 (ja) | 2012-05-09 | 2018-05-02 | 立体構造的に特異的なウイルス免疫原 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022128985A Active JP7472209B2 (ja) | 2012-05-09 | 2022-08-12 | 立体構造的に特異的なウイルス免疫原 |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US20130302366A1 (https=) |
| EP (2) | EP2846828B1 (https=) |
| JP (4) | JP2015518819A (https=) |
| AU (5) | AU2013259548A1 (https=) |
| CA (1) | CA2873048C (https=) |
| IN (1) | IN2014DN09445A (https=) |
| WO (1) | WO2013169961A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015013551A1 (en) * | 2013-07-25 | 2015-01-29 | Marshall Christopher Patrick | Conformationally stabilized rsv pre-fusion f proteins |
| US9393297B2 (en) | 2013-08-03 | 2016-07-19 | Avatar Medical, Llc | Influenza hemagglutinin proteins and methods of use thereof |
| WO2019032480A1 (en) | 2017-08-07 | 2019-02-14 | Avatar Medical, Llc | PROTEINS F PRE-FUSION OF RSV STABILIZED IN TERMS OF CONFORMATION |
| US11623004B2 (en) | 2018-03-16 | 2023-04-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Compositions and methods for vaccination against respiratory syncytial virus infection |
| AU2021271016A1 (en) * | 2020-05-12 | 2023-01-19 | The Regents Of The University Of California | SARS-CoV2 neutralizing single domain antibody constructs |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7311920B1 (en) * | 1999-10-08 | 2007-12-25 | University Of Maryland Biotechnology Institute | Virus coat protein/receptor chimeras and methods of use |
| DE60043708D1 (de) * | 1999-10-13 | 2010-03-04 | Novartis Vaccines & Diagnostic | Verfahren zur erhaltung zellimmuneantworten gegen proteinen |
| CA2387870C (en) | 1999-10-15 | 2012-02-14 | Avatar Medical, Llc | Stabilized proteins |
| US6465425B1 (en) | 2000-02-10 | 2002-10-15 | Alkermes Controlled Therapeutics, Inc. | Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins |
| US7179468B1 (en) * | 2000-06-08 | 2007-02-20 | Cornell Research Foundation, Inc. | Antigen for developing neutralizing antibodies to human immunodeficiency virus |
| EP1463521A4 (en) | 2001-12-17 | 2009-06-24 | Us Gov Health & Human Serv | INHIBITOR OF GP41 |
| WO2004069863A2 (en) | 2003-02-04 | 2004-08-19 | New York University | Constrained hiv v3 loop peptides as immunogens and receptor antagonists |
| JP5009614B2 (ja) * | 2003-07-03 | 2012-08-22 | アバター バイオテクノロジーズ，インク． | 免疫原性を低減した分子の取得方法 |
| EP1755667B1 (en) * | 2004-06-01 | 2013-07-17 | Merck Sharp & Dohme Corp. | Stable peptide mimetic of hiv gp41 fusion intermediate |
| CA2655934A1 (en) * | 2006-06-19 | 2007-12-27 | Progenics Pharmaceuticals, Inc. | Soluble stabilized trimeric hiv env proteins and uses thereof |
| PL2565204T3 (pl) * | 2007-07-27 | 2016-03-31 | Immatics Biotechnologies Gmbh | Nowe immunogenne epitopy do immunoterapii |
| US8933197B2 (en) | 2007-08-15 | 2015-01-13 | Amunix Operating Inc. | Compositions comprising modified biologically active polypeptides |
| US20090246191A1 (en) * | 2007-10-11 | 2009-10-01 | University Of Tennessee Research Foundation | Preparation of Purified Covalently Cross-linked Abeta Oligomers and Uses Thereof |
| SMT202000101T1 (it) * | 2008-10-10 | 2020-03-13 | Childrens Medical Center | Vaccino con trimero di env di hiv-1 stabilizzato biochimicamente |
| WO2011066221A1 (en) | 2009-11-24 | 2011-06-03 | International Aids Vaccine Initiative | Immunogen prioritization for vaccine design |
| EP2572196A4 (en) | 2010-05-18 | 2014-04-23 | Christopher P Marshall | ASSAY TO IDENTIFY ANTIGENES FOR THE ACTIVATION OF B-CELL RECEPTORS WITH NEUTRALIZING ANTIBODIES |
| US20130149336A1 (en) * | 2011-10-27 | 2013-06-13 | Brian L. Hjelle | Methods for Screening Viral Like Particles and Identifying Neutralizing Epitopes and Related Vaccines, Constructs, and Libraries |
| EP2804948B1 (en) | 2012-01-20 | 2020-04-15 | The Government of The Hong Kong Special Administrative Region of The People's Republic of China | A novel paramyxovirus and uses thereof |
-
2013
- 2013-05-08 US US13/890,226 patent/US20130302366A1/en not_active Abandoned
- 2013-05-09 JP JP2015511675A patent/JP2015518819A/ja active Pending
- 2013-05-09 EP EP13787969.8A patent/EP2846828B1/en not_active Not-in-force
- 2013-05-09 WO PCT/US2013/040228 patent/WO2013169961A1/en not_active Ceased
- 2013-05-09 CA CA2873048A patent/CA2873048C/en active Active
- 2013-05-09 EP EP18200812.8A patent/EP3483174A1/en active Pending
- 2013-05-09 US US13/890,465 patent/US20130317205A1/en not_active Abandoned
- 2013-05-09 AU AU2013259548A patent/AU2013259548A1/en not_active Abandoned
- 2013-05-09 IN IN9445DEN2014 patent/IN2014DN09445A/en unknown
-
2017
- 2017-02-03 US US15/424,107 patent/US10155023B2/en active Active
-
2018
- 2018-01-22 AU AU2018200502A patent/AU2018200502B2/en not_active Ceased
- 2018-05-02 JP JP2018088600A patent/JP6692853B2/ja not_active Expired - Fee Related
- 2018-12-08 US US16/214,074 patent/US20190105368A1/en not_active Abandoned
-
2019
- 2019-08-16 AU AU2019216695A patent/AU2019216695A1/en not_active Abandoned
-
2020
- 2020-04-15 JP JP2020073065A patent/JP2020125323A/ja active Pending
- 2020-11-30 US US17/107,067 patent/US11752191B2/en active Active
-
2021
- 2021-06-21 AU AU2021204169A patent/AU2021204169B2/en active Active
-
2022
- 2022-08-12 JP JP2022128985A patent/JP7472209B2/ja active Active
-
2023
- 2023-08-25 US US18/455,787 patent/US20240238369A1/en not_active Abandoned
-
2024
- 2024-02-22 AU AU2024201200A patent/AU2024201200A1/en not_active Abandoned
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