JP2020114847A5 - - Google Patents

Info

Publication number

JP2020114847A5

JP2020114847A5 JP2020054620A JP2020054620A JP2020114847A5 JP 2020114847 A5 JP2020114847 A5 JP 2020114847A5 JP 2020054620 A JP2020054620 A JP 2020054620A JP 2020054620 A JP2020054620 A JP 2020054620A JP 2020114847 A5 JP2020114847 A5 JP 2020114847A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

hemichannel

small molecule

composition according

connexin

Prior art date

2020-03-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 45
• 102000001045 Connexin 43 Human genes 0.000 claims 32
• 108010069241 Connexin 43 Proteins 0.000 claims 32
• 150000003384 small molecules Chemical class 0.000 claims 29
• 125000000217 alkyl group Chemical group 0.000 claims 9
• 125000003709 fluoroalkyl group Chemical group 0.000 claims 9
• 239000003607 modifier Substances 0.000 claims 9
• 150000001875 compounds Chemical class 0.000 claims 7
• 230000002792 vascular Effects 0.000 claims 7
• 206010064930 age-related macular degeneration Diseases 0.000 claims 6
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 4
• 206010012689 Diabetic retinopathy Diseases 0.000 claims 4
• 125000004429 atom Chemical group 0.000 claims 4
• 230000002207 retinal effect Effects 0.000 claims 4
• 230000009885 systemic effect Effects 0.000 claims 4
• 206010021143 Hypoxia Diseases 0.000 claims 3
• 206010030113 Oedema Diseases 0.000 claims 3
• 230000033115 angiogenesis Effects 0.000 claims 3
• 230000000694 effects Effects 0.000 claims 3
• 230000007954 hypoxia Effects 0.000 claims 3
• 208000002780 macular degeneration Diseases 0.000 claims 3
• 230000010412 perfusion Effects 0.000 claims 3
• 206010012688 Diabetic retinal oedema Diseases 0.000 claims 2
• 206010015943 Eye inflammation Diseases 0.000 claims 2
• 206010016654 Fibrosis Diseases 0.000 claims 2
• 208000008069 Geographic Atrophy Diseases 0.000 claims 2
• 108010034143 Inflammasomes Proteins 0.000 claims 2
• 206010061218 Inflammation Diseases 0.000 claims 2
• 206010036626 Presbyacusis Diseases 0.000 claims 2
• 201000007527 Retinal artery occlusion Diseases 0.000 claims 2
• 208000027418 Wounds and injury Diseases 0.000 claims 2
• 229960002685 biotin Drugs 0.000 claims 2
• 235000020958 biotin Nutrition 0.000 claims 2
• 239000011616 biotin Substances 0.000 claims 2
• 230000000740 bleeding effect Effects 0.000 claims 2
• 201000005667 central retinal vein occlusion Diseases 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 230000006378 damage Effects 0.000 claims 2
• 206010012601 diabetes mellitus Diseases 0.000 claims 2
• 201000011190 diabetic macular edema Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 208000035475 disorder Diseases 0.000 claims 2
• 210000002889 endothelial cell Anatomy 0.000 claims 2
• 230000004761 fibrosis Effects 0.000 claims 2
• 125000001153 fluoro group Chemical group F* 0.000 claims 2
• 230000004054 inflammatory process Effects 0.000 claims 2
• 208000014674 injury Diseases 0.000 claims 2
• 230000000938 luteal effect Effects 0.000 claims 2
• 208000009800 presbycusis Diseases 0.000 claims 2
• 210000001525 retina Anatomy 0.000 claims 2
• 208000004644 retinal vein occlusion Diseases 0.000 claims 2
• 238000007910 systemic administration Methods 0.000 claims 2
• 206010059245 Angiopathy Diseases 0.000 claims 1
• 206010003694 Atrophy Diseases 0.000 claims 1
• 208000002691 Choroiditis Diseases 0.000 claims 1
• 208000020564 Eye injury Diseases 0.000 claims 1
• 206010065534 Macular ischaemia Diseases 0.000 claims 1
• 108091008099 NLRP3 inflammasome Proteins 0.000 claims 1
• 208000034247 Pattern dystrophy Diseases 0.000 claims 1
• 208000003971 Posterior uveitis Diseases 0.000 claims 1
• 208000017442 Retinal disease Diseases 0.000 claims 1
• 206010038923 Retinopathy Diseases 0.000 claims 1
• 206010038926 Retinopathy hypertensive Diseases 0.000 claims 1
• 206010053649 Vascular rupture Diseases 0.000 claims 1
• 150000001371 alpha-amino acids Chemical class 0.000 claims 1
• 235000008206 alpha-amino acids Nutrition 0.000 claims 1
• 150000001450 anions Chemical class 0.000 claims 1
• 230000037444 atrophy Effects 0.000 claims 1
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
• 210000003161 choroid Anatomy 0.000 claims 1
• 230000001684 chronic effect Effects 0.000 claims 1
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
• 230000007850 degeneration Effects 0.000 claims 1
• 210000000981 epithelium Anatomy 0.000 claims 1
• 208000030533 eye disease Diseases 0.000 claims 1
• 201000001948 hypertensive retinopathy Diseases 0.000 claims 1
• 230000002757 inflammatory effect Effects 0.000 claims 1
• 150000002923 oximes Chemical class 0.000 claims 1
• 238000007911 parenteral administration Methods 0.000 claims 1
• 239000000049 pigment Substances 0.000 claims 1
• 230000002028 premature Effects 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 230000001105 regulatory effect Effects 0.000 claims 1
• 230000000699 topical effect Effects 0.000 claims 1