JP2020109094A - Viscous disinfectant - Google Patents

Abstract

To provide a disinfectant containing ethanol and an acid which is uniformly dissolved without causing white turbidity and sedimentation even when a thickener is added thereto, prevents generation of twisting that is a pasty peeled matter which may be generated when a disinfectant and a cosmetic with a thickener are rubbed into hands, and has good use feeling.SOLUTION: A viscous disinfectant contains ethanol, a phosphoric acid, a phosphate and a thickening compound (cellulose derivative) represented by a formula (1), in which a content ratio of the thickening compound is 0.1 wt.% to 20 wt.% and pH at 25°C is 2.5 to 5.0.SELECTED DRAWING: None

Description

The present invention is not only fungi, but also a virus, particularly norovirus, poliovirus, adenovirus and other non-enveloped non-enveloped viruses that exhibit inefficiency such as inactivation, suppression of growth, elimination, etc. Disinfectant having

Conventionally, a preparation containing alcohol and an acidic substance as an active ingredient has been used as a disinfectant having the effect of suppressing the growth of not only fungi but also non-enveloped viruses having no envelope such as norovirus, poliovirus and adenovirus. Has become known.

For example, in Patent Document 1, at least alcohols of ethanol or isopropyl alcohol, lactic acid, citric acid, and a zinc-containing compound are used as a disinfectant having high effectiveness against non-enveloped viruses that are ineffective in general disinfecting ethanol. Disinfectants each containing a predetermined amount are disclosed.

JP, 2008-255101, A

However, in the market, there is a demand that it will not easily spill from the palm when it is attached to the hand, that it will not spatter more than necessary when sprayed and will not adhere to the wall, and that it will not suck alcohol etc. when sprayed. That is, there is a case where a disinfectant having a viscosity higher than that of water, ethanol or the like is desired. However, although various thickeners are described in paragraph 0026 of the specification of Patent Document 1, in the examples. There is no specific example containing a thickener.

When we actually tried to improve the viscosity of the disinfectant containing ethanol and acid by using various thickeners, the thickener did not dissolve in ethanol and became cloudy and precipitated. The disinfectant or the cosmetics of No. 1 was pasty, which was a paste-like peeling product that could occur when rubbed into the hand, and the product was uncomfortable to use, and it was far from being commercialized.

Therefore, in the present invention, with respect to a disinfectant containing ethanol and an acid, even if a thickener is added, the disinfectant is uniformly dissolved without clouding and precipitation, and a disinfectant containing a thickener or a cosmetic is rubbed into the hand. It is an object of the present invention to provide a disinfectant having a good feeling of use, which is free from sticking, which is a paste-like peeled product, or stickiness.

［式中、Ｒ¹、Ｒ²、Ｒ³、Ｒ⁴、Ｒ⁵及びＲ⁶は、それぞれ水素原子、低級アルキル基、ヒドロキシエチル基：−［ＣＨ₂ＣＨ₂Ｏ］_mＨ、ヒドロキシプロピル基：−［ＣＨ₂ＣＨ（ＣＨ₃）Ｏ］_mＨ、基：−ＣＨ₂ＣＨ（ＯＨ）ＣＨ₂Ｏ−Ｃ_kＨ_2k+1、基：−［ＣＨ₂ＣＨ（ＯＨ）ＣＨ₂Ｏ］_m−Ｃ_kＨ_2k+1、又は、基：−［ＣＨ₂ＣＨ₂Ｏ］_mＣＨ₂ＣＨ（ＯＨ）ＣＨ₂Ｏ−Ｃ_kＨ_2k+1のいずれか一つである。ただし、すべて同時に水素原子、又は、低級アルキル基である場合を除く。ｎは５０〜５０００の整数、ｍは１〜１０の整数、ｋは６〜２２の整数を示す。］ (1) That is, ethanol, phosphoric acid, and sodium salt or potassium salt of phosphoric acid,
A viscous disinfectant containing a thickening compound represented by the following formula (1), wherein the content of the thickening compound is 0.1% by weight to 20% by weight, and the pH at 25°C is 2.5. It is a viscous disinfectant characterized by being -5.0.

[Wherein R ¹ , R ² , R ³ , R ⁴ , R ⁵ and R ⁶ are each a hydrogen atom, a lower alkyl group, a hydroxyethyl group: -[CH ₂ CH ₂ O] _m H, a hydroxypropyl group: _{- [CH 2 CH (CH 3} ) O] m H, _{group: -CH 2 CH (OH) CH} 2 O-C k H 2k + 1, based _{on: - [CH 2 CH (OH} ) CH 2 O] m - C _k H _{2k + 1,} or a group: - a one of _{[CH 2 CH 2 O] m} CH 2 CH (OH) CH 2 O-C k H 2k + 1. However, the case where all are simultaneously hydrogen atoms or lower alkyl groups is excluded. n is an integer of 50 to 5000, m is an integer of 1 to 10, and k is an integer of 6 to 22. ]

(2) The viscous disinfectant according to (1), wherein the ethanol is contained in an amount of 40% by weight to 99% by weight.

(3) And viscosity at 25 degreeC is 100-6000 mPa*s, It is the viscous disinfectant as described in said (1) or (2) characterized by the above-mentioned.

According to this structure, the disinfectant containing ethanol and acid can be uniformly dissolved without adding a thickening agent even if the thickening agent is added, and the disinfectant containing the thickening agent or the cosmetic can be rubbed into the hand. It is possible to improve the feeling of use without causing sticking, which is a paste-like peeled product, or stickiness.

Hereinafter, embodiments of the viscous disinfectant of the present invention will be described in detail. When there is a notation indicating a range in the description, the upper limit and the lower limit are included.

Ethanol in the present invention inhibits the growth of bacteria, kills them, and inactivates non-enveloped viruses that do not have envelopes such as norovirus, poliovirus, and adenovirus by coexisting with acid, and suppresses growth. It is an active ingredient with efficacy.

The content ratio of ethanol is preferably 40% by weight to 99% by weight, more preferably 50% by weight to 85% by weight, and most preferably 55% by weight to 80% by weight with respect to the disinfectant. When the content ratio of ethanol is within this range, it has effects such as inactivation against bacteria and viruses and suppression of growth, and can evenly disperse the thickening compound.

The acid in the present invention inhibits the growth of the bacterium, kills it, and inactivates it even against non-enveloped viruses having no envelope such as norovirus, poliovirus, and adenovirus by coexisting with ethanol, and suppresses the growth. It is an active ingredient with efficacy.

The acid is preferably an organic acid such as citric acid, lactic acid, formic acid, acetic acid, oxalic acid or propionic acid, or an inorganic acid such as phosphoric acid or sulfuric acid. These acids can be used alone or in combination of two or more. If necessary, the sodium salt, potassium salt, calcium salt or the like of the acid can be used in combination.

The content ratio of the acid is preferably 0.1% by weight to 5.0% by weight, more preferably 0.2% by weight to 4.0% by weight, and 0.3% by weight to 3.0% by weight with respect to the disinfectant. % Is most preferred. When the content ratio of the acid is in this range, the thickening compound can be uniformly dispersed while having the effect of inactivating and inhibiting the growth of bacteria and viruses.

［式中、Ｒ¹、Ｒ²、Ｒ³、Ｒ⁴、Ｒ⁵及びＲ⁶は、それぞれ水素原子、炭素数１〜３の低級アルキル基、ヒドロキシエチル基：−［ＣＨ₂ＣＨ₂Ｏ］_mＨ、ヒドロキシプロピル基：−［ＣＨ₂ＣＨ（ＣＨ₃）Ｏ］_mＨ、基：−ＣＨ₂ＣＨ（ＯＨ）ＣＨ₂Ｏ−Ｃ_kＨ_2k+1、基：−［ＣＨ₂ＣＨ（ＯＨ）ＣＨ₂Ｏ］_m−Ｃ_kＨ_2k+1、又は、基：−［ＣＨ₂ＣＨ₂Ｏ］_mＣＨ₂ＣＨ（ＯＨ）ＣＨ₂Ｏ−Ｃ_kＨ_2k+1のいずれか一つである。ただし、すべて同時に水素原子、又は、低級アルキル基である場合を除く。ｎは５０〜５０００の整数、ｍは１〜１０の整数、ｋは６〜２２の整数を示す。］
増粘化合物は、消毒剤の粘性を向上させるとともに、手など肌に付け広げたときの使用感を向上させるための化合物であり、具体的にはヒドロキシエチル基が導入されたセルロース誘導体であるヒドロキシエチルセルロース、ヒドロキシプロピル基が導入されたセルロース誘導体であるヒドロキシプロピルセルロース、ヒドロキシプロピル基及び低級アルキル基のうちメチル基が導入されたセルロース誘導体であるヒドロキシプロピルメチルセルロース、ヒドロキシプロピルメチルセルロースにステアリルグリシジルエーテルなどの疎水性のアルキル基を有するグリシジルエーテルを反応させて得られる疎水化ヒドロキシプロピルメチルセルロース、ヒドロキシエチル基及びヒドロキシプロピル基が導入されたセルロースであるヒドロキシエチルヒドロキシプロピルセルロースなどである。また、疎水化ヒドロキシプロピルメチルセルロースにおいては、疎水基がステアリル基だけでなく炭素数６〜２２などの中鎖及び長鎖アルキル基を用いることもできる。なお、導入されるヒドロキシエチル基及びヒドロキシプロピル基は、セルロース中の水酸基１つに対して１または複数付加することができ、１〜１０付加されていることが好ましい。特に、ヒドロキシエチルセルロースを用いることにより、消毒剤を組成したときに白濁や沈殿が見られないだけでなく、長期間保存したときにも白濁や沈殿が見られない保存安定性が優れる点において好適である。 The thickening compound in the present invention is represented by the following formula (1).

[Wherein, R ¹ , R ² , R ³ , R ⁴ , R ⁵ and R ⁶ are each a hydrogen atom, a lower alkyl group having 1 to 3 carbon atoms, a hydroxyethyl group: -[CH ₂ CH ₂ O] _m H, hydroxypropyl _{groups: - [CH 2 CH (CH} 3) O] m H, _{group: -CH 2 CH (OH) CH} 2 O-C k H 2k + 1, based _{on: - [CH 2 CH (OH} ) _{CH 2 O] m -C k H} 2k + 1, or a group: - [a one of _{CH 2 CH 2 O] m CH} 2 CH (OH) CH 2 O-C k H 2k + 1. However, the case where all are simultaneously hydrogen atoms or lower alkyl groups is excluded. n is an integer of 50 to 5000, m is an integer of 1 to 10, and k is an integer of 6 to 22. ]
The thickening compound is a compound for improving the viscosity of the disinfectant and for improving the feeling of use when it is spread on the skin such as hands, and specifically, it is a hydroxyethyl group which is a cellulose derivative having a hydroxyethyl group introduced. Ethyl cellulose, hydroxypropyl cellulose, which is a cellulose derivative having a hydroxypropyl group introduced therein, hydroxypropylmethyl cellulose, which is a cellulose derivative having a methyl group introduced among hydroxypropyl group and lower alkyl group, and hydrophobicity such as stearyl glycidyl ether in hydroxypropyl methylcellulose. Examples include hydrophobized hydroxypropylmethyl cellulose obtained by reacting glycidyl ether having a hydrophilic alkyl group, hydroxyethyl hydroxypropyl cellulose which is a cellulose having a hydroxyethyl group and a hydroxypropyl group introduced therein, and the like. Further, in the hydrophobized hydroxypropylmethylcellulose, not only the stearyl group but also the medium chain and long chain alkyl groups having 6 to 22 carbon atoms can be used as the hydrophobic group. The hydroxyethyl group and hydroxypropyl group to be introduced can be added one or more to one hydroxyl group in cellulose, and preferably 1 to 10 are added. In particular, by using hydroxyethyl cellulose, it is preferable that not only white turbidity or precipitation is not observed when a disinfectant is formed, but also white turbidity or precipitation is not observed even after long-term storage, which is excellent in storage stability is there.

Where the viscosity of the disinfectant is improved by blending the thickening compound, the viscosity of the disinfectant in the state where various components are blended and stirred to form a uniform colorless and clear solution is the Brook described in JIS K7117-1. In measurement using a field type rotational viscometer B type (manufactured by Toki Sangyo Co., Ltd., trade name “TVB-10M”), it is preferably 100 to 6000 mPa·s, and 200 to 5000 mPa·s at 25° C. Is more preferable, and it is most preferable that it is 300 to 2000 mPa·s. When the viscosity is in this range, even if the disinfectant solution adheres to the skin such as hands, it does not immediately run off, and it is easy to spread when spreading.

The content ratio of the thickening compound is preferably 0.1% by weight to 20% by weight, more preferably 0.2% by weight to 15% by weight, most preferably 0.5% by weight to 10% by weight with respect to the disinfectant. .. When the content ratio of the thickening compound is in this range, even if the disinfectant solution adheres to the skin such as hands, it does not immediately run off, it is easy to spread when spreading, and it is evenly dispersed in the disinfectant. You can

In the viscous disinfectant of the present invention, in addition to the above-mentioned components, if necessary, polyhydric alcohol which is a moisturizing agent such as glycerin, propylene glycol, butylene glycol, and sorbit, a foaming agent such as carbonate, and a nonionic agent. It is also possible to add a surface active agent such as a cationic/anionic/cationic agent, an antioxidant such as BHT, a pH adjusting agent, a buffering agent, a perfume and a dye.

Hereinafter, examples of the present invention will be specifically described. The present invention is not limited to the examples below. Also, the expression indicating the numerical range includes an upper limit and a lower limit.

<Example 1>
In a Griffin beaker with a capacity of 200 ml, 55.0 g of ethanol, 1.0 g of phosphoric acid, 0.5 g of trisodium phosphate, 2.0 g of glycerin, hydroxyethyl cellulose (manufactured by Daicel Finechem, trade name: HEC Daicel SE900) (1.0 g) and purified water (32.5 g) were added, and the mixture was stirred until a uniform colorless and transparent solution was obtained to obtain a total of 92.0 g of the disinfectant.

<Example 2>
As a thickening compound, a total of 92.0 g of disinfectant was obtained in the same manner as in Example 1 except that 1.0 g of hydroxypropyl cellulose (manufactured by Nippon Soda Co., Ltd., trade name: HPC-H) was used.

<Example 3>
A total of 92.0 g of a disinfectant was obtained in the same manner as in Example 1 except that 1.0 g of hydroxypropylmethyl cellulose (trade name: METOLOSE 65SH-4000 manufactured by Shin-Etsu Chemical Co., Ltd.) was used as the thickening compound.

<Example 4>
As a thickening compound, a total of 92.0 g of a disinfectant was obtained in the same manner as in Example 1 except that stearoxyhydroxypropylmethylcellulose (manufactured by Daido Kasei Kogyo Co., Ltd., trade name: Sangerose) was 1.0 g.

<Example 5>
A total of 92.0 g of disinfectant was obtained in the same manner as in Example 1 except that phosphoric acid was 2.0 g and purified water was 31.5 g.

<Example 6>
A total of 90.6 g of a disinfectant was obtained in the same manner as in Example 1 except that 0.5 g of phosphoric acid, 0.3 g of trisodium phosphate and 31.8 g of purified water were used.

<Example 7>
A total of 89.8 g of disinfectant was obtained in the same manner as in Example 1 except that 70.0 g of ethanol, 1.5 g of phosphoric acid, 1.3 g of trisodium phosphate and 14.0 g of purified water were used. ..

<Example 8>
A total of 93.0 g of disinfectant was obtained in the same manner as in Example 1 except that 1.0 g of lactic acid and 34.0 g of purified water were used instead of adding phosphoric acid and trisodium phosphate.

<Example 9>
A total of 93.0 g of disinfectant was obtained in the same manner as in Example 1 except that citric acid was 1.0 g and purified water was 34.0 g instead of adding phosphoric acid and trisodium phosphate.

<Comparative Example 1>
A total of 92.0 g of disinfectant was obtained in the same manner as in Example 1 except that sodium polyacrylate was 1.0 g instead of hydroxyethyl cellulose.

<Comparative example 2>
A total of 92.0 g of the disinfectant was obtained in the same manner as in Example 1 except that sodium alginate was changed to 1.0 g instead of hydroxyethyl cellulose.

<Comparative example 3>
A total of 92.0 g of the disinfectant was obtained in the same manner as in Example 1 except that 1.0 g of carboxyvinyl polymer was used instead of hydroxyethyl cellulose.

<Comparative example 4>
A total of 92.0 g of the disinfectant was obtained in the same manner as in Example 1 except that carboxymethyl cellulose was replaced by 1.0 g instead of hydroxyethyl cellulose.

<Comparative Example 5>
A total of 92.0 g of disinfectant was obtained in the same manner as in Example 1 except that xanthan gum was 1.0 g instead of hydroxyethyl cellulose.

The compositions of Examples 1 to 9 and Comparative Examples 1 to 5 are summarized in Table 1.

The evaluation method of the disinfectant was confirmed by the following method.

Regarding the appearance, the compounded disinfectant was left standing for 1 hour and visually confirmed. A colorless and transparent product was evaluated as ◯, white turbidity and dullness were slightly evaluated as Δ, and white turbidity, dullness, and precipitate were significantly evaluated as x. Among these, ◯ and Δ were judged to be good, and x was judged to be bad. The results are also shown in Table 1.

Regarding pH, pH 7 (neutral phosphate) standard solution (pH 6.86 at 25°C) is set as a zero point, and pH 4 (phthalate) standard solution (pH 4.01 at 25°C) or pH 9 (borate) ) Using a pH meter (manufactured by Horiba, Ltd., trade name F-52) calibrated with a standard solution (pH 9.18 at 25°C), the value was corrected to 25°C and measured. The results are also shown in Table 1.

The feeling of use was evaluated by sensory feeling when the compounded disinfectant was dropped on the palm and spread. An object without any stickiness or stickiness was evaluated as ◯, an object which felt a little stickiness was evaluated as Δ, and an object having at least one of stickiness or stickiness was evaluated as x. Among these, ◯ and Δ were judged to be good, and x was judged to be bad. The results are also shown in Table 1.

Further, the disinfectants of Examples 1 to 9 were allowed to stand in a thermostatic chamber at 40°C for 6 months, and then evaluated for appearance, viscosity, pH, and feeling of use in the same manner as above. The criteria for judging the appearance and feeling of use are as described above.

As shown in Table 1, in the disinfectants of Examples 1 to 9, even if a thickener was added, immediately after compounding, it was dissolved into a uniform colorless clear solution without clouding and precipitation. It was possible to obtain a good feeling of use without causing sticking or sticking, which is a pasty product that could occur when rubbing cosmetics or cosmetics into the hand. On the other hand, in the disinfectants of Comparative Examples 2 to 5, white turbidity, dullness, and precipitates were largely generated in the appearance after 1 hour from blending, and physical properties such as viscosity and pH and sensory evaluation of usability cannot be performed. It was In addition, the disinfectant of Comparative Example 1 was colorless and clear in appearance one hour after the compounding, but it was sticky in use and was not actually usable. Further, when an accelerated test was carried out on the storage stability in a thermostatic chamber at 40° C., the disinfectant of Example 1 was colorless and clear in appearance and was good with no change, which was a more preferable result.

The compositions of Examples 1 to 7 and Comparative Examples 1 to 5 are summarized in Table 1.

As shown in Table 1, in the disinfectants of Examples 1 to 7 , even if a thickener was added, immediately after compounding, it was dissolved into a uniform colorless clear solution without clouding and precipitation. It was possible to obtain a good feeling of use without sticking or sticking, which is a pasty substance that could occur when the agent or cosmetic was rubbed into the hand. On the other hand, in the disinfectants of Comparative Examples 2 to 5, white turbidity, dullness, and precipitates were largely generated in the appearance one hour after blending, and physical properties such as viscosity, pH, and sensory evaluation of usability can be performed. Was not. In addition, the disinfectant of Comparative Example 1 was colorless and clear in appearance one hour after the compounding, and was good, but it was sticky in use and was not actually usable. Furthermore, when an accelerated test was carried out on the storage stability in a thermostatic chamber at 40° C., the disinfectant of Example 1 was colorless and clear in appearance and was good with no change, which was a more preferable result.

Claims (3)

With ethanol,
With phosphoric acid,
With sodium or potassium salt of phosphoric acid,
A viscous disinfectant containing a thickening compound represented by the following formula (1):
The content ratio of the thickening compound is 0.1% by weight to 20% by weight,
A viscous disinfectant having a pH at 25°C of 2.5 to 5.0.

[Wherein, R ¹ , R ² , R ³ , R ⁴ , R ⁵ and R ⁶ are each a hydrogen atom, a lower alkyl group, a hydroxyethyl group: -[CH ₂ CH ₂ O] _m H, a hydroxypropyl group: _{- [CH 2 CH (CH 3} ) O] m H, _{group: -CH 2 CH (OH) CH} 2 O-C k H 2k + 1, based _{on: - [CH 2 CH (OH} ) CH 2 O] m - C _k H _{2k + 1,} or a group: - a one of _{[CH 2 CH 2 O] m} CH 2 CH (OH) CH 2 O-C k H 2k + 1. However, the case where all are simultaneously hydrogen atoms or lower alkyl groups is excluded. n is an integer of 50 to 5000, m is an integer of 1 to 10, and k is an integer of 6 to 22. ] The viscous disinfectant according to claim 1, wherein the ethanol is contained in an amount of 40% by weight to 99% by weight. The viscous disinfectant according to claim 1 or 2, wherein the viscosity at 25°C is 100 to 6000 mPa·s.