JP2020097536A - Oral product - Google Patents

Abstract

To provide an oral product that makes it possible to visually grasp a buffer ability of saliva, and resists color fading during its storage to show good temporal stability, and is suitable for inspection of a saliva buffer ability.SOLUTION: An oral product has a powder composition containing (A) anthocyanin dye powder and (B) an inorganic base that is solid at 5-40°C, the powder composition being charged into a moisture-proof container. The powder composition further has either one or both of (C) a humectant that is solid at 5-40°C and (D) a bactericidal antibacterial that is solid at 5-40°C.SELECTED DRAWING: None

Description

TECHNICAL FIELD The present invention relates to a product for oral cavity, which is suitable for inspection of saliva buffering capacity, since the buffering capacity of saliva is visually grasped.

Nowadays, there is a demand for extension of healthy life expectancy, and also in the oral field, there is a demand for a technique and a product for preventing the occurrence of oral defects such as tooth decay, periodontal disease and bad breath before they become apparent. As a means to encourage consumers to voluntarily take preventive actions against problems in the oral cavity, it is thought that it is necessary to have them grasp the health condition of their oral cavity by visual check, etc. There were few means on the market to check daily oral health condition easily and inexpensively.
By the way, saliva has a buffering action for keeping the oral cavity neutral (around pH 7) when it contains an alkali or an acid, and this buffering action affects the oral health condition, and It is considered that it is also involved in prevention, and that the consumer correctly understands the saliva buffering ability as his saliva force, it is possible to easily judge the health condition in the oral cavity and prevent the above oral malfunctions. Since it is expensive, it was desired to develop an accurate and simple grasping method.

Patent Document 1 (Japanese Patent Publication No. 2015-500348) discloses a first component containing an immobilized sparingly soluble acid or base (for example, solid particles or a matrix containing a sparingly soluble acid or base) and an inert liquid, if necessary. An oral care, skin care or home care composition containing a second component comprising a different inert liquid, one or more further components, wherein the inert liquid immobilizes a poorly soluble acid during storage. It proposes a composition that does not come into contact with a base, but when used, the inactive liquid comes into contact with the immobilized sparingly soluble acid or base to change the pH of the solution, and anthocyanin is described as the inactive liquid. Patent Document 2 (Japanese Patent Laid-Open No. 2001-299298) discloses a beverage in which a fruit or the like is added to a beverage to lower the pH and the color tone of the anthocyanin pigment contained in the beverage is changed to change the color tone of the beverage. Proposed, Patent Document 3 (JP 2012-219049A) proposes a dentifrice composition containing an anthocyanin dye and a silica-based abrasive, and realizing a color change during use.

Japanese Patent Publication No. 2015-500348 JP, 2001-299298, A JP 2012-219049 A

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide an oral product that can visually and clearly grasp the saliva buffering capacity and is suitable for testing the saliva buffering capacity.

As a result of earnest studies to achieve the above object, the present inventors have found that a powder composition containing (A) anthocyanin pigment powder and (B) a solid inorganic base at 5 to 40° C. is moisture-proof. It was found that the above-mentioned problems and objects can be achieved by the oral cavity product filled in the container. That is, in the present invention, the oral product, in particular, the powder composition taken out from the moisture-proof container at the time of use is dissolved in water to be used as a liquid preparation, and the oral preparation is rinsed with the liquid preparation. When applied to, the saliva buffering ability can be visually clearly and easily grasped by distinguishing the strength of the saliva buffering effect from the color change of the preparation, and the fading of the powder composition above can be observed when the product is stored. The present invention has been completed on the basis of the finding that it is possible to provide stability over time by suppressing the above, and thus it can be applied to the test of saliva buffering capacity of an individual.

Among the flavonoid pigments, the anthocyanin pigment is known as a food additive and is also known to have a remarkable change in color tone due to pH, but it is difficult to stabilize and is not only weak against light and heat, but also depending on the pH. It also decomposed quickly and sometimes faded. However, in the present invention, the powder composition in which the component (A) and the component (B) are used together in a powder state is filled in a moisture-proof container, taken out from the container at the time of use, and dissolved in water to be used as a liquid preparation or the like. As a result, the component (A) is moderately stabilized, and the effect of distinguishing the saliva buffering capacity in the oral cavity can be improved by the degree of color change due to the component (A), and thus the saliva buffering capacity can be visually recognized easily. It was possible to obtain an oral product which has excellent discriminating ability and which is suppressed in fading during storage and has good stability over time. In this case, it is particularly preferable that (A)/(B), which represents the amount ratio of the components (A) and (B), be in a specific range as a mass ratio, and further that the pH of the liquid preparation be in a specific range. It was possible to more easily understand the discrimination of Noh, and it was possible to give more excellent effects.
The effect of the present invention is specifically obtained by the combined use of the components (A) and (B), and is poor when the component (A) or (B) is lacking, and the components (A) and (B) are used in combination. However, it was inferior when filled in an inappropriate container. As shown in Comparative Examples described later, when the component (A) or the component (B) was lacking, the saliva buffering ability was poorly understood (Comparative Examples 1 to 3 and 5 to 7). When the component (A) is lacking, curcumin, which is a turmeric pigment that is a flavonoid-based pigment as in the component (A), and carminic acid, which is a cotinyl pigment that is a polyphenol as in the component (A), are used, Even if the pH is appropriate, the saliva buffering ability is poorly understood (Comparative Examples 2 and 3), and when the component (B) is lacking, monoethanolamine (liquid organic base) or sodium hydroxide, which is a base, is used. Even if the pH of the aqueous solution was appropriate, including the aqueous solution (liquid inorganic base), the saliva buffering ability was inferior (Comparative Examples 5, 6, and 7). In addition, even if the components (A) and (B) were used in combination, the saliva buffering ability was poorly understood when the filling container was non-moisture proof (Comparative Example 4). On the other hand, the oral products of the present invention shown in the Examples were excellent in the saliva buffering ability, and were stable in time (no discoloration).

In the present invention, an oral moisturizing effect can be imparted to the powder composition by further adding (C) a solid wetting agent at 5 to 40°C, and further (D) at 5 to 40°C. By incorporating a solid bactericidal antibacterial agent, it is possible to impart a breath odor suppressing effect, and by these, it is possible to simultaneously perform oral care.

Therefore, the present invention provides the following oral products.
[1]
An oral product in which a moisture-proof container is filled with a powder composition containing (A) anthocyanin-based pigment powder and (B) a solid inorganic base at 5 to 40°C.
[2]
(B) The solid inorganic base at 5 to 40° C. is sodium carbonate, potassium carbonate, sodium hydrogencarbonate, potassium hydrogencarbonate, sodium dihydrogenphosphate, disodium hydrogenphosphate, sodium hydroxide, potassium hydroxide and hydroxylation. The oral product according to [1], which is one or more inorganic base powders selected from lithium.
[3]
(B) The oral product according to [2], wherein the inorganic base solid at 5 to 40° C. is selected from sodium carbonate, potassium carbonate, sodium hydroxide and potassium hydroxide.
[4]
(A)/(B) is 0.01-12.5 as a mass ratio, The product for oral cavity in any one of [1]-[3].
[5]
The oral product according to any one of [1] to [4], wherein the powder composition further contains (C) a wetting agent that is solid at 5 to 40°C.
[6]
The oral product according to any one of [1] to [5], wherein the powder composition further contains (D) a bactericidal antibacterial agent which is solid at 5 to 40°C.
[7]
The oral cavity according to any one of [1] to [6], wherein the moisture-proof container is a sealable container formed of a moisture-proof film having aluminum vapor deposition or a sealable synthetic resin container containing a desiccant. For products.
[8]
The oral product according to any one of [1] to [7], which is used as a liquid preparation by dissolving the powder composition taken out from the moisture-proof container at the time of use in water.
[9]
The oral product according to [8], wherein the liquid formulation has a pH of 8 to 10 at 25°C.
[10]
The oral product according to [8] or [9], wherein the liquid preparation is a mouthwash.
[11]
The oral product according to any one of [1] to [10], which is for testing saliva buffering capacity.

ADVANTAGE OF THE INVENTION According to this invention, the buffering ability of saliva can be grasped|ascertained visually, fading is suppressed at the time of storage, stability over time is also good, and the oral cavity product suitable for a test|inspection of saliva buffering ability can be provided. This oral product can clearly and easily grasp the saliva buffering capacity, and can also give an excellent oral moisturizing effect and bad breath control effect. It can also be used.

Hereinafter, the present invention will be described in more detail. The oral cavity product of the present invention is obtained by filling a moisture-proof container with (A) anthocyanin-based pigment powder and (B) a powder composition containing a solid inorganic base at 5 to 40°C. This oral product is suitable for testing saliva buffering capacity.

The (A) anthocyanin pigment is a general term for water-soluble pigments widely existing in the plant kingdom such as flowers, fruits, and leaves, and exhibits colors such as red, purple, and blue. Anthocyanidins exist as aglycones in the form of glycosides linked to sugars and sugar chains. It is abundant in perilla, radish, red cabbage, red turnip, purple potato, etc. Anthocyanin dyes are known as food additives, and in particular, the color tone changes at pH 6 to 10, and generally has the property of exhibiting red color when acidic and blue color when alkaline.

As the (A) anthocyanin dye, a commercially available product may be used, and a dye containing this may be used. Specifically, San Red YM (purple potato dye 43 mass%/citric acid (crystal) 7 mass%/dextrin 50) manufactured by San-Ei Gen FFI Co., Ltd., which is a widely used food additive. %) and Sun Red RCU (red cabbage pigment 36% by mass/citric acid (crystal) 4% by mass/powdered starch syrup 60% by mass) and the like are preferable.
Incidentally, instead of the component (A), when curcumin, which is a turmeric dye even if it is a flavonoid system like an anthocyanin dye, is used, or when carminic acid is a cotinyl dye, even when it is a polyphenol like an anthocyanin dye. When it is used or when the rack dye is used, the color change at pH 6 to 10 is unclear, and the saliva buffering capacity cannot be determined and cannot be grasped (see Comparative Examples 2 and 3 described later).

The blending amount of the component (A) is preferably 0.06 to 41.6% (mass %, the same applies below) of the entire powder composition, and more preferably 0.13 to 39.5%.
Further, when the powder composition contains the components (A) and (B) and does not contain the components (C) and (D), the amount of the component (A) to be added is 1.0 to 10% of the total amount of the powder composition. 41.6%, especially 18.0 to 39.5% is preferable. Further, when the powder composition contains the components (A), (B) and (C), and further the component (D), the blending amount of the component (A) is 0.06 to 2 of the entire powder composition. 0.5%, particularly 0.13 to 0.65% is preferable.
When the blending amount of the component (A) is within the above range, the color change is clear and the saliva buffering ability is sufficiently distinguished.

When the powder composition is used by dissolving it in 20 mL of water, the amount of the component (A) is preferably 0.2 to 20 mg, particularly 1 to 10 mg, and especially 1.0 to 5.0 mg. It is desirable to set the blending amount of the component (A) in the powder composition within the range that satisfies this. Within the above range, the color change is clear, the saliva buffering capacity is more easily discriminated, and sufficient temporal stability is obtained.

The component (B) is a solid inorganic base at 5 to 40°C. In the present invention, the component (B) improves the action of discriminating the saliva buffering ability of the component (A). Further, the component (B) has a function of adjusting the pH of the liquid preparation after the powder composition is dissolved in water. If an inappropriate base such as an organic base or an inorganic base that is liquid at 5 to 40° C. is used instead of the component (B), even if the pH of the aqueous solution after dissolving the powder composition in water is appropriate, The saliva buffering capacity cannot be satisfactorily discriminated, and the temporal stability (no discoloration) of the powder composition deteriorates, so that the effects of the present invention cannot be obtained.

(B) As the inorganic base which is solid at 5 to 40° C., an alkali metal salt of carbonic acid or phosphoric acid (or a hydrogen salt may be used) or an alkali metal hydroxide may be used, and the alkali metal is sodium, potassium, sodium or the like. Is. Particularly, an alkali metal salt of carbonic acid and a hydroxide of alkali metal are preferable, and an alkali metal salt of carbonic acid is more preferable.
Examples of the component (B) include sodium carbonate, potassium carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium hydroxide, potassium hydroxide, lithium hydroxide, and the like. One or more inorganic base powders selected from the above can be used. Among these, sodium carbonate, potassium carbonate, sodium hydrogen carbonate, sodium hydroxide can be uniformly mixed as a powder, and can be raised to pH 8 to 10 (25° C.) where the saliva buffering ability due to color tone change is easy to understand. , Potassium hydroxide is preferable, and especially sodium carbonate, potassium carbonate, sodium hydroxide, and hydroxide can be raised from the viewpoint that the saliva buffering capacity due to the change in color tone can be easily raised to pH 8.5 to 10 (25° C.). More preferred is potassium. Especially, sodium carbonate is preferable from the viewpoint of low deliquescent property.

The blending amount of the component (B) is preferably adjusted according to the blending amount of the component (A), and particularly preferably within the range where the ratio of the amounts of the two components is appropriate. The content of the component (B) is preferably 0.04 to 97.8%, and more preferably 0.08 to 58% of the total powder composition.
Furthermore, when the powder composition contains the components (A) and (B) and does not contain the components (C) and (D), the blending amount of the component (B) is 3.3 to 10% of the total amount of the powder composition. 97.8%, particularly 9.0 to 58.0% is preferable. When the powder composition contains the components (C) and (D) in addition to the components (A) and (B), the content of the component (B) is 0 in the whole powder composition. 0.04 to 1.5%, especially 0.08 to 0.4% is preferable.
When the blending amount of the component (B) is within the above range, the saliva buffering capacity can be determined sufficiently easily.

In addition, the amount of the component (B) used is preferably 0.2 to 200 mg, particularly 0.4 to 80 mg when the powder composition is dissolved in 20 mL of water and used. It is desirable to set the blending amount of the component (B) in the body composition. Within the above range, the color change is clear, the saliva buffering capacity is more easily discriminated, and sufficient temporal stability is obtained.
Furthermore, when an inorganic base selected from sodium carbonate, potassium carbonate, sodium hydroxide, lithium hydroxide and potassium hydroxide is used as the component (B), these are used in such amounts that the powder composition is dissolved in 20 mL of water. When used, it is preferably 0.2 to 4.0 mg, more preferably 0.4 to 2.0 mg. Within this range, the saliva buffering capacity can be discriminated sufficiently easily. If the amount used is less than 0.2 mg or more than 4.0 mg, an aqueous solution having a desired pH range cannot be obtained when dissolved in water, and the saliva buffering capacity may not be determined.
When an inorganic base selected from hydrogen salts such as sodium hydrogencarbonate, potassium hydrogencarbonate, sodium dihydrogenphosphate, and disodium hydrogenphosphate is used as the component (B), the amount of these used depends on the powder composition. When used by dissolving in 20 mL of water, 20 to 200 mg is preferable, and 40 to 80 mg is more preferable. Within this range, the saliva buffering capacity can be discriminated sufficiently easily. If the amount used is less than 20 mg, an aqueous solution having a desired pH range may not be obtained when dissolved in water, and the saliva buffering capacity may not be discriminated. If it exceeds 200 mg, solubility in water may be poor.

In the present invention, (A)/(B), which indicates the amount ratio of the component (A) and the component (B), is 0.01 to 12. as a mass ratio, particularly from the viewpoint of easy discrimination of saliva buffering capacity. 5 is preferable, and 0.31 to 4.33 is more preferable. Within the above range, the saliva buffering ability is more easily understood.

In the present invention, in addition to the components (A) and (B), the powder composition preferably further comprises (C) a solid wetting agent at 5 to 40°C. By adding the component (C), an excellent effect of moisturizing in the oral cavity can be imparted.

As the wetting agent (C) solid at 5 to 40° C., one or more sugar alcohols such as sorbitol, trehalose, xylitol, maltitol, lactitol, and erythritol can be used, and powders thereof are preferable. Of these, sorbitol, xylitol, and trehalose are preferable, and sorbitol and xylitol are more preferable, from the viewpoint of solubility.

As the component (C), a commercially available product can be used. Specifically, sorbit (D-sorbitol, LTS-PG-3, manufactured by Mitsubishi Corporation Foodtech Co., Ltd.), trehalose (manufactured by Hayashibara Corporation), xylitol (xylitol powder, manufactured by Mitsubishi Corporation Foodtech Co., Ltd.), etc. Can be used.

When the component (C) is blended, its blending amount is preferably 90.0 to 99.81% of the entire powder composition.
Furthermore, when the component (C) is blended and the component (D) is not included, the blending amount of the component (C) is preferably 93.0 to 99.81% of the entire powder composition, and more preferably 95. 7-99.5% is preferable. When the component (D) is included, the content of the component (C) is preferably 92.7 to 98.7%, and more preferably 96.7 to 98.6% of the entire powder composition.
When the blending amount of the component (C) is within the above range, a sufficient moisturizing effect can be imparted.

The amount of the component (C) used is preferably 100 to 4,000 mg, particularly 500 to 4,000 mg, and especially 500 to 2,000 mg when the powder composition is used by dissolving it in 20 mL of water. It is desirable to set the blending amount of the component (C) in the powder composition within the range that satisfies the above conditions. Within the above range, a sufficient moisturizing effect can be obtained. When the content is 100 mg or more, the discriminability of the saliva buffering capacity is further improved, and the moisturizing effect is sufficiently obtained. When it is 4,000 mg or less, the solubility in water can be sufficiently ensured.

In the present invention, a solid germicidal antibacterial agent (D) at 5 to 40°C can be further added to the powder composition. By adding the component (D), it is possible to impart an excellent effect of suppressing bad breath.
As the sterilizing and antibacterial agent (D) solid at 5 to 40°C, known bactericidal agents and antibacterial agents for oral cavity can be used. For example, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, chlorhexidine hydrochloride, cationic fungicides such as berberine chloride, amphoteric fungicides such as alkyldiaminoethylglycine hydrochloride, copper gluconate, sodium copper chlorophyllin, copper sulfate, Examples thereof include water-soluble copper compounds and zinc compounds having a germicidal antibacterial action such as zinc chloride and zinc citrate, and one or more selected from these can be used, and powders thereof are preferable. Among these, cetylpyridinium chloride, benzalkonium chloride, and benzethonium chloride, which have a small amount and have a high bactericidal and antibacterial effect, are preferable.

When the component (D) is blended, the blending amount thereof is preferably 0.19 to 1.23%, and more preferably 0.20 to 1.0%, based on the entire powder composition. Within the above range, a sufficient bad breath suppressing effect can be imparted.

The amount of component (D) used is preferably 0.2 to 50 mg, particularly 1.0 to 50 mg, and especially 1.5 to 20 mg when the powder composition is used by dissolving it in 20 mL of water. It is desirable to set the blending amount of the component (D) in the powder composition within the range that satisfies the condition. Within the above range, a sufficient bad breath suppressing effect can be obtained. When the amount used is 0.2 mg or more, a sufficient breath odor suppressing effect can be obtained, and when the amount is 50 mg or less, sufficient solubility in water can be secured.

In the present invention, the total amount of the powder composition can be within the range of the total amount of the components used when the powder composition is dissolved in 20 mL of water and used.
The total amount of components (A) and (B) is preferably in the range of 0.4 to 400 mg when the powder composition is used by dissolving it in 20 mL of water.
When the component (C) is blended in addition to the components (A) and (B), the total amount thereof is preferably 100.4 to 4,220 mg when the powder composition is dissolved in 20 mL of water before use. It is a range.
When the components (C) and (D) are blended in addition to the components (A) and (B), the total amount thereof is preferably 100.6 to 10 when the powder composition is used by dissolving it in 20 mL of water. It is in the range of 4,270 mg.

In the powder composition according to the present invention, known components that can be used for the oral cavity can be added in addition to the above components within a range that does not impair the effects of the present invention. For example, starch, carrageenan, gellan gum, natural polymeric substances such as xanthan gum, sodium carboxymethyl cellulose usable for oral composition, synthetic polymeric substances such as hydroxypropylmethyl cellulose, polysaccharides such as dextrin, extracts, and fragrances. These may be used alone or in combination of two or more.
The total amount of the powder composition to be filled in the moisture-proof container is preferably 100 to 4,200 mg, more preferably 500 to 2,100 mg, from the viewpoint of easy determination of saliva buffering capacity and stability over time.

The moisture-proof container filled and sealed with the powder composition according to the present invention is not particularly limited as long as it has moisture-proof property, but a sealable film formed of a moisture-proof film such as a film in which aluminum vapor deposition is applied to at least the inner layer of the container. It is preferable to use a cylindrical container or a bag-shaped container made of a sealable synthetic resin (for example, polyethylene, polypropylene, etc.) containing a desiccant such as silica gel or alumina gel. When the powder composition is filled in a container containing the desiccant, it is desirable to store and package the powder composition together with the desiccant. By using such a moisture-proof container, discoloration of the powder composition due to the component (A) can be sufficiently prevented and stabilized even over time, and the discriminability of saliva buffering ability can be improved. Of these, a sealable film-like container formed of the moisture-proof film is preferable from the viewpoint of stability over time (no discoloration) and manufacturability of the powder composition. The moisture-proof container is preferably hermetically packaged with a sealer or the like after filling the powder composition.
As the moisture-proof container, a commercially available product can be used. For example, as an aluminum vapor deposition film which is a moisture-proof film, JYK5K5, HNZ8K5 manufactured by Toppan Printing Co., Ltd., VM-CPP, VM-OPP, VM-PET manufactured by Toray Film Co., Ltd., etc. And a container formed of these can be used.

The oral product of the present invention is preferably used as a liquid preparation by dissolving the powder composition in water when used in the oral cavity, and more preferably used as a mouthwash. In this case, the oral product can be used as a liquid oral preparation by opening the moisture-proof container, filling and taking out all the sealed powder composition, and dissolving it in an appropriate amount of water.
The powder composition is preferably used by dissolving it in an appropriate amount of water within a range satisfying the use amounts of the above components. When the powder composition contains the component (C), it is preferably dissolved in water in an amount of 2 to 250 times, particularly 25 to 200 times, and when the powder composition does not contain the component (C), it is 500 to It is preferable to use it after dissolving it in 20,000-fold amount, especially 1,000-10,000-fold amount of water.

The pH (25° C.) of the liquid preparation after dissolution in water is preferably 8 to 10, particularly 8.5 to 10 from the viewpoint of easy understanding of saliva buffering ability. Within the above range, the saliva buffering ability is more easily understood.

The oral product of the present invention is used in a liquid formulation as described above, for example, 5 to 50 mL of the liquid formulation is contained in the mouth, and the oral cavity is rinsed and exhaled several times by a usual method, and the color change at that time causes a change. It is possible to judge and grasp the saliva buffering capacity of an individual. It can be determined that the saliva buffering power is weaker as it is closer to blue and stronger as it is closer to red. It is desirable to contain 10 to 30 mL in the mouth from the viewpoint of easy judgment of the saliva buffering capacity.

Hereinafter, the present invention will be specifically described by showing Examples and Comparative Examples, but the present invention is not limited to the following Examples. In the following examples,% means mass% unless otherwise specified.

[Examples and Comparative Examples]
A composition was prepared by using the components shown in Tables 1 to 8 by the following method, put into a container and packaged to obtain an oral product. With respect to the obtained oral products, the intelligibility of saliva buffering ability and the stability over time (no discoloration) were evaluated by the following methods. Further, the oral products shown in Tables 5 and 6 were evaluated for the oral moisturizing effect by the following method, and the oral products shown in Tables 7 and 8 were evaluated for the oral moisturizing effect and the bad breath suppressing effect by the following methods. did. The results are also shown in Tables 1-8.

<Manufacturing method>
Manufacturing method of Examples 1-10, 12-31 and Comparative Examples 1-3, 5-7:
The amounts of the components (A) and (B) shown in the table, and further the components (C) and (D), were weighed using a precision balance (MS-TS analytical balance, manufactured by METTLER TRADE Co., Ltd.) to obtain a composition ( Powder), and formed with an aluminum vapor-deposited film (constitution; polyethylene terephthalate 12 μm/aluminum 7 μm/axially stretched polypropylene 40 μm, product name: HNZ8K5, manufactured by Toppan Printing Co., Ltd.)) in order from the outermost layer. A film-like container (hereinafter abbreviated as an aluminum vapor-deposited film) was filled and hermetically sealed using a sealer (manufactured by Fuji Impulse Co., Ltd., model: FIK-300). For Comparative Example, a composition was prepared according to the above method, similarly filled in a container, sealed and packaged. The compositions of Comparative Examples 1 to 5 were powders, whereas the compositions of Comparative Examples 6 and 7 were liquids.
Manufacturing method of Example 11:
The components (A) and (B) in the amounts shown in the table were each weighed using a precision balance (MS-TS analytical balance, manufactured by METTLER TRADE CO., LTD.) to prepare a composition (powder), and then polyethylene in the container. A bag (product CD: FPE-B9-80 (50 mm×70 mm, thickness 40 μm), manufactured by Just Corporation), a polyethylene bag (product CD: FPE-S-40 (40 mm×55 mm, thickness 40 μm), Just Corporation) 0.5 g of silica gel (manufactured by Kanto Kagaku Co., Ltd.) placed in and sealed in (manufactured by K.K.) was filled (hereinafter abbreviated as silica gel-containing polyethylene bag), and sealed and packaged.
Manufacturing method of Comparative Example 4:
The components (A) and (B) in the amounts shown in the table were each weighed using a precision balance (MS-TS analytical balance, manufactured by METTLER TRADE CO., LTD.) to prepare a composition (powder), and then polyethylene in the container. A bag (product CD: FPE-S-40 (40 mm×55 mm, thickness 40 μm) manufactured by Just Corporation Co., Ltd.) was filled, sealed and packaged.

In addition, the container of the oral cavity product of each example was opened, the composition was taken out, and the pH (25° C.) of the aqueous solution after being dissolved in 20 mL of tap water at 25° C. was adjusted to Compact PH meter LAQUATwin-PH-22B, Inc. Measured by Horiba, Ltd., and also shown in the table.

<Evaluation method of saliva buffering ability for easy understanding>
The container of the oral product of each example was opened, the composition was taken out, and dissolved in 20 mL of tap water at 25°C. Each of the nine test subjects contained 20 mL of the obtained aqueous solution in their mouth, rinsed the inside of the mouth 10 times, then vomited, and judged the saliva buffering capacity from the color change of the preparation. The aqueous solution taken out of the container and dissolved in water (before containing it in the mouth for use) was blue.
Regarding the buffer capacity of saliva, it was judged that the closer it was to blue, the weaker the buffering capacity was, and the closer it was to red, the stronger the buffering capacity was. In this judgment of the buffer capacity of saliva, "visual easiness of buffer capacity (ease of recognizing color change of preparation)" was evaluated, and the color change was clearly and clearly recognized and the buffer capacity of saliva was improved. The ones that were easy to understand were judged to be acceptable, and the ease of understanding of the buffer capacity was evaluated based on the following criteria from the number of people who were judged to be acceptable.
Evaluation Criteria ◎: 6 or more people evaluated it as easy to understand ○: 4-5 people evaluated it as easy to understand ×: 3 people or less evaluated it as easy to understand

<Evaluation method of stability over time (no fading)>
After the oral products of each example were stored at room temperature for one week, the container was opened and the composition was taken out, and the appearance change (no discoloration) of the composition compared with the composition immediately after preparation was judged, and the time elapsed according to the following criteria. Stability (no fading) was evaluated.
Evaluation criteria ○: No change and no fading observed ×: Fading observed

<Evaluation method of oral moisturizing effect>
Regarding the oral products of Examples 18 to 31, the container of each product was opened and the composition was taken out and dissolved in 20 mL of tap water at 25°C. Each of the nine test subjects contained 20 mL of the obtained aqueous solution in their mouth, rinsed the inside of the oral cavity 10 times, and then spit out to evaluate the "moisturized feeling in the oral cavity". Those that felt that the oral cavity was moisturized compared to before use were judged to be acceptable, and the oral moisturizing effect was evaluated based on the following criteria from the number of people judged to be acceptable.
Evaluation Criteria ⊚: Eight or more people evaluated that they felt moisturizing feeling after use ○: 6 to 7 people evaluated that they felt moisturized feeling after use Δ: 4 to 5 people evaluated that they felt moisturized feeling after use × : 3 or less people evaluated that they felt moisturizing feeling after use.

<Evaluation method of bad breath control effect>
Regarding the oral products of Examples 25 to 31, the container of each product was opened and the composition was taken out and dissolved in 20 mL of tap water at 25°C. Each of the nine test subjects contained 20 mL of the obtained aqueous solution in their mouth, rinsed the inside of the mouth 10 times, then vomited, and evaluated "feeling that bad breath was suppressed". Those who felt that bad breath was suppressed compared to before use were judged to be acceptable, and the bad breath suppressing effect was evaluated based on the following criteria from the number of people judged to be acceptable.
Evaluation Criteria ⊚: Eight or more people evaluated that the bad breath was suppressed after use. ○: 6 to 7 people evaluated that the bad breath was suppressed after use. Δ: 4 to 5 people felt the bad breath after use. It was evaluated that it felt suppressed. ×: 3 or less people evaluated that they felt that bad breath was suppressed after use.

Details of the raw materials used are shown below.
(A) Powder Sun Red YM (trade name, containing 43% anthocyanin dye, Sanei Gen F.
(Manufactured by FI Corporation)
Powder Sun Red RCU (trade name, containing 36% anthocyanin dye, Sanei Gen F
・F-I Co., Ltd.)
Carminic acid (powder, cochineal dye, comparative ingredient, Saneigen FFI Corporation)
Curcumin (powder, turmeric pigment, comparative ingredient, Sanei Gen FFI Co., Ltd.)
(B) Sodium carbonate (powder, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.)
Sodium hydrogen carbonate (powder, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.)
Sodium hydroxide (powder, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.)
Potassium hydroxide (powder, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.)
Monoethanolamine (comparative component) (liquid organic base, manufactured by Tokyo Chemical Industry Co., Ltd.)
10% sodium hydroxide aqueous solution (comparative component) (manufactured by FUJIFILM Wako Pure Chemical Industries, Ltd.)
(C) Solbit (powder, D-sorbitol, LTS-PG-3, Mitsubishi Foodstuff
KU Co., Ltd.)
Trehalose (powder, manufactured by Hayashibara Co., Ltd.)
Xylitol (Xylit powder, manufactured by Mitsubishi Corporation Foodtech Co., Ltd.)
(D) Cetylpyridinium chloride (powder, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.)
Benzalkonium chloride (powder, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.)

＊；アントシアニン系色素の純分量（以下同様）
＊＊；（Ａ）成分のアントシアニン系色素としての量／（Ｂ）成分量（以下同様）

*: Pure amount of anthocyanin dye (same below)
**: Amount of component (A) as anthocyanin dye/amount of component (B) (same below)

＊＊＊；液状の組成物

*** Liquid composition

Claims (11)

An oral product in which a moisture-proof container is filled with a powder composition containing (A) anthocyanin-based pigment powder and (B) a solid inorganic base at 5 to 40°C. (B) The solid inorganic base at 5 to 40° C. is sodium carbonate, potassium carbonate, sodium hydrogencarbonate, potassium hydrogencarbonate, sodium dihydrogenphosphate, disodium hydrogenphosphate, sodium hydroxide, potassium hydroxide and hydroxylation. The oral product according to claim 1, which is one or more kinds of inorganic base powder selected from lithium. The oral product according to claim 2, wherein the inorganic base (B) which is solid at 5 to 40°C is selected from sodium carbonate, potassium carbonate, sodium hydroxide and potassium hydroxide. The oral product according to any one of claims 1 to 3, wherein (A)/(B) has a mass ratio of 0.01 to 12.5. The oral composition according to any one of claims 1 to 4, wherein the powder composition further contains (C) a wetting agent that is solid at 5 to 40°C. The oral product according to any one of claims 1 to 5, wherein the powder composition further contains (D) a bactericidal antibacterial agent which is solid at 5 to 40°C. The oral cavity according to any one of claims 1 to 6, wherein the moisture-proof container is a sealable container formed of a moisture-proof film having aluminum vapor deposition or a sealable synthetic resin container containing a desiccant. Product. The oral product according to any one of claims 1 to 7, which is used as a liquid preparation by dissolving the powder composition taken out of the moisture-proof container at the time of use in water. The oral product according to claim 8, wherein the pH of the liquid preparation at 25°C is 8 to 10. The oral product according to claim 8 or 9, wherein the liquid preparation is a mouthwash. The oral product according to any one of claims 1 to 10, which is for testing saliva buffering ability.