JP2020079307A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020079307A5 JP2020079307A5 JP2020029699A JP2020029699A JP2020079307A5 JP 2020079307 A5 JP2020079307 A5 JP 2020079307A5 JP 2020029699 A JP2020029699 A JP 2020029699A JP 2020029699 A JP2020029699 A JP 2020029699A JP 2020079307 A5 JP2020079307 A5 JP 2020079307A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- hydroxy
- acetamide
- inden
- dimethoxybenzylidene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- -1 thiazepanyl Chemical group 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 239000000651 prodrug Substances 0.000 claims 10
- 229940002612 prodrug Drugs 0.000 claims 10
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- 150000002431 hydrogen Chemical class 0.000 claims 8
- 125000001425 triazolyl group Chemical group 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical class OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 125000001188 haloalkyl group Chemical group 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Natural products OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 3
- 239000005711 Benzoic acid Substances 0.000 claims 3
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 3
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 claims 3
- 229910000147 aluminium phosphate Chemical class 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 125000005199 aryl carbonyloxy group Chemical group 0.000 claims 3
- 125000005200 aryloxy carbonyloxy group Chemical group 0.000 claims 3
- 235000010233 benzoic acid Nutrition 0.000 claims 3
- 150000001558 benzoic acid derivatives Chemical class 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 102000016914 ras Proteins Human genes 0.000 claims 2
- 108010014186 ras Proteins Proteins 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- XAUGGEJFEMACPG-FBHDLOMBSA-N 2-[(3Z)-3-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-6-methoxy-2-methylinden-1-yl]-N-(1H-pyrrol-2-ylmethyl)acetamide Chemical compound N1C(=CC=C1)CNC(CC1=C(/C(/C2=CC=C(C=C12)OC)=C/C1=CC(=C(C(=C1)OC)O)OC)C)=O XAUGGEJFEMACPG-FBHDLOMBSA-N 0.000 claims 1
- UAKZJXKRCGQOGT-UKWGHVSLSA-N 2-[(3Z)-6-fluoro-3-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-2-methylinden-1-yl]-N-(1H-pyrrol-2-ylmethyl)acetamide Chemical compound N1C(=CC=C1)CNC(CC1=C(/C(/C2=CC=C(C=C12)F)=C/C1=CC(=C(C(=C1)OC)O)OC)C)=O UAKZJXKRCGQOGT-UKWGHVSLSA-N 0.000 claims 1
- QGUQCLKABYTHQG-UKWGHVSLSA-N 2-[(3Z)-6-fluoro-3-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-2-methylinden-1-yl]-N-(furan-2-ylmethyl)-N-(trifluoromethyl)acetamide Chemical compound FC=1C=C2C(=C(/C(/C2=CC=1)=C/C1=CC(=C(C(=C1)OC)O)OC)C)CC(=O)N(C(F)(F)F)CC=1OC=CC=1 QGUQCLKABYTHQG-UKWGHVSLSA-N 0.000 claims 1
- CJBUOVAXMPVXFB-UKWGHVSLSA-N 2-[(3Z)-6-fluoro-3-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-2-methylinden-1-yl]-N-(furan-2-ylmethyl)acetamide Chemical compound FC=1C=C2C(=C(/C(/C2=CC=1)=C/C1=CC(=C(C(=C1)OC)O)OC)C)CC(=O)NCC=1OC=CC=1 CJBUOVAXMPVXFB-UKWGHVSLSA-N 0.000 claims 1
- GEGVKQRPGNRAIH-FBHDLOMBSA-N 2-[(3Z)-6-fluoro-3-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-2-methylinden-1-yl]-N-[(1-methylpyrrol-2-yl)methyl]acetamide Chemical compound FC=1C=C2C(=C(/C(/C2=CC=1)=C/C1=CC(=C(C(=C1)OC)O)OC)C)CC(=O)NCC=1N(C=CC=1)C GEGVKQRPGNRAIH-FBHDLOMBSA-N 0.000 claims 1
- OJOZWNKVCAHSQU-NHDPSOOVSA-N 2-[(3Z)-6-fluoro-3-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-2-methylinden-1-yl]-N-phenoxyacetamide Chemical compound FC=1C=C2C(=C(/C(/C2=CC=1)=C/C1=CC(=C(C(=C1)OC)O)OC)C)CC(=O)NOC1=CC=CC=C1 OJOZWNKVCAHSQU-NHDPSOOVSA-N 0.000 claims 1
- PYPMRDWDNXBVHT-NHDPSOOVSA-N N-(furan-2-ylmethyl)-2-[(3Z)-3-[(4-hydroxy-3-methoxyphenyl)methylidene]-6-methoxy-2-methylinden-1-yl]acetamide Chemical compound O1C(=CC=C1)CNC(CC1=C(/C(/C2=CC=C(C=C12)OC)=C/C1=CC(=C(C=C1)O)OC)C)=O PYPMRDWDNXBVHT-NHDPSOOVSA-N 0.000 claims 1
- IWYGOZQVWOCZNE-JJFYIABZSA-N N-benzyl-2-[(3Z)-6-fluoro-3-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-2-methylinden-1-yl]acetamide Chemical compound C(C1=CC=CC=C1)NC(CC1=C(/C(/C2=CC=C(C=C12)F)=C/C1=CC(=C(C(=C1)OC)O)OC)C)=O IWYGOZQVWOCZNE-JJFYIABZSA-N 0.000 claims 1
- 101150040459 RAS gene Proteins 0.000 claims 1
- RBCKJOAMDLCFEH-UHFFFAOYSA-N SN=[N+]=[N-] Chemical compound SN=[N+]=[N-] RBCKJOAMDLCFEH-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 1
- 125000005530 alkylenedioxy group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 125000005325 aryloxy aryl group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000003725 azepanyl group Chemical group 0.000 claims 1
- 125000002785 azepinyl group Chemical group 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 235000013877 carbamide Nutrition 0.000 claims 1
- GNVMUORYQLCPJZ-UHFFFAOYSA-N carbamothioic s-acid Chemical compound NC(S)=O GNVMUORYQLCPJZ-UHFFFAOYSA-N 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000004966 cyanoalkyl group Chemical group 0.000 claims 1
- 125000002576 diazepinyl group Chemical group N1N=C(C=CC=C1)* 0.000 claims 1
- 125000005331 diazinyl group Chemical group N1=NC(=CC=C1)* 0.000 claims 1
- 125000000532 dioxanyl group Chemical group 0.000 claims 1
- 125000000597 dioxinyl group Chemical group 0.000 claims 1
- 125000005879 dioxolanyl group Chemical group 0.000 claims 1
- 125000005883 dithianyl group Chemical group 0.000 claims 1
- 125000005303 dithiazolyl group Chemical group S1SNC(=C1)* 0.000 claims 1
- 125000005411 dithiolanyl group Chemical group S1SC(CC1)* 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 125000002632 imidazolidinyl group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000004628 isothiazolidinyl group Chemical group S1N(CCC1)* 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 125000003965 isoxazolidinyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 1
- 125000005961 oxazepanyl group Chemical group 0.000 claims 1
- 125000000160 oxazolidinyl group Chemical group 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 125000003585 oxepinyl group Chemical group 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 claims 1
- 125000003072 pyrazolidinyl group Chemical group 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 108700042226 ras Genes Proteins 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical group [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims 1
- 229940124530 sulfonamide Drugs 0.000 claims 1
- 150000003456 sulfonamides Chemical class 0.000 claims 1
- 150000003457 sulfones Chemical class 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
- 125000005247 tetrazinyl group Chemical group N1=NN=NC(=C1)* 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 1
- 125000005458 thianyl group Chemical group 0.000 claims 1
- 125000005308 thiazepinyl group Chemical group S1N=C(C=CC=C1)* 0.000 claims 1
- 125000004305 thiazinyl group Chemical group S1NC(=CC=C1)* 0.000 claims 1
- 125000001984 thiazolidinyl group Chemical group 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000001583 thiepanyl group Chemical group 0.000 claims 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 claims 1
- 125000004306 triazinyl group Chemical group 0.000 claims 1
- 125000005455 trithianyl group Chemical group 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021145211A JP2021185193A (ja) | 2014-12-16 | 2021-09-07 | インデニル化合物、医薬組成物、およびその医学的使用 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/571,647 | 2014-12-16 | ||
| US14/571,647 US9862698B2 (en) | 2014-12-16 | 2014-12-16 | Indenyl compounds, pharmaceutical compositions, and medical uses thereof |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017533501A Division JP6698089B2 (ja) | 2014-12-16 | 2015-12-16 | インデニル化合物、医薬組成物、およびその医学的使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021145211A Division JP2021185193A (ja) | 2014-12-16 | 2021-09-07 | インデニル化合物、医薬組成物、およびその医学的使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020079307A JP2020079307A (ja) | 2020-05-28 |
| JP2020079307A5 true JP2020079307A5 (cg-RX-API-DMAC10.html) | 2020-07-09 |
Family
ID=55085918
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017533501A Active JP6698089B2 (ja) | 2014-12-16 | 2015-12-16 | インデニル化合物、医薬組成物、およびその医学的使用 |
| JP2020029699A Withdrawn JP2020079307A (ja) | 2014-12-16 | 2020-02-25 | インデニル化合物、医薬組成物、およびその医学的使用 |
| JP2021145211A Withdrawn JP2021185193A (ja) | 2014-12-16 | 2021-09-07 | インデニル化合物、医薬組成物、およびその医学的使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017533501A Active JP6698089B2 (ja) | 2014-12-16 | 2015-12-16 | インデニル化合物、医薬組成物、およびその医学的使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021145211A Withdrawn JP2021185193A (ja) | 2014-12-16 | 2021-09-07 | インデニル化合物、医薬組成物、およびその医学的使用 |
Country Status (16)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9862698B2 (en) | 2014-12-16 | 2018-01-09 | Adt Pharmaceuticals, Inc. | Indenyl compounds, pharmaceutical compositions, and medical uses thereof |
| US20160168108A1 (en) | 2014-12-16 | 2016-06-16 | Adt Pharmaceuticals, Inc. | Method of treating or preventing ras-mediated diseases |
| US11040027B2 (en) | 2017-01-17 | 2021-06-22 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| WO2018170410A1 (en) * | 2017-03-17 | 2018-09-20 | University Of South Alabama | Derivatives of sulindac can protect normal cells against oxidative damage |
| AU2018323528B2 (en) * | 2017-08-31 | 2023-01-12 | Leukogene Therapeutics Incorporated | Indene derivatives and uses thereof |
| US11186596B2 (en) | 2018-04-26 | 2021-11-30 | Adt Pharmaceuticals, Llc | Anticancer indenes, indanes, azaindenes, azaindanes, pharmaceutical compositions and uses |
| CN113289020B (zh) * | 2021-05-17 | 2023-04-18 | 福州大学 | 蛋白质二硫键异构酶小分子抑制剂及其应用 |
| WO2025006967A1 (en) | 2023-06-30 | 2025-01-02 | Bristol-Myers Squibb Company | Kras inhibitors |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3325358A (en) * | 1962-06-06 | 1967-06-13 | Merck & Co Inc | Method of treating inflammation |
| NL7005270A (cg-RX-API-DMAC10.html) | 1969-04-29 | 1970-11-02 | ||
| US3888902A (en) | 1972-10-30 | 1975-06-10 | Merck & Co Inc | Cyano-indenyl acetic acids |
| US3642785A (en) | 1969-08-11 | 1972-02-15 | Merck & Co Inc | Indenyl-3-aliphatic amines |
| NL7200058A (cg-RX-API-DMAC10.html) | 1971-01-21 | 1972-07-25 | ||
| FI750366A7 (cg-RX-API-DMAC10.html) * | 1974-02-28 | 1975-08-29 | Merck & Co Inc | |
| DE3476550D1 (en) | 1983-07-21 | 1989-03-09 | Troponwerke Gmbh & Co Kg | Thermoplastics containing antiphlogistics |
| US4656190A (en) | 1983-11-14 | 1987-04-07 | Merck & Co., Inc. | Indene derivatives and their use as PAF-antagonists |
| US5093356A (en) | 1990-01-16 | 1992-03-03 | Merck Frosst Canada, Inc. | Indenyl hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase |
| EP0508586B1 (en) | 1991-03-08 | 1995-05-31 | Fgn, Inc. | Substituted indenyl compounds |
| US5401774A (en) | 1991-03-08 | 1995-03-28 | University Of Arizona | Method for treating patients with precancerous lesions by administering substituted sulfonyl idenyl acetic and propionic acids and esters to patients with lesions sensitive to such compounds |
| CA2195850A1 (en) | 1994-08-03 | 1996-02-15 | Asta Medica Aktiengesellschaft | Substituted indoles |
| US6063818A (en) | 1996-06-13 | 2000-05-16 | Cell Pathways Inc. | Substituted benzylidene indenyl formamides, acetamides and propionamides |
| US5965619A (en) | 1996-06-13 | 1999-10-12 | Cell Pathways Inc. | Method for treating patients having precancerous lesions with substituted indene derivatives |
| US6121321A (en) | 1996-06-13 | 2000-09-19 | Cell Pathways, Inc. | Substituted methoxy benzylidene indenyl acetic and propionic acids for treating patients with precancerous lesions |
| US6071934A (en) | 1997-03-25 | 2000-06-06 | Cell Pathways, Inc. | Indenyl hydroxamic acids, (hydroxy) ureas and urethanes for treating patients with precancerous lesions |
| HUP9903620A3 (en) | 1997-06-12 | 2001-03-28 | Univ Arizona Tucson | Pharmaceutical compositions containing substituted benzylidene indenyl formamides, acetamide and propionamide derivatives and use of these compounds |
| CA2314339C (en) | 1997-12-12 | 2009-09-08 | Cell Pathways, Inc. | N-benzyl-3-indenylacetamide derivatives for treating neoplasia |
| US6028116A (en) * | 1998-04-03 | 2000-02-22 | Cell Pathways, Inc. | Substituted condensation products of 1H-indenyl-hydroxyalkanes with aldehydes for neoplasia |
| US6025394A (en) * | 1999-01-29 | 2000-02-15 | Cell Pathways, Inc. | Method for treating patients with acne by administering substituted sulfonyl indenyl acetic acids, amides and alcohols |
| JP2003523958A (ja) | 1999-12-23 | 2003-08-12 | ニトロメド インコーポレーテッド | ニトロソ化およびニトロシル化されたシクロオキシゲナーゼ−２の阻害剤、組成物ならびに使用法 |
| CN1280300C (zh) | 1999-12-28 | 2006-10-18 | 巴塞尔技术有限公司 | 杂环茂金属化合物及其在生产烯烃聚合物的催化剂体系中的用途 |
| WO2002028831A1 (en) | 2000-10-02 | 2002-04-11 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| US20030176316A1 (en) * | 2001-08-24 | 2003-09-18 | Whitehead Clark M. | Methods for treatment of rheumatoid arthritis |
| DE10163426A1 (de) * | 2001-12-21 | 2003-07-03 | Max Planck Gesellschaft | Pharmakologisch wirksame Inden-Derivate |
| US20030194750A1 (en) | 2002-04-05 | 2003-10-16 | Han Li | Methods for treatment of diseases where GSK 3-beta is desired, and methods to identify compounds usefule for that |
| US6538029B1 (en) | 2002-05-29 | 2003-03-25 | Cell Pathways | Methods for treatment of renal cell carcinoma |
| JP2005535642A (ja) | 2002-06-28 | 2005-11-24 | ニトロメッド インコーポレーティッド | オキシムおよび／またはヒドラゾンを含有するニトロソ化および／またはニトロシル化シクロオキシゲナーゼ−２選択的阻害剤、組成物、および使用方法 |
| AU2005244770A1 (en) | 2004-04-26 | 2005-12-01 | Vanderbilt University | Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity |
| WO2006124874A2 (en) | 2005-05-12 | 2006-11-23 | Kalypsys, Inc. | Inhibitors of b-raf kinase |
| CA2628856A1 (en) | 2005-11-08 | 2007-05-18 | Jordi Frigola-Constansa | Indene derivatives, their preparation and use as medicaments |
| GB0525143D0 (en) | 2005-12-09 | 2006-01-18 | Novartis Ag | Organic compounds |
| EP1968616A4 (en) | 2006-01-04 | 2009-10-21 | Southern Res Inst | DERIVATIVES OF SULINDAC, USE AND PREPARATION THEREOF |
| AU2006346195B2 (en) | 2006-07-09 | 2013-03-07 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aspirin |
| AU2013206215C9 (en) | 2006-07-09 | 2018-03-08 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aspirin |
| US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
| AU2013231152B2 (en) | 2006-07-18 | 2016-06-09 | Techfields Biochem Co. Ltd | Positively charged water-soluble pro-drugs of ibuprofen |
| HUE033687T2 (en) | 2006-07-18 | 2017-12-28 | Techfields Biochem Co Ltd | Ibuprofen positively charged water soluble prodrugs with very fast skin penetration rates |
| PL2046727T3 (pl) | 2006-07-25 | 2014-08-29 | Techfields Biochem Co Ltd | Dodatnio naładowane rozpuszczalne w wodzie proleki diklofenaku o bardzo szybkim stopniu przenikania przez skórę |
| CN101500983B (zh) | 2006-07-26 | 2015-09-16 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的水溶性二氟尼柳及相关化合物的前药 |
| CN101500984A (zh) | 2006-07-27 | 2009-08-05 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的水溶性酮洛芬及相关化合物的前药 |
| WO2008019357A2 (en) | 2006-08-07 | 2008-02-14 | Ironwood Pharmaceuticals, Inc. | Indole compounds |
| PT2049482E (pt) | 2006-08-08 | 2016-02-24 | Techfields Biochem Co Ltd | Profármacos solúveis em água carregados positivamente de ácidos aril- e heteroarilacéticos com velocidade de penetração na pele muito rápida |
| AU2013206218B2 (en) | 2006-08-15 | 2016-06-30 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate |
| EP2054384A4 (en) | 2006-08-15 | 2010-11-03 | Techfields Biochem Co Ltd | POSITIVELY LOADED WATER-SOLUBLE PRODRUGS OF ARYL AND HETEROARYLPROPIONIC ACIDS WITH A VERY FAST SKIN PUNCHING RATE |
| AU2014201024B2 (en) | 2006-09-03 | 2016-05-05 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of acetaminophen and related compounds with very fast skin penetration rate |
| EP3388417A1 (en) | 2006-09-03 | 2018-10-17 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of acetaminophen and related compounds with very fast skin penetration rate |
| PL2084132T3 (pl) | 2006-09-03 | 2019-03-29 | Techfields Biochem Co. Ltd | Dodatnio naładowane rozpuszczalne w wodzie proleki z kwasów n-arylantranilowych z bardzo szybką penetracją skóry |
| EP2084165B1 (en) | 2006-10-11 | 2013-06-12 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of oxicams and related compounds with very high skin penetration rate |
| JP2010529101A (ja) | 2007-06-04 | 2010-08-26 | テックフィールズ インコーポレイテッド | 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用 |
| EA201201031A1 (ru) | 2010-01-25 | 2013-02-28 | Энанта Фармасьютиклз, Инк. | Ингибиторы вируса гепатита с |
| WO2012135650A1 (en) * | 2011-04-01 | 2012-10-04 | Southern Research Institute | Derivatives of sulindac, use thereof and preparation thereof |
| CA2885740A1 (en) | 2012-09-21 | 2014-03-27 | Basil Rigas | Compounds and compositions for use in the prevention and treatment of inflammation-related disorders, pain and fever, skin disorders, cancer and precancerous conditions thereof |
| ES2699416T3 (es) | 2013-04-09 | 2019-02-11 | Materia Inc | Preparación de tensioactivos mediante metátesis cruzada |
| WO2015126462A1 (en) | 2014-02-19 | 2015-08-27 | Materia, Inc. | Preparation of surfactants via cross-metathesis |
| US20170342021A1 (en) | 2014-12-16 | 2017-11-30 | Adt Pharmaceuticals, Inc. | Ras-inhibiting indenyl acetamide compounds, compositions, and uses |
| US9862698B2 (en) | 2014-12-16 | 2018-01-09 | Adt Pharmaceuticals, Inc. | Indenyl compounds, pharmaceutical compositions, and medical uses thereof |
| US20160168108A1 (en) | 2014-12-16 | 2016-06-16 | Adt Pharmaceuticals, Inc. | Method of treating or preventing ras-mediated diseases |
| WO2017106520A1 (en) | 2015-12-16 | 2017-06-22 | Adt Pharmaceuticals, Inc. | Compounds, compositions and methods of treating cancer |
| US11186596B2 (en) | 2018-04-26 | 2021-11-30 | Adt Pharmaceuticals, Llc | Anticancer indenes, indanes, azaindenes, azaindanes, pharmaceutical compositions and uses |
-
2014
- 2014-12-16 US US14/571,647 patent/US9862698B2/en active Active
-
2015
- 2015-12-16 MX MX2017007840A patent/MX386761B/es unknown
- 2015-12-16 JP JP2017533501A patent/JP6698089B2/ja active Active
- 2015-12-16 MX MX2021012096A patent/MX2021012096A/es unknown
- 2015-12-16 EP EP15823453.4A patent/EP3233794B1/en active Active
- 2015-12-16 BR BR112017013012-2A patent/BR112017013012A2/pt not_active Application Discontinuation
- 2015-12-16 WO PCT/US2015/066146 patent/WO2016100542A1/en not_active Ceased
- 2015-12-16 EP EP22157443.7A patent/EP4053105A1/en not_active Withdrawn
- 2015-12-16 CA CA2970803A patent/CA2970803A1/en active Pending
- 2015-12-16 RU RU2017125024A patent/RU2017125024A/ru not_active Application Discontinuation
- 2015-12-16 SG SG11201704934YA patent/SG11201704934YA/en unknown
- 2015-12-16 KR KR1020177019639A patent/KR20170135820A/ko not_active Withdrawn
- 2015-12-16 CN CN201580076108.1A patent/CN107531615B/zh not_active Expired - Fee Related
- 2015-12-16 CN CN202010795274.XA patent/CN112047909A/zh active Pending
- 2015-12-16 US US15/537,292 patent/US10526307B2/en active Active
- 2015-12-16 AU AU2015364696A patent/AU2015364696B2/en not_active Ceased
-
2017
- 2017-06-14 IL IL252897A patent/IL252897A0/en unknown
- 2017-06-14 CL CL2017001539A patent/CL2017001539A1/es unknown
- 2017-06-16 PH PH12017501130A patent/PH12017501130A1/en unknown
- 2017-07-14 CO CONC2017/0007076A patent/CO2017007076A2/es unknown
-
2019
- 2019-10-04 US US16/593,806 patent/US10981886B2/en active Active
- 2019-10-04 US US16/593,776 patent/US10975054B2/en active Active
-
2020
- 2020-02-25 JP JP2020029699A patent/JP2020079307A/ja not_active Withdrawn
- 2020-03-30 US US16/834,348 patent/US11130744B2/en not_active Expired - Fee Related
- 2020-03-30 US US16/834,267 patent/US11407727B2/en active Active
-
2021
- 2021-09-07 JP JP2021145211A patent/JP2021185193A/ja not_active Withdrawn
-
2022
- 2022-06-08 US US17/835,551 patent/US12479813B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7611278B2 (ja) | 金属酵素阻害剤化合物 | |
| JP2021107415A (ja) | 統合ストレス経路のモジュレーター | |
| AU2013211575B2 (en) | Amidine substituted beta - lactam compounds, their preparation and use as antibacterial agents | |
| JP2018505145A5 (cg-RX-API-DMAC10.html) | ||
| JP2016503009A5 (cg-RX-API-DMAC10.html) | ||
| JP2014528464A5 (cg-RX-API-DMAC10.html) | ||
| CN1794988B (zh) | 用于治疗血管渗透性过高疾病的组合物 | |
| WO2011163518A1 (en) | Pyrazolo [1, 5 -a] pyrimidines as antiviral agents | |
| KR20170065637A (ko) | 신경활성 화합물 및 그의 사용 방법 | |
| JP2009528989A5 (cg-RX-API-DMAC10.html) | ||
| CA2898615A1 (en) | Metalloenzyme inhibitor compounds | |
| TNSN04246A1 (fr) | Derives d'heteroarylamides benzocondenses de thienopyridines utiles comme agents therapeutiques, compositions pharmaceutiques les contenant et methodes pour leur utilisation | |
| JP2009507011A5 (cg-RX-API-DMAC10.html) | ||
| RU2010109898A (ru) | Соединения индола и индазола в качестве ингибитора некроза клетки | |
| CN105085429B (zh) | 芳杂环类衍生物及其在药物上的应用 | |
| RU2005140379A (ru) | Замещенные циклопропильной группой оксазолидиноновые антибиотики и их производные | |
| JP2017538772A5 (cg-RX-API-DMAC10.html) | ||
| JP2007515476A5 (cg-RX-API-DMAC10.html) | ||
| RU2015144385A (ru) | Ациклические цианоэтилпиразолопиридоны в качестве ингибиторов янус-киназы | |
| JP2017516796A5 (cg-RX-API-DMAC10.html) | ||
| JP2013529684A (ja) | フラビウイルス感染の処置または予防のための化合物および方法 | |
| ES2728159T3 (es) | Composiciones de difluorolactama para enfermedades y afecciones relacionadas con la osteoporosis mediadas por EP4 | |
| TW202114985A (zh) | Ｅｐ拮抗劑 | |
| IL184116A0 (en) | Use of thiazolidinone derivatives as antiangiogenic agents | |
| RU2017125024A (ru) | Инденилсодержащие соединения, фармацевтические композиции и их применения в медицине |