JP2020070263A - Liquid composition for oral cavity - Google Patents

Abstract

To provide a liquid composition for oral cavity having excellent cool feeling and lastingness of the feeling, and satisfactory use feeling.SOLUTION: A liquid composition for oral cavity is made up by blending (A) O/W type emulsion in which dispersoid is fat being liquid at 25°C, and (B) one type or more selected from N-(2-(2-pyridinyl)ethyl)-2-isopropyl-5-methylcyclohexanecarboxamide and N-(4-cyanomethylphenyl)-2-isopropyl-5-methylhexanecarboxamide, and the content of the fat being liquid at 25°C is 0.05 to 0.4 mass% for the entire composition and the content of ethanol in the composition is 0 to 100 ppm.SELECTED DRAWING: None

Description

  TECHNICAL FIELD The present invention relates to a liquid oral composition having excellent cool feeling and its durability.

In recent years, the use of oral preparations that give a high cooling sensation to the oral cavity has tended to be preferred for the purpose of eliminating refreshing feelings and drowsiness and refreshing mood among young people. Menthol or its derivatives, mint oil, etc. have been conventionally blended as a technique for imparting a cool sensation to oral preparations. However, even if these components are blended to provide a cooling sensation, particularly in liquid formulations, the cooling sensation is felt only immediately after use of the formulation in the oral cavity for a short period of time, for example, after a few minutes, and the persistent feeling is maintained. Was not satisfied.
By the way, chewing gum and candy need to continue to hold these preparations in the oral cavity in order to maintain a cool sensation, and depending on the situation, they may be hesitant to use them on the etiquette side. On the other hand, it is not useful for the user because he has to choose a TPO such as when and where to use it.

Patent Document 1 discloses that when a non-menthol-based cooling agent, p-menthane-3-carboxamides, is used in a liquid oral composition, a refreshing feeling and a refreshing feeling can be enhanced or its durability can be enhanced. ~ 6 are proposed.
On the other hand, it has been proposed in Patent Documents 7 to 14 that the emulsion can be applied to the stabilization of liquid oral compositions and the incorporation of sparingly water-soluble components such as perfume oils and medicinal components.

JP, 2014-125440, A JP, 2005-182983, A JP, 2016-102076, A Japanese Patent Publication No. 2014-507440 Special table 2012-508741 gazette Special table 2011-520925 gazette JP, 2009-96724, A Japanese Patent Publication No. 2015-521604 Japanese Patent No. 3938632 Japanese Patent No. 6104498 Japanese Patent No. 6333141 International Publication No. 2015/163284 International Publication No. 2011/077847 JP, 2015-89870, A

  The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a liquid oral composition that is excellent in cool feeling and its durability.

  MEANS TO SOLVE THE PROBLEM As a result of earnestly studying in order to achieve the said objective, this inventor is suitable combining a specific oral O / W type emulsion and a cooling agent with a liquid oral composition, especially the liquid oral composition containing no ethanol. It has been found that the effect of imparting a cooling sensation by the cooling agent is improved and that the persistence of the cooling sensation is particularly improved when blended with the above. That is, according to the present invention, (A) an O / W emulsion in which the dispersoid is a liquid fat at 25 ° C., and (B) N- (2- (2-pyridinyl) ethyl) -2-isopropyl-5. -Methylcyclohexanecarboxamide and one or more selected from N- (4-cyanomethylphenyl) -2-isopropyl-5-methylhexanecarboxamide, and the content of the liquid oil at 25 ° C is the same as that of the entire composition. Provided is a liquid oral composition, which has an excellent cooling feeling and its durability, and also has a good feeling in use when the content of ethanol is 0.05 to 0.4% by mass and the content of ethanol in the composition is 0 to 100 ppm. The inventors have discovered that they can do so and have completed the present invention.

In the present invention, the content of the oil or fat as the dispersoid of the specific O / W type emulsion of the component (A) is within the specific range, and the component (A) suppresses the occurrence of stickiness after use. The effect of imparting a cooling sensation by the component (B) is improved, and a high cooling sensation can be imparted immediately after use and after a relatively long time has elapsed.
The action and effect of the present invention are inferior unless the component (A) or (B) is blended, and inferior even if another cooling agent is used in place of the component (B), and the action and effect specific to the component (B). Met. As shown in the comparative example described below, if the component (A) is not blended even if the component (B) is blended, the cooling feeling lasts poorly (Comparative Example 1), and the component (B) is blended. If not, even if a general fragrance containing menthol and further N-ethyl-p-menthane-3-carboxamide such as p-menthane-3-carboxamides are blended together with the component (A), a cooling feeling is obtained. Was poor in sustainability (Comparative Examples 4 and 5). Further, even if the components (A) and (B) are blended, if the content of the specific fat is too low, the cooling sensation is inferior in sustainability, and if the content is too high, the stickiness after use is poor and immediately after use. The cooling sensation was slightly lowered (Comparative Examples 2 and 3). On the other hand, as shown in Examples, the composition for liquid oral cavity in which the components (A) and (B) of the present invention are appropriately blended is excellent in cooling feeling immediately after use and durability of cooling feeling, A high cooling sensation was felt immediately after use for 15 minutes or more, and no stickiness was felt after use, and the feeling of use was good.

Accordingly, the present invention provides the following liquid oral composition.
[1]
(A) an O / W emulsion in which the dispersoid is a liquid fat at 25 ° C., and (B) N- (2- (2-pyridinyl) ethyl) -2-isopropyl-5-methylcyclohexanecarboxamide and N- ( 4-cyanomethylphenyl) -2-isopropyl-5-methylhexanecarboxamide is blended with one or more kinds thereof, and the content of the liquid oil at 25 ° C. is 0.05 to 0.4 of the total composition. A composition for a liquid oral cavity, characterized in that the composition has a mass% of 0 to 100 ppm of ethanol in the composition.
[2]
The liquid oral composition according to [1], wherein the fat or oil that is liquid at 25 ° C. is one or more selected from trifatty acid glyceryl having 6 to 12 carbon atoms in fatty acid, olive oil, camellia oil, and castor oil.
[3]
The composition for liquid oral cavity according to [1] or [2], wherein the O / W type emulsion in which the dispersoid is a liquid fat at 25 ° C. has an average particle size of emulsion particles of 30 to 300 nm.
[4]
The composition for liquid oral cavity according to any one of [1] to [3], wherein the compounding amount of the component (B) is 0.00000001 to 0.01% by mass of the entire composition.
[5]
The liquid composition for oral cavity according to any one of [1] to [4], which is a mouthwash or a spray for oral cavity.

  ADVANTAGE OF THE INVENTION According to this invention, the liquid oral composition which is excellent in cooling feeling and its durability, and also has a good usability can be provided. The liquid oral composition of the present invention, specifically, a mouthwash, an oral spray, and the like can give a continuous cooling sensation in the oral cavity at any time and place, and can enhance a refreshing feeling. ..

  The present invention will be described in more detail below. The liquid oral composition of the present invention comprises (A) an O / W emulsion in which the dispersoid is a liquid oil at 25 ° C., and (B) N- (2- (2-pyridinyl) ethyl) -2-isopropyl. -5-methylcyclohexanecarboxamide and one or more selected from N- (4-cyanomethylphenyl) -2-isopropyl-5-methylhexanecarboxamide.

  The component (A) is an O / W emulsion (hereinafter abbreviated as emulsion (A)) in which the dispersoid is a liquid fat at 25 ° C. The emulsion (A) has the effect of improving the cooling effect imparting effect of the component (B), and particularly improving the durability of the cooling feeling.

  The emulsion (A) is not particularly limited as long as it is an O / W type (oil-in-water type) emulsion in which the dispersoid contained in the emulsion particles is a liquid fat at 25 ° C., and examples thereof include polyhydric alcohol and water. It is possible to use an O / W type emulsion obtained by emulsifying the above-mentioned specific fat or oil which is a dispersoid with an emulsifier, using the above as a dispersion medium, or can be added and blended by a usual method. In the emulsion (A), oil droplet particles of an O / W type emulsion are dispersed in the added liquid oral composition, and the dispersion medium is mixed with the aqueous phase of the liquid oral composition to give O / W. It exists as a W type emulsion.

In the emulsion (A), the average particle size of emulsion particles is preferably 30 to 300 nm, particularly 30 to 150 nm, and particularly 30 to 70 nm. When the average particle diameter is within the above range, the cooling feeling and its durability are higher, and the stickiness after use is sufficiently suppressed. If the average particle size is too small, the cooling sensation may not last long enough, and if it is too large, the cooling sensation may not last long enough and stickiness may be felt after use. Furthermore, during long-term storage, emulsion particles may float in the upper layer of the liquid oral composition, leading to deterioration in stability over time.
The average particle diameter of the emulsion particles was measured by the following method.
Using a dynamic light scattering photometer DLS-8000 manufactured by Otsuka Electronics Co., Ltd., the emulsion was diluted 1,000 times with purified water, put into a cell, and the average particle diameter at 25 ° C. was measured.
The scattering intensity was measured by the dynamic light scattering method and calculated by cumulant analysis to obtain the average particle size.

  In the emulsion (A), the dispersoid is the above-mentioned specific fat and oil, and the average particle size is preferably within the above range, and the type and blending amount of the dispersoid, the dispersion medium, and the emulsifier used for the preparation are not particularly limited, Furthermore, the preparation conditions such as emulsification are not limited and can be appropriately set, and a usual method can be adopted. For example, the following substances can be used as the dispersoid, the dispersion medium, and the emulsifier.

  Examples of fats and oils that are liquid at 25 ° C. that are dispersoids include trifatty acid glyceryl having a carbon chain length of 6 to 12 and liquid vegetable oils such as olive oil, camellia oil, and castor oil, and one selected from these alone or Two or more kinds may be used in combination. Examples of the tri-fatty acid glyceryl include glyceryl tricaprylate, glyceryl tricaprate, and glyceryl tri (capryl-caprate). As the above-mentioned oils and fats, tri-fatty acid glyceryl, especially tri (capryl-capric acid) glyceryl, is preferable because it is stable and hardly discolored by oxidation.

  As the dispersion medium, in addition to water, polyhydric alcohols such as glycerin, propylene glycol, 1,3-butylene glycol, dipropylene glycol and polyethylene glycol having an average molecular weight of 190 to 630 can be used.

As the emulsifier, one or more nonionic surfactants such as glycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, and polyoxyethylene alkyl ether can be used, and those having an HLB value of 10 to 16 are preferable. Examples of the glycerin fatty acid ester include decaglycerin monofatty acid ester having 12 to 16 fatty acid carbon atoms such as decaglyceryl monomyristate and decaglyceryl monolaurate. The average number of moles of ethylene oxide added to polyoxyethylene hydrogenated castor oil is preferably 10 to 100 moles, and particularly preferably 20 to 60 moles. The average number of moles of ethylene oxide added to the polyoxyethylene alkyl ether is 4 to 20 moles, and particularly preferably 6 to 15 moles.
Among them, decaglycerin monofatty acid ester, polyoxyethylene hydrogenated castor oil, particularly decaglyceryl monomyristate, polyoxyethylene hydrogenated castor oil are preferable from the viewpoint of stability.

The amount of the specific fat or oil (oil or fat liquid at 25 ° C.) in the emulsion (A) is not particularly limited, but is preferably 10 to 60% (mass%, the same applies hereinafter) of the entire emulsion including the dispersion medium, 20 to 50% is particularly preferable.
The amount of emulsifier in the emulsion (A) is not particularly limited, but is preferably 5 to 30%, and particularly preferably 5 to 20% of the total emulsion including the dispersion medium.

As a method for preparing the emulsion (A), a known method can be adopted.
For example, after stirring a predetermined amount of an emulsifier such as a nonionic surfactant, a polyhydric alcohol as a dispersion medium, and half amount of water with a homomixer, an oily component is added to form an emulsion, and finally the remaining water is added. Thus, an O / W type emulsion can be prepared. After that, the average particle size of the prepared emulsion can be adjusted using a high pressure homogenizer.
In emulsification with a high-pressure homogenizer, the average particle size is adjusted by the difference in shearing force. When the emulsified particles become finer, the stability over time is further improved. As the high-pressure homogenizer, a Microfluidizer (manufactured by Microfludex International CO., Ltd.), a Gorin homogenizer (manufactured by Rani Gorin Co., Ltd.), an optimizer (manufactured by Sugino Machine Co., Ltd.) and the like can be used, but are not limited to these models. Any model may be used as long as it has a similar mechanism. The pressure at the time of emulsification (high pressure emulsification) is usually 30 MPa or more, preferably 30 to 100 MPa. It is preferable to add the oil phase to the water phase and emulsify it under a temperature condition of about 25 to 50 ° C.

  As the emulsion (A), a commercially available product may be used. Specifically, a product name manufactured by Nikko Chemicals Co., Ltd .; NETTE-50 or the like can be used.

In the liquid composition for oral cavity of the present invention, the emulsion (A) is added and blended so that the content of the liquid fat or oil at 25 ° C. which is the dispersoid of the emulsion (A) falls within a specific range with respect to the entire composition.
The content of the above-mentioned specific fat and oil (oil and fat at 25 ° C.) is 0.05 to 0.4% of the total composition, preferably 0.1 to 0.3%, more preferably 0.1 to 0.3%. It is 0.2%. Within the above range, the stickiness after use can be suppressed, the effect of imparting a cool feeling by the component (B) can be improved, and a high cool feeling and its durability can be provided. If it is less than 0.05%, the cooling sensation is poor in sustainability, and if it exceeds 0.4%, the cooling sensation immediately after use deteriorates. Also, stickiness may be felt after use.

  The component (B) is selected from N- (2- (2-pyridinyl) ethyl) -2-isopropyl-5-methylcyclohexanecarboxamide and N- (4-cyanomethylphenyl) -2-isopropyl-5-methylhexanecarboxamide. P-menthane-3-carboxamide, which may be used alone or in combination of two kinds. These are cooling sensation agents and have an effect of imparting a cooling sensation.

  As the component (B), a commercially available product can be used. For example, N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide (trade name of Everbod Japan KK; Evercool G-180), N- (2- (2-pyridinyl) ethyl). 2-isopropyl-5-methylcyclohexanecarboxamide (trade name of Everbod Japan Co., Ltd .; Evercool G-190) and the like can be used.

  The compounding amount of the component (B) is preferably 0.00000001 to 0.01% of the total composition, and more preferably 0.00000005 to 0.005%. Within this range, the cooling feeling and the durability thereof are more excellent, and it is possible to sufficiently prevent the feeling of irritation from being expressed. When the blending amount is 0.00000001% or more, a sufficient cooling sensation and its durability can be obtained, and when it is 0.01% or less, the stimulating sensation can be sufficiently suppressed.

  The liquid composition for oral cavity of the present invention is prepared as a mouthwash, liquid dentifrice, etc., and in addition to the above-mentioned components, known components depending on the dosage form can be added within the range not impairing the effects of the present invention. For example, a wetting agent, a thickening agent, a surfactant, a solvent, and if necessary, a pH adjusting agent, a sweetening agent, a coloring agent, a perfume, an active ingredient and the like can be contained.

  Examples of the wetting agent include sugar alcohols such as sorbitol, xylit, maltite, and lactit, and polyhydric alcohols such as glycerin and propylene glycol. The amount of the wetting agent added is usually 5 to 20%, particularly 5 to 15%, of the whole composition. The total amount of the emulsion of the component (A) including the dispersion medium is preferably within the above range.

  Examples of the thickener include xanthan gum, sodium alginate, polyvinyl alcohol, hydroxymethyl cellulose, hydroxyethyl cellulose and the like. The content of the thickener is usually 0 to 1%, especially 0 to 0.5% of the total composition.

As the surfactant, in addition to the surfactant used as an emulsifier in the emulsion of the component (A), other surfactant can be blended. Specifically, those commonly used in liquid oral compositions, for example, polyethylene glycol fatty acid ester, sucrose fatty acid ester as a nonionic surfactant, alkyldimethylaminoacetic acid betaine as an amphoteric surfactant, fatty acid amide propyldimethyl. Amino acid such as betaine acetate-type amphoteric surfactant such as aminoacetic acid betaine, imidazoline-type amphoteric surfactant such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salt, N-fatty acid acyl-L-alginate salt and the like Type surfactants. The content of these surfactants is preferably 0.1 to 2%, particularly preferably 0.1 to 1.0% of the total composition.
The anionic surfactant, for example, alkyl sulfate such as sodium lauryl sulfate, acyl sarcosinate such as sodium lauroyl sarcosinate, etc. may not be blended, but when blended, the blending amount thereof is 0.2% or less, particularly 0.1% or less is preferable.

  Purified water is generally used as the solvent, and the content thereof is usually 60% or more of the total composition, particularly 60 to 95%, and particularly 80 to 90%.

  Examples of the pH adjusting agent include phthalic acid, phosphoric acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, carbonic acid and their potassium salts, sodium salts and ammonium salts, ribonucleic acid and its salts, and sodium hydroxide. .. The pH of the composition may be within the general range for liquid oral compositions, and is preferably 4.5 to 9 at 25 ° C.

  Examples of the sweetener include saccharin sodium and steviocyte. Examples of the colorant include highly safe water-soluble dyes such as Blue No. 1, Green No. 3, Yellow No. 4, and Red No. 105.

Fragrances include peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime. Oil, lavender oil, rosemary oil, laurel oil, chamomile oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie oil. , Natural fragrances such as yuzu oil, iris concrete, absolute peppermint, absolute rose, and orange flower, and processing of these natural fragrances (pre-cut, post-cut, fractionation, liquid-liquid extraction, essence, powdered fragrance) Fragrance, menthol, carbo , Anethole, cineole, methyl salicylate, cinnamic aldehyde, eugenol, 3-l-menthoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted-paramenthane-3 -Carboxamide, pinene, octyl aldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methylphenylglycidate, vanillin, undecalactone, hexanal , Butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cyclotene, furfural, trimethylpyrazine, ethyl lactate, ethylthioa For oral composition such as single flavors such as tate, and further fragrances such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. Known perfume materials used can be used in combination. The blending amount of these fragrances is preferably 0.00001 to 3% with respect to the entire composition as long as the effect of the present invention is not impaired.
The liquid composition for oral cavity of the present invention may be blended with menthol that gives a cooling sensation, and the blending amount of menthol is preferably 0.001 to 0.2% of the entire composition. According to the present invention, a high cooling sensation and its durability can be obtained even if the amount of menthol blended is relatively small.

  Active ingredients are bactericides such as isopropylmethylphenol, triclosan, cetylpyridinium chloride, benzethonium chloride, anti-inflammatory agents such as tranexamic acid, epsilon-aminocaproic acid, enzymes such as dextranase, sodium fluoride, sodium monofluorophosphate. Fluorine-containing compounds such as, vitamins, and plant extracts. These active ingredients can be added in effective amounts within a range that does not impair the effects of the present invention.

  The liquid composition for oral cavity of the present invention preferably contains substantially no ethanol from the viewpoint of emulsion stability, and preferably contains no ethanol. Here, "substantially free of ethanol" means that the composition may contain a trace amount of ethanol derived from a blending component such as a fragrance, and in consideration of this, other than the trace amount of ethanol, The intention is that it is preferable not to contain ethanol. Specifically, the content of ethanol in the composition is preferably 100 ppm or less, particularly 50 ppm or less, especially 10 ppm or less, and may be 0 ppm.

  Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. In the following examples,% means mass% unless otherwise specified.

[Examples and Comparative Examples]
Liquid oral compositions (mouthwashes) having the compositions shown in Tables 1 and 2 were prepared by a conventional method, and these were used as samples and evaluated by the following methods. The results are also shown in Tables 1 and 2.

The preparation method and composition of the emulsion used as the component (A) are as follows. The prepared emulsions 1 and 2 were blended in the amounts shown in the table.
<Emulsion preparation method>
An O / W type emulsion having the composition shown below was prepared by the following method. The stirring with a homomixer was carried out at 25 to 50 ° C. by using a known high-pressure homogenizer (pressure condition of 30 to 100 MPa), adding the oil phase to the aqueous phase, and emulsifying.
The average particle diameter of the emulsion particles shown below was measured by using a dynamic light scattering photometer DLS-8000 manufactured by Otsuka Electronics Co., Ltd. and putting the emulsion in a cell to measure the average particle diameter at 25 ° C. The scattering intensity was measured by the dynamic light scattering method and calculated by cumulant analysis to obtain the average particle size.

Emulsion 1 (average particle size 200 nm)
Decaglyceryl monomyristate 15
Tri (caprylic / capric acid) glyceryl 50
Glycerin 10
Water 25
Total 100%
Glycerin, half the amount of water, and decaglyceryl monomyristate were pre-stirred, tri (capryl-caprate) glyceryl was added, and the mixture was stirred with a homomixer, and finally the remaining water was added to prepare.
Emulsion 2 (average particle size 50 nm)
Polyoxyethylene (20) hydrogenated castor oil 20
Glyceryl tri (caprylic / capric acid) 20
Dipropylene glycol 10
Water 50
Total 100%
Dipropylene glycol, half amount of water, and polyoxyethylene (20) hydrogenated castor oil were pre-stirred, then tri (capryl capric acid) glyceryl was added, and the mixture was stirred with a homomixer, and finally the remaining water was added to prepare. ..

Further, details of raw materials used other than the above are shown below.
(B) N- (2- (2-pyridinyl) ethyl) -2-isopropyl-5-methylcyclohexanecarboxamide:
Product name: Evercool G-190, manufactured by Givaudan Japan KK (B) N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide:
Product name: Evercool G-180, manufactured by Givaudan Japan Ltd.
N-ethyl-p-menthane-3-carboxamide (comparative product):
Product name: WS-3, ethyl-3- (p-menthan-3-carboxamide) acetate (comparative product) manufactured by Givaudan Japan Ltd .:
Product name; WS-5, manufactured by Givaudan Japan Co., Ltd. As the fragrance, the fragrance composition A having the following composition was used.
Fragrance composition A
l-menthol 30
1,8-cineole 5
Cassia oil 1
Clove oil 1
Propylene glycol 63
Total 100%

(1) Evaluation Method of Cool Feeling Immediately After Use Five subjects included 20 mL of a sample in their mouths, rinsed for 30 seconds, and then evaluated the cool feeling immediately after use according to the following rating criteria. The average point was determined and indicated by ⊚, ◯, Δ, and x according to the following evaluation criteria.
Rating criteria 4 points: Very cool feeling 3 points: Cool feeling 2 points: Cool feeling is not felt 1 point: Cool feeling is not felt Evaluation criteria ◎: 3.5 points or more 4.0 points or less ○ : 3.0 points or more and less than 3.5 points B: 2.0 points or more and less than 3.0 points x: 1.0 points or more and less than 2.0 points (2) Evaluation method of cooling sensation persistence , 20 mL of the sample was contained in the mouth, and after rinsing for 30 seconds, the time (duration) during which the cooling feeling continued was measured. The average duration was calculated and indicated by ⊚, ◯, Δ, and x according to the following evaluation criteria.
Evaluation criteria ◎: 15 minutes or more ○: 10 minutes or more and less than 15 minutes △: 5 minutes or more and less than 10 minutes ×: Less than 5 minutes

(3) Evaluation method of non-stickiness after use Five subjects included 20 mL of sample in their mouths, rinsed for 30 seconds, and then judged non-stickiness according to the following rating criteria. The average point was determined and indicated by ⊚, ◯, Δ, and x according to the following evaluation criteria.
Rating criteria 4 points: No stickiness is felt 3 points: Stickiness is not felt much 2 points: Stickiness is felt a little 1 point: Stickiness is felt Evaluation criteria ◎: 3.5 points or more and 4.0 points or less ○: 3. 0 points or more and less than 3.5 points △: 2.0 points or more and less than 3.0 points x: 1.0 points or more and less than 2.0 points

  As shown in Table 2, when the component (A) is not blended, the cooling sensation lasts poorly (Comparative Example 1), and when the component (B) is not blended, a general fragrance containing menthol is added. Even when N-ethyl-p-menthane-3-carboxamide or ethyl-3- (p-menthane-3-carboxamide) acetate was added, the cooling sensation was poorly maintained (Comparative Example 4, 5). In addition, even if the components (A) and (B) are blended, if the content of the fats and oils contained in the emulsion particles of the component (A) is too small with respect to the entire composition, the sustainability of cooling sensation is poor (comparison Example 3), when the content was too large, the cooling feeling immediately after use was slightly lower than that of Example 3 in Table 1, and the stickiness after use was poor (Comparative Example 2).

Claims (5)

(A) an O / W emulsion in which the dispersoid is a liquid fat at 25 ° C., and (B) N- (2- (2-pyridinyl) ethyl) -2-isopropyl-5-methylcyclohexanecarboxamide and N- ( 4-cyanomethylphenyl) -2-isopropyl-5-methylhexanecarboxamide is blended with one or more kinds thereof, and the content of the liquid oil at 25 ° C. is 0.05 to 0.4 of the total composition. A composition for a liquid oral cavity, characterized in that the composition has a mass% of 0 to 100 ppm of ethanol in the composition.   The liquid oral composition according to claim 1, wherein the oil or fat that is liquid at 25 ° C. is one or more selected from tri-fatty acid glyceryl having a carbon number of fatty acid of 6 to 12, olive oil, camellia oil, and castor oil.   The composition for liquid oral cavity according to claim 1 or 2, wherein the O / W type emulsion in which the dispersoid is a liquid fat at 25 ° C is an emulsion particle having an average particle size of 30 to 300 nm.   The composition for liquid oral cavity according to any one of claims 1 to 3, wherein the compounding amount of the component (B) is 0.00000001 to 0.01% by mass of the entire composition.   The composition for liquid oral cavity according to any one of claims 1 to 4, which is a mouthwash or a spray for oral cavity.