JP2019537428A5 - - Google Patents
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- Publication number
- JP2019537428A5 JP2019537428A5 JP2019515316A JP2019515316A JP2019537428A5 JP 2019537428 A5 JP2019537428 A5 JP 2019537428A5 JP 2019515316 A JP2019515316 A JP 2019515316A JP 2019515316 A JP2019515316 A JP 2019515316A JP 2019537428 A5 JP2019537428 A5 JP 2019537428A5
- Authority
- JP
- Japan
- Prior art keywords
- test compound
- eye irritation
- group
- irritation index
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 11
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 206010015946 Eye irritation Diseases 0.000 claims 6
- 231100000013 eye irritation Toxicity 0.000 claims 6
- 230000014509 gene expression Effects 0.000 claims 6
- -1 CCL22 Proteins 0.000 claims 4
- 230000002018 overexpression Effects 0.000 claims 4
- 102100028672 C-type lectin domain family 4 member D Human genes 0.000 claims 3
- 102100035904 Caspase-1 Human genes 0.000 claims 3
- 101000766905 Homo sapiens C-type lectin domain family 4 member D Proteins 0.000 claims 3
- 101000715398 Homo sapiens Caspase-1 Proteins 0.000 claims 3
- 101000928535 Homo sapiens Protein delta homolog 1 Proteins 0.000 claims 3
- 102100036467 Protein delta homolog 1 Human genes 0.000 claims 3
- 102000003898 interleukin-24 Human genes 0.000 claims 3
- 108090000237 interleukin-24 Proteins 0.000 claims 3
- 102100021407 ATP-dependent RNA helicase DDX18 Human genes 0.000 claims 2
- 108010058546 Cyclin D1 Proteins 0.000 claims 2
- 108010019961 Cysteine-Rich Protein 61 Proteins 0.000 claims 2
- 102000005889 Cysteine-Rich Protein 61 Human genes 0.000 claims 2
- 102100027627 Follicle-stimulating hormone receptor Human genes 0.000 claims 2
- 102100024165 G1/S-specific cyclin-D1 Human genes 0.000 claims 2
- 102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 claims 2
- 101000862396 Homo sapiens Follicle-stimulating hormone receptor Proteins 0.000 claims 2
- 101001016865 Homo sapiens Heat shock protein HSP 90-alpha Proteins 0.000 claims 2
- 101000599858 Homo sapiens Intercellular adhesion molecule 2 Proteins 0.000 claims 2
- 101000623900 Homo sapiens Mucin-13 Proteins 0.000 claims 2
- 101000972286 Homo sapiens Mucin-4 Proteins 0.000 claims 2
- 101000990908 Homo sapiens Neutrophil collagenase Proteins 0.000 claims 2
- 101000651890 Homo sapiens Slit homolog 2 protein Proteins 0.000 claims 2
- 101000651893 Homo sapiens Slit homolog 3 protein Proteins 0.000 claims 2
- 108090000320 Hyaluronan Synthases Proteins 0.000 claims 2
- 102100037872 Intercellular adhesion molecule 2 Human genes 0.000 claims 2
- 102100036672 Interleukin-23 receptor Human genes 0.000 claims 2
- 102100023124 Mucin-13 Human genes 0.000 claims 2
- 102100022693 Mucin-4 Human genes 0.000 claims 2
- 102100030411 Neutrophil collagenase Human genes 0.000 claims 2
- 102100027340 Slit homolog 2 protein Human genes 0.000 claims 2
- 102000004061 Transcription Factor CHOP Human genes 0.000 claims 2
- 108010057666 Transcription Factor CHOP Proteins 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 108040001844 interleukin-23 receptor activity proteins Proteins 0.000 claims 2
- 230000007794 irritation Effects 0.000 claims 2
- 102100027211 Albumin Human genes 0.000 claims 1
- 102100024335 Collagen alpha-1(VII) chain Human genes 0.000 claims 1
- 102100031518 Collagen alpha-2(VI) chain Human genes 0.000 claims 1
- 102100034221 Growth-regulated alpha protein Human genes 0.000 claims 1
- 102100040352 Heat shock 70 kDa protein 1A Human genes 0.000 claims 1
- 101000693913 Homo sapiens Albumin Proteins 0.000 claims 1
- 101000909498 Homo sapiens Collagen alpha-1(VII) chain Proteins 0.000 claims 1
- 101000941585 Homo sapiens Collagen alpha-2(VI) chain Proteins 0.000 claims 1
- 101000851054 Homo sapiens Elastin Proteins 0.000 claims 1
- 101001065295 Homo sapiens Fas-binding factor 1 Proteins 0.000 claims 1
- 101001069921 Homo sapiens Growth-regulated alpha protein Proteins 0.000 claims 1
- 101001037759 Homo sapiens Heat shock 70 kDa protein 1A Proteins 0.000 claims 1
- 101000598002 Homo sapiens Interferon regulatory factor 1 Proteins 0.000 claims 1
- 101001128156 Homo sapiens Nanos homolog 3 Proteins 0.000 claims 1
- 101001124309 Homo sapiens Nitric oxide synthase, endothelial Proteins 0.000 claims 1
- 101000687673 Homo sapiens Small integral membrane protein 6 Proteins 0.000 claims 1
- 101000990915 Homo sapiens Stromelysin-1 Proteins 0.000 claims 1
- 102100036981 Interferon regulatory factor 1 Human genes 0.000 claims 1
- 102100031893 Nanos homolog 3 Human genes 0.000 claims 1
- 102100024806 Small integral membrane protein 6 Human genes 0.000 claims 1
- 102100030416 Stromelysin-1 Human genes 0.000 claims 1
- 210000002919 epithelial cell Anatomy 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1658746 | 2016-09-19 | ||
| FR1658746A FR3056227B1 (fr) | 2016-09-19 | 2016-09-19 | Methode d'evaluation du potentiel d'irritation oculaire de produits chimiques |
| PCT/EP2017/073675 WO2018050927A1 (fr) | 2016-09-19 | 2017-09-19 | Methode d'evaluation du potentiel d'irritation oculaire de produits chimiques |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019537428A JP2019537428A (ja) | 2019-12-26 |
| JP2019537428A5 true JP2019537428A5 (https=) | 2020-11-12 |
| JP7030795B2 JP7030795B2 (ja) | 2022-03-07 |
Family
ID=57583238
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019515316A Active JP7030795B2 (ja) | 2016-09-19 | 2017-09-19 | 化学物質の眼刺激性を評価するための方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US12410472B2 (https=) |
| EP (1) | EP3516070B1 (https=) |
| JP (1) | JP7030795B2 (https=) |
| DK (1) | DK3516070T3 (https=) |
| ES (1) | ES2906329T3 (https=) |
| FR (1) | FR3056227B1 (https=) |
| HU (1) | HUE057698T2 (https=) |
| PL (1) | PL3516070T3 (https=) |
| WO (1) | WO2018050927A1 (https=) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| CA2318641A1 (en) * | 1998-01-23 | 1999-07-29 | University Of Ottawa | Artificial cornea |
| FR2957090A1 (fr) * | 2010-03-05 | 2011-09-09 | Immunosearch | Methode d'evaluation du potentiel irritant d'un compose test |
-
2016
- 2016-09-19 FR FR1658746A patent/FR3056227B1/fr active Active
-
2017
- 2017-09-19 DK DK17768146.7T patent/DK3516070T3/da active
- 2017-09-19 EP EP17768146.7A patent/EP3516070B1/fr active Active
- 2017-09-19 PL PL17768146T patent/PL3516070T3/pl unknown
- 2017-09-19 HU HUE17768146A patent/HUE057698T2/hu unknown
- 2017-09-19 US US16/334,269 patent/US12410472B2/en active Active
- 2017-09-19 JP JP2019515316A patent/JP7030795B2/ja active Active
- 2017-09-19 ES ES17768146T patent/ES2906329T3/es active Active
- 2017-09-19 WO PCT/EP2017/073675 patent/WO2018050927A1/fr not_active Ceased
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