JP2019531163A - 熱療法および活性物質の送達のための相転移物質 - Google Patents

熱療法および活性物質の送達のための相転移物質 Download PDF

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Publication number
JP2019531163A
JP2019531163A JP2019524138A JP2019524138A JP2019531163A JP 2019531163 A JP2019531163 A JP 2019531163A JP 2019524138 A JP2019524138 A JP 2019524138A JP 2019524138 A JP2019524138 A JP 2019524138A JP 2019531163 A JP2019531163 A JP 2019531163A
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styrene
thermoplastic elastomer
therapeutic
therapeutic garment
thermoformable
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Pending
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JP2019524138A
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Japanese (ja)
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JP2019531163A5 (https=
JPWO2018034793A5 (https=
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アルド・ラーギ
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ALPS South LLC
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ALPS South LLC
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Publication of JP2019531163A5 publication Critical patent/JP2019531163A5/ja
Publication of JPWO2018034793A5 publication Critical patent/JPWO2018034793A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02Compresses or poultices for effecting heating or cooling
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/00051Accessories for dressings
    • A61F13/00063Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/06Bandages or dressings; Absorbent pads specially adapted for feet or legs; Corn-pads; Corn-rings
    • A61F13/08Elastic stockings; for contracting aneurisms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/12Bandages or dressings; Absorbent pads specially adapted for the head or neck
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00Devices for applying media, e.g. remedies, on the human body
    • A61M35/10Wearable devices, e.g. garments, glasses or masks
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0001Body part
    • A61F2007/0002Head or parts thereof
    • A61F2007/0003Face
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0001Body part
    • A61F2007/0002Head or parts thereof
    • A61F2007/0004Eyes or part of the face surrounding the eyes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0001Body part
    • A61F2007/0002Head or parts thereof
    • A61F2007/0009Throat or neck
    • A61F2007/001Throat only
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0001Body part
    • A61F2007/0052Body part for treatment of skin or hair
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02Compresses or poultices for effecting heating or cooling
    • A61F2007/0225Compresses or poultices for effecting heating or cooling connected to the body or a part thereof
    • A61F2007/0228Compresses or poultices for effecting heating or cooling connected to the body or a part thereof with belt or strap, e.g. with buckle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02Compresses or poultices for effecting heating or cooling
    • A61F2007/0225Compresses or poultices for effecting heating or cooling connected to the body or a part thereof
    • A61F2007/0231Compresses or poultices for effecting heating or cooling connected to the body or a part thereof hook and loop-type fastener
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02Compresses or poultices for effecting heating or cooling
    • A61F2007/0244Compresses or poultices for effecting heating or cooling with layers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02Compresses or poultices for effecting heating or cooling
    • A61F2007/0261Compresses or poultices for effecting heating or cooling medicated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02Compresses or poultices for effecting heating or cooling
    • A61F2007/0292Compresses or poultices for effecting heating or cooling using latent heat produced or absorbed during phase change of materials, e.g. of super-cooled solutions
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L9/00Compositions of homopolymers or copolymers of conjugated diene hydrocarbons
    • C08L9/06Copolymers with styrene

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Thermal Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Otolaryngology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019524138A 2016-07-21 2017-07-21 熱療法および活性物質の送達のための相転移物質 Pending JP2019531163A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662364998P 2016-07-21 2016-07-21
US62/364,998 2016-07-21
PCT/US2017/043296 WO2018034793A1 (en) 2016-07-21 2017-07-21 Phase change material for thermal therapy and delivery of active ingredients

Publications (3)

Publication Number Publication Date
JP2019531163A true JP2019531163A (ja) 2019-10-31
JP2019531163A5 JP2019531163A5 (https=) 2022-06-20
JPWO2018034793A5 JPWO2018034793A5 (https=) 2022-06-20

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JP2019524138A Pending JP2019531163A (ja) 2016-07-21 2017-07-21 熱療法および活性物質の送達のための相転移物質

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Country Link
US (1) US11389326B2 (https=)
EP (1) EP3487461A4 (https=)
JP (1) JP2019531163A (https=)
CN (1) CN109661216A (https=)
WO (1) WO2018034793A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11707556B2 (en) 2015-01-22 2023-07-25 Alps South, LLC Phase change material for thermal therapy and delivery of active ingredients
JP2024503743A (ja) * 2021-01-22 2024-01-26 シラグ・ゲーエムベーハー・インターナショナル バイオマーカ監視に基づく止血問題の予測

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190231598A1 (en) * 2015-01-22 2019-08-01 Alps South, LLC Phase Change Material For Medical And Cosmetic Applications
US11290818B1 (en) 2018-07-11 2022-03-29 Apple Inc. Wearable electronic device with speakers and sensors
WO2020222997A1 (en) * 2019-04-12 2020-11-05 Alps South, LLC Phase change material for medical and cosmetic applications
WO2022093784A1 (en) * 2020-10-29 2022-05-05 Alps South, LLC Phase change material for thermal therapy and delivery of active ingredients
US20250345189A1 (en) * 2024-05-10 2025-11-13 Alps South, LLC Bonded Prosthetic Liner
CN119157684B (zh) * 2024-11-20 2025-03-04 成都中医药大学 一种针灸辅助用精油热敷装置

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US4964402A (en) * 1988-08-17 1990-10-23 Royce Medical Company Orthopedic device having gel pad with phase change material
US5452712A (en) * 1995-01-13 1995-09-26 Richardson; James M. Disposable smoke hood with mask and dual strap arrangement
US6019101A (en) * 1996-10-31 2000-02-01 Sleepnet Corporation Nasal air mask
US20050187502A1 (en) * 2004-02-23 2005-08-25 Aqueduct Medical, Inc. Temperature-controllable device
US7709570B2 (en) * 2004-04-02 2010-05-04 Alps South, LLC Surface modification of triblock copolymer elastomers
US7744640B1 (en) * 1999-08-11 2010-06-29 Medical Products, Inc. Thermal treatment garment and method of thermally treating body portions
JP2010253695A (ja) * 2009-04-21 2010-11-11 Idemitsu Unitech Co Ltd 熱可塑性樹脂製エンボスシートの製造方法および製造装置
JP2011525122A (ja) * 2008-05-15 2011-09-15 ワイス・エルエルシー 可搬式湿熱システム
JP2012502108A (ja) * 2008-09-10 2012-01-26 シリポス インコーポレイテッド ゲル状エラストマー組成物
WO2012070543A1 (ja) * 2010-11-22 2012-05-31 株式会社資生堂 温熱マスク装置
US20120244312A1 (en) * 2008-10-03 2012-09-27 Edizone, Llc Breathable gel
JP2013500334A (ja) * 2009-07-29 2013-01-07 メドトロニック,インコーポレイテッド 痛みおよび/または炎症の処置のための可逆的相転移物質を有する埋め込み式薬物デポー
US20140243471A1 (en) * 2011-10-21 2014-08-28 Polyone Corporation Thermoplastic elastomer compounds exhibiting high latent heat of fusion in solid state
WO2016019764A1 (zh) * 2014-08-06 2016-02-11 陈蕾 一种多功能自发调节温度的膜及由其制备的面膜和眼膜
US20160051412A1 (en) * 2014-08-25 2016-02-25 Ansell Limited Wound care mask
US20160051402A1 (en) * 2014-08-22 2016-02-25 Alps South, LLC Post-surgical articles for reduction of swelling, edema, and bruising

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US5006342A (en) 1986-12-22 1991-04-09 Cygnus Corporation Resilient transdermal drug delivery device
US5565132A (en) 1995-06-06 1996-10-15 The University Of Dayton Thermoplastic, moldable, non-exuding phase change materials
US6328992B1 (en) 1997-03-03 2001-12-11 Lawrence L. Brooke Cannabinoid patch and method for cannabis transdermal delivery
US20100178323A1 (en) 2007-07-10 2010-07-15 Agis Kydonieus Dermal Delivery Device
US8895090B2 (en) 2010-09-22 2014-11-25 K-Fee System Gmbh Portion capsule and method for producing the same
US20140242127A1 (en) 2013-02-27 2014-08-28 Elc Management Llc Compositions With Thermally-Regulating Material
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Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4964402A (en) * 1988-08-17 1990-10-23 Royce Medical Company Orthopedic device having gel pad with phase change material
US5452712A (en) * 1995-01-13 1995-09-26 Richardson; James M. Disposable smoke hood with mask and dual strap arrangement
US6019101A (en) * 1996-10-31 2000-02-01 Sleepnet Corporation Nasal air mask
US7744640B1 (en) * 1999-08-11 2010-06-29 Medical Products, Inc. Thermal treatment garment and method of thermally treating body portions
US20050187502A1 (en) * 2004-02-23 2005-08-25 Aqueduct Medical, Inc. Temperature-controllable device
US7709570B2 (en) * 2004-04-02 2010-05-04 Alps South, LLC Surface modification of triblock copolymer elastomers
JP2011525122A (ja) * 2008-05-15 2011-09-15 ワイス・エルエルシー 可搬式湿熱システム
JP2012502108A (ja) * 2008-09-10 2012-01-26 シリポス インコーポレイテッド ゲル状エラストマー組成物
US20120244312A1 (en) * 2008-10-03 2012-09-27 Edizone, Llc Breathable gel
JP2010253695A (ja) * 2009-04-21 2010-11-11 Idemitsu Unitech Co Ltd 熱可塑性樹脂製エンボスシートの製造方法および製造装置
JP2013500334A (ja) * 2009-07-29 2013-01-07 メドトロニック,インコーポレイテッド 痛みおよび/または炎症の処置のための可逆的相転移物質を有する埋め込み式薬物デポー
WO2012070543A1 (ja) * 2010-11-22 2012-05-31 株式会社資生堂 温熱マスク装置
US20140243471A1 (en) * 2011-10-21 2014-08-28 Polyone Corporation Thermoplastic elastomer compounds exhibiting high latent heat of fusion in solid state
WO2016019764A1 (zh) * 2014-08-06 2016-02-11 陈蕾 一种多功能自发调节温度的膜及由其制备的面膜和眼膜
US20160051402A1 (en) * 2014-08-22 2016-02-25 Alps South, LLC Post-surgical articles for reduction of swelling, edema, and bruising
US20160051412A1 (en) * 2014-08-25 2016-02-25 Ansell Limited Wound care mask

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11707556B2 (en) 2015-01-22 2023-07-25 Alps South, LLC Phase change material for thermal therapy and delivery of active ingredients
JP2024503743A (ja) * 2021-01-22 2024-01-26 シラグ・ゲーエムベーハー・インターナショナル バイオマーカ監視に基づく止血問題の予測

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Publication number Publication date
US11389326B2 (en) 2022-07-19
US20180021169A1 (en) 2018-01-25
CN109661216A (zh) 2019-04-19
EP3487461A1 (en) 2019-05-29
WO2018034793A1 (en) 2018-02-22
EP3487461A4 (en) 2020-03-18

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