JP2019530449A - 幹細胞様メモリーt細胞の生成および養子免疫療法における使用 - Google Patents

幹細胞様メモリーt細胞の生成および養子免疫療法における使用 Download PDF

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JP2019530449A
JP2019530449A JP2019515991A JP2019515991A JP2019530449A JP 2019530449 A JP2019530449 A JP 2019530449A JP 2019515991 A JP2019515991 A JP 2019515991A JP 2019515991 A JP2019515991 A JP 2019515991A JP 2019530449 A JP2019530449 A JP 2019530449A
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cells
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cancer
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JP2019530449A5 (OSRAM
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リチャード ジョン オライリー,
リチャード ジョン オライリー,
アイシャ ナスリーン ハサン,
アイシャ ナスリーン ハサン,
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メモリアル スローン ケタリング キャンサー センター
メモリアル スローン ケタリング キャンサー センター
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Publication of JP2019530449A publication Critical patent/JP2019530449A/ja
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JP2019515991A 2016-09-23 2017-09-22 幹細胞様メモリーt細胞の生成および養子免疫療法における使用 Ceased JP2019530449A (ja)

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JP2022068256A JP2022087340A (ja) 2016-09-23 2022-04-18 幹細胞様メモリーt細胞の生成および養子免疫療法における使用

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US201662399311P 2016-09-23 2016-09-23
US62/399,311 2016-09-23
PCT/US2017/052846 WO2018057823A1 (en) 2016-09-23 2017-09-22 Generation and use in adoptive immunotherapy of stem cell-like memory t cells

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JP2022068256A Pending JP2022087340A (ja) 2016-09-23 2022-04-18 幹細胞様メモリーt細胞の生成および養子免疫療法における使用

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US (1) US10857182B2 (OSRAM)
EP (1) EP3515461A1 (OSRAM)
JP (2) JP2019530449A (OSRAM)
AR (1) AR109707A1 (OSRAM)
AU (1) AU2017330379B2 (OSRAM)
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WO (1) WO2018057823A1 (OSRAM)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021085398A1 (ja) * 2019-10-28 2021-05-06 第一三共株式会社 Cd45ra+およびccr7+の細胞表面マーカーを有するt細胞の製造方法
JP2025504968A (ja) * 2022-01-27 2025-02-19 上海市第一人民医院 サイトメガロウイルス抗原を標的とするtcrおよびそれを発現するt細胞ならびに使用

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL288241B2 (en) * 2012-06-11 2023-10-01 Wilson Wolf Mfg Corporation Improved cell culture methods for stress cell therapy
AU2017330379B2 (en) 2016-09-23 2023-07-13 Memorial Sloan Kettering Cancer Center Generation and use in adoptive immunotherapy of stem cell-like memory T cells
US20190119636A1 (en) 2017-10-23 2019-04-25 Poseida Therapeutics, Inc. Modified stem cell memory t cells, methods of making and methods of using same
WO2019220209A1 (en) * 2018-05-18 2019-11-21 The Council Of The Queensland Institute Of Medical Research Adoptive t-cell therapy for cmv infection and cmv-associated diseases
KR20220104217A (ko) 2019-11-26 2022-07-26 노파르티스 아게 Cd19 및 cd22 키메라 항원 수용체 및 이의 용도
US12365871B2 (en) 2020-04-28 2025-07-22 Lyell Immunopharma, Inc. Methods for culturing cells
TW202307210A (zh) 2021-06-01 2023-02-16 瑞士商諾華公司 Cd19和cd22嵌合抗原受體及其用途
CN113512529B (zh) * 2021-07-21 2022-11-25 上海赛傲生物技术有限公司 特异性抗病毒过继免疫细胞ab的制备方法
CN114578048B (zh) * 2021-12-22 2023-08-08 重庆医科大学附属儿童医院 一种t淋巴细胞发育亚群免疫分型的方法和试剂盒
WO2024139780A1 (zh) * 2022-12-26 2024-07-04 上海市第一人民医院 靶向巨细胞病毒pp65的T细胞受体和表达其的T细胞及应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3753357A (en) 1970-12-14 1973-08-21 Ovitron Res Corp Method and apparatus for the preservation of cells and tissues
US4199022A (en) 1978-12-08 1980-04-22 The United States Of America As Represented By The Department Of Energy Method of freezing living cells and tissues with improved subsequent survival
US4559298A (en) 1982-11-23 1985-12-17 American National Red Cross Cryopreservation of biological materials in a non-frozen or vitreous state
AUPO784197A0 (en) 1997-07-10 1997-08-07 Csl Limited Treatment of nasopharyngeal carcinoma
US7163685B2 (en) 2003-04-16 2007-01-16 City Of Hope Human cytomegalovirus antigens expressed in MVA and methods of use
DK3156069T3 (da) 2008-06-20 2020-09-21 Univ Duke Sammensætninger, fremgangsmåder, og kits til fremkaldelse af et immunrespons
US20140086888A1 (en) 2010-09-01 2014-03-27 Helen E. Heslop Ebv-specific cytotoxic t-lymphocytes for the treatment of locoregional nasopharyngeal carcinoma (npc)
WO2014039044A1 (en) * 2012-09-06 2014-03-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of producing t memory stem cell populations
AU2015218865B2 (en) 2014-02-21 2021-06-10 Coimmune, Inc. TSCM cells and methods for use
TWI673365B (zh) 2014-11-05 2019-10-01 美國紀念斯隆 凱特琳癌症中心 選擇用於過繼性細胞療法之t細胞株及其供體之方法
IL258935B2 (en) * 2015-10-28 2024-08-01 Life Tech As Selective expansion of different subpopulations of t cells by the alteration of cell surfacing signals and signal ratio
AU2017330379B2 (en) 2016-09-23 2023-07-13 Memorial Sloan Kettering Cancer Center Generation and use in adoptive immunotherapy of stem cell-like memory T cells

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BONE MARROW TRANSPLANTATION, vol. 51, JPN6021034560, 2016, pages 1163 - 1172, ISSN: 0004800281 *
THE JOURNAL OF IMMUNOLOGY, vol. 194, JPN6021034561, 2015, pages 5559 - 5567, ISSN: 0004800280 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021085398A1 (ja) * 2019-10-28 2021-05-06 第一三共株式会社 Cd45ra+およびccr7+の細胞表面マーカーを有するt細胞の製造方法
JP2025504968A (ja) * 2022-01-27 2025-02-19 上海市第一人民医院 サイトメガロウイルス抗原を標的とするtcrおよびそれを発現するt細胞ならびに使用

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CA3037002A1 (en) 2018-03-29
JP2022087340A (ja) 2022-06-09
EP3515461A1 (en) 2019-07-31
US20200009189A1 (en) 2020-01-09
AU2017330379A1 (en) 2019-04-18
WO2018057823A1 (en) 2018-03-29
AR109707A1 (es) 2019-01-16
AU2017330379B2 (en) 2023-07-13

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