JP2019529571A5 - - Google Patents
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- Publication number
- JP2019529571A5 JP2019529571A5 JP2019538580A JP2019538580A JP2019529571A5 JP 2019529571 A5 JP2019529571 A5 JP 2019529571A5 JP 2019538580 A JP2019538580 A JP 2019538580A JP 2019538580 A JP2019538580 A JP 2019538580A JP 2019529571 A5 JP2019529571 A5 JP 2019529571A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- functional rna
- rna molecule
- composition
- small molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 46
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 23
- 229940126586 small molecule drug Drugs 0.000 claims 18
- 229920001184 polypeptide Polymers 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 108091034117 Oligonucleotide Proteins 0.000 claims 5
- 230000008685 targeting Effects 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000002105 nanoparticle Substances 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 239000002502 liposome Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- CXURGFRDGROIKG-UHFFFAOYSA-N 3,3-bis(chloromethyl)oxetane Chemical compound ClCC1(CCl)COC1 CXURGFRDGROIKG-UHFFFAOYSA-N 0.000 claims 1
- 102000037982 Immune checkpoint proteins Human genes 0.000 claims 1
- 108091008036 Immune checkpoint proteins Proteins 0.000 claims 1
- 101710148893 Internalin B Proteins 0.000 claims 1
- 108010039918 Polylysine Proteins 0.000 claims 1
- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims 1
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims 1
- 108091027967 Small hairpin RNA Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 229940100198 alkylating agent Drugs 0.000 claims 1
- 239000002168 alkylating agent Substances 0.000 claims 1
- 229940045799 anthracyclines and related substance Drugs 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 229960004679 doxorubicin Drugs 0.000 claims 1
- 108010034429 heregulin alpha Proteins 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229920000656 polylysine Polymers 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 239000004055 small Interfering RNA Substances 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662403595P | 2016-10-03 | 2016-10-03 | |
| US62/403,595 | 2016-10-03 | ||
| PCT/US2017/054884 WO2018067526A1 (en) | 2016-10-03 | 2017-10-03 | Functional rna and small-molecule drug therapeutic complexes and nanoparticle delivery vehicles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019529571A JP2019529571A (ja) | 2019-10-17 |
| JP2019529571A5 true JP2019529571A5 (enExample) | 2020-11-12 |
Family
ID=61831202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019538580A Pending JP2019529571A (ja) | 2016-10-03 | 2017-10-03 | 機能性ｒｎａと小分子薬の治療用複合体、およびナノ粒子送達ビヒクル |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20190240344A1 (enExample) |
| EP (1) | EP3518939A4 (enExample) |
| JP (1) | JP2019529571A (enExample) |
| CN (1) | CN109890393A (enExample) |
| AU (1) | AU2017339456A1 (enExample) |
| CA (1) | CA3039040A1 (enExample) |
| WO (1) | WO2018067526A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010085665A2 (en) | 2009-01-23 | 2010-07-29 | Cedars-Sinai Medical Center | Targeted delivery system |
| RU2682335C2 (ru) | 2014-01-17 | 2019-03-19 | Сидарс-Синай Медикал Сентр | Рецептор-направленные конструкции и их применение |
| WO2019136005A1 (en) * | 2018-01-02 | 2019-07-11 | Cedars-Sinai Medical Center | Nanoparticles for the targeted delivery of therapeutic polypeptides |
| CN109432430B (zh) * | 2018-11-22 | 2021-12-17 | 华南理工大学 | 一种siRNA和抗癌药物疏水性复合物及其制备方法与应用 |
| CN119015258A (zh) * | 2019-09-06 | 2024-11-26 | 加利福尼亚大学董事会 | 核酸介导的治疗剂的递送 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1206285A2 (en) * | 1999-08-09 | 2002-05-22 | The General Hospital Corporation | Drug-carrier complexes and methods of use thereof |
| ATE513843T1 (de) * | 2002-09-25 | 2011-07-15 | Univ Massachusetts | Abstellen von genen in vivo durch chemischmodifizierte und stabile sirna |
| US9078927B2 (en) * | 2007-07-06 | 2015-07-14 | Cedars-Sinai Medical Center | Self-assembling complex for targeting chemical agents to cells |
| JP5252618B2 (ja) * | 2007-10-26 | 2013-07-31 | 独立行政法人産業技術総合研究所 | ＲＮＡ干渉効果が高い芳香環修飾ｓｉＲＮＡ |
| WO2010085665A2 (en) * | 2009-01-23 | 2010-07-29 | Cedars-Sinai Medical Center | Targeted delivery system |
| RU2682335C2 (ru) * | 2014-01-17 | 2019-03-19 | Сидарс-Синай Медикал Сентр | Рецептор-направленные конструкции и их применение |
| MX2018014576A (es) * | 2016-05-27 | 2019-06-06 | Cedars Sinai Medical Center | Nanopartículas para el suministro de fármaco y tratamientos para el cáncer resistente a fármacos. |
-
2017
- 2017-10-03 WO PCT/US2017/054884 patent/WO2018067526A1/en not_active Ceased
- 2017-10-03 CA CA3039040A patent/CA3039040A1/en not_active Abandoned
- 2017-10-03 AU AU2017339456A patent/AU2017339456A1/en not_active Abandoned
- 2017-10-03 EP EP17858997.4A patent/EP3518939A4/en not_active Withdrawn
- 2017-10-03 CN CN201780061209.0A patent/CN109890393A/zh active Pending
- 2017-10-03 JP JP2019538580A patent/JP2019529571A/ja active Pending
- 2017-10-03 US US16/338,909 patent/US20190240344A1/en not_active Abandoned
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