JP2019529481A - 胆汁酸誘導体の結晶形態 - Google Patents
胆汁酸誘導体の結晶形態 Download PDFInfo
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
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- Hematology (AREA)
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- Heart & Thoracic Surgery (AREA)
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- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662402813P | 2016-09-30 | 2016-09-30 | |
| US62/402,813 | 2016-09-30 | ||
| PCT/US2017/054227 WO2018064441A1 (en) | 2016-09-30 | 2017-09-29 | Crystalline forms of a bile acid derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019529481A true JP2019529481A (ja) | 2019-10-17 |
| JP2019529481A5 JP2019529481A5 (OSRAM) | 2020-09-17 |
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| JP2019516972A Withdrawn JP2019529481A (ja) | 2016-09-30 | 2017-09-29 | 胆汁酸誘導体の結晶形態 |
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|---|---|
| US (1) | US20200024299A1 (OSRAM) |
| EP (1) | EP3518937A4 (OSRAM) |
| JP (1) | JP2019529481A (OSRAM) |
| KR (1) | KR20190057108A (OSRAM) |
| CN (1) | CN109963567A (OSRAM) |
| AU (1) | AU2017336803A1 (OSRAM) |
| BR (1) | BR112019006242A2 (OSRAM) |
| CA (1) | CA3038534A1 (OSRAM) |
| IL (1) | IL265621A (OSRAM) |
| MX (1) | MX2019003684A (OSRAM) |
| WO (1) | WO2018064441A1 (OSRAM) |
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| JP2022552655A (ja) | 2019-10-07 | 2022-12-19 | キャリーオペ，インク． | Ｇｐｒ１１９アゴニスト |
| PH12022552277A1 (en) | 2020-02-28 | 2024-03-04 | Kallyope Inc | Gpr40 agonists |
| CA3178994A1 (en) | 2020-05-19 | 2021-11-25 | Iyassu Sebhat | Ampk activators |
| JP2023531726A (ja) | 2020-06-26 | 2023-07-25 | キャリーオペ，インク． | Ａｍｐｋアクチベーター |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008002573A2 (en) * | 2006-06-27 | 2008-01-03 | Intercept Pharmaceuticals, Inc. | Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated deseases or conditions |
| CN101528752A (zh) * | 2006-10-16 | 2009-09-09 | 辉瑞产品公司 | 治疗性吡唑基噻吩并吡啶 |
| JP5441705B2 (ja) * | 2007-10-15 | 2014-03-12 | 武田薬品工業株式会社 | アミド化合物およびその用途 |
| EP2468762A1 (en) * | 2010-11-30 | 2012-06-27 | Dr. Falk Pharma Gmbh | Optimized synthesis of pure, non-polymorphic, crystalline bile acids with defined particle size |
| ES2822375T3 (es) * | 2012-06-19 | 2021-04-30 | Intercept Pharmaceuticals Inc | Preparación de la forma no cristalina del ácido obeticólico |
| WO2014066819A1 (en) * | 2012-10-26 | 2014-05-01 | Intercept Pharmaceuticals, Inc. | Process for preparing bile acid derivatives |
| KR102106186B1 (ko) * | 2012-11-28 | 2020-05-04 | 인터셉트 파마슈티컬즈, 인크. | 폐 질환의 치료 |
| HUP1300504A2 (en) * | 2013-08-27 | 2015-03-30 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Sorafenib salts |
| BR112018002499A2 (pt) * | 2015-08-07 | 2018-09-18 | Intercept Pharmaceuticals Inc | método de preparação de um composto da fórmula (a) ou um seu sal, solvato ou conjugado de aminoácido farmaceuticamente aceitável, composto produzido pelo método e composição farmacêutica |
| KR20180052756A (ko) * | 2015-09-24 | 2018-05-18 | 인터셉트 파마슈티컬즈, 인크. | 담즙산 유도체 제조를 위한 방법 및 중간체 |
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2017
- 2017-09-29 WO PCT/US2017/054227 patent/WO2018064441A1/en not_active Ceased
- 2017-09-29 AU AU2017336803A patent/AU2017336803A1/en not_active Abandoned
- 2017-09-29 US US16/337,982 patent/US20200024299A1/en not_active Abandoned
- 2017-09-29 MX MX2019003684A patent/MX2019003684A/es unknown
- 2017-09-29 EP EP17857474.5A patent/EP3518937A4/en not_active Withdrawn
- 2017-09-29 BR BR112019006242A patent/BR112019006242A2/pt not_active IP Right Cessation
- 2017-09-29 JP JP2019516972A patent/JP2019529481A/ja not_active Withdrawn
- 2017-09-29 KR KR1020197012131A patent/KR20190057108A/ko not_active Withdrawn
- 2017-09-29 CN CN201780071347.7A patent/CN109963567A/zh active Pending
- 2017-09-29 CA CA3038534A patent/CA3038534A1/en not_active Abandoned
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2019
- 2019-03-26 IL IL265621A patent/IL265621A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20190057108A (ko) | 2019-05-27 |
| AU2017336803A1 (en) | 2019-04-18 |
| MX2019003684A (es) | 2019-08-05 |
| BR112019006242A2 (pt) | 2019-06-18 |
| WO2018064441A1 (en) | 2018-04-05 |
| IL265621A (en) | 2019-05-30 |
| EP3518937A1 (en) | 2019-08-07 |
| CN109963567A (zh) | 2019-07-02 |
| EP3518937A4 (en) | 2020-04-29 |
| US20200024299A1 (en) | 2020-01-23 |
| CA3038534A1 (en) | 2018-04-05 |
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