JP2019529344A5 - - Google Patents
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- JP2019529344A5 JP2019529344A5 JP2019501691A JP2019501691A JP2019529344A5 JP 2019529344 A5 JP2019529344 A5 JP 2019529344A5 JP 2019501691 A JP2019501691 A JP 2019501691A JP 2019501691 A JP2019501691 A JP 2019501691A JP 2019529344 A5 JP2019529344 A5 JP 2019529344A5
- Authority
- JP
- Japan
- Prior art keywords
- ala
- change
- phenylalanine
- combination
- arginine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 100
- COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 100
- 108010062877 Bacteriocins Proteins 0.000 claims description 76
- 239000004475 Arginine Chemical group 0.000 claims description 70
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Chemical group OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 70
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims description 64
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical group C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 55
- 235000004279 alanine Nutrition 0.000 claims description 55
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims description 42
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims description 42
- 235000009582 asparagine Nutrition 0.000 claims description 42
- 229960001230 asparagine Drugs 0.000 claims description 42
- 239000000203 mixture Substances 0.000 claims description 41
- 230000035772 mutation Effects 0.000 claims description 38
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical group CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 36
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 36
- 229960000310 isoleucine Drugs 0.000 claims description 36
- 102220465932 Beta-1,3-glucuronyltransferase LARGE2_R13A_mutation Human genes 0.000 claims description 34
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical group NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 34
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 32
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 32
- 150000001413 amino acids Chemical group 0.000 claims description 32
- 239000004474 valine Substances 0.000 claims description 32
- 238000000034 method Methods 0.000 claims description 29
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 27
- 241000894006 Bacteria Species 0.000 claims description 24
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 22
- 235000003704 aspartic acid Nutrition 0.000 claims description 22
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 22
- 102000040430 polynucleotide Human genes 0.000 claims description 20
- 108091033319 polynucleotide Proteins 0.000 claims description 20
- 239000002157 polynucleotide Substances 0.000 claims description 20
- 239000004471 Glycine Substances 0.000 claims description 19
- 230000000845 anti-microbial effect Effects 0.000 claims description 18
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 17
- 239000004599 antimicrobial Substances 0.000 claims description 16
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical group CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 15
- 230000001580 bacterial effect Effects 0.000 claims description 13
- 102220597698 NAD-dependent protein deacetylase sirtuin-3, mitochondrial_R13Q_mutation Human genes 0.000 claims description 12
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims description 12
- 108010035587 R13Q Proteins 0.000 claims description 12
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims description 12
- 102220231544 rs281865209 Human genes 0.000 claims description 12
- 102220245498 rs886041141 Human genes 0.000 claims description 12
- 230000004481 post-translational protein modification Effects 0.000 claims description 11
- 235000001014 amino acid Nutrition 0.000 claims description 10
- 229940024606 amino acid Drugs 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical group OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 8
- QWCKQJZIFLGMSD-UHFFFAOYSA-N alpha-aminobutyric acid Chemical group CCC(N)C(O)=O QWCKQJZIFLGMSD-UHFFFAOYSA-N 0.000 claims description 8
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 8
- 239000012528 membrane Substances 0.000 claims description 7
- DWPCPZJAHOETAG-IMJSIDKUSA-N L-lanthionine Chemical compound OC(=O)[C@@H](N)CSC[C@H](N)C(O)=O DWPCPZJAHOETAG-IMJSIDKUSA-N 0.000 claims description 6
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 6
- DWPCPZJAHOETAG-UHFFFAOYSA-N meso-lanthionine Natural products OC(=O)C(N)CSCC(N)C(O)=O DWPCPZJAHOETAG-UHFFFAOYSA-N 0.000 claims description 6
- 102220226043 rs1064794935 Human genes 0.000 claims description 6
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- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 5
- 239000004473 Threonine Substances 0.000 claims description 5
- 239000003085 diluting agent Substances 0.000 claims description 5
- QWWVBNODQCWBAZ-WHFBIAKZSA-N (2r)-2-amino-3-[(2r)-2-carboxy-2-(methylamino)ethyl]sulfanylpropanoic acid Chemical group CN[C@H](C(O)=O)CSC[C@H](N)C(O)=O QWWVBNODQCWBAZ-WHFBIAKZSA-N 0.000 claims description 4
- -1 aminovinyl group Chemical group 0.000 claims description 4
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- 230000000844 anti-bacterial effect Effects 0.000 claims description 3
- 239000003429 antifungal agent Substances 0.000 claims description 3
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- 239000004220 glutamic acid Substances 0.000 claims description 3
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- 102000007698 Alcohol dehydrogenase Human genes 0.000 claims description 2
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims description 2
- QWCKQJZIFLGMSD-GSVOUGTGSA-N D-alpha-aminobutyric acid Chemical group CC[C@@H](N)C(O)=O QWCKQJZIFLGMSD-GSVOUGTGSA-N 0.000 claims description 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical group OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical group C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 238000003786 synthesis reaction Methods 0.000 claims description 2
- 241000024188 Andala Species 0.000 claims 1
- 241000406668 Loxodonta cyclotis Species 0.000 claims 1
- 230000001323 posttranslational effect Effects 0.000 claims 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 19
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- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 description 12
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 8
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- 241000193470 Clostridium sporogenes Species 0.000 description 3
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- 241000186427 Cutibacterium acnes Species 0.000 description 3
- 241000192125 Firmicutes Species 0.000 description 3
- 241000194046 Streptococcus intermedius Species 0.000 description 3
- 241000193996 Streptococcus pyogenes Species 0.000 description 3
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- 206010013023 diphtheria Diseases 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
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- 241000588832 Bordetella pertussis Species 0.000 description 2
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662362788P | 2016-07-15 | 2016-07-15 | |
| US201662362809P | 2016-07-15 | 2016-07-15 | |
| US62/362,788 | 2016-07-15 | ||
| US62/362,809 | 2016-07-15 | ||
| US201662420328P | 2016-11-10 | 2016-11-10 | |
| US62/420,328 | 2016-11-10 | ||
| PCT/US2017/042206 WO2018013967A1 (en) | 2016-07-15 | 2017-07-14 | Lantibiotic variants and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019529344A JP2019529344A (ja) | 2019-10-17 |
| JP2019529344A5 true JP2019529344A5 (enExample) | 2020-08-27 |
Family
ID=59626658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019501691A Pending JP2019529344A (ja) | 2016-07-15 | 2017-07-14 | ランチビオティックバリアントおよびその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20190315814A1 (enExample) |
| EP (1) | EP3484442A1 (enExample) |
| JP (1) | JP2019529344A (enExample) |
| KR (1) | KR20190028746A (enExample) |
| CN (1) | CN109715132A (enExample) |
| AU (1) | AU2017296061B2 (enExample) |
| CA (1) | CA3027673A1 (enExample) |
| IL (1) | IL263682A (enExample) |
| SG (1) | SG11201810952PA (enExample) |
| WO (1) | WO2018013967A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10577399B2 (en) | 2016-10-28 | 2020-03-03 | The Texas A&M University System | Modified lantibiotics and methods of making and using the modified lantibiotics |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| JP2022085803A (ja) * | 2020-11-27 | 2022-06-08 | 株式会社三六九 | スポット式換気クリーンシステム、並びに可変式フェイスシールド |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4366246A (en) | 1977-11-08 | 1982-12-28 | Genentech, Inc. | Method for microbial polypeptide expression |
| US5607672A (en) | 1995-06-07 | 1997-03-04 | University Of Florida Research Foundation, Inc. | Replacement therapy for dental caries |
| US6964760B2 (en) | 1997-06-10 | 2005-11-15 | University Of Florida Research Foundation | Antimicrobial polypeptide, nucleic acid, and methods of use |
| ATE512158T1 (de) | 2005-08-12 | 2011-06-15 | Oragenics Inc | Differenziell geschützte, orthogonale lanthionintechnologie |
| US20090215985A1 (en) | 2005-08-12 | 2009-08-27 | Oragenics, Inc. | Differentially protected orthogonal lanthionine technology |
| CA2865405C (en) * | 2012-02-27 | 2021-11-16 | Oragenics, Inc. | Replacement therapy for dental caries |
-
2017
- 2017-07-14 AU AU2017296061A patent/AU2017296061B2/en not_active Ceased
- 2017-07-14 KR KR1020197004029A patent/KR20190028746A/ko not_active Ceased
- 2017-07-14 WO PCT/US2017/042206 patent/WO2018013967A1/en not_active Ceased
- 2017-07-14 US US16/316,328 patent/US20190315814A1/en not_active Abandoned
- 2017-07-14 CN CN201780043960.8A patent/CN109715132A/zh active Pending
- 2017-07-14 SG SG11201810952PA patent/SG11201810952PA/en unknown
- 2017-07-14 EP EP17752195.2A patent/EP3484442A1/en not_active Withdrawn
- 2017-07-14 CA CA3027673A patent/CA3027673A1/en not_active Abandoned
- 2017-07-14 JP JP2019501691A patent/JP2019529344A/ja active Pending
-
2018
- 2018-12-12 IL IL263682A patent/IL263682A/en unknown
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