JP2019528774A5 - - Google Patents
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- JP2019528774A5 JP2019528774A5 JP2019518451A JP2019518451A JP2019528774A5 JP 2019528774 A5 JP2019528774 A5 JP 2019528774A5 JP 2019518451 A JP2019518451 A JP 2019518451A JP 2019518451 A JP2019518451 A JP 2019518451A JP 2019528774 A5 JP2019528774 A5 JP 2019528774A5
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662405184P | 2016-10-06 | 2016-10-06 | |
| US62/405,184 | 2016-10-06 | ||
| PCT/US2017/055661 WO2018068022A1 (en) | 2016-10-06 | 2017-10-06 | Inducible caspases and methods for use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019528774A JP2019528774A (ja) | 2019-10-17 |
| JP2019528774A5 true JP2019528774A5 (https=) | 2020-10-08 |
| JP7054694B2 JP7054694B2 (ja) | 2022-04-14 |
Family
ID=60190939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019518451A Active JP7054694B2 (ja) | 2016-10-06 | 2017-10-06 | 誘導性カスパーゼおよび使用方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US11377480B2 (https=) |
| EP (2) | EP4640273A3 (https=) |
| JP (1) | JP7054694B2 (https=) |
| KR (1) | KR102447083B1 (https=) |
| CN (1) | CN110267980A (https=) |
| AU (1) | AU2017339511B2 (https=) |
| BR (1) | BR112019006865A2 (https=) |
| DK (1) | DK3523325T3 (https=) |
| ES (1) | ES3051391T3 (https=) |
| FI (1) | FI3523325T3 (https=) |
| HR (1) | HRP20251387T1 (https=) |
| IL (1) | IL265664B2 (https=) |
| LT (1) | LT3523325T (https=) |
| MX (1) | MX2019003983A (https=) |
| PL (1) | PL3523325T3 (https=) |
| PT (1) | PT3523325T (https=) |
| RS (1) | RS67390B1 (https=) |
| RU (1) | RU2757058C2 (https=) |
| SI (1) | SI3523325T1 (https=) |
| WO (1) | WO2018068022A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3523325T (pt) | 2016-10-06 | 2025-11-12 | Poseida Therapeutics Inc | Caspases induzíveis e métodos de utilização |
| WO2020037142A1 (en) | 2018-08-17 | 2020-02-20 | Yale University | Compositions and methods for high-throughput activation screening to boost t cell effector function |
| US20220042038A1 (en) | 2018-12-20 | 2022-02-10 | Poseida Therapeutics, Inc. | Nanotransposon compositions and methods of use |
| CN114761424B (zh) | 2019-09-05 | 2025-09-19 | 波赛达治疗公司 | 同种异体细胞组合物和使用方法 |
| CA3162246A1 (en) | 2019-12-20 | 2021-06-24 | Poseida Therapeutics, Inc. | Anti-muc1 compositions and methods of use |
| WO2021183795A1 (en) | 2020-03-11 | 2021-09-16 | Poseida Therapeutics, Inc. | Chimeric stimulatory receptors and methods of use in t cell activation and differentiation |
| EP4298205A1 (en) | 2021-02-23 | 2024-01-03 | Poseida Therapeutics, Inc. | Genetically modified induced pluripotent stem cells and methods of use thereof |
| EP4413141A1 (en) | 2021-10-04 | 2024-08-14 | Poseida Therapeutics, Inc. | Transposon compositions and methods of use thereof |
| CN113999873B (zh) * | 2021-12-31 | 2022-05-20 | 北京市疾病预防控制中心 | 一种基因修饰的非人动物的构建方法及其应用 |
| CN114736306B (zh) * | 2022-03-01 | 2024-04-19 | 中国科学院深圳先进技术研究院 | 一种受化学调控的蛋白酶工具及其配套底物 |
| WO2023173137A1 (en) * | 2022-03-11 | 2023-09-14 | Yale University | Compositions and methods for efficient and stable genetic modification of eukaryotic cells |
| CN118185901B (zh) * | 2022-12-12 | 2025-03-21 | 北京精缮生物科技有限责任公司 | 一种PBase蛋白、融合蛋白、核酸和基因整合系统及应用 |
| EP4669745A1 (en) | 2023-02-21 | 2025-12-31 | Poseida Therapeutics, Inc. | COMPOSITIONS AND GENOMIC EDITING PROCESSES |
| JP2026507648A (ja) | 2023-02-21 | 2026-03-04 | ポセイダ セラピューティクス，インコーポレイティド | ゲノム編集のための組成物及び方法 |
| KR20250173518A (ko) | 2023-04-05 | 2025-12-10 | 포세이다 테라퓨틱스, 인크. | 트랜스포사제 폴리뉴클레오티드 및 그의 용도 |
| WO2025029171A1 (ru) * | 2023-07-29 | 2025-02-06 | Общество с ограниченной ответственностью "Генетические технологии" (ООО "Генетические технологии") | Векторы экспрессии на основе аденоассоциированного вируса |
| WO2025038655A1 (en) | 2023-08-14 | 2025-02-20 | Ponce Therapeutics, Inc. | Multimerizer pharmaceutical compositions of rimiducid |
| WO2026080393A1 (en) | 2024-10-07 | 2026-04-16 | Poseida Therapeutics, Inc. | Compositions and methods for use in car cell therapies |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4656134A (en) | 1982-01-11 | 1987-04-07 | Board Of Trustees Of Leland Stanford Jr. University | Gene amplification in eukaryotic cells |
| US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4766067A (en) | 1985-05-31 | 1988-08-23 | President And Fellows Of Harvard College | Gene amplification |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US4889818A (en) | 1986-08-22 | 1989-12-26 | Cetus Corporation | Purified thermostable enzyme |
| US4795699A (en) | 1987-01-14 | 1989-01-03 | President And Fellows Of Harvard College | T7 DNA polymerase |
| US4921794A (en) | 1987-01-14 | 1990-05-01 | President And Fellows Of Harvard College | T7 DNA polymerase |
| US5130238A (en) | 1988-06-24 | 1992-07-14 | Cangene Corporation | Enhanced nucleic acid amplification process |
| US5142033A (en) | 1988-09-23 | 1992-08-25 | Hoffmann-La Roche Inc. | Structure-independent DNA amplification by the polymerase chain reaction |
| US5091310A (en) | 1988-09-23 | 1992-02-25 | Cetus Corporation | Structure-independent dna amplification by the polymerase chain reaction |
| US5066584A (en) | 1988-09-23 | 1991-11-19 | Cetus Corporation | Methods for generating single stranded dna by the polymerase chain reaction |
| US4994370A (en) | 1989-01-03 | 1991-02-19 | The United States Of America As Represented By The Department Of Health And Human Services | DNA amplification technique |
| US5266491A (en) | 1989-03-14 | 1993-11-30 | Mochida Pharmaceutical Co., Ltd. | DNA fragment and expression plasmid containing the DNA fragment |
| US5580734A (en) | 1990-07-13 | 1996-12-03 | Transkaryotic Therapies, Inc. | Method of producing a physical map contigous DNA sequences |
| US5733761A (en) | 1991-11-05 | 1998-03-31 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| US5641670A (en) | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| US6835394B1 (en) | 1999-12-14 | 2004-12-28 | The Trustees Of The University Of Pennsylvania | Polymersomes and related encapsulating membranes |
| MXPA04002103A (es) * | 2001-09-04 | 2004-06-07 | Yeda Res & Dev | Una proteina de union a caspasa-8, su preparacion y uso. |
| WO2006133398A2 (en) | 2005-06-08 | 2006-12-14 | Invitrogen Corporation | In vitro activated donor t-cells to promote transplant engraftment |
| JP4563491B1 (ja) | 2009-07-07 | 2010-10-13 | 株式会社片岡製作所 | レーザ加工機 |
| US8808748B2 (en) | 2010-04-20 | 2014-08-19 | Vindico NanoBio Technology Inc. | Biodegradable nanoparticles as novel hemoglobin-based oxygen carriers and methods of using the same |
| WO2011146862A1 (en) | 2010-05-21 | 2011-11-24 | Bellicum Pharmaceuticals, Inc. | Methods for inducing selective apoptosis |
| DK2661275T3 (en) | 2011-01-07 | 2019-04-15 | Poseida Therapeutics Inc | COMPOSITIONS AND METHODS FOR ADMINISTRATING THE HIGH OXYGEN EFFICIENCY TO TUMORS FOR THE ADMINISTRATION |
| CA2912172A1 (en) | 2013-06-05 | 2014-12-11 | Bellicum Pharmaceuticals, Inc. | Methods for inducing partial apoptosis using caspase polypeptides |
| CA2940460A1 (en) * | 2014-03-07 | 2015-09-11 | Bellicum Pharmaceuticals, Inc. | Caspase polypeptides having modified activity and uses thereof |
| CA2957552C (en) | 2014-08-08 | 2024-01-16 | Vindico Nanobiotechnology, Llc | Compositions and methods for inducing nanoparticle-mediated microvascular embolization of tumors |
| WO2016090111A1 (en) | 2014-12-05 | 2016-06-09 | Vindico NanoBio Technology Inc. | Compositions and methods for inducing nanoparticle-mediated microvascular embolization of tumors |
| GB201503133D0 (en) * | 2015-02-24 | 2015-04-08 | Ucl Business Plc And Syncona Partners Llp | Chimeric protein |
| US10456452B2 (en) | 2015-07-02 | 2019-10-29 | Poseida Therapeutics, Inc. | Compositions and methods for improved encapsulation of functional proteins in polymeric vesicles |
| US20170000743A1 (en) | 2015-07-02 | 2017-01-05 | Vindico NanoBio Technology Inc. | Compositions and Methods for Delivery of Gene Editing Tools Using Polymeric Vesicles |
| US9834743B2 (en) | 2016-04-23 | 2017-12-05 | Seid Mehdi Naeini | Removing pets urin, odor and mildew out of hand made rugs |
| ES2865481T3 (es) | 2016-04-29 | 2021-10-15 | Poseida Therapeutics Inc | Micelas basadas en poli(histidina) para la complejación y el aporte de proteínas y ácidos nucleicos |
| PT3523325T (pt) | 2016-10-06 | 2025-11-12 | Poseida Therapeutics Inc | Caspases induzíveis e métodos de utilização |
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