JP2019525989A5 - - Google Patents
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- JP2019525989A5 JP2019525989A5 JP2019506372A JP2019506372A JP2019525989A5 JP 2019525989 A5 JP2019525989 A5 JP 2019525989A5 JP 2019506372 A JP2019506372 A JP 2019506372A JP 2019506372 A JP2019506372 A JP 2019506372A JP 2019525989 A5 JP2019525989 A5 JP 2019525989A5
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- JP
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- Prior art keywords
- polymer
- article
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- poly
- Prior art date
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- 229920000642 polymer Polymers 0.000 claims description 138
- 238000000034 method Methods 0.000 claims description 129
- 239000010410 layer Substances 0.000 claims description 93
- 239000000178 monomer Substances 0.000 claims description 65
- 239000000758 substrate Substances 0.000 claims description 58
- -1 poly(glycerol) Polymers 0.000 claims description 52
- 239000003999 initiator Substances 0.000 claims description 38
- 238000006116 polymerization reaction Methods 0.000 claims description 28
- 239000007787 solid Substances 0.000 claims description 26
- 230000000977 initiatory effect Effects 0.000 claims description 19
- 150000003254 radicals Chemical class 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 14
- 239000013047 polymeric layer Substances 0.000 claims description 11
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 10
- 229920001223 polyethylene glycol Polymers 0.000 claims description 10
- 239000002904 solvent Substances 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 10
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 claims description 8
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 8
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 8
- 229920000578 graft copolymer Polymers 0.000 claims description 7
- 108010043958 Peptoids Proteins 0.000 claims description 6
- 239000004695 Polyether sulfone Substances 0.000 claims description 6
- 239000002202 Polyethylene glycol Substances 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 229920006393 polyether sulfone Polymers 0.000 claims description 6
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 6
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 6
- 239000000017 hydrogel Substances 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 239000002033 PVDF binder Substances 0.000 claims description 4
- 239000004696 Poly ether ether ketone Substances 0.000 claims description 4
- 239000004698 Polyethylene Substances 0.000 claims description 4
- 239000004743 Polypropylene Substances 0.000 claims description 4
- 239000004793 Polystyrene Substances 0.000 claims description 4
- 229920002125 Sokalan® Polymers 0.000 claims description 4
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 4
- 239000004433 Thermoplastic polyurethane Substances 0.000 claims description 4
- 229920001577 copolymer Polymers 0.000 claims description 4
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 claims description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 4
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 4
- 229920001652 poly(etherketoneketone) Polymers 0.000 claims description 4
- 239000005014 poly(hydroxyalkanoate) Substances 0.000 claims description 4
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 4
- 229920000052 poly(p-xylylene) Polymers 0.000 claims description 4
- 229920006260 polyaryletherketone Polymers 0.000 claims description 4
- 229920001707 polybutylene terephthalate Polymers 0.000 claims description 4
- 239000004417 polycarbonate Substances 0.000 claims description 4
- 229920002530 polyetherether ketone Polymers 0.000 claims description 4
- 229920000139 polyethylene terephthalate Polymers 0.000 claims description 4
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 4
- 229920000223 polyglycerol Polymers 0.000 claims description 4
- 229920000903 polyhydroxyalkanoate Polymers 0.000 claims description 4
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 claims description 4
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 4
- 239000004814 polyurethane Substances 0.000 claims description 4
- 239000004800 polyvinyl chloride Substances 0.000 claims description 4
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 4
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 4
- CIHOLLKRGTVIJN-UHFFFAOYSA-N tert‐butyl hydroperoxide Chemical compound CC(C)(C)OO CIHOLLKRGTVIJN-UHFFFAOYSA-N 0.000 claims description 4
- 229920002803 thermoplastic polyurethane Polymers 0.000 claims description 4
- 229920001187 thermosetting polymer Polymers 0.000 claims description 4
- 208000010412 Glaucoma Diseases 0.000 claims description 3
- 239000000560 biocompatible material Substances 0.000 claims description 3
- 230000002265 prevention Effects 0.000 claims description 3
- KDGNCLDCOVTOCS-UHFFFAOYSA-N (2-methylpropan-2-yl)oxy propan-2-yl carbonate Chemical compound CC(C)OC(=O)OOC(C)(C)C KDGNCLDCOVTOCS-UHFFFAOYSA-N 0.000 claims description 2
- HSLFISVKRDQEBY-UHFFFAOYSA-N 1,1-bis(tert-butylperoxy)cyclohexane Chemical compound CC(C)(C)OOC1(OOC(C)(C)C)CCCCC1 HSLFISVKRDQEBY-UHFFFAOYSA-N 0.000 claims description 2
- CCNDOQHYOIISTA-UHFFFAOYSA-N 1,2-bis(2-tert-butylperoxypropan-2-yl)benzene Chemical compound CC(C)(C)OOC(C)(C)C1=CC=CC=C1C(C)(C)OOC(C)(C)C CCNDOQHYOIISTA-UHFFFAOYSA-N 0.000 claims description 2
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2,2'-azo-bis-isobutyronitrile Substances N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 claims description 2
- HQOVXPHOJANJBR-UHFFFAOYSA-N 2,2-bis(tert-butylperoxy)butane Chemical compound CC(C)(C)OOC(C)(CC)OOC(C)(C)C HQOVXPHOJANJBR-UHFFFAOYSA-N 0.000 claims description 2
- ODBCKCWTWALFKM-UHFFFAOYSA-N 2,5-bis(tert-butylperoxy)-2,5-dimethylhex-3-yne Chemical compound CC(C)(C)OOC(C)(C)C#CC(C)(C)OOC(C)(C)C ODBCKCWTWALFKM-UHFFFAOYSA-N 0.000 claims description 2
- DMWVYCCGCQPJEA-UHFFFAOYSA-N 2,5-bis(tert-butylperoxy)-2,5-dimethylhexane Chemical compound CC(C)(C)OOC(C)(C)CCC(C)(C)OOC(C)(C)C DMWVYCCGCQPJEA-UHFFFAOYSA-N 0.000 claims description 2
- XMNIXWIUMCBBBL-UHFFFAOYSA-N 2-(2-phenylpropan-2-ylperoxy)propan-2-ylbenzene Chemical compound C=1C=CC=CC=1C(C)(C)OOC(C)(C)C1=CC=CC=C1 XMNIXWIUMCBBBL-UHFFFAOYSA-N 0.000 claims description 2
- HWSSEYVMGDIFMH-UHFFFAOYSA-N 2-[2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOCCOC(=O)C(C)=C HWSSEYVMGDIFMH-UHFFFAOYSA-N 0.000 claims description 2
- NLGDWWCZQDIASO-UHFFFAOYSA-N 2-hydroxy-1-(7-oxabicyclo[4.1.0]hepta-1,3,5-trien-2-yl)-2-phenylethanone Chemical compound OC(C(=O)c1cccc2Oc12)c1ccccc1 NLGDWWCZQDIASO-UHFFFAOYSA-N 0.000 claims description 2
- XMLYCEVDHLAQEL-UHFFFAOYSA-N 2-hydroxy-2-methyl-1-phenylpropan-1-one Chemical compound CC(C)(O)C(=O)C1=CC=CC=C1 XMLYCEVDHLAQEL-UHFFFAOYSA-N 0.000 claims description 2
- RFSCGDQQLKVJEJ-UHFFFAOYSA-N 2-methylbutan-2-yl benzenecarboperoxoate Chemical compound CCC(C)(C)OOC(=O)C1=CC=CC=C1 RFSCGDQQLKVJEJ-UHFFFAOYSA-N 0.000 claims description 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 2
- FRIBMENBGGCKPD-UHFFFAOYSA-N 3-(2,3-dimethoxyphenyl)prop-2-enal Chemical compound COC1=CC=CC(C=CC=O)=C1OC FRIBMENBGGCKPD-UHFFFAOYSA-N 0.000 claims description 2
- DNHDSWZXBHTLDP-UHFFFAOYSA-N 3-(2-ethenylpyridin-1-ium-1-yl)propane-1-sulfonate Chemical compound [O-]S(=O)(=O)CCC[N+]1=CC=CC=C1C=C DNHDSWZXBHTLDP-UHFFFAOYSA-N 0.000 claims description 2
- LEPRPXBFZRAOGU-UHFFFAOYSA-N 3-trichlorosilylpropyl prop-2-enoate Chemical compound Cl[Si](Cl)(Cl)CCCOC(=O)C=C LEPRPXBFZRAOGU-UHFFFAOYSA-N 0.000 claims description 2
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 2
- 239000004342 Benzoyl peroxide Substances 0.000 claims description 2
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims description 2
- 239000004593 Epoxy Substances 0.000 claims description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Natural products OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 2
- YIVJZNGAASQVEM-UHFFFAOYSA-N Lauroyl peroxide Chemical compound CCCCCCCCCCCC(=O)OOC(=O)CCCCCCCCCCC YIVJZNGAASQVEM-UHFFFAOYSA-N 0.000 claims description 2
- YRKCREAYFQTBPV-UHFFFAOYSA-N acetylacetone Natural products CC(=O)CC(C)=O YRKCREAYFQTBPV-UHFFFAOYSA-N 0.000 claims description 2
- 230000004913 activation Effects 0.000 claims description 2
- 229920006187 aquazol Polymers 0.000 claims description 2
- 230000004888 barrier function Effects 0.000 claims description 2
- JUPQTSLXMOCDHR-UHFFFAOYSA-N benzene-1,4-diol;bis(4-fluorophenyl)methanone Chemical compound OC1=CC=C(O)C=C1.C1=CC(F)=CC=C1C(=O)C1=CC=C(F)C=C1 JUPQTSLXMOCDHR-UHFFFAOYSA-N 0.000 claims description 2
- 239000012965 benzophenone Substances 0.000 claims description 2
- 150000008366 benzophenones Chemical class 0.000 claims description 2
- 235000019400 benzoyl peroxide Nutrition 0.000 claims description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
- 239000000227 bioadhesive Substances 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 150000005829 chemical entities Chemical class 0.000 claims description 2
- 230000008878 coupling Effects 0.000 claims description 2
- 238000010168 coupling process Methods 0.000 claims description 2
- 238000005859 coupling reaction Methods 0.000 claims description 2
- LSXWFXONGKSEMY-UHFFFAOYSA-N di-tert-butyl peroxide Chemical compound CC(C)(C)OOC(C)(C)C LSXWFXONGKSEMY-UHFFFAOYSA-N 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 210000000959 ear middle Anatomy 0.000 claims description 2
- SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 claims description 2
- 230000008020 evaporation Effects 0.000 claims description 2
- 238000001704 evaporation Methods 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims description 2
- 239000004811 fluoropolymer Substances 0.000 claims description 2
- 229920002313 fluoropolymer Polymers 0.000 claims description 2
- 239000011521 glass Substances 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 238000007917 intracranial administration Methods 0.000 claims description 2
- 238000007912 intraperitoneal administration Methods 0.000 claims description 2
- 235000014655 lactic acid Nutrition 0.000 claims description 2
- 239000004310 lactic acid Substances 0.000 claims description 2
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims description 2
- 230000000149 penetrating effect Effects 0.000 claims description 2
- 210000003200 peritoneal cavity Anatomy 0.000 claims description 2
- 150000002978 peroxides Chemical class 0.000 claims description 2
- 229910000073 phosphorus hydride Inorganic materials 0.000 claims description 2
- 229920002120 photoresistant polymer Polymers 0.000 claims description 2
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 claims description 2
- 210000003281 pleural cavity Anatomy 0.000 claims description 2
- 229920001308 poly(aminoacid) Polymers 0.000 claims description 2
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims description 2
- 229920002492 poly(sulfone) Polymers 0.000 claims description 2
- 229920002401 polyacrylamide Polymers 0.000 claims description 2
- 239000004584 polyacrylic acid Substances 0.000 claims description 2
- 229920000515 polycarbonate Polymers 0.000 claims description 2
- 229920000573 polyethylene Polymers 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 229920001296 polysiloxane Polymers 0.000 claims description 2
- 229920002223 polystyrene Polymers 0.000 claims description 2
- 229920002635 polyurethane Polymers 0.000 claims description 2
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 claims description 2
- 238000010526 radical polymerization reaction Methods 0.000 claims description 2
- 210000005245 right atrium Anatomy 0.000 claims description 2
- 239000010703 silicon Substances 0.000 claims description 2
- 229910052710 silicon Inorganic materials 0.000 claims description 2
- 238000007920 subcutaneous administration Methods 0.000 claims description 2
- GJBRNHKUVLOCEB-UHFFFAOYSA-N tert-butyl benzenecarboperoxoate Chemical compound CC(C)(C)OOC(=O)C1=CC=CC=C1 GJBRNHKUVLOCEB-UHFFFAOYSA-N 0.000 claims description 2
- SWAXTRYEYUTSAP-UHFFFAOYSA-N tert-butyl ethaneperoxoate Chemical compound CC(=O)OOC(C)(C)C SWAXTRYEYUTSAP-UHFFFAOYSA-N 0.000 claims description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 2
- 229920002554 vinyl polymer Polymers 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 239000012620 biological material Substances 0.000 description 1
- 210000003703 cisterna magna Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662371706P | 2016-08-05 | 2016-08-05 | |
| US62/371,706 | 2016-08-05 | ||
| PCT/US2017/045259 WO2018027009A1 (en) | 2016-08-05 | 2017-08-03 | Polymeric devices and methods of making |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019525989A JP2019525989A (ja) | 2019-09-12 |
| JP2019525989A5 true JP2019525989A5 (enExample) | 2020-08-20 |
| JP7042514B2 JP7042514B2 (ja) | 2022-03-28 |
Family
ID=61073534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019506372A Active JP7042514B2 (ja) | 2016-08-05 | 2017-08-03 | ポリマーデバイスおよび作製方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20190185629A1 (enExample) |
| EP (1) | EP3494151A4 (enExample) |
| JP (1) | JP7042514B2 (enExample) |
| CN (1) | CN110088158A (enExample) |
| AU (1) | AU2017305431A1 (enExample) |
| CA (1) | CA3033064A1 (enExample) |
| WO (1) | WO2018027009A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11103892B1 (en) * | 2018-09-25 | 2021-08-31 | Facebook Technologies, Llc | Initiated chemical vapor deposition method for forming nanovoided polymers |
| DE102019107090A1 (de) * | 2019-03-20 | 2020-09-24 | Joanneum Research Forschungsgesellschaft Mbh | Mikrostruktur mit thermoplastischer Prägelackschicht und Herstellungsverfahren |
| US11039954B2 (en) * | 2019-03-21 | 2021-06-22 | Microoptx Inc. | Implantable ocular drug delivery devices and methods |
| EP4022284A4 (en) * | 2019-08-29 | 2024-01-10 | Entopsis, Inc. | Detectable arrays for distinguishing analytes and diagnosis, and methods and systems related thereto |
| DE102020114621A1 (de) | 2020-06-02 | 2021-12-02 | Joanneum Research Forschungsgesellschaft Mbh | Bauteil mit Mikrofluidikstrukturen, Herstellungsverfahren und Verwendung |
| NL2030209B1 (en) * | 2021-12-21 | 2023-06-29 | Surfix B V | Process for manufacturing a microfluidic device |
| CN116102179B (zh) * | 2022-12-29 | 2024-07-23 | 杭州楠大环保科技有限公司 | 一种用于污水处理强化脱氮的多核复合型碳源 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4938831A (en) * | 1988-01-25 | 1990-07-03 | The Kendall Company | Bonding method for preparing automotive headlamp assemblies |
| JP2005526972A (ja) * | 2002-05-02 | 2005-09-08 | シファーゲン バイオシステムズ， インコーポレイテッド | 多糖系ヒドロゲルをコーティングした表面を有するバイオチップ |
| WO2007021762A2 (en) * | 2005-08-09 | 2007-02-22 | The University Of North Carolina At Chapel Hill | Methods and materials for fabricating microfluidic devices |
| SG150506A1 (en) * | 2004-02-13 | 2009-03-30 | Univ North Carolina State | Functional materials and novel methods for the fabrication of microfluidic devices |
| US20090136982A1 (en) * | 2005-01-18 | 2009-05-28 | Biocept, Inc. | Cell separation using microchannel having patterned posts |
| US20060228386A1 (en) * | 2005-02-22 | 2006-10-12 | University Of Tennessee Research Foundation | Polymeric microstructures |
| CN101283042A (zh) * | 2005-08-09 | 2008-10-08 | 查珀尔希尔北卡罗来纳大学 | 制造微流体器件的方法和材料 |
| WO2009070124A1 (en) * | 2007-11-28 | 2009-06-04 | Agency For Science, Technology And Research | A low temperature method of bonding substrates having at least one surface that includes a layer of su8 |
| BR112012031161A2 (pt) * | 2010-06-09 | 2016-11-01 | Semprus Biosciences Corp | composições de enxerto não incrustante, antimicrobiano, antitrombogênico |
| TWI473823B (zh) * | 2010-06-21 | 2015-02-21 | Novartis Ag | 具有經降低的閃光之高折射率、丙烯酸系眼科裝置材料 |
| EP2622002B1 (en) * | 2010-10-01 | 2016-02-24 | Mercene Labs AB | Method for the manufacture of articles of thiol-ene polymers |
| KR101767207B1 (ko) * | 2012-11-30 | 2017-08-11 | (주)아모레퍼시픽 | 생체친화성 고분자로 코팅된 무기분체 및 이를 함유하는 화장료 조성물 |
| WO2015103331A1 (en) * | 2013-12-31 | 2015-07-09 | Canon U.S. Life Sciences, Inc. | Methods and systems for continuous flow cell lysis in a microfluidic device |
-
2017
- 2017-08-03 US US16/323,481 patent/US20190185629A1/en not_active Abandoned
- 2017-08-03 AU AU2017305431A patent/AU2017305431A1/en not_active Abandoned
- 2017-08-03 EP EP17837666.1A patent/EP3494151A4/en not_active Withdrawn
- 2017-08-03 WO PCT/US2017/045259 patent/WO2018027009A1/en not_active Ceased
- 2017-08-03 CA CA3033064A patent/CA3033064A1/en not_active Abandoned
- 2017-08-03 CN CN201780061251.2A patent/CN110088158A/zh active Pending
- 2017-08-03 JP JP2019506372A patent/JP7042514B2/ja active Active
-
2020
- 2020-11-25 US US17/105,111 patent/US20210079178A1/en not_active Abandoned
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