JP2019525922A5 - - Google Patents
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- Publication number
- JP2019525922A5 JP2019525922A5 JP2019503470A JP2019503470A JP2019525922A5 JP 2019525922 A5 JP2019525922 A5 JP 2019525922A5 JP 2019503470 A JP2019503470 A JP 2019503470A JP 2019503470 A JP2019503470 A JP 2019503470A JP 2019525922 A5 JP2019525922 A5 JP 2019525922A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- hydrogen
- composition according
- pharmaceutical
- chlorine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000006178 malignant mesothelioma Diseases 0.000 claims description 4
- JLYAXFNOILIKPP-KXQOOQHDSA-N navitoclax Chemical compound C([C@@H](NC1=CC=C(C=C1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)C1=CC=C(C=C1)N1CCN(CC1)CC1=C(CCC(C1)(C)C)C=1C=CC(Cl)=CC=1)CSC=1C=CC=CC=1)CN1CCOCC1 JLYAXFNOILIKPP-KXQOOQHDSA-N 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 30
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 6
- 229910052801 chlorine Inorganic materials 0.000 claims 6
- 239000000460 chlorine Substances 0.000 claims 6
- 239000012664 BCL-2-inhibitor Substances 0.000 claims 5
- 229940123711 Bcl2 inhibitor Drugs 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 229950004847 navitoclax Drugs 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 102000016776 Midkine Human genes 0.000 claims 2
- 108010092801 Midkine Proteins 0.000 claims 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 2
- -1 -OCH 3 Inorganic materials 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 206010027406 Mesothelioma Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 102000051485 Bcl-2 family Human genes 0.000 description 1
- 108700038897 Bcl-2 family Proteins 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 239000010425 asbestos Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 201000005282 malignant pleural mesothelioma Diseases 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 229910052895 riebeckite Inorganic materials 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022006978A JP2022064923A (ja) | 2016-07-28 | 2022-01-20 | 癌を治療するための方法および組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662367832P | 2016-07-28 | 2016-07-28 | |
| US62/367,832 | 2016-07-28 | ||
| PCT/US2017/044335 WO2018022973A1 (en) | 2016-07-28 | 2017-07-28 | Methods and compositions to treat cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022006978A Division JP2022064923A (ja) | 2016-07-28 | 2022-01-20 | 癌を治療するための方法および組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019525922A JP2019525922A (ja) | 2019-09-12 |
| JP2019525922A5 true JP2019525922A5 (https=) | 2020-09-03 |
Family
ID=61017221
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019503470A Pending JP2019525922A (ja) | 2016-07-28 | 2017-07-28 | 癌を治療するための方法および組成物 |
| JP2022006978A Pending JP2022064923A (ja) | 2016-07-28 | 2022-01-20 | 癌を治療するための方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022006978A Pending JP2022064923A (ja) | 2016-07-28 | 2022-01-20 | 癌を治療するための方法および組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US10668078B2 (https=) |
| EP (1) | EP3490555A4 (https=) |
| JP (2) | JP2019525922A (https=) |
| AU (1) | AU2017302617A1 (https=) |
| WO (1) | WO2018022973A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019525922A (ja) | 2016-07-28 | 2019-09-12 | チルドレンズ ホスピタル メディカル センター | 癌を治療するための方法および組成物 |
| MX2022005375A (es) | 2019-11-05 | 2022-10-07 | Abbvie Inc | Regímenes de dosificación para usar en el tratamiento de la mielofibrosis y trastornos relacionados con neoplasias mieloproliferativas (nmp) con navitoclax. |
| AU2023255538A1 (en) * | 2022-04-22 | 2024-10-31 | Astellas Engineered Small Molecules US, Incorporated | Transcription factor eb activators and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010094009A2 (en) | 2009-02-13 | 2010-08-19 | Children's Hospital Medical Center | Methods and compositions for the treatment of ras associated disorders |
| US20100278921A1 (en) | 2009-04-30 | 2010-11-04 | Fischer Cristina M | Solid oral formulation of abt-263 |
| WO2013049585A1 (en) | 2011-09-30 | 2013-04-04 | Hengrui (Usa), Ltd. | Arylsubstituted thiazolotriazoles and thiazoloimidazoles |
| EP2923203B1 (en) * | 2012-11-20 | 2018-10-03 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Assay to measure midkine or pleiotrophin level for diagnosing a growth |
| CA2907960C (en) | 2013-05-22 | 2021-10-19 | Children's Hospital Medical Center | Combination therapy for mds |
| WO2014205132A2 (en) | 2013-06-20 | 2014-12-24 | Children's Hospital Medical Center | Methods and compositions to treat cancer |
| JP2019525922A (ja) | 2016-07-28 | 2019-09-12 | チルドレンズ ホスピタル メディカル センター | 癌を治療するための方法および組成物 |
-
2017
- 2017-07-28 JP JP2019503470A patent/JP2019525922A/ja active Pending
- 2017-07-28 US US16/312,478 patent/US10668078B2/en active Active
- 2017-07-28 EP EP17835328.0A patent/EP3490555A4/en not_active Withdrawn
- 2017-07-28 WO PCT/US2017/044335 patent/WO2018022973A1/en not_active Ceased
- 2017-07-28 AU AU2017302617A patent/AU2017302617A1/en not_active Abandoned
-
2020
- 2020-04-24 US US16/857,285 patent/US11026950B2/en active Active
-
2021
- 2021-05-05 US US17/308,179 patent/US11672806B2/en active Active
-
2022
- 2022-01-20 JP JP2022006978A patent/JP2022064923A/ja active Pending
-
2023
- 2023-05-02 US US18/142,308 patent/US12303513B2/en active Active
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