JP2019523779A5 - - Google Patents
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- JP2019523779A5 JP2019523779A5 JP2018566499A JP2018566499A JP2019523779A5 JP 2019523779 A5 JP2019523779 A5 JP 2019523779A5 JP 2018566499 A JP2018566499 A JP 2018566499A JP 2018566499 A JP2018566499 A JP 2018566499A JP 2019523779 A5 JP2019523779 A5 JP 2019523779A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- oil
- formula
- compound
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 7
- 239000012453 solvate Substances 0.000 claims 7
- 239000003921 oil Substances 0.000 claims 5
- 235000019198 oils Nutrition 0.000 claims 5
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- BLUAFEHZUWYNDE-NNWCWBAJSA-N artemisinin Chemical compound C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2OC(=O)[C@@H]4C BLUAFEHZUWYNDE-NNWCWBAJSA-N 0.000 claims 2
- 239000008159 sesame oil Substances 0.000 claims 2
- 235000011803 sesame oil Nutrition 0.000 claims 2
- XEEQGYMUWCZPDN-DOMZBBRYSA-N (-)-(11S,2'R)-erythro-mefloquine Chemical compound C([C@@H]1[C@@H](O)C=2C3=CC=CC(=C3N=C(C=2)C(F)(F)F)C(F)(F)F)CCCN1 XEEQGYMUWCZPDN-DOMZBBRYSA-N 0.000 claims 1
- WHTVZRBIWZFKQO-AWEZNQCLSA-N (S)-chloroquine Chemical compound ClC1=CC=C2C(N[C@@H](C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-AWEZNQCLSA-N 0.000 claims 1
- OVCDSSHSILBFBN-UHFFFAOYSA-N Amodiaquine Chemical compound C1=C(O)C(CN(CC)CC)=CC(NC=2C3=CC=C(Cl)C=C3N=CC=2)=C1 OVCDSSHSILBFBN-UHFFFAOYSA-N 0.000 claims 1
- 125000003358 C2-C20 alkenyl group Chemical group 0.000 claims 1
- 125000000739 C2-C30 alkenyl group Chemical group 0.000 claims 1
- 235000001258 Cinchona calisaya Nutrition 0.000 claims 1
- 235000019482 Palm oil Nutrition 0.000 claims 1
- 235000019483 Peanut oil Nutrition 0.000 claims 1
- 235000019484 Rapeseed oil Nutrition 0.000 claims 1
- 235000019485 Safflower oil Nutrition 0.000 claims 1
- 235000019486 Sunflower oil Nutrition 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 229960001444 amodiaquine Drugs 0.000 claims 1
- 239000003430 antimalarial agent Substances 0.000 claims 1
- 229960004191 artemisinin Drugs 0.000 claims 1
- 229930101531 artemisinin Natural products 0.000 claims 1
- -1 atovacon Chemical compound 0.000 claims 1
- 229960003677 chloroquine Drugs 0.000 claims 1
- WHTVZRBIWZFKQO-UHFFFAOYSA-N chloroquine Natural products ClC1=CC=C2C(NC(C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-UHFFFAOYSA-N 0.000 claims 1
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 claims 1
- 229960002227 clindamycin Drugs 0.000 claims 1
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 claims 1
- 239000002285 corn oil Substances 0.000 claims 1
- 235000005687 corn oil Nutrition 0.000 claims 1
- 235000012343 cottonseed oil Nutrition 0.000 claims 1
- 239000002385 cottonseed oil Substances 0.000 claims 1
- 229960003722 doxycycline Drugs 0.000 claims 1
- XQTWDDCIUJNLTR-CVHRZJFOSA-N doxycycline monohydrate Chemical compound O.O=C1C2=C(O)C=CC=C2[C@H](C)[C@@H]2C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]1[C@H]2O XQTWDDCIUJNLTR-CVHRZJFOSA-N 0.000 claims 1
- WZDNKHCQIZRDKW-UHFFFAOYSA-N elq-300 Chemical compound O=C1C=2C=C(Cl)C(OC)=CC=2NC(C)=C1C(C=C1)=CC=C1OC1=CC=C(OC(F)(F)F)C=C1 WZDNKHCQIZRDKW-UHFFFAOYSA-N 0.000 claims 1
- 201000004792 malaria Diseases 0.000 claims 1
- 229960001962 mefloquine Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000004006 olive oil Substances 0.000 claims 1
- 235000008390 olive oil Nutrition 0.000 claims 1
- 239000002540 palm oil Substances 0.000 claims 1
- 239000000312 peanut oil Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 229960005179 primaquine Drugs 0.000 claims 1
- INDBQLZJXZLFIT-UHFFFAOYSA-N primaquine Chemical compound N1=CC=CC2=CC(OC)=CC(NC(C)CCCN)=C21 INDBQLZJXZLFIT-UHFFFAOYSA-N 0.000 claims 1
- SSOLNOMRVKKSON-UHFFFAOYSA-N proguanil Chemical compound CC(C)\N=C(/N)N=C(N)NC1=CC=C(Cl)C=C1 SSOLNOMRVKKSON-UHFFFAOYSA-N 0.000 claims 1
- 229960005385 proguanil Drugs 0.000 claims 1
- WKSAUQYGYAYLPV-UHFFFAOYSA-N pyrimethamine Chemical compound CCC1=NC(N)=NC(N)=C1C1=CC=C(Cl)C=C1 WKSAUQYGYAYLPV-UHFFFAOYSA-N 0.000 claims 1
- 229960000611 pyrimethamine Drugs 0.000 claims 1
- 229960000948 quinine Drugs 0.000 claims 1
- 235000005713 safflower oil Nutrition 0.000 claims 1
- 239000003813 safflower oil Substances 0.000 claims 1
- 239000003549 soybean oil Substances 0.000 claims 1
- 235000012424 soybean oil Nutrition 0.000 claims 1
- 239000002600 sunflower oil Substances 0.000 claims 1
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 1
- 239000008158 vegetable oil Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662352455P | 2016-06-20 | 2016-06-20 | |
| US62/352,455 | 2016-06-20 | ||
| PCT/US2017/038173 WO2017222996A1 (en) | 2016-06-20 | 2017-06-19 | Antimalarial compositions and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019523779A JP2019523779A (ja) | 2019-08-29 |
| JP2019523779A5 true JP2019523779A5 (enExample) | 2020-04-16 |
Family
ID=60784061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018566499A Pending JP2019523779A (ja) | 2016-06-20 | 2017-06-19 | 抗マラリア組成物およびその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10947176B2 (enExample) |
| EP (1) | EP3471711A4 (enExample) |
| JP (1) | JP2019523779A (enExample) |
| KR (1) | KR20190020774A (enExample) |
| CN (2) | CN109715147A (enExample) |
| AU (1) | AU2017281426B2 (enExample) |
| BR (1) | BR112018076619A2 (enExample) |
| CA (1) | CA3028392A1 (enExample) |
| EA (1) | EA201990064A1 (enExample) |
| MA (1) | MA45411A (enExample) |
| SG (2) | SG10202112759SA (enExample) |
| WO (1) | WO2017222996A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109715147A (zh) * | 2016-06-20 | 2019-05-03 | 斯克利普斯研究院 | 抗疟疾组合物及其用途 |
| US20210330585A1 (en) * | 2018-09-04 | 2021-10-28 | President And Fellows Of Harvard College | Method for reducing parasite burden in a mosquito |
| US20230167065A1 (en) * | 2020-05-11 | 2023-06-01 | Oregon Health & Science University | Novel intermediates and synthesis for endochin-like quinolone compounds |
| WO2022144920A1 (en) * | 2020-12-30 | 2022-07-07 | Ipca Laboratories Limited | Atovaquone prodrugs |
| WO2025151263A1 (en) * | 2024-01-09 | 2025-07-17 | Sri International | Oil-based compositions and methods of making and use thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8819477D0 (en) * | 1988-08-16 | 1988-09-21 | Wellcome Found | Medicaments |
| IE65715B1 (en) * | 1988-08-16 | 1995-11-15 | Wellcome Found | Medicaments |
| US5206268A (en) * | 1988-08-16 | 1993-04-27 | Burroughs Wellcome Co. | Medicaments |
| US5021426A (en) * | 1990-02-26 | 1991-06-04 | Merck & Co., Inc. | Method of traeting malaria with cyproheptadine derivatives |
| GB9207517D0 (en) | 1992-04-06 | 1992-05-20 | Wellcome Found | Heterocyclic compounds |
| MY118354A (en) * | 1995-05-01 | 2004-10-30 | Scarista Ltd | 1,3-propane diol derivatives as bioactive compounds |
| ITMI20070941A1 (it) * | 2007-05-09 | 2008-11-10 | Chimico Internazi0Nale S P A L | Procedimento per la preparazione di naftochinoni trans2,3-disostituiti |
| CN109715147A (zh) * | 2016-06-20 | 2019-05-03 | 斯克利普斯研究院 | 抗疟疾组合物及其用途 |
-
2017
- 2017-06-19 CN CN201780050449.0A patent/CN109715147A/zh active Pending
- 2017-06-19 KR KR1020197001880A patent/KR20190020774A/ko not_active Ceased
- 2017-06-19 BR BR112018076619-4A patent/BR112018076619A2/pt not_active IP Right Cessation
- 2017-06-19 EA EA201990064A patent/EA201990064A1/ru unknown
- 2017-06-19 WO PCT/US2017/038173 patent/WO2017222996A1/en not_active Ceased
- 2017-06-19 JP JP2018566499A patent/JP2019523779A/ja active Pending
- 2017-06-19 EP EP17816008.1A patent/EP3471711A4/en not_active Withdrawn
- 2017-06-19 SG SG10202112759SA patent/SG10202112759SA/en unknown
- 2017-06-19 US US16/311,869 patent/US10947176B2/en not_active Expired - Fee Related
- 2017-06-19 AU AU2017281426A patent/AU2017281426B2/en not_active Ceased
- 2017-06-19 CN CN202111196136.0A patent/CN114569552A/zh active Pending
- 2017-06-19 CA CA3028392A patent/CA3028392A1/en active Pending
- 2017-06-19 SG SG11201811434RA patent/SG11201811434RA/en unknown
- 2017-06-19 MA MA045411A patent/MA45411A/fr unknown
-
2021
- 2021-02-17 US US17/177,314 patent/US11485697B2/en active Active
-
2022
- 2022-10-27 US US17/974,569 patent/US20230111793A1/en not_active Abandoned
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