JP2019522626A5 - - Google Patents
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- Publication number
- JP2019522626A5 JP2019522626A5 JP2018557105A JP2018557105A JP2019522626A5 JP 2019522626 A5 JP2019522626 A5 JP 2019522626A5 JP 2018557105 A JP2018557105 A JP 2018557105A JP 2018557105 A JP2018557105 A JP 2018557105A JP 2019522626 A5 JP2019522626 A5 JP 2019522626A5
- Authority
- JP
- Japan
- Prior art keywords
- hiv
- protein
- modified
- vaccine composition
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 33
- 102000004169 proteins and genes Human genes 0.000 claims 28
- 108090000623 proteins and genes Proteins 0.000 claims 28
- 229940033332 HIV-1 vaccine Drugs 0.000 claims 15
- 101800001690 Transmembrane protein gp41 Proteins 0.000 claims 12
- 239000002105 nanoparticle Substances 0.000 claims 8
- 239000013638 trimer Substances 0.000 claims 7
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 230000002163 immunogen Effects 0.000 claims 6
- 238000003776 cleavage reaction Methods 0.000 claims 5
- 230000007017 scission Effects 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 108010068996 6,7-dimethyl-8-ribityllumazine synthase Proteins 0.000 claims 2
- 208000031886 HIV Infections Diseases 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 230000000087 stabilizing effect Effects 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 125000001560 (R)-dihydrolipoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@](S[H])([H])C([H])([H])C([H])([H])S[H] 0.000 claims 1
- 102000057234 Acyl transferases Human genes 0.000 claims 1
- 108700016155 Acyl transferases Proteins 0.000 claims 1
- 102000008857 Ferritin Human genes 0.000 claims 1
- 108050000784 Ferritin Proteins 0.000 claims 1
- 238000008416 Ferritin Methods 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 239000013639 protein trimer Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662330604P | 2016-05-02 | 2016-05-02 | |
| US62/330,604 | 2016-05-02 | ||
| PCT/US2017/030375 WO2017192434A1 (en) | 2016-05-02 | 2017-05-01 | Compositions and methods related to hiv-1 immunogens |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019522626A JP2019522626A (ja) | 2019-08-15 |
| JP2019522626A5 true JP2019522626A5 (enExample) | 2020-02-06 |
| JP7046832B2 JP7046832B2 (ja) | 2022-04-04 |
Family
ID=60203504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018557105A Active JP7046832B2 (ja) | 2016-05-02 | 2017-05-01 | Ｈｉｖ－１免疫原に関連した組成物および方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US10647748B2 (enExample) |
| EP (1) | EP3452494A4 (enExample) |
| JP (1) | JP7046832B2 (enExample) |
| CN (1) | CN109153704A (enExample) |
| AU (2) | AU2017259275C1 (enExample) |
| BR (1) | BR112018072248A2 (enExample) |
| CA (1) | CA3022826A1 (enExample) |
| EA (1) | EA201892233A1 (enExample) |
| IL (2) | IL299962A (enExample) |
| MX (1) | MX2018013455A (enExample) |
| SG (1) | SG11201809387QA (enExample) |
| WO (1) | WO2017192434A1 (enExample) |
| ZA (1) | ZA201807216B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019241483A1 (en) * | 2018-06-13 | 2019-12-19 | The Scripps Research Institute | Nanoparticle vaccines with novel structural components |
| US20220041650A1 (en) * | 2018-12-03 | 2022-02-10 | Duke University | Purification method for recombinant proteins and nanoparticles |
| WO2021021603A2 (en) * | 2019-07-26 | 2021-02-04 | The Scripps Research Institute | Engineered hcv e2 immunogens and related vaccine compositions |
| AU2020381082B2 (en) * | 2019-11-07 | 2022-09-22 | Janssen Vaccines & Prevention B.V. | Protein purification |
| CN111647078B (zh) * | 2020-06-22 | 2022-04-26 | 中国医学科学院医学生物学研究所 | 一种抗hiv的单克隆抗体及其制备方法和应用 |
| US10906944B2 (en) | 2020-06-29 | 2021-02-02 | The Scripps Research Institute | Stabilized coronavirus spike (S) protein immunogens and related vaccines |
| EP4245767A4 (en) * | 2020-11-12 | 2025-04-30 | Xiamen University | MODIFIED HUMAN IMMUNODEFICIENCY VIRUS MEMBRANE PROTEIN AND USE THEREOF |
| CN116769053B (zh) * | 2023-05-26 | 2023-12-15 | 华中农业大学 | 重组AaLS-BPP融合肽、制备方法及应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0735893B1 (en) | 1993-09-14 | 2008-11-26 | Pharmexa Inc. | Pan dr-binding peptides for enhancement of the immune response |
| US7550143B2 (en) | 2005-04-06 | 2009-06-23 | Ibc Pharmaceuticals, Inc. | Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses |
| CA2667358A1 (en) * | 2006-10-23 | 2008-05-29 | Progenics Pharmaceuticals, Inc. | Modified gp140 envelope polypeptides of hiv-1 isolates, compositions, stabilized trimeric complexes, and uses thereof |
| JP2011502521A (ja) | 2007-11-12 | 2011-01-27 | ザ ヘンリー エム． ジャクソン ファウンデーション フォー ザ アドヴァンスメント オブ ミリタリー メディシン インコーポレイテッド | Ｈｉｖ−１外被糖タンパク質オリゴマー及び使用方法 |
| RU2540871C2 (ru) | 2008-02-01 | 2015-02-10 | Альфа-О Пептидес Аг | Самоорганизующиеся пептидные наночастицы, полезные в качестве вакцин |
| EP2765138B1 (en) | 2012-11-05 | 2018-01-10 | International Aids Vaccine Initiative | HIV-1 envelope glycoprotein |
| CN105263506B (zh) | 2013-01-07 | 2018-03-09 | 贝丝以色列女执事医疗中心 | 稳定的人免疫缺陷病毒(HIV)包膜(EnV)三聚体疫苗及其使用方法 |
| US10400015B2 (en) | 2014-09-04 | 2019-09-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Recombinant HIV-1 envelope proteins and their use |
| US10501733B2 (en) | 2015-02-27 | 2019-12-10 | University Of Washington | Polypeptide assemblies and methods for the production thereof |
| SG10202001956UA (en) * | 2016-09-15 | 2020-04-29 | Janssen Vaccines & Prevention Bv | Trimer stabilizing hiv envelope protein mutations |
-
2017
- 2017-05-01 WO PCT/US2017/030375 patent/WO2017192434A1/en not_active Ceased
- 2017-05-01 CN CN201780027483.6A patent/CN109153704A/zh active Pending
- 2017-05-01 AU AU2017259275A patent/AU2017259275C1/en active Active
- 2017-05-01 EP EP17793064.1A patent/EP3452494A4/en active Pending
- 2017-05-01 SG SG11201809387QA patent/SG11201809387QA/en unknown
- 2017-05-01 BR BR112018072248-0A patent/BR112018072248A2/pt unknown
- 2017-05-01 MX MX2018013455A patent/MX2018013455A/es unknown
- 2017-05-01 EA EA201892233A patent/EA201892233A1/ru unknown
- 2017-05-01 CA CA3022826A patent/CA3022826A1/en active Pending
- 2017-05-01 JP JP2018557105A patent/JP7046832B2/ja active Active
- 2017-05-01 IL IL299962A patent/IL299962A/en unknown
-
2018
- 2018-10-24 IL IL262582A patent/IL262582B2/en unknown
- 2018-10-29 ZA ZA2018/07216A patent/ZA201807216B/en unknown
- 2018-10-31 US US16/176,200 patent/US10647748B2/en active Active
-
2020
- 2020-02-03 US US16/780,495 patent/US11236134B2/en active Active
-
2021
- 2021-08-25 AU AU2021221582A patent/AU2021221582B2/en active Active
- 2021-12-16 US US17/553,070 patent/US11767347B2/en active Active
-
2023
- 2023-08-15 US US18/449,739 patent/US20240083954A1/en not_active Abandoned
-
2024
- 2024-08-28 US US18/817,389 patent/US20250122247A1/en active Pending
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