JP2019521101A5 - - Google Patents
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- Publication number
- JP2019521101A5 JP2019521101A5 JP2018563562A JP2018563562A JP2019521101A5 JP 2019521101 A5 JP2019521101 A5 JP 2019521101A5 JP 2018563562 A JP2018563562 A JP 2018563562A JP 2018563562 A JP2018563562 A JP 2018563562A JP 2019521101 A5 JP2019521101 A5 JP 2019521101A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- inner ear
- expression
- hes1 gene
- gsk
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 51
- 210000003027 ear inner Anatomy 0.000 claims 22
- 101150092640 HES1 gene Proteins 0.000 claims 16
- 230000014509 gene expression Effects 0.000 claims 16
- 102000002254 Glycogen Synthase Kinase 3 Human genes 0.000 claims 10
- 108010014905 Glycogen Synthase Kinase 3 Proteins 0.000 claims 10
- 239000003112 inhibitor Substances 0.000 claims 10
- 239000002105 nanoparticle Substances 0.000 claims 8
- 108020004459 Small interfering RNA Proteins 0.000 claims 6
- DDLZLOKCJHBUHD-WAVHTBQISA-N 6-bromoindirubin-3'-oxime Chemical group O=C/1NC2=CC(Br)=CC=C2C\1=C\1/C(=N/O)/C2=CC=CC=C2N/1 DDLZLOKCJHBUHD-WAVHTBQISA-N 0.000 claims 4
- 229920002988 biodegradable polymer Polymers 0.000 claims 4
- 239000004621 biodegradable polymer Substances 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- WTFXARWRTYJXII-UHFFFAOYSA-N iron(2+);iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+2].[Fe+3].[Fe+3] WTFXARWRTYJXII-UHFFFAOYSA-N 0.000 claims 4
- 239000002245 particle Substances 0.000 claims 4
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 4
- 230000037452 priming Effects 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 239000012528 membrane Substances 0.000 claims 3
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 2
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 2
- 229920000436 Poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide) Polymers 0.000 claims 2
- 239000003221 ear drop Substances 0.000 claims 2
- 229940047652 ear drops Drugs 0.000 claims 2
- 238000001802 infusion Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 108060000903 Beta-catenin Proteins 0.000 claims 1
- 102000015735 Beta-catenin Human genes 0.000 claims 1
- 206010011878 Deafness Diseases 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 210000002768 hair cell Anatomy 0.000 claims 1
- 230000010370 hearing loss Effects 0.000 claims 1
- 231100000888 hearing loss Toxicity 0.000 claims 1
- 208000016354 hearing loss disease Diseases 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022147792A JP2022180476A (ja) | 2016-06-03 | 2022-09-16 | 内耳感覚有毛細胞の再生／置換のための併用療法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662345740P | 2016-06-03 | 2016-06-03 | |
| US62/345,740 | 2016-06-03 | ||
| PCT/US2017/035673 WO2017210553A1 (en) | 2016-06-03 | 2017-06-02 | Combination therapies for inner ear sensory hair cell regeneration/replacement |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022147792A Division JP2022180476A (ja) | 2016-06-03 | 2022-09-16 | 内耳感覚有毛細胞の再生／置換のための併用療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019521101A JP2019521101A (ja) | 2019-07-25 |
| JP2019521101A5 true JP2019521101A5 (cg-RX-API-DMAC7.html) | 2020-07-09 |
| JP7523209B2 JP7523209B2 (ja) | 2024-07-26 |
Family
ID=60477923
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018563562A Active JP7523209B2 (ja) | 2016-06-03 | 2017-06-02 | 内耳感覚有毛細胞の再生／置換のための併用療法 |
| JP2022147792A Pending JP2022180476A (ja) | 2016-06-03 | 2022-09-16 | 内耳感覚有毛細胞の再生／置換のための併用療法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022147792A Pending JP2022180476A (ja) | 2016-06-03 | 2022-09-16 | 内耳感覚有毛細胞の再生／置換のための併用療法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11013752B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3463417A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP7523209B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN109562140B (cg-RX-API-DMAC7.html) |
| CA (1) | CA3066107A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017210553A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020254249A1 (en) * | 2019-06-21 | 2020-12-24 | Proqr Therapeutics Ii B.V. | Delivery of nucleic acids for the treatment of auditory disorders |
| JP2023106639A (ja) * | 2020-06-09 | 2023-08-02 | 株式会社オトリンク | 内耳前駆細胞の製造方法、内耳有毛細胞の製造方法、薬剤の評価方法、及び内耳細胞分化誘導用組成物 |
| CN114736924B (zh) * | 2021-01-07 | 2024-11-22 | 中国科学院脑科学与智能技术卓越创新中心 | 异位联合过表达Atoh1和Ikzf2再生耳蜗外毛细胞及其应用 |
| CN116440249A (zh) * | 2022-01-05 | 2023-07-18 | 中国科学院脑科学与智能技术卓越创新中心 | 异位联合表达Atoh1和Tbx2基因促进内毛细胞再生及其应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6593290B1 (en) * | 1996-11-01 | 2003-07-15 | Genentech, Inc. | Treatment of inner ear hair cells |
| US6156728A (en) | 1996-11-01 | 2000-12-05 | Genentech, Inc. | Treatment of inner ear hair cells |
| CA2493289C (en) | 2002-07-31 | 2014-12-16 | Phafag Ag | A pharmaceutical formulation and its use in the treatment of inner ear diseases |
| US20060030042A1 (en) * | 2003-12-19 | 2006-02-09 | Ali Brivanlou | Maintenance of embryonic stem cells by the GSK-3 inhibitor 6-bromoindirubin-3'-oxime |
| EP1838852A2 (en) * | 2004-11-12 | 2007-10-03 | Asuragen, Inc. | Methods and compositions involving mirna and mirna inhibitor molecules |
| CA2725953A1 (en) * | 2007-05-29 | 2008-12-11 | Christopher B. Reid | Methods for production and uses of multipotent cell populations, pluripotent cell populations, neuronal cell populations, and muscle cell populations |
| WO2010060088A2 (en) * | 2008-11-24 | 2010-05-27 | Massachusetts Eye & Ear Infirmary | Pathways to generate hair cells |
| CN101732723B (zh) * | 2009-12-30 | 2012-07-25 | 上海市肿瘤研究所 | 聚乙二醇-聚乳酸羟基乙酸-聚赖氨酸纳米递送系统、制备方法及其应用 |
| US9101647B2 (en) * | 2010-06-04 | 2015-08-11 | Hough Ear Institute | Composition and method for inner ear sensory hair cell regeneration and replacement |
| WO2012069428A1 (en) | 2010-11-22 | 2012-05-31 | Noscira, S.A. | Bipyridine sulfonamide derivatives for the treatment of neurodegenerative diseases or conditions |
| US20150018404A1 (en) * | 2011-08-03 | 2015-01-15 | Quark Pharmaceuticals, Inc. | Double-stranded oligonucleotide compounds for treating hearing and balance disorders |
| EP2609918A1 (en) * | 2011-12-27 | 2013-07-03 | Zytoprotec GmbH | Peritoneal dialysis fluid comprising a GSK-3 inhibitor |
| US20150209406A1 (en) * | 2012-09-07 | 2015-07-30 | Massachusetts Eye And Ear Infirmary | Methods and compositions for regenerating hair cells and/or supporting cells |
| PT3702443T (pt) | 2013-03-14 | 2022-02-17 | Massachusetts Inst Technology | Composições e métodos para expansão e cultura de células estaminais epiteliais |
| US20150126507A1 (en) * | 2013-09-05 | 2015-05-07 | Fate Therapeutics, Inc. | Compounds to treat hearing loss |
| CA2959404A1 (en) * | 2014-09-03 | 2016-03-10 | The Brigham And Women's Hospital, Inc. | Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss |
| EP3212773B1 (en) | 2014-10-29 | 2021-09-15 | Massachusetts Eye and Ear Infirmary | Efficient delivery of therapeutic molecules to cells of the inner ear |
| WO2017132530A1 (en) * | 2016-01-29 | 2017-08-03 | Massachusetts Eye And Ear Infirmary | Expansion and differentiation of inner ear supporting cells and methods of use thereof |
| US20190142969A1 (en) | 2016-04-26 | 2019-05-16 | Massachusetts Eye And Ear Infirmary | ISL1-Based Gene Therapy to Treat Hearing Loss |
| CN111655228B (zh) | 2017-05-03 | 2024-02-09 | 听治疗有限责任公司 | 预防和治疗听力损失的组合物和方法 |
| WO2019053727A1 (en) | 2017-09-18 | 2019-03-21 | Ramot At Tel-Aviv University Ltd. | REDIFFERENCING IN VITRO DEVELOPED CELLS FROM HUMAN PANCREATIC ISLAND BEA CELLS ADULPTED BY SMALL MOLECULE INHIBITORS OF THE SIGNALING PATH |
| EP3462349A1 (en) | 2017-10-02 | 2019-04-03 | Koninklijke Philips N.V. | Assessment of notch cellular signaling pathway activity using mathematical modelling of target gene expression |
-
2017
- 2017-06-02 CN CN201780048020.8A patent/CN109562140B/zh active Active
- 2017-06-02 CA CA3066107A patent/CA3066107A1/en active Pending
- 2017-06-02 US US15/612,872 patent/US11013752B2/en active Active
- 2017-06-02 WO PCT/US2017/035673 patent/WO2017210553A1/en not_active Ceased
- 2017-06-02 EP EP17807565.1A patent/EP3463417A4/en active Pending
- 2017-06-02 CN CN202211437383.XA patent/CN115814097A/zh active Pending
- 2017-06-02 JP JP2018563562A patent/JP7523209B2/ja active Active
-
2021
- 2021-04-26 US US17/241,001 patent/US20210252038A1/en not_active Abandoned
-
2022
- 2022-09-16 JP JP2022147792A patent/JP2022180476A/ja active Pending
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