JP2019520343A5 - - Google Patents

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Publication number
JP2019520343A5
JP2019520343A5 JP2018563056A JP2018563056A JP2019520343A5 JP 2019520343 A5 JP2019520343 A5 JP 2019520343A5 JP 2018563056 A JP2018563056 A JP 2018563056A JP 2018563056 A JP2018563056 A JP 2018563056A JP 2019520343 A5 JP2019520343 A5 JP 2019520343A5
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JP
Japan
Prior art keywords
pharmaceutically acceptable
acceptable salt
hydroxy
nitrogen
vinca
Prior art date
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Granted
Application number
JP2018563056A
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English (en)
Japanese (ja)
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JP6963312B2 (ja
JP2019520343A (ja
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Priority claimed from PCT/US2017/035027 external-priority patent/WO2017210206A1/en
Publication of JP2019520343A publication Critical patent/JP2019520343A/ja
Publication of JP2019520343A5 publication Critical patent/JP2019520343A5/ja
Application granted granted Critical
Publication of JP6963312B2 publication Critical patent/JP6963312B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2018563056A 2016-05-31 2017-05-30 超強力ビンカアルカロイド：付加された分子の複雑さがチューブリンの二量体−二量体界面を更に破壊する Expired - Fee Related JP6963312B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662343490P 2016-05-31 2016-05-31
US62/343,490 2016-05-31
PCT/US2017/035027 WO2017210206A1 (en) 2016-05-31 2017-05-30 Ultra-potent vina alkaloids: added molecular complexity further disrupts the tublin dimer-dimer interface

Publications (3)

Publication Number Publication Date
JP2019520343A JP2019520343A (ja) 2019-07-18
JP2019520343A5 true JP2019520343A5 (OSRAM) 2020-07-09
JP6963312B2 JP6963312B2 (ja) 2021-11-05

Family

ID=60478938

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018563056A Expired - Fee Related JP6963312B2 (ja) 2016-05-31 2017-05-30 超強力ビンカアルカロイド：付加された分子の複雑さがチューブリンの二量体−二量体界面を更に破壊する

Country Status (5)

Country Link
US (1) US10975101B2 (OSRAM)
EP (1) EP3464289B1 (OSRAM)
JP (1) JP6963312B2 (OSRAM)
ES (1) ES2879679T3 (OSRAM)
WO (1) WO2017210206A1 (OSRAM)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101868961B1 (ko) * 2016-06-21 2018-06-19 울산과학기술원 미세 유체 장치
CA2993378C (en) * 2017-09-15 2021-10-05 The Scripps Research Institute Vinblastine 20' amides: synthetic analogs that maintain or improve potency and simultaneously overcome pgp-derived efflux and resistance
CN111689989B (zh) * 2020-07-10 2021-11-02 北京燕化集联光电技术有限公司 一种含so2多杂环化合物及其应用
CN111747970B (zh) * 2020-07-10 2021-11-16 北京燕化集联光电技术有限公司 一种含so2多杂环的化合物及其应用
CN111662309B (zh) * 2020-07-10 2021-11-09 北京燕化集联光电技术有限公司 一种多杂环结构化合物及其应用
CN111662308B (zh) * 2020-07-10 2021-11-16 北京燕化集联光电技术有限公司 一种so2多杂环结构化合物及其应用
CN111689985B (zh) * 2020-07-10 2021-11-16 北京燕化集联光电技术有限公司 一种含so2多杂环结构的化合物及其应用
CN111689984B (zh) * 2020-07-10 2021-11-09 北京燕化集联光电技术有限公司 一种含多杂环结构的化合物及其应用
CN111747961B (zh) * 2020-07-10 2021-11-02 北京燕化集联光电技术有限公司 一种含多杂环的化合物及应用
CN111635420B (zh) * 2020-07-10 2022-05-13 北京燕化集联光电技术有限公司 一种新型多杂环化合物及其应用
CN111689971B (zh) * 2020-07-10 2021-11-02 北京燕化集联光电技术有限公司 一种多杂环化合物及应用
CN111662298B (zh) * 2020-07-10 2021-08-10 北京燕化集联光电技术有限公司 一种含多杂环化合物及其在有机电致发光器件中的应用
CN112321647B (zh) * 2020-11-05 2022-08-16 北京燕化集联光电技术有限公司 一种含苯并咪唑结构的铱配合物及其应用
CN112175016B (zh) * 2020-11-05 2022-11-11 北京燕化集联光电技术有限公司 一种有机电致磷光发光材料及其应用
CN112341499B (zh) * 2020-11-05 2022-07-12 北京燕化集联光电技术有限公司 一种含硫有机电致磷光发光材料及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8039453B2 (en) * 2006-09-12 2011-10-18 Albany Molecular Research, Inc. Vinca derivatives
WO2011103007A2 (en) 2010-02-22 2011-08-25 The Scripps Research Institute 10'-fluorinated vinca alkaloids provide enhanced biological activity against mdr cancer cells
AU2013356664B2 (en) 2012-12-03 2018-01-18 The Scripps Research Institute C20'-urea derivatives of Vinca alkaloids
HU230462B1 (hu) * 2013-05-30 2016-07-28 Richter Gedeon Nyrt. Új bisz-indol alkaloidok mint rákellenes gyógyszerek
CA2993378C (en) 2017-09-15 2021-10-05 The Scripps Research Institute Vinblastine 20' amides: synthetic analogs that maintain or improve potency and simultaneously overcome pgp-derived efflux and resistance

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