JP2019518050A - 抗菌薬としての複素環式化合物 - Google Patents

抗菌薬としての複素環式化合物 Download PDF

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JP2019518050A
JP2019518050A JP2018565691A JP2018565691A JP2019518050A JP 2019518050 A JP2019518050 A JP 2019518050A JP 2018565691 A JP2018565691 A JP 2018565691A JP 2018565691 A JP2018565691 A JP 2018565691A JP 2019518050 A JP2019518050 A JP 2019518050A
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alkyl
ring
compound
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substituted
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JP2019518050A5 (enExample
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エミール ジョルジュ ギーユモン，ジェローム
エミール ジョルジュ ギーユモン，ジェローム
ジャン−マリー ベルナルド ラボイソン，ピエール
ジャン−マリー ベルナルド ラボイソン，ピエール
ターリ，アブデラ
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ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー
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Publication of JP2019518050A publication Critical patent/JP2019518050A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
JP2018565691A 2016-06-16 2017-06-15 抗菌薬としての複素環式化合物 Pending JP2019518050A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16174722 2016-06-16
EP16174722.5 2016-06-16
PCT/EP2017/064654 WO2017216283A1 (en) 2016-06-16 2017-06-15 Heterocyclic compounds as antibacte rials

Publications (2)

Publication Number Publication Date
JP2019518050A true JP2019518050A (ja) 2019-06-27
JP2019518050A5 JP2019518050A5 (enExample) 2020-08-13

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JP2018565691A Pending JP2019518050A (ja) 2016-06-16 2017-06-15 抗菌薬としての複素環式化合物

Country Status (12)

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US (1) US20200308169A1 (enExample)
EP (1) EP3472152A1 (enExample)
JP (1) JP2019518050A (enExample)
KR (1) KR20190018681A (enExample)
CN (1) CN109415349A (enExample)
AU (1) AU2017286370B2 (enExample)
BR (1) BR112018075939A2 (enExample)
CA (1) CA3025727A1 (enExample)
EA (1) EA201990044A1 (enExample)
MA (1) MA45375A (enExample)
MX (1) MX2018015657A (enExample)
WO (1) WO2017216283A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20220339T1 (hr) 2015-07-02 2022-05-13 Janssen Sciences Ireland Unlimited Company Antibakterijski spojevi
IL257743B (en) 2015-09-17 2022-08-01 Marvin J Miller Benzyl amine-containing heterocyclic compounds and compositions useful against mycobacterial infection
AU2017286368B2 (en) 2016-06-16 2021-02-25 Janssen Sciences Ireland Unlimited Company Heterocyclic compounds as antibacterials
EP3589323B1 (en) 2017-03-01 2024-04-03 Janssen Sciences Ireland Unlimited Company Combination therapy for the treatment of tuberculosis
TWI861208B (zh) 2019-09-10 2024-11-11 日商鹽野義製藥股份有限公司 對分枝桿菌感染有用之含苄胺的 5,6-雜芳族化合物
CN114423758B (zh) * 2019-09-13 2025-05-27 爱尔兰詹森科学公司 抗细菌化合物
EP4038067A1 (en) 2019-09-30 2022-08-10 Janssen Sciences Ireland Unlimited Company 4-quinolinone antibacterial compounds
WO2021063915A1 (en) 2019-09-30 2021-04-08 Janssen Sciences Ireland Unlimited Company Antibacterial compounds
AU2022237769A1 (en) 2021-03-16 2023-11-02 Janssen Sciences Ireland Unlimited Company Antibacterial compounds
WO2022194905A1 (en) 2021-03-17 2022-09-22 Janssen Sciences Ireland Unlimited Company Antibacterial compounds
EP4308579A1 (en) 2021-03-17 2024-01-24 Janssen Sciences Ireland Unlimited Company Antibacterial compounds
WO2022214520A1 (en) 2021-04-07 2022-10-13 Janssen Sciences Ireland Unlimited Company Antibacterial compounds
WO2022214519A1 (en) 2021-04-07 2022-10-13 Janssen Sciences Ireland Unlimited Company Antibacterial compounds
KR20240090864A (ko) 2021-10-28 2024-06-21 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 세균성 감염의 치료에 사용하기 위한 이미다조피리딘 아미드 및 관련 화합물
WO2024089170A1 (en) 2022-10-27 2024-05-02 Janssen Sciences Ireland Unlimited Company Antibacterial compounds
WO2024223859A1 (en) 2023-04-26 2024-10-31 Janssen Pharmaceutica Nv Antibacterial compounds

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011057145A2 (en) * 2009-11-05 2011-05-12 University Of Notre Dame Du Lac Imidazo[1,2-a] pyridine compounds, synthesis thereof, and methods of using same
JP2013522253A (ja) * 2010-03-18 2013-06-13 インスティチュート・パスツール・コリア 抗感染化合物
WO2015014993A2 (en) * 2013-08-02 2015-02-05 Institut Pasteur Korea Anti-infective compounds
JP2015522622A (ja) * 2012-07-18 2015-08-06 モラスキ，ギャレット ５，５−ヘテロ芳香族抗感染症化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA008937B1 (ru) 2002-07-25 2007-10-26 Янссен Фармацевтика Н.В. Производные хинолина и их применение в качестве микобактериальных ингибиторов
US9199981B2 (en) 2011-09-01 2015-12-01 Novartis Ag Compounds and compositions as C-kit kinase inhibitors
AP2014007493A0 (en) 2011-09-01 2014-03-31 Irm Llc Compounds and compositions as C-KIT kinase inhibitors
CN105524058B (zh) * 2014-10-21 2018-03-27 广州艾格生物科技有限公司 吡唑并[1,5‑a]吡啶类化合物及其应用

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011057145A2 (en) * 2009-11-05 2011-05-12 University Of Notre Dame Du Lac Imidazo[1,2-a] pyridine compounds, synthesis thereof, and methods of using same
JP2013522253A (ja) * 2010-03-18 2013-06-13 インスティチュート・パスツール・コリア 抗感染化合物
JP2015522622A (ja) * 2012-07-18 2015-08-06 モラスキ，ギャレット ５，５−ヘテロ芳香族抗感染症化合物
WO2015014993A2 (en) * 2013-08-02 2015-02-05 Institut Pasteur Korea Anti-infective compounds

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Title
DATABASE REGISTRY ON STN, JPN7021001311, 17 December 2015 (2015-12-17), ISSN: 0004666767 *
DATABASE REGISTRY ON STN, JPN7021001312, 24 September 2014 (2014-09-24), ISSN: 0004666768 *
DATABASE REGISTRY ON STN, JPN7021001315, 21 August 2011 (2011-08-21), ISSN: 0004666769 *
DATABASE REGISTRY ON STN, JPN7021001316, 24 May 2011 (2011-05-24), ISSN: 0004666770 *
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BR112018075939A2 (pt) 2019-04-09
WO2017216283A1 (en) 2017-12-21
MX2018015657A (es) 2019-03-14
EA201990044A1 (ru) 2019-05-31
EP3472152A1 (en) 2019-04-24
US20200308169A1 (en) 2020-10-01
MA45375A (fr) 2019-04-24
CA3025727A1 (en) 2017-12-21
AU2017286370B2 (en) 2021-09-09
AU2017286370A1 (en) 2018-12-06
CN109415349A (zh) 2019-03-01
KR20190018681A (ko) 2019-02-25

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