JP2019517523A5 - - Google Patents
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- JP2019517523A5 JP2019517523A5 JP2018563453A JP2018563453A JP2019517523A5 JP 2019517523 A5 JP2019517523 A5 JP 2019517523A5 JP 2018563453 A JP2018563453 A JP 2018563453A JP 2018563453 A JP2018563453 A JP 2018563453A JP 2019517523 A5 JP2019517523 A5 JP 2019517523A5
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- -1 PPAR delta agonist Substances 0.000 claims description 14
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- 230000001225 therapeutic effect Effects 0.000 claims description 5
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| EP2545964A1 (en) | 2011-07-13 | 2013-01-16 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
| US11571431B2 (en) | 2013-12-04 | 2023-02-07 | Galmed Research And Development Ltd | Aramchol salts |
| IL243707A0 (en) | 2016-01-20 | 2016-05-01 | Galmed Res And Dev Ltd | Treatment to regulate the microbiota in the intestine |
| SG11201810602YA (en) * | 2016-06-03 | 2018-12-28 | Chemocentryx Inc | Method of treating liver fibrosis |
| JP6678779B2 (ja) | 2016-06-13 | 2020-04-08 | ギリアード サイエンシーズ， インコーポレイテッド | Ｆｘｒ（ｎｒ１ｈ４）調節化合物 |
| CA3252823A1 (en) | 2016-06-13 | 2025-02-25 | Gilead Sciences, Inc. | Fxr (nr1h4) modulating compounds |
| US11197870B2 (en) | 2016-11-10 | 2021-12-14 | Galmed Research And Development Ltd | Treatment for hepatic fibrosis |
| KR20190083659A (ko) * | 2016-11-10 | 2019-07-12 | 갈메드 리서치 앤드 디벨롭먼트 리미티드 | 섬유증에 대한 치료 |
| PT4122464T (pt) | 2017-03-28 | 2024-06-27 | Gilead Sciences Inc | Combinações terapêuticas para o tratamento de doenças do fígado |
| KR102600115B1 (ko) | 2017-06-05 | 2023-11-09 | 바이킹 테라퓨틱스 인코포레이티드 | 섬유증 치료를 위한 조성물 |
| CN111406051A (zh) | 2017-09-03 | 2020-07-10 | 安吉昂生物医药公司 | 作为rho相关卷曲螺旋激酶(rock)抑制剂的乙烯基杂环 |
| US11292785B2 (en) | 2018-02-02 | 2022-04-05 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Nitrogen-containing benzoheterocycle compound comprising carboxylic acid group, preparation method and use thereof |
| WO2019183004A1 (en) | 2018-03-22 | 2019-09-26 | Viking Therapeutics, Inc. | Crystalline forms and methods of producing crystalline forms of a compound |
| CN113683597A (zh) * | 2018-06-12 | 2021-11-23 | 四川海思科制药有限公司 | 甲状腺激素受体激动剂及其用途 |
| CN112996490A (zh) * | 2018-08-14 | 2021-06-18 | 阿沃林特有限公司 | 治疗原发性硬化性胆管炎的方法 |
| GB201813678D0 (en) * | 2018-08-22 | 2018-10-03 | Keybioscience Ag | Acylated calcitonin mimetics |
| US12102646B2 (en) * | 2018-12-05 | 2024-10-01 | Viking Therapeutics, Inc. | Compositions for the treatment of fibrosis and inflammation |
| SG11202107434PA (en) | 2019-01-15 | 2021-08-30 | Gilead Sciences Inc | Fxr (nr1h4) modulating compounds |
| CN118388473A (zh) | 2019-02-19 | 2024-07-26 | 吉利德科学公司 | Fxr激动剂的固体形式 |
| WO2020181163A1 (en) * | 2019-03-06 | 2020-09-10 | Tobira Therapeutics, Inc. | Lipid-based formulation of cenicriviroc |
| PE20220255A1 (es) | 2019-05-08 | 2022-02-16 | Aligos Therapeutics Inc | Moduladores de thr y metodos de uso de estos |
| CN114207143A (zh) * | 2019-07-30 | 2022-03-18 | Ko生物技术有限公司 | 预测或诊断非酒精性脂肪肝病的试剂盒及诊断非酒精性脂肪肝病的方法 |
| JP7499841B2 (ja) | 2019-07-30 | 2024-06-14 | コバイオラブス，インコーポレーテッド | 非アルコール性脂肪性肝疾患の予測若しくは診断用キット、および診断方法 |
| WO2021102251A1 (en) * | 2019-11-22 | 2021-05-27 | Avolynt | Use of sglt2 inhibitors to treat primary billiary cholangitis |
| CN113274368B (zh) * | 2020-02-20 | 2023-08-22 | 甘莱制药有限公司 | 一种用于治疗脂肪性肝炎的药物组合物及其制备方法 |
| US11478533B2 (en) * | 2020-04-27 | 2022-10-25 | Novo Nordisk A/S | Semaglutide for use in medicine |
| MX2023003401A (es) * | 2020-10-08 | 2023-04-25 | Curome Biosciences Co Ltd | Composicion farmaceutica para prevenir o tratar enfermedad hepatica colestasica, que contiene beta-lapachona como ingrediente activo. |
| CN120899882A (zh) * | 2025-06-16 | 2025-11-07 | 中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心) | Klb蛋白在制备治疗血吸虫感染的药物上的应用 |
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| WO2005118578A1 (en) * | 2004-05-26 | 2005-12-15 | Janssen Pharmaceutica N.V. | Mercaptoimidazoles as ccr2 receptor antagonists |
| US7622583B2 (en) | 2005-01-14 | 2009-11-24 | Chemocentryx, Inc. | Heteroaryl sulfonamides and CCR2 |
| EP2474532A1 (en) | 2005-01-14 | 2012-07-11 | ChemoCentryx, Inc. | Heteroaryl sulfonamides and CCR2 |
| US8067457B2 (en) * | 2005-11-01 | 2011-11-29 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of CCR2 |
| US20070219245A1 (en) * | 2006-03-14 | 2007-09-20 | Cuifen Hou | Method of use for substituted dipiperidine ccr2 antagonists |
| US8519135B2 (en) | 2006-07-14 | 2013-08-27 | Chemocentryx, Inc. | Heteroaryl sulfonamides and CCR2/CCR9 |
| US7683176B2 (en) * | 2006-07-14 | 2010-03-23 | Chemocentryx, Inc. | Triazolyl pyridyl benzenesulfonamides |
| US7776877B2 (en) * | 2007-06-22 | 2010-08-17 | Chemocentryx, Inc. | N-(2-(hetaryl)aryl) arylsulfonamides and N-(2-(hetaryl) hetaryl arylsulfonamides |
| ATE548039T1 (de) * | 2007-07-12 | 2012-03-15 | Chemocentryx Inc | Kondensierte heteroarylpyridyl- und phenylbenzensulfonamide als ccr2-modulatoren zur behandlung von entzündungen |
| PE20100156A1 (es) * | 2008-06-03 | 2010-02-23 | Boehringer Ingelheim Int | Tratamiento de nafld |
| MX2011001911A (es) | 2008-08-18 | 2011-07-04 | Pfizer | Anticuerpos para ccr2. |
| WO2011073154A1 (en) * | 2009-12-17 | 2011-06-23 | Boehringer Ingelheim International Gmbh | New ccr2 receptor antagonists and uses thereof |
| WO2012114223A1 (en) * | 2011-02-25 | 2012-08-30 | Pfizer Limited | A method of treating liver fibrosis |
| US8658787B2 (en) * | 2011-09-16 | 2014-02-25 | Galectin Therapeutics Inc. | Galacto-rhamnogalacturonate compositions for the treatment of non-alcoholic steatohepatitis and non-alcoholic fatty liver disease |
| JP2015516404A (ja) * | 2012-05-09 | 2015-06-11 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 代謝疾患の処置のための合剤 |
| TWI696462B (zh) * | 2013-07-10 | 2020-06-21 | 日商興和股份有限公司 | 非酒精性脂肪性肝疾病治療劑 |
| EP3191100A4 (en) * | 2014-09-12 | 2018-05-30 | Tobira Therapeutics, Inc. | Cenicriviroc combination therapy for the treatment of fibrosis |
| SG11201810602YA (en) * | 2016-06-03 | 2018-12-28 | Chemocentryx Inc | Method of treating liver fibrosis |
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2018
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