JP2019515748A - 内頚動脈血栓摘出デバイスおよび方法 - Google Patents
内頚動脈血栓摘出デバイスおよび方法 Download PDFInfo
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- JP2019515748A JP2019515748A JP2018558196A JP2018558196A JP2019515748A JP 2019515748 A JP2019515748 A JP 2019515748A JP 2018558196 A JP2018558196 A JP 2018558196A JP 2018558196 A JP2018558196 A JP 2018558196A JP 2019515748 A JP2019515748 A JP 2019515748A
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- sheath
- balloon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/01—Filters implantable into blood vessels
- A61F2/011—Instruments for their placement or removal
-
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- A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22038—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for with a guide wire
- A61B2017/22047—Means for immobilising the guide wire in the patient
- A61B2017/22048—Balloons
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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- A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22051—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
- A61B2017/22065—Functions of balloons
- A61B2017/22067—Blocking; Occlusion
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- A61B17/32—Surgical cutting instruments
- A61B17/3205—Excision instruments
- A61B17/3207—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions
- A61B2017/320716—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions comprising means for preventing embolism by dislodged material
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- A61B2217/005—Auxiliary appliance with suction drainage system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/01—Filters implantable into blood vessels
- A61F2002/016—Filters implantable into blood vessels made from wire-like elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M25/0045—Catheters; Hollow probes characterised by structural features multi-layered, e.g. coated
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/06—Body-piercing guide needles or the like
- A61M25/0662—Guide tubes
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1052—Balloon catheters with special features or adapted for special applications for temporarily occluding a vessel for isolating a sector
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1061—Balloon catheters with special features or adapted for special applications having separate inflations tubes, e.g. coaxial tubes or tubes otherwise arranged apart from the catheter tube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1093—Balloon catheters with special features or adapted for special applications having particular tip characteristics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0009—Making of catheters or other medical or surgical tubes
- A61M25/0013—Weakening parts of a catheter tubing, e.g. by making cuts in the tube or reducing thickness of a layer at one point to adjust the flexibility
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
- A61M25/0108—Steering means as part of the catheter or advancing means; Markers for positioning using radio-opaque or ultrasound markers
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1006—Balloons formed between concentric tubes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Surgical Instruments (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662332495P | 2016-05-06 | 2016-05-06 | |
| US62/332,495 | 2016-05-06 | ||
| PCT/US2017/031311 WO2017192999A1 (en) | 2016-05-06 | 2017-05-05 | Internal carotid artery thrombectomy devices and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019515748A true JP2019515748A (ja) | 2019-06-13 |
| JP2019515748A5 JP2019515748A5 (enExample) | 2020-06-11 |
Family
ID=60203659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018558196A Pending JP2019515748A (ja) | 2016-05-06 | 2017-05-05 | 内頚動脈血栓摘出デバイスおよび方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20200246036A1 (enExample) |
| EP (1) | EP3451953B1 (enExample) |
| JP (1) | JP2019515748A (enExample) |
| MA (1) | MA44884A (enExample) |
| WO (1) | WO2017192999A1 (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10233085B4 (de) | 2002-07-19 | 2014-02-20 | Dendron Gmbh | Stent mit Führungsdraht |
| WO2007092820A2 (en) | 2006-02-03 | 2007-08-16 | Lazarus Effect, Inc. | Methods and devices for restoring blood flow within blocked vasculature |
| US11202646B2 (en) | 2007-04-17 | 2021-12-21 | Covidien Lp | Articulating retrieval devices |
| US10076346B2 (en) | 2007-04-17 | 2018-09-18 | Covidien Lp | Complex wire formed devices |
| US11337714B2 (en) | 2007-10-17 | 2022-05-24 | Covidien Lp | Restoring blood flow and clot removal during acute ischemic stroke |
| US10123803B2 (en) | 2007-10-17 | 2018-11-13 | Covidien Lp | Methods of managing neurovascular obstructions |
| CN102036611B (zh) | 2007-12-26 | 2015-01-28 | 拉撒路效应公司 | 取回系统及其使用方法 |
| CN102014772B (zh) | 2008-02-22 | 2013-11-13 | 泰科保健集团有限合伙公司 | 用于去除血栓的自扩张装置和可去除的结合血栓的装置 |
| WO2012009675A2 (en) | 2010-07-15 | 2012-01-19 | Lazarus Effect, Inc. | Retrieval systems and methods for use thereof |
| BR112013030183A2 (pt) | 2011-05-23 | 2017-12-05 | Lazarus Effect Inc | dispositivo médico intervencional para recuperar e assegurrar uma obstrução dentro de um lúmen de vaso, método de assegurar uma obstrução dentro de um vaso, método de preparação de um dispositivo de recuperação, sistema de recuperação de dispositivo médico, para assegurar uma obstrução dentro de um lúmen de vaso e para uso com um cateter configurado para ser navegado através da vasculatura, dispositivo médico intervencional para assegurar um dispositivo de recuperação tendo uma ou mais obstruções localizadas nele para remoção de um corpo e dispositivo de recuperação do stent para se expandir contra um ou mais corpos oclusivos em uma vasculatura |
| US9072624B2 (en) | 2012-02-23 | 2015-07-07 | Covidien Lp | Luminal stenting |
| US9314248B2 (en) | 2012-11-06 | 2016-04-19 | Covidien Lp | Multi-pivot thrombectomy device |
| US10076399B2 (en) | 2013-09-13 | 2018-09-18 | Covidien Lp | Endovascular device engagement |
| US9592139B2 (en) | 2013-10-04 | 2017-03-14 | Covidien Lp | Stents twisted prior to deployment and untwisted during deployment |
| WO2015073704A1 (en) | 2013-11-13 | 2015-05-21 | Covidien Lp | Galvanically assisted attachment of medical devices to thrombus |
| US10456560B2 (en) | 2015-02-11 | 2019-10-29 | Covidien Lp | Expandable tip medical devices and methods |
| WO2016197036A1 (en) | 2015-06-03 | 2016-12-08 | Brian Martin | Flexible intravascular treatment devices and associated systems and methods of use |
| EP3542737B1 (en) | 2015-09-25 | 2021-06-16 | Covidien LP | Medical device delivery system |
| US10537344B2 (en) | 2015-10-23 | 2020-01-21 | Covidien Lp | Rotatable connection between an intervention member and a manipulation member of an endovascular device |
| US10874410B2 (en) | 2015-11-04 | 2020-12-29 | Covidien Lp | Clot removal by adhesion |
| US10265089B2 (en) | 2016-02-12 | 2019-04-23 | Covidien Lp | Vascular device visibility |
| US10052185B2 (en) | 2016-02-12 | 2018-08-21 | Covidien Lp | Vascular device marker attachment |
| US10709464B2 (en) | 2017-05-12 | 2020-07-14 | Covidien Lp | Retrieval of material from vessel lumens |
| US11129630B2 (en) | 2017-05-12 | 2021-09-28 | Covidien Lp | Retrieval of material from vessel lumens |
| US10722257B2 (en) | 2017-05-12 | 2020-07-28 | Covidien Lp | Retrieval of material from vessel lumens |
| US11298145B2 (en) | 2017-05-12 | 2022-04-12 | Covidien Lp | Retrieval of material from vessel lumens |
| US11191555B2 (en) | 2017-05-12 | 2021-12-07 | Covidien Lp | Retrieval of material from vessel lumens |
| CN110612057B (zh) | 2017-06-07 | 2022-05-31 | 柯惠有限合伙公司 | 用于检测中风的系统和方法 |
| WO2018232044A1 (en) | 2017-06-12 | 2018-12-20 | Covidien Lp | Tools for sheathing treatment devices and associated systems and methods |
| US10478322B2 (en) | 2017-06-19 | 2019-11-19 | Covidien Lp | Retractor device for transforming a retrieval device from a deployed position to a delivery position |
| US10575864B2 (en) | 2017-06-22 | 2020-03-03 | Covidien Lp | Securing element for resheathing an intravascular device and associated systems and methods |
| US10342686B2 (en) | 2017-08-10 | 2019-07-09 | Covidien Lp | Thin film mesh hybrid for treating vascular defects |
| US10835398B2 (en) | 2017-11-03 | 2020-11-17 | Covidien Lp | Meshes and devices for treating vascular defects |
| US10709463B2 (en) | 2017-12-11 | 2020-07-14 | Covidien Lp | Electrically enhanced retrieval of material from vessel lumens |
| US11974752B2 (en) | 2019-12-12 | 2024-05-07 | Covidien Lp | Electrically enhanced retrieval of material from vessel lumens |
| US12004803B2 (en) | 2021-03-15 | 2024-06-11 | Covidien Lp | Thrombectomy treatment system |
| US11058444B2 (en) | 2017-12-11 | 2021-07-13 | Covidien Lp | Electrically enhanced retrieval of material from vessel lumens |
| US12318126B2 (en) | 2021-06-25 | 2025-06-03 | Covidien Lp | Current generator for a medical treatment system |
| US11090071B2 (en) | 2018-06-22 | 2021-08-17 | Covidien Lp | Electrically enhanced retrieval of material from vessel lumens |
| EP3863537A4 (en) * | 2018-10-10 | 2022-06-29 | Marblehead Medical, LLC | Internal carotid artery thrombectomy devices and methods |
| WO2020132003A1 (en) | 2018-12-19 | 2020-06-25 | Marblehead Medical Llc | Internal carotid artery thrombectomy devices and methods |
| US12514722B2 (en) | 2019-01-31 | 2026-01-06 | Mayo Foundation For Medical Education And Research | Carotid artery stenting systems and methods |
| US11612430B2 (en) | 2019-03-19 | 2023-03-28 | Covidien Lp | Electrically enhanced retrieval of material from vessel lumens |
| US11607531B2 (en) | 2019-05-09 | 2023-03-21 | Neuravi Limited | Balloon catheter with venting of residual air in a proximal direction |
| US11931522B2 (en) * | 2019-05-09 | 2024-03-19 | Neuravi Limited | Inflation lumen kink protection and balloon profile |
| US11571553B2 (en) | 2019-05-09 | 2023-02-07 | Neuravi Limited | Balloon guide catheter with thermally expandable material |
| US11957855B2 (en) * | 2019-05-09 | 2024-04-16 | Neuravi Limited | Balloon guide catheter with positive venting of residual air |
| US11523838B2 (en) | 2019-06-12 | 2022-12-13 | Covidien Lp | Retrieval of material from corporeal lumens |
| US11191558B2 (en) | 2019-06-12 | 2021-12-07 | Covidien Lp | Retrieval of material from corporeal lumens |
| US11395668B2 (en) | 2019-12-12 | 2022-07-26 | Covidien Lp | Electrically enhanced retrieval of material from vessel lumens |
| US12263020B2 (en) | 2020-02-17 | 2025-04-01 | Covidien Lp | Systems and methods for detecting strokes |
| US12364397B2 (en) | 2020-02-17 | 2025-07-22 | Covidien Lp | Systems and methods for detecting strokes |
| CN113648516B (zh) * | 2020-05-12 | 2024-04-02 | 先健科技(深圳)有限公司 | 球囊导管及取栓装置 |
| WO2022047215A1 (en) | 2020-08-28 | 2022-03-03 | Covidien Lp | Detection of patient conditions using signals sensed on or near the head |
| US12433598B2 (en) | 2020-10-13 | 2025-10-07 | Asahi Intecc Co., Ltd. | Thrombus aspiration systems and related methods |
| US20240226506A9 (en) * | 2021-03-16 | 2024-07-11 | Atricure, Inc. | Delivery devices and related methods |
| US11963713B2 (en) | 2021-06-02 | 2024-04-23 | Covidien Lp | Medical treatment system |
| US11944374B2 (en) | 2021-08-30 | 2024-04-02 | Covidien Lp | Electrical signals for retrieval of material from vessel lumens |
| US12076020B2 (en) | 2021-11-18 | 2024-09-03 | Covidien Lp | Retrieval of material from corporeal lumens |
| US12102782B2 (en) | 2022-01-27 | 2024-10-01 | Contego Medical, Inc. | Thrombectomy and aspiration system and methods of use |
| CN117414480B (zh) * | 2023-11-14 | 2026-07-17 | 南京普微森医疗科技有限公司 | 一种直径可调节的抽吸导管 |
| CN119564288B (zh) * | 2025-02-10 | 2025-06-20 | 鼎科医疗技术(苏州)有限公司 | 一种取栓球囊 |
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| US20030023204A1 (en) * | 1998-03-13 | 2003-01-30 | Vo Hung Van | Catheter having a funnel-shaped occlusion balloon of uniform thickness and methods of manufacture |
| JP2011530353A (ja) * | 2008-08-08 | 2011-12-22 | インセプト,エルエルシー | 体管腔にアクセスして物質を除去する装置および方法 |
| US20140107575A1 (en) * | 2001-06-26 | 2014-04-17 | Concentric Medical, Inc. | Balloon Catheter |
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| US5135482A (en) * | 1985-12-31 | 1992-08-04 | Arnold Neracher | Hydrodynamic device for the elimination of an organic deposit obstructing a vessel of a human body |
| US5263959A (en) * | 1991-10-21 | 1993-11-23 | Cathco, Inc. | Dottering auger catheter system and method |
| US5569218A (en) * | 1994-02-14 | 1996-10-29 | Scimed Life Systems, Inc. | Elastic guide catheter transition element |
| CA2410971C (en) * | 2000-05-31 | 2007-12-18 | Tyco Healthcare Group, Lp | Embolization protection system for vascular procedures |
| US6569129B1 (en) * | 2000-09-13 | 2003-05-27 | Mayo Foundation For Medical Education And Research | Biological revascularization |
| WO2003061457A2 (en) | 2002-01-24 | 2003-07-31 | The Johns Hopkins University | Methods and devices for percutaneous and surgical interventions |
| US9320831B2 (en) * | 2005-03-04 | 2016-04-26 | W. L. Gore & Associates, Inc. | Polymer shrink tubes and novel uses therefor |
| IES20090239A2 (en) * | 2008-03-28 | 2009-10-28 | Henry William Lupton | A device for unblocking an occluded vessel, and a method for unblocking an occluded vessel |
| US20120116350A1 (en) * | 2010-07-07 | 2012-05-10 | Reverse Medical Corporation | Translation dilator and stand alone vascular guide catheter |
| WO2014204860A1 (en) * | 2013-06-18 | 2014-12-24 | Slik Road Medical, Inc. | Methods and systems for tretment of acute ischemic stroke |
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2017
- 2017-05-05 US US16/319,764 patent/US20200246036A1/en not_active Abandoned
- 2017-05-05 WO PCT/US2017/031311 patent/WO2017192999A1/en not_active Ceased
- 2017-05-05 JP JP2018558196A patent/JP2019515748A/ja active Pending
- 2017-05-05 EP EP17793452.8A patent/EP3451953B1/en active Active
- 2017-05-05 MA MA044884A patent/MA44884A/fr unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030023204A1 (en) * | 1998-03-13 | 2003-01-30 | Vo Hung Van | Catheter having a funnel-shaped occlusion balloon of uniform thickness and methods of manufacture |
| US20140107575A1 (en) * | 2001-06-26 | 2014-04-17 | Concentric Medical, Inc. | Balloon Catheter |
| JP2011530353A (ja) * | 2008-08-08 | 2011-12-22 | インセプト,エルエルシー | 体管腔にアクセスして物質を除去する装置および方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20200246036A1 (en) | 2020-08-06 |
| MA44884A (fr) | 2019-03-13 |
| EP3451953B1 (en) | 2025-12-10 |
| EP3451953A1 (en) | 2019-03-13 |
| EP3451953A4 (en) | 2020-04-29 |
| WO2017192999A1 (en) | 2017-11-09 |
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