JP2019512550A5 - - Google Patents
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- JP2019512550A5 JP2019512550A5 JP2019500726A JP2019500726A JP2019512550A5 JP 2019512550 A5 JP2019512550 A5 JP 2019512550A5 JP 2019500726 A JP2019500726 A JP 2019500726A JP 2019500726 A JP2019500726 A JP 2019500726A JP 2019512550 A5 JP2019512550 A5 JP 2019512550A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- pharmaceutically acceptable
- acceptable salt
- hydrate
- cooh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610180518.7 | 2016-03-25 | ||
| CN201610180518 | 2016-03-25 | ||
| CN201610867918 | 2016-09-29 | ||
| CN201610867918.5 | 2016-09-29 | ||
| PCT/CN2017/078139 WO2017162206A1 (zh) | 2016-03-25 | 2017-03-24 | 作为雌激素受体降解剂的吲哚并取代哌啶类化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019512550A JP2019512550A (ja) | 2019-05-16 |
| JP2019512550A5 true JP2019512550A5 (enExample) | 2019-11-28 |
| JP6790222B2 JP6790222B2 (ja) | 2020-11-25 |
Family
ID=59899253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019500726A Active JP6790222B2 (ja) | 2016-03-25 | 2017-03-24 | エストロゲン受容体ダウンレギュレーターとしての置換インドール化合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10519143B2 (enExample) |
| EP (1) | EP3434668B1 (enExample) |
| JP (1) | JP6790222B2 (enExample) |
| KR (1) | KR102111792B1 (enExample) |
| CN (1) | CN108884035B (enExample) |
| AU (1) | AU2017239348B2 (enExample) |
| CA (1) | CA3018801C (enExample) |
| ES (1) | ES2821407T3 (enExample) |
| RU (1) | RU2722441C2 (enExample) |
| SG (1) | SG11201808363TA (enExample) |
| WO (1) | WO2017162206A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111032627B (zh) * | 2017-09-25 | 2023-10-20 | 罗欣健康科技发展(北京)有限公司 | 一种雌激素受体抑制剂的晶型及其制备方法 |
| JP7571006B2 (ja) | 2018-08-17 | 2024-10-22 | ジェネンテック， インコーポレイテッド | 乳がんの処置のための診断的および治療的方法 |
| WO2020108154A1 (zh) | 2018-11-28 | 2020-06-04 | 罗欣药业(上海)有限公司 | 一种雌激素受体下调剂的盐型、晶型及其制备方法 |
| EP3889133B1 (en) | 2018-12-17 | 2026-01-28 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 4-[[2-[[5-[1-(1h-indol-2-yl)-2-(phenyl)-1-ethen-1-yl]-2-pyridinyl]oxy]ethyl]amino]-2-butenamide derivatives for the treatment of estrogen receptor positive breast cancer |
| CN116891461A (zh) * | 2022-03-30 | 2023-10-17 | 罗欣药业(上海)有限公司 | 一种serd中间体的合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW397821B (en) * | 1996-04-19 | 2000-07-11 | American Home Produits Corp | 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof |
| US20100317635A1 (en) * | 2009-06-16 | 2010-12-16 | Endorecherche, Inc. | Treatment of hot flushes, vasomotor symptoms, and night sweats with sex steroid precursors in combination with selective estrogen receptor modulators |
| GB0917571D0 (en) | 2009-10-07 | 2009-11-25 | Karobio Ab | Novel estrogen receptor ligands |
| GB2483736B (en) * | 2010-09-16 | 2012-08-29 | Aragon Pharmaceuticals Inc | Estrogen receptor modulators and uses thereof |
| US9499538B2 (en) | 2012-03-20 | 2016-11-22 | Seragon Pharmaceuticals, Inc. | Estrogen receptor modulators and uses thereof |
| SG11201607339VA (en) * | 2014-03-13 | 2016-10-28 | Hoffmann La Roche | Methods and compositions for modulating estrogen receptor mutants |
| WO2015136016A2 (en) * | 2014-03-13 | 2015-09-17 | F. Hoffmann-La Roche Ag | Therapeutic combinations with estrogen receptor modulators |
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2017
- 2017-03-24 KR KR1020187030877A patent/KR102111792B1/ko active Active
- 2017-03-24 CA CA3018801A patent/CA3018801C/en active Active
- 2017-03-24 EP EP17769483.3A patent/EP3434668B1/en active Active
- 2017-03-24 AU AU2017239348A patent/AU2017239348B2/en active Active
- 2017-03-24 RU RU2018135203A patent/RU2722441C2/ru active
- 2017-03-24 US US16/087,861 patent/US10519143B2/en active Active
- 2017-03-24 SG SG11201808363TA patent/SG11201808363TA/en unknown
- 2017-03-24 JP JP2019500726A patent/JP6790222B2/ja active Active
- 2017-03-24 CN CN201780019970.8A patent/CN108884035B/zh active Active
- 2017-03-24 ES ES17769483T patent/ES2821407T3/es active Active
- 2017-03-24 WO PCT/CN2017/078139 patent/WO2017162206A1/zh not_active Ceased