JP2019510501A5 - - Google Patents
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- Publication number
- JP2019510501A5 JP2019510501A5 JP2018552172A JP2018552172A JP2019510501A5 JP 2019510501 A5 JP2019510501 A5 JP 2019510501A5 JP 2018552172 A JP2018552172 A JP 2018552172A JP 2018552172 A JP2018552172 A JP 2018552172A JP 2019510501 A5 JP2019510501 A5 JP 2019510501A5
- Authority
- JP
- Japan
- Prior art keywords
- target
- sequence
- primer
- dna
- dna sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 42
- 238000000034 method Methods 0.000 claims 19
- 239000000523 sample Substances 0.000 claims 19
- 108020004414 DNA Proteins 0.000 claims 13
- 239000002773 nucleotide Substances 0.000 claims 13
- 125000003729 nucleotide group Chemical group 0.000 claims 13
- 230000003321 amplification Effects 0.000 claims 11
- 238000003199 nucleic acid amplification method Methods 0.000 claims 11
- 230000000295 complement effect Effects 0.000 claims 8
- 238000000137 annealing Methods 0.000 claims 7
- 238000001514 detection method Methods 0.000 claims 6
- 108091093088 Amplicon Proteins 0.000 claims 5
- 239000011541 reaction mixture Substances 0.000 claims 5
- 239000003153 chemical reaction reagent Substances 0.000 claims 4
- 230000001351 cycling effect Effects 0.000 claims 3
- 230000001419 dependent effect Effects 0.000 claims 3
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 claims 2
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 claims 2
- 239000005549 deoxyribonucleoside Substances 0.000 claims 2
- 238000009396 hybridization Methods 0.000 claims 2
- 238000002844 melting Methods 0.000 claims 2
- 230000008018 melting Effects 0.000 claims 2
- 238000003752 polymerase chain reaction Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 238000007423 screening assay Methods 0.000 claims 2
- 239000001226 triphosphate Substances 0.000 claims 2
- 235000011178 triphosphate Nutrition 0.000 claims 2
- 125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 claims 2
- BAVYZALUXZFZLV-UHFFFAOYSA-O Methylammonium ion Chemical compound [NH3+]C BAVYZALUXZFZLV-UHFFFAOYSA-O 0.000 claims 1
- 238000012408 PCR amplification Methods 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- GEYMMMXKROUBAI-UHFFFAOYSA-N chlorane Chemical compound Cl.Cl.Cl.Cl.Cl GEYMMMXKROUBAI-UHFFFAOYSA-N 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 238000007847 digital PCR Methods 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000007837 multiplex assay Methods 0.000 claims 1
- 238000005382 thermal cycling Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662319332P | 2016-04-07 | 2016-04-07 | |
| US62/319,332 | 2016-04-07 | ||
| PCT/US2017/026088 WO2017176852A1 (en) | 2016-04-07 | 2017-04-05 | Multiplex nucleic acid assay methods capable of detecting closely related alleles, and reagents therefor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019510501A JP2019510501A (ja) | 2019-04-18 |
| JP2019510501A5 true JP2019510501A5 (https=) | 2020-07-09 |
| JP6933858B2 JP6933858B2 (ja) | 2021-09-08 |
Family
ID=60000654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018552172A Active JP6933858B2 (ja) | 2016-04-07 | 2017-04-05 | 類縁アレルを検出可能な多重核酸アッセイ法およびその試薬 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11542547B2 (https=) |
| EP (1) | EP3440226B1 (https=) |
| JP (1) | JP6933858B2 (https=) |
| CN (1) | CN109312398B (https=) |
| AU (1) | AU2017246663B2 (https=) |
| NZ (1) | NZ748011A (https=) |
| SG (1) | SG11201808740TA (https=) |
| WO (1) | WO2017176852A1 (https=) |
| ZA (1) | ZA201807405B (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| AU2011358564B9 (en) | 2011-02-09 | 2017-07-13 | Natera, Inc | Methods for non-invasive prenatal ploidy calling |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| US20180173845A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| WO2016183106A1 (en) | 2015-05-11 | 2016-11-17 | Natera, Inc. | Methods and compositions for determining ploidy |
| WO2017181202A2 (en) | 2016-04-15 | 2017-10-19 | Natera, Inc. | Methods for lung cancer detection |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| JP2021506342A (ja) | 2017-12-14 | 2021-02-22 | ティーエーアイ ダイアグノスティックス インコーポレイテッドＴａｉ Ｄｉａｇｎｏｓｔｉｃｓ，Ｉｎｃ． | 移植のための移植片適合性の評価 |
| CN111699269B (zh) * | 2018-01-12 | 2025-12-05 | 纳特拉公司 | 新引物及其用途 |
| CA3090426A1 (en) | 2018-04-14 | 2019-10-17 | Natera, Inc. | Methods for cancer detection and monitoring by means of personalized detection of circulating tumor dna |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| CA3292164A1 (en) * | 2018-09-25 | 2025-11-29 | Co Diagnostics Inc | Allele-specific design of cooperative primers for improved nucleic acid variant genotyping |
| CN110964814B (zh) * | 2018-09-30 | 2024-05-03 | 迈克生物股份有限公司 | 用于核酸序列变异检测的引物、组合物及方法 |
| CN111349691B (zh) * | 2018-12-21 | 2023-10-20 | 迈克生物股份有限公司 | Egfr基因缺失突变检测用组合物、试剂盒及检测方法 |
| CN110592215A (zh) * | 2019-09-27 | 2019-12-20 | 迈克生物股份有限公司 | 检测核酸序列的组合物及检测方法 |
| CN110541033B (zh) * | 2019-09-27 | 2023-11-14 | 迈克生物股份有限公司 | Egfr基因突变检测用组合物及检测方法 |
| CN114555829B (zh) * | 2019-10-02 | 2026-02-27 | 新泽西鲁特格斯州立大学 | 检测稀有序列变体的测定方法和试剂盒 |
| CN112824535B (zh) * | 2019-11-21 | 2023-07-04 | 迈克生物股份有限公司 | 基因突变多重检测用引物组合物及其试剂盒 |
| CN116121358B (zh) * | 2022-11-11 | 2024-07-23 | 重庆浦济生命科技有限公司 | 用于精神药物基因检测的组合物、试剂盒及使用方法 |
| EP4488384A1 (en) | 2023-07-05 | 2025-01-08 | Infiniplex Ltd. | Primers for selective amplification of rare target sequences |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7198897B2 (en) | 2001-12-19 | 2007-04-03 | Brandeis University | Late-PCR |
| US20060141518A1 (en) | 2004-03-24 | 2006-06-29 | Lao Kai Q | Detection of gene expression |
| EP2857526B1 (en) * | 2006-12-13 | 2016-08-17 | Luminex Corporation | Systems and methods for multiplex analysis of PCR in real time |
| CN110195097B (zh) * | 2013-02-07 | 2025-01-24 | 新泽西鲁特格斯州立大学 | 高度选择性核酸扩增引物 |
| US10480035B2 (en) * | 2013-09-13 | 2019-11-19 | Rutgers, The State University Of New Jersey | Multiplex diagnostic assays for Lyme disease and other tick-borne diseases |
| GB201409786D0 (en) * | 2014-06-02 | 2014-07-16 | Primer Design Ltd | Nucleic acid amplification system |
| CA2956174A1 (en) * | 2014-07-24 | 2016-01-28 | Brandeis University | Linear-expo-linear pcr (lel-pcr) |
-
2017
- 2017-04-05 CN CN201780035794.7A patent/CN109312398B/zh active Active
- 2017-04-05 US US16/091,824 patent/US11542547B2/en active Active
- 2017-04-05 EP EP17779722.2A patent/EP3440226B1/en active Active
- 2017-04-05 NZ NZ748011A patent/NZ748011A/en unknown
- 2017-04-05 AU AU2017246663A patent/AU2017246663B2/en active Active
- 2017-04-05 JP JP2018552172A patent/JP6933858B2/ja active Active
- 2017-04-05 SG SG11201808740TA patent/SG11201808740TA/en unknown
- 2017-04-05 WO PCT/US2017/026088 patent/WO2017176852A1/en not_active Ceased
-
2018
- 2018-11-05 ZA ZA2018/07405A patent/ZA201807405B/en unknown
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