JP2019509055A5 - - Google Patents

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Publication number
JP2019509055A5
JP2019509055A5 JP2018555841A JP2018555841A JP2019509055A5 JP 2019509055 A5 JP2019509055 A5 JP 2019509055A5 JP 2018555841 A JP2018555841 A JP 2018555841A JP 2018555841 A JP2018555841 A JP 2018555841A JP 2019509055 A5 JP2019509055 A5 JP 2019509055A5
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JP
Japan
Prior art keywords
cancer
miac
abm2
abm3
linked
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Withdrawn
Application number
JP2018555841A
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English (en)
Japanese (ja)
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JP2019509055A (ja
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Priority claimed from PCT/US2017/013512 external-priority patent/WO2017124002A1/en
Publication of JP2019509055A publication Critical patent/JP2019509055A/ja
Publication of JP2019509055A5 publication Critical patent/JP2019509055A5/ja
Withdrawn legal-status Critical Current

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JP2018555841A 2016-01-13 2017-01-13 多特異性免疫調節抗原結合構築物 Withdrawn JP2019509055A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662278359P 2016-01-13 2016-01-13
US62/278,359 2016-01-13
US201662361842P 2016-07-13 2016-07-13
US62/361,842 2016-07-13
PCT/US2017/013512 WO2017124002A1 (en) 2016-01-13 2017-01-13 Multispecific immunomodulatory antigen-binding constructs

Publications (2)

Publication Number Publication Date
JP2019509055A JP2019509055A (ja) 2019-04-04
JP2019509055A5 true JP2019509055A5 (https=) 2020-02-27

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ID=59311459

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018555841A Withdrawn JP2019509055A (ja) 2016-01-13 2017-01-13 多特異性免疫調節抗原結合構築物

Country Status (9)

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US (1) US20190031785A1 (https=)
EP (1) EP3402519A4 (https=)
JP (1) JP2019509055A (https=)
CN (1) CN109562162A (https=)
AU (1) AU2017207480A1 (https=)
BR (1) BR112018014368A2 (https=)
CA (1) CA3011535A1 (https=)
MA (1) MA43874A (https=)
WO (1) WO2017124002A1 (https=)

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WO2016115274A1 (en) * 2015-01-14 2016-07-21 Compass Therapeutics Llc Multispecific immunomodulatory antigen-binding constructs
SG11201907299XA (en) 2017-02-08 2019-09-27 Dragonfly Therapeutics Inc Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer
IL268755B2 (en) 2017-02-20 2025-12-01 Dragonfly Therapeutics Inc Proteins that bind her2, nkg2d, and cd16
SG11201913137VA (en) 2017-07-11 2020-01-30 Compass Therapeutics Llc Agonist antibodies that bind human cd137 and uses thereof
AU2018322178A1 (en) * 2017-08-23 2020-02-20 Dragonfly Therapeutics, Inc. Proteins binding NKG2D, CD16 and a tumor-associated antigen
WO2019089753A2 (en) 2017-10-31 2019-05-09 Compass Therapeutics Llc Cd137 antibodies and pd-1 antagonists and uses thereof
US11851497B2 (en) 2017-11-20 2023-12-26 Compass Therapeutics Llc CD137 antibodies and tumor antigen-targeting antibodies and uses thereof
EP3740505A1 (en) * 2018-01-16 2020-11-25 Lakepharma Inc. Bispecific antibody that binds cd3 and another target
EA202091887A1 (ru) 2018-02-08 2020-10-23 Драгонфлай Терапьютикс, Инк. Комбинированная терапия рака с применением мультиспецифических связывающих белков, которые активируют естественные клетки-киллеры
DK3749346T3 (da) 2018-02-08 2024-09-09 Dragonfly Therapeutics Inc Antistof variable domænekombinationer rettet mod nkg2d-receptoren
WO2019164930A1 (en) 2018-02-20 2019-08-29 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use
AU2019228128A1 (en) * 2018-03-02 2020-09-03 Cdr-Life Ag Trispecific antigen binding proteins
WO2019222449A1 (en) * 2018-05-16 2019-11-21 Dragonfly Therapeutics, Inc. Protein binding nkg2d, cd16 and a fibroblast activation protein
CA3099308A1 (en) * 2018-05-21 2019-11-28 Compass Therapeutics Llc Compositions and methods for enhancing the killing of target cells by nk cells
UY38251A (es) 2018-06-01 2019-12-31 Novartis Ag Moléculas de unión contra bcma y usos de las mismas
US12378318B2 (en) 2018-08-08 2025-08-05 Dragonfly Therapeutics, Inc. Proteins binding NKG2D, CD16 and a tumor-associated antigen
EA202091888A1 (ru) 2018-08-08 2020-10-23 Драгонфлай Терапьютикс, Инк. Вариабельные домены антител, нацеленные на рецептор nkg2d
WO2020033630A1 (en) 2018-08-08 2020-02-13 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use
US11046769B2 (en) 2018-11-13 2021-06-29 Compass Therapeutics Llc Multispecific binding constructs against checkpoint molecules and uses thereof
EP3966247B1 (en) * 2019-05-06 2026-01-07 Brown University Bispecific antibodies against chi3l1 and pd1 with enhanced t cell-mediated cytotoxic effects on tumor cells
EP3972993A1 (en) 2019-05-21 2022-03-30 Novartis AG Variant cd58 domains and uses thereof
CN118994397A (zh) 2019-05-21 2024-11-22 诺华股份有限公司 针对bcma的三特异性结合分子及其用途
PE20220568A1 (es) 2019-05-21 2022-04-20 Novartis Ag Moleculas de union a cd19 y usos de las mismas
CN116574183A (zh) * 2019-08-22 2023-08-11 盛禾(中国)生物制药有限公司 多功能抗体、其制备及其用途
CN112409484B (zh) * 2019-08-22 2023-03-21 盛禾(中国)生物制药有限公司 多功能抗体、其制备及其用途
TWI888487B (zh) * 2020-02-14 2025-07-01 日商協和麒麟股份有限公司 與cd3結合之雙特異性抗體
CN116249549A (zh) 2020-03-27 2023-06-09 诺华股份有限公司 用于治疗增殖性疾病和自身免疫病症的双特异性组合疗法
MX2022013944A (es) 2020-05-06 2022-11-30 Dragonfly Therapeutics Inc Proteinas que se unen al receptor activador de celulas asesinas naturales grupo 2 miembro d (nkg2d), cumulo de diferenciacion (cd16) y miembro a de la familia de dominios de lectina tipo c 12 (clec12a).
MX2023000005A (es) * 2020-06-26 2023-03-06 Sorrento Therapeutics Inc Virus del herpes simple (vhs) oncolíticos que expresan proteínas de fusión inmunomoduladoras.
TW202231292A (zh) 2020-10-13 2022-08-16 美商健生生物科技公司 用於調節分化簇iv及/或viii的經生物工程改造之t細胞介導之免疫力、材料、及其他方法
US20240025993A1 (en) 2020-11-06 2024-01-25 Novartis Ag Cd19 binding molecules and uses thereof
US20250215081A1 (en) 2020-11-06 2025-07-03 Novartis Ag Anti-cd19 agent and b cell targeting agent combination therapy for treating b cell malignancies
CN114736291B (zh) * 2021-01-07 2023-08-11 中国科学院微生物研究所 特异性结合发热伴血小板减少综合征病毒的囊膜蛋白Gn的人源单克隆抗体及其用途
WO2022170619A1 (en) * 2021-02-11 2022-08-18 Adagene Pte. Ltd. Anti-cd3 antibodies and methods of use thereof
JP2024508894A (ja) 2021-03-03 2024-02-28 ドラゴンフライ セラピューティクス, インコーポレイテッド Nkg2d、cd16、及び腫瘍関連抗原に結合する多特異性結合タンパク質を使用して癌を治療する方法
WO2022200478A1 (en) * 2021-03-24 2022-09-29 Pieris Pharmaceuticals Gmbh Tumor treatment with a 4-1bb/her2-bispecific agent and a her2-targeted tyrosine kinase inhibitor
US20240218065A1 (en) * 2021-06-15 2024-07-04 Shenghe (China) Biopharmaceutical Co. Multispecific antigen-binding protein and use thereof
CA3216098A1 (en) * 2021-07-30 2023-02-02 Uwe Reusch Duplexbodies
US20240327543A1 (en) * 2021-08-02 2024-10-03 Shenghe (China) Biopharmaceutical Co., Ltd. Multispecific antigen-binding protein and use thereof
WO2023192973A1 (en) * 2022-04-01 2023-10-05 Cytomx Therapeutics, Inc. Activatable multispecific molecules and methods of use thereof

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KR20100058509A (ko) * 2007-07-31 2010-06-03 메디뮨 엘엘씨 다중특이적 에피토프 결합 단백질 및 이의 용도
CA2832389A1 (en) * 2011-04-20 2012-10-26 Genmab A/S Bispecific antibodies against her2 and cd3
EP2760892A1 (en) * 2011-09-29 2014-08-06 Apo-T B.V. Multi-specific binding molecules targeting aberrant cells
US20130165638A1 (en) * 2011-12-27 2013-06-27 Development Center For Biotechnology Light chain-bridged bispecific antibody
WO2016115274A1 (en) * 2015-01-14 2016-07-21 Compass Therapeutics Llc Multispecific immunomodulatory antigen-binding constructs

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