JP2019508448A5 - - Google Patents
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- JP2019508448A5 JP2019508448A5 JP2018548207A JP2018548207A JP2019508448A5 JP 2019508448 A5 JP2019508448 A5 JP 2019508448A5 JP 2018548207 A JP2018548207 A JP 2018548207A JP 2018548207 A JP2018548207 A JP 2018548207A JP 2019508448 A5 JP2019508448 A5 JP 2019508448A5
- Authority
- JP
- Japan
- Prior art keywords
- humanized antibody
- human
- seq
- composition
- dose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 208000024908 graft versus host disease Diseases 0.000 claims description 29
- 238000001802 infusion Methods 0.000 claims description 29
- 208000009329 Graft vs Host Disease Diseases 0.000 claims description 27
- 230000000735 allogeneic effect Effects 0.000 claims description 24
- 239000000427 antigen Substances 0.000 claims description 18
- 102000036639 antigens Human genes 0.000 claims description 18
- 108091007433 antigens Proteins 0.000 claims description 18
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 18
- 150000001413 amino acids Chemical class 0.000 claims description 16
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims description 12
- 102000006495 integrins Human genes 0.000 claims description 12
- 108010044426 integrins Proteins 0.000 claims description 12
- 229960000485 methotrexate Drugs 0.000 claims description 12
- 206010028980 Neoplasm Diseases 0.000 claims description 11
- 201000011510 cancer Diseases 0.000 claims description 11
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 8
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims description 8
- 229960001967 tacrolimus Drugs 0.000 claims description 8
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims description 8
- 238000011282 treatment Methods 0.000 claims description 8
- 229960004914 vedolizumab Drugs 0.000 claims description 8
- 230000003750 conditioning effect Effects 0.000 claims description 7
- 230000001154 acute effect Effects 0.000 claims description 6
- 208000024340 acute graft versus host disease Diseases 0.000 claims description 6
- 239000000090 biomarker Substances 0.000 claims description 6
- 238000011134 hematopoietic stem cell transplantation Methods 0.000 claims description 6
- 208000026278 immune system disease Diseases 0.000 claims description 6
- 238000001990 intravenous administration Methods 0.000 claims description 6
- 208000032839 leukemia Diseases 0.000 claims description 6
- 239000012931 lyophilized formulation Substances 0.000 claims description 6
- 208000019838 Blood disease Diseases 0.000 claims description 5
- 208000014951 hematologic disease Diseases 0.000 claims description 5
- 208000018706 hematopoietic system disease Diseases 0.000 claims description 5
- 230000003211 malignant effect Effects 0.000 claims description 5
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 4
- 229940122739 Calcineurin inhibitor Drugs 0.000 claims description 4
- 102100024123 Calcineurin-binding protein cabin-1 Human genes 0.000 claims description 4
- 101710192106 Calcineurin-binding protein cabin-1 Proteins 0.000 claims description 4
- 102000013691 Interleukin-17 Human genes 0.000 claims description 4
- 108050003558 Interleukin-17 Proteins 0.000 claims description 4
- 102000004889 Interleukin-6 Human genes 0.000 claims description 4
- 108090001005 Interleukin-6 Proteins 0.000 claims description 4
- 206010025323 Lymphomas Diseases 0.000 claims description 4
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims description 4
- 210000004027 cell Anatomy 0.000 claims description 4
- 201000005787 hematologic cancer Diseases 0.000 claims description 4
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims description 4
- 210000000987 immune system Anatomy 0.000 claims description 4
- 229940100601 interleukin-6 Drugs 0.000 claims description 4
- 230000000968 intestinal effect Effects 0.000 claims description 4
- 210000000265 leukocyte Anatomy 0.000 claims description 4
- 210000003071 memory t lymphocyte Anatomy 0.000 claims description 4
- 230000001400 myeloablative effect Effects 0.000 claims description 4
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims description 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims description 2
- 208000023275 Autoimmune disease Diseases 0.000 claims description 2
- 208000018240 Bone Marrow Failure disease Diseases 0.000 claims description 2
- 208000005623 Carcinogenesis Diseases 0.000 claims description 2
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims description 2
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 claims description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 2
- 208000014905 bone marrow failure syndrome Diseases 0.000 claims description 2
- 230000036952 cancer formation Effects 0.000 claims description 2
- 231100000504 carcinogenesis Toxicity 0.000 claims description 2
- 230000001186 cumulative effect Effects 0.000 claims description 2
- 239000012636 effector Substances 0.000 claims description 2
- 208000034737 hemoglobinopathy Diseases 0.000 claims description 2
- 230000028993 immune response Effects 0.000 claims description 2
- 230000001506 immunosuppresive effect Effects 0.000 claims description 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims description 2
- 210000000440 neutrophil Anatomy 0.000 claims description 2
- 210000005259 peripheral blood Anatomy 0.000 claims description 2
- 239000011886 peripheral blood Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 37
- 230000002265 prevention Effects 0.000 claims 2
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims 1
- 230000002411 adverse Effects 0.000 claims 1
- 208000018337 inherited hemoglobinopathy Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 description 65
- 239000005557 antagonist Substances 0.000 description 8
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022116951A JP2022163078A (ja) | 2016-03-14 | 2022-07-22 | 移植片対宿主病予防の方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662307896P | 2016-03-14 | 2016-03-14 | |
| US62/307,896 | 2016-03-14 | ||
| PCT/US2017/022065 WO2017160699A2 (en) | 2016-03-14 | 2017-03-13 | Method of preventing graft versus host disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022116951A Division JP2022163078A (ja) | 2016-03-14 | 2022-07-22 | 移植片対宿主病予防の方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019508448A JP2019508448A (ja) | 2019-03-28 |
| JP2019508448A5 true JP2019508448A5 (enExample) | 2020-05-14 |
Family
ID=58448610
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018548207A Withdrawn JP2019508448A (ja) | 2016-03-14 | 2017-03-13 | 移植片対宿主病予防の方法 |
| JP2022116951A Pending JP2022163078A (ja) | 2016-03-14 | 2022-07-22 | 移植片対宿主病予防の方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022116951A Pending JP2022163078A (ja) | 2016-03-14 | 2022-07-22 | 移植片対宿主病予防の方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20200002422A1 (enExample) |
| EP (1) | EP3430052A2 (enExample) |
| JP (2) | JP2019508448A (enExample) |
| KR (1) | KR102710759B1 (enExample) |
| CN (2) | CN116327920A (enExample) |
| AU (1) | AU2017234009B2 (enExample) |
| BR (1) | BR112018068628A2 (enExample) |
| CA (1) | CA3017743A1 (enExample) |
| EA (1) | EA201892071A1 (enExample) |
| IL (1) | IL261750B2 (enExample) |
| MA (1) | MA44408A (enExample) |
| MX (2) | MX2018011169A (enExample) |
| WO (1) | WO2017160699A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA43755A (fr) * | 2016-03-14 | 2018-11-28 | Millennium Pharm Inc | Méthodes de traitement ou de prévention d'une maladie du greffon contre l'hôte |
| WO2017218434A1 (en) | 2016-06-12 | 2017-12-21 | Millennium Pharmaceuticals, Inc. | Method of treating inflammatory bowel disease |
| ES3012854T3 (en) | 2018-02-08 | 2025-04-10 | Univ Leland Stanford Junior | Allogenic hematopoietic stem cell transplantation |
| EP4142755A4 (en) * | 2020-04-27 | 2024-06-12 | Children's Hospital Medical Center | Precision dosing regimen |
| EP4720125A1 (en) | 2023-05-30 | 2026-04-08 | Paragon Therapeutics, Inc. | Alpha4beta7 integrin antibody compositions and methods of use |
| EP4762093A1 (en) | 2023-08-14 | 2026-06-24 | Paragon Therapeutics, Inc. | Alpha 4 beta 7 integrin binding proteins and methods of use |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・２・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| JP3095168B2 (ja) | 1988-02-05 | 2000-10-03 | エル． モリソン，シェリー | ドメイン‐変性不変部を有する抗体 |
| EP0590058B1 (en) | 1991-06-14 | 2003-11-26 | Genentech, Inc. | HUMANIZED Heregulin ANTIBODy |
| AU691811B2 (en) | 1993-06-16 | 1998-05-28 | Celltech Therapeutics Limited | Antibodies |
| US5840299A (en) | 1994-01-25 | 1998-11-24 | Athena Neurosciences, Inc. | Humanized antibodies against leukocyte adhesion molecule VLA-4 |
| ATE366809T1 (de) | 1995-02-10 | 2007-08-15 | Millennium Pharm Inc | Addressine der schleimhaut und der blutgefässe und ihre verwendung |
| US7803904B2 (en) | 1995-09-01 | 2010-09-28 | Millennium Pharmaceuticals, Inc. | Mucosal vascular addressing and uses thereof |
| US7147851B1 (en) * | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
| US20010046496A1 (en) | 2000-04-14 | 2001-11-29 | Brettman Lee R. | Method of administering an antibody |
| AU2003248549B2 (en) | 2002-05-24 | 2010-04-08 | Millennium Pharmaceuticals, Inc. | CCR9 inhibitors and methods of use thereof |
| AU2003298661B2 (en) | 2002-11-18 | 2007-05-10 | Chemocentryx, Inc. | Aryl sulfonamides |
| DOP2005000002A (es) | 2004-01-09 | 2005-08-15 | Pfizer | "anticuerpos contra madcam" |
| ES2377979T3 (es) | 2004-09-03 | 2012-04-03 | Genentech, Inc. | Antagonistas anti-beta7 humanizados y utilizaciones para los mismos |
| CA2654446C (en) * | 2005-06-07 | 2014-02-25 | The Regents Of The University Of Colorado | Inhibitors of serine protease activity and their use in methods and compositions for treatment of graft rejection and promotion of graft survival |
| EP1948691A1 (en) | 2005-11-17 | 2008-07-30 | Millennium Pharmaceuticals, Inc. | HUMANIZED IMMUNOGLOBULIN REACTIVE WITH a4ß7INTEGRIN |
| JP5798036B2 (ja) * | 2008-11-07 | 2015-10-21 | アムゲン リサーチ （ミュンヘン） ゲーエムベーハー | 小児急性リンパ芽球性白血病の新規治療 |
| PE20120497A1 (es) | 2009-03-20 | 2012-05-14 | Amgen Inc | Anticuerpo antagonista especifico para el heterodimero de alfa-4-beta-7 |
| DK2637672T3 (en) * | 2010-11-12 | 2018-10-22 | Gentium S R L | DEFIBROTID FOR USE IN PROPHYLAXY AND / OR TREATMENT OF GRAPHIC VERSUS HOST DISEASE (GVHD) |
| UY34054A (es) * | 2011-05-02 | 2012-11-30 | Millennium Pharm Inc | FORMULACIÓN PARA ANTICUERPO ANTI-a(alfa)4B(Beta)7 |
| UA116189C2 (uk) * | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
| WO2013123114A2 (en) * | 2012-02-16 | 2013-08-22 | Santarus, Inc. | Antibody formulations |
| EP2744830A4 (en) * | 2012-06-21 | 2015-06-17 | Compugen Ltd | LSR ANTIBODIES AND USES THEREOF FOR THE TREATMENT OF CANCER |
| RU2017109122A (ru) * | 2014-08-21 | 2018-09-21 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Способы лечения с использованием гетероциклических амидов в качестве ингибиторов киназы |
| MA41636A (fr) * | 2015-03-06 | 2018-01-09 | Millennium Pharm Inc | Méthode de traitement de la cholangite sclérosante primitive |
| MA43755A (fr) * | 2016-03-14 | 2018-11-28 | Millennium Pharm Inc | Méthodes de traitement ou de prévention d'une maladie du greffon contre l'hôte |
-
2017
- 2017-03-13 EP EP17714328.6A patent/EP3430052A2/en active Pending
- 2017-03-13 KR KR1020187027194A patent/KR102710759B1/ko active Active
- 2017-03-13 EA EA201892071A patent/EA201892071A1/ru unknown
- 2017-03-13 AU AU2017234009A patent/AU2017234009B2/en active Active
- 2017-03-13 MX MX2018011169A patent/MX2018011169A/es unknown
- 2017-03-13 IL IL261750A patent/IL261750B2/en unknown
- 2017-03-13 CA CA3017743A patent/CA3017743A1/en active Pending
- 2017-03-13 US US16/084,383 patent/US20200002422A1/en active Pending
- 2017-03-13 CN CN202211678697.9A patent/CN116327920A/zh active Pending
- 2017-03-13 BR BR112018068628-0A patent/BR112018068628A2/pt not_active Application Discontinuation
- 2017-03-13 WO PCT/US2017/022065 patent/WO2017160699A2/en not_active Ceased
- 2017-03-13 CN CN201780017510.1A patent/CN109071660A/zh active Pending
- 2017-03-13 JP JP2018548207A patent/JP2019508448A/ja not_active Withdrawn
- 2017-03-13 MA MA044408A patent/MA44408A/fr unknown
-
2018
- 2018-09-14 MX MX2025001934A patent/MX2025001934A/es unknown
-
2022
- 2022-07-22 JP JP2022116951A patent/JP2022163078A/ja active Pending
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