JP2019502741A - がんを処置するための方法 - Google Patents

がんを処置するための方法 Download PDF

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Publication number
JP2019502741A
JP2019502741A JP2018538604A JP2018538604A JP2019502741A JP 2019502741 A JP2019502741 A JP 2019502741A JP 2018538604 A JP2018538604 A JP 2018538604A JP 2018538604 A JP2018538604 A JP 2018538604A JP 2019502741 A JP2019502741 A JP 2019502741A
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Prior art keywords
patient
cancer
composition
immune checkpoint
checkpoint inhibitor
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JP2018538604A
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English (en)
Japanese (ja)
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JP2019502741A5 (enExample
Inventor
ロバート ディー アルバイト
ロバート ディー アルバイト
ポーラ マリー ラガン
ポーラ マリー ラガン
Original Assignee
エックス４ ファーマシューティカルズ， インコーポレイテッド
エックス４ ファーマシューティカルズ， インコーポレイテッド
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Application filed by エックス４ ファーマシューティカルズ， インコーポレイテッド, エックス４ ファーマシューティカルズ， インコーポレイテッド filed Critical エックス４ ファーマシューティカルズ， インコーポレイテッド
Publication of JP2019502741A publication Critical patent/JP2019502741A/ja
Publication of JP2019502741A5 publication Critical patent/JP2019502741A5/ja
Priority to JP2022034549A priority Critical patent/JP2022082565A/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2018538604A 2016-01-22 2017-01-23 がんを処置するための方法 Pending JP2019502741A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022034549A JP2022082565A (ja) 2016-01-22 2022-03-07 がんを処置するための方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662281962P 2016-01-22 2016-01-22
US62/281,962 2016-01-22
PCT/US2017/014578 WO2017127811A1 (en) 2016-01-22 2017-01-23 Methods for treating cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022034549A Division JP2022082565A (ja) 2016-01-22 2022-03-07 がんを処置するための方法

Publications (2)

Publication Number Publication Date
JP2019502741A true JP2019502741A (ja) 2019-01-31
JP2019502741A5 JP2019502741A5 (enExample) 2020-12-24

Family

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Family Applications (2)

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JP2018538604A Pending JP2019502741A (ja) 2016-01-22 2017-01-23 がんを処置するための方法
JP2022034549A Abandoned JP2022082565A (ja) 2016-01-22 2022-03-07 がんを処置するための方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022034549A Abandoned JP2022082565A (ja) 2016-01-22 2022-03-07 がんを処置するための方法

Country Status (6)

Country Link
US (1) US20190030023A1 (enExample)
EP (1) EP3405203A4 (enExample)
JP (2) JP2019502741A (enExample)
CN (1) CN108883132A (enExample)
CA (1) CA3010617A1 (enExample)
WO (1) WO2017127811A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3008279A1 (en) 2015-12-14 2017-06-22 X4 Pharmaceuticals, Inc. Methods for treating cancer
CA3008272A1 (en) 2015-12-14 2017-06-22 X4 Pharmaceuticals, Inc. Methods for treating cancer
EP3393468B1 (en) 2015-12-22 2022-09-14 X4 Pharmaceuticals, Inc. Methods for treating immunodeficiency disease
JP2019510785A (ja) 2016-04-08 2019-04-18 エックス４ ファーマシューティカルズ， インコーポレイテッド 癌を処置する方法
CA3027498A1 (en) 2016-06-21 2017-12-28 X4 Pharmaceuticals, Inc. Cxcr4 inhibitors and uses thereof
US10988465B2 (en) 2016-06-21 2021-04-27 X4 Pharmaceuticals, Inc. CXCR4 inhibitors and uses thereof
WO2017223243A1 (en) 2016-06-21 2017-12-28 X4 Pharmaceuticals, Inc. Cxcr4 inhibitors and uses thereof
JP2020525427A (ja) * 2017-06-21 2020-08-27 エックス４ ファーマシューティカルズ， インコーポレイテッド 癌を処置するための方法
BR112020016331A8 (pt) 2018-02-13 2023-02-07 Merck Sharp & Dohme Métodos para tratar câncer com anticorpos anti-pd-1
US20210025895A1 (en) * 2018-04-13 2021-01-28 X4 Pharmaceuticals, Inc. Cancer serum biomarkers and methods of use thereof
US10548889B1 (en) 2018-08-31 2020-02-04 X4 Pharmaceuticals, Inc. Compositions of CXCR4 inhibitors and methods of preparation and use
EP3878446A1 (en) * 2020-03-09 2021-09-15 Universite De Geneve Hsd11b1 inhibitors for use in immunotherapy and uses thereof
EP4117662A4 (en) 2020-03-10 2024-04-03 X4 Pharmaceuticals, Inc. METHODS OF TREATING NEUTROPENIA

Citations (3)

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JP2007332141A (ja) * 2006-06-12 2007-12-27 Pfizer Prod Inc 薬
WO2011147026A2 (en) * 2010-05-28 2011-12-01 Pharmascience, Inc. A stable pharmaceutical formulation comprising telmisartan and hydrochlorothiazide
US20150352208A1 (en) * 2013-08-05 2015-12-10 Cambridge Enterprise Limited Inhibition of cxcr4 signaling in cancer immunotherapy

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US20070259040A1 (en) * 2006-05-01 2007-11-08 Cherukuri S R Novel triptan formulations and methods for making them
BR112015022367B1 (pt) * 2013-03-15 2021-06-22 The Trustees Of The University Of Pennsylvania Vacina, molécula de ácido nucleico, e, molécula de aminoácido
IL292510A (en) * 2013-11-05 2022-06-01 Cognate Bioservices Inc Combinations of checkpoint inhibitors and therapeutics to treat cancer
EP3119397B1 (en) * 2014-03-19 2022-03-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
EP3552615B8 (en) * 2014-07-16 2022-03-02 Transgene Oncolytic virus for expression of immune checkpoint modulators
JP2018516969A (ja) * 2015-06-12 2018-06-28 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｐｄ−１およびｃｘｃｒ４シグナル伝達経路の組合せ遮断による癌の処置
CA3008272A1 (en) * 2015-12-14 2017-06-22 X4 Pharmaceuticals, Inc. Methods for treating cancer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007332141A (ja) * 2006-06-12 2007-12-27 Pfizer Prod Inc 薬
WO2011147026A2 (en) * 2010-05-28 2011-12-01 Pharmascience, Inc. A stable pharmaceutical formulation comprising telmisartan and hydrochlorothiazide
US20150352208A1 (en) * 2013-08-05 2015-12-10 Cambridge Enterprise Limited Inhibition of cxcr4 signaling in cancer immunotherapy

Non-Patent Citations (4)

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Title
BRITISH JOURNAL OF CANCER, vol. 108, no. 8, JPN6021044343, 2013, pages 1634 - 1640, ISSN: 0004786094 *
CLINICAL CANCER RESEARCH, vol. 21, no. 13, JPN6021044342, 2015, pages 2892 - 2897, ISSN: 0004786095 *
ＴＨＥ ＮＥＷ ＥＮＧＬＡＮＤ ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＥ, vol. 369, JPN6021007232, 2013, pages 134 - 144, ISSN: 0004786092 *
河上裕: "ヒト腫瘍免疫学とがん免疫療法のさらなる発展をめざして", 医学のあゆみ, vol. 252, no. 1, JPN6021007235, 2015, pages 105 - 110, ISSN: 0004786093 *

Also Published As

Publication number Publication date
EP3405203A4 (en) 2019-07-24
US20190030023A1 (en) 2019-01-31
EP3405203A1 (en) 2018-11-28
CA3010617A1 (en) 2017-07-27
WO2017127811A1 (en) 2017-07-27
CN108883132A (zh) 2018-11-23
JP2022082565A (ja) 2022-06-02

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