JP2019502384A - 疾患の不均一性を特徴づけるための転移性疾患における、循環腫瘍細胞(ctc)の単一細胞ゲノムプロファイリング - Google Patents
疾患の不均一性を特徴づけるための転移性疾患における、循環腫瘍細胞(ctc)の単一細胞ゲノムプロファイリング Download PDFInfo
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- JP2019502384A JP2019502384A JP2018535034A JP2018535034A JP2019502384A JP 2019502384 A JP2019502384 A JP 2019502384A JP 2018535034 A JP2018535034 A JP 2018535034A JP 2018535034 A JP2018535034 A JP 2018535034A JP 2019502384 A JP2019502384 A JP 2019502384A
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G—PHYSICS
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57555—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the prostate
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
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- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1429—Signal processing
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
- G01N33/57585—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds identifiable in body fluids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/16—Assays for determining copy number or wherein the copy number is of special importance
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Dispersion Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Signal Processing (AREA)
- Physiology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021054561A JP2021118689A (ja) | 2016-01-06 | 2021-03-29 | 疾患の不均一性を特徴づけるための転移性疾患における、循環腫瘍細胞(ctc)の単一細胞ゲノムプロファイリング |
| JP2023086666A JP2023116530A (ja) | 2016-01-06 | 2023-05-26 | 疾患の不均一性を特徴づけるための転移性疾患における、循環腫瘍細胞(ctc)の単一細胞ゲノムプロファイリング |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662275659P | 2016-01-06 | 2016-01-06 | |
| US62/275,659 | 2016-01-06 | ||
| US201662344703P | 2016-06-02 | 2016-06-02 | |
| US62/344,703 | 2016-06-02 | ||
| PCT/US2017/012317 WO2017120324A1 (en) | 2016-01-06 | 2017-01-05 | Single cell genomic profiling of circulating tumor cells (ctcs) in metastatic disease to characterize disease heterogeneity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021054561A Division JP2021118689A (ja) | 2016-01-06 | 2021-03-29 | 疾患の不均一性を特徴づけるための転移性疾患における、循環腫瘍細胞(ctc)の単一細胞ゲノムプロファイリング |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019502384A true JP2019502384A (ja) | 2019-01-31 |
| JP2019502384A5 JP2019502384A5 (https=) | 2020-02-06 |
Family
ID=59273946
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018535034A Pending JP2019502384A (ja) | 2016-01-06 | 2017-01-05 | 疾患の不均一性を特徴づけるための転移性疾患における、循環腫瘍細胞(ctc)の単一細胞ゲノムプロファイリング |
| JP2021054561A Pending JP2021118689A (ja) | 2016-01-06 | 2021-03-29 | 疾患の不均一性を特徴づけるための転移性疾患における、循環腫瘍細胞(ctc)の単一細胞ゲノムプロファイリング |
| JP2023086666A Pending JP2023116530A (ja) | 2016-01-06 | 2023-05-26 | 疾患の不均一性を特徴づけるための転移性疾患における、循環腫瘍細胞(ctc)の単一細胞ゲノムプロファイリング |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021054561A Pending JP2021118689A (ja) | 2016-01-06 | 2021-03-29 | 疾患の不均一性を特徴づけるための転移性疾患における、循環腫瘍細胞(ctc)の単一細胞ゲノムプロファイリング |
| JP2023086666A Pending JP2023116530A (ja) | 2016-01-06 | 2023-05-26 | 疾患の不均一性を特徴づけるための転移性疾患における、循環腫瘍細胞(ctc)の単一細胞ゲノムプロファイリング |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20190025312A1 (https=) |
| EP (1) | EP3400311A4 (https=) |
| JP (3) | JP2019502384A (https=) |
| CN (2) | CN115323054A (https=) |
| AU (2) | AU2017205443A1 (https=) |
| CA (1) | CA3010311A1 (https=) |
| EA (1) | EA201891571A1 (https=) |
| WO (1) | WO2017120324A1 (https=) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022527264A (ja) * | 2019-03-26 | 2022-06-01 | テンプス ラブス,インコーポレイティド | 病理組織スライド画像からのバイオマーカーの判定方法 |
| JP2023543667A (ja) * | 2020-09-04 | 2023-10-18 | コーニンクレッカ フィリップス エヌ ヴェ | 2つ以上のゲノム突然変異および/または遺伝子発現関連パラメータの値に基づいて腫瘍の不均一性を推定するための方法および対応する装置 |
| US12165236B2 (en) | 2018-05-14 | 2024-12-10 | Tempus Ai, Inc. | Predicting total nucleic acid yield and dissection boundaries for histology slides |
| US12524826B2 (en) | 2018-05-14 | 2026-01-13 | Tempus Ai, Inc. | Determining biomarkers from histopathology slide images |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3045918B1 (en) | 2009-10-21 | 2017-12-06 | The Scripps Research Institute | Method of using non-rare cells to detect rare cells |
| EA201691496A1 (ru) | 2014-01-27 | 2016-12-30 | Эпик Сайенсиз, Инк. | Диагностика биомаркеров рака предстательной железы с помощью циркулирующих опухолевых клеток |
| EA201691682A1 (ru) | 2014-02-21 | 2017-02-28 | Эпик Сайенсиз, Инк. | Способы анализирования редких циркулирующих в крови клеток |
| US11514289B1 (en) | 2016-03-09 | 2022-11-29 | Freenome Holdings, Inc. | Generating machine learning models using genetic data |
| US11222194B2 (en) * | 2016-12-30 | 2022-01-11 | Ventana Medical Systems, Inc. | Automated system and method for creating and executing a scoring guide to assist in the analysis of tissue specimen |
| EP3431611A1 (en) | 2017-07-21 | 2019-01-23 | Menarini Silicon Biosystems S.p.A. | Improved method and kit for the generation of dna libraries for massively parallel sequencing |
| CN109060989B (zh) * | 2018-08-29 | 2021-07-30 | 重庆市肿瘤研究所 | 应用iTRAQ技术研究三阴性乳腺癌外泌体差异表达蛋白的方法 |
| CN109658981B (zh) * | 2018-12-10 | 2022-10-04 | 海南大学 | 一种单细胞测序的数据分类方法 |
| KR102343947B1 (ko) * | 2019-09-30 | 2021-12-27 | 주식회사 피디젠 | 환자 정보 분석을 이용한 암 재발 및 전이 모니터링 시스템을 이용한 비즈니스모델 |
| CN112164420B (zh) * | 2020-09-07 | 2021-07-20 | 厦门艾德生物医药科技股份有限公司 | 一种基因组瘢痕模型的建立方法 |
| WO2022225995A1 (en) * | 2021-04-19 | 2022-10-27 | F. Hoffmann-La Roche Ag | Methods and systems for gene alteration prediction from pathology slide images |
| EP4445141A1 (en) * | 2021-12-07 | 2024-10-16 | Epic Sciences, Inc. | Enhanced characterization of breast cancer |
| JP2025505920A (ja) * | 2021-12-21 | 2025-03-05 | ファウンデーション・メディシン・インコーポレイテッド | ゲノムプロファイリングの成功を予測するための方法及びシステム |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014050404A (ja) * | 2005-09-20 | 2014-03-20 | Veridex Llc | ユニーク配列のdnaプローブを作製するための方法および組成物、dnaプローブの標識、ならびにこれらプローブの使用 |
| WO2014165785A2 (en) * | 2013-04-05 | 2014-10-09 | Myriad Genetics, Inc. | Methods and materials for assessing homologous recombination deficiency |
| WO2015048740A1 (en) * | 2013-09-30 | 2015-04-02 | The Scripps Research Institute | Genotypic and phenotypic analysis of circulating tumor cells to monitor tumor evolution in prostate cancer patients |
| US20150212089A1 (en) * | 2014-01-30 | 2015-07-30 | Epic Sciences, Inc. | Circulating tumor cell diagnostics for biomarkers predictive of resistance to androgen receptor (ar) targeted therapies |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2937051A1 (en) * | 2014-01-17 | 2015-07-23 | Ontario Institute For Cancer Research (Oicr) | Biopsy-driven genomic signature for prostate cancer prognosis |
| WO2015112999A1 (en) * | 2014-01-27 | 2015-07-30 | Epic Sciences, Inc. | Detection of prostate specific membrane antigen (psma) expression on circulating tumor cells (ctc) |
| EA201691496A1 (ru) * | 2014-01-27 | 2016-12-30 | Эпик Сайенсиз, Инк. | Диагностика биомаркеров рака предстательной железы с помощью циркулирующих опухолевых клеток |
-
2017
- 2017-01-05 US US16/068,348 patent/US20190025312A1/en not_active Abandoned
- 2017-01-05 JP JP2018535034A patent/JP2019502384A/ja active Pending
- 2017-01-05 AU AU2017205443A patent/AU2017205443A1/en not_active Abandoned
- 2017-01-05 WO PCT/US2017/012317 patent/WO2017120324A1/en not_active Ceased
- 2017-01-05 CA CA3010311A patent/CA3010311A1/en active Pending
- 2017-01-05 CN CN202210926315.3A patent/CN115323054A/zh active Pending
- 2017-01-05 EP EP17736324.9A patent/EP3400311A4/en active Pending
- 2017-01-05 EA EA201891571A patent/EA201891571A1/ru unknown
- 2017-01-05 CN CN201780015212.9A patent/CN108884494A/zh active Pending
-
2021
- 2021-03-29 JP JP2021054561A patent/JP2021118689A/ja active Pending
-
2022
- 2022-01-19 US US17/579,437 patent/US20220390451A1/en not_active Abandoned
-
2023
- 2023-04-13 AU AU2023202282A patent/AU2023202282A1/en not_active Abandoned
- 2023-05-26 JP JP2023086666A patent/JP2023116530A/ja active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014050404A (ja) * | 2005-09-20 | 2014-03-20 | Veridex Llc | ユニーク配列のdnaプローブを作製するための方法および組成物、dnaプローブの標識、ならびにこれらプローブの使用 |
| WO2014165785A2 (en) * | 2013-04-05 | 2014-10-09 | Myriad Genetics, Inc. | Methods and materials for assessing homologous recombination deficiency |
| WO2015048740A1 (en) * | 2013-09-30 | 2015-04-02 | The Scripps Research Institute | Genotypic and phenotypic analysis of circulating tumor cells to monitor tumor evolution in prostate cancer patients |
| US20150212089A1 (en) * | 2014-01-30 | 2015-07-30 | Epic Sciences, Inc. | Circulating tumor cell diagnostics for biomarkers predictive of resistance to androgen receptor (ar) targeted therapies |
Non-Patent Citations (3)
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| ANALYTICAL CHEMISTRY, vol. vol.86, no.22, p.11013-11017, JPN6020036716, 2014, ISSN: 0004355425 * |
| BREAST CANCER RESEARCH, vol. vol.16:211, JPN6020036714, 2014, ISSN: 0004514880 * |
| J. CIRC. BIOMARK., vol. vol.4:3, doi:10.5772/60725, JPN6020036712, 2015, ISSN: 0004514879 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12165236B2 (en) | 2018-05-14 | 2024-12-10 | Tempus Ai, Inc. | Predicting total nucleic acid yield and dissection boundaries for histology slides |
| US12524826B2 (en) | 2018-05-14 | 2026-01-13 | Tempus Ai, Inc. | Determining biomarkers from histopathology slide images |
| JP2022527264A (ja) * | 2019-03-26 | 2022-06-01 | テンプス ラブス,インコーポレイティド | 病理組織スライド画像からのバイオマーカーの判定方法 |
| JP7548932B2 (ja) | 2019-03-26 | 2024-09-10 | テンプス エーアイ,インコーポレイティド | 病理組織スライド画像からのバイオマーカーの判定方法 |
| JP2023543667A (ja) * | 2020-09-04 | 2023-10-18 | コーニンクレッカ フィリップス エヌ ヴェ | 2つ以上のゲノム突然変異および/または遺伝子発現関連パラメータの値に基づいて腫瘍の不均一性を推定するための方法および対応する装置 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023116530A (ja) | 2023-08-22 |
| AU2017205443A1 (en) | 2018-07-19 |
| CN108884494A (zh) | 2018-11-23 |
| AU2023202282A1 (en) | 2023-05-11 |
| JP2021118689A (ja) | 2021-08-12 |
| EP3400311A4 (en) | 2019-07-03 |
| CA3010311A1 (en) | 2017-07-13 |
| US20220390451A1 (en) | 2022-12-08 |
| WO2017120324A1 (en) | 2017-07-13 |
| EP3400311A1 (en) | 2018-11-14 |
| CN115323054A (zh) | 2022-11-11 |
| EA201891571A1 (ru) | 2019-01-31 |
| US20190025312A1 (en) | 2019-01-24 |
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