JP2019196327A - Hair growth promoter, medicine, food and cosmetic containing extract of passion fruit seeds as active ingredient - Google Patents
Hair growth promoter, medicine, food and cosmetic containing extract of passion fruit seeds as active ingredient Download PDFInfo
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- JP2019196327A JP2019196327A JP2018090987A JP2018090987A JP2019196327A JP 2019196327 A JP2019196327 A JP 2019196327A JP 2018090987 A JP2018090987 A JP 2018090987A JP 2018090987 A JP2018090987 A JP 2018090987A JP 2019196327 A JP2019196327 A JP 2019196327A
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- alopecia
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Abstract
Description
本発明は、パッションフルーツ種子の抽出物を有効成分とする発毛促進剤、医薬、食品および化粧品に関する。 The present invention relates to a hair growth-promoting agent, a medicine, a food, and a cosmetic comprising an extract of passion fruit seed as an active ingredient.
パッションフルーツ種子の抽出物及びピセアタンノールは、これまで、滋養・強壮作用、虚弱体質改善作用、病後の体力低下改善作用、胃腸虚弱改善作用、食欲不振改善作用、血色不良改善作用、冷え性改善作用、性機能改善作用、更年期障害改善作用、活気低下改善作用、肝機能改善作用、美肌作用、美白作用、日焼け予防作用、日焼けの回復作用、シミやソバカス等の色素沈着の予防作用、メラニン生成抑制作用(例えば、特許文献1、2、非特許文献1、2など)、抗酸化作用(例えば、非特許文献2など)、皮膚粘弾性改善作用、肌弾力の維持作用、経表皮水分蒸散量改善作用、角層水分量改善作用、肌のハリ感向上作用、肌の乾燥抑制作用、肌のくすみ改善作用、肌の潤い改善作用、肌の明るさ(ツヤ)改善作用、肌の化粧ノリ改善作用、肌のたるみ改善作用、シワの改善作用、むくみ改善作用、リンパ管腔形成促進作用、リンパ管内皮細胞増殖促進作用(例えば、特許文献3など)、腎機能改善作用、利尿作用、整腸作用、下痢止め作用、中性脂肪値改善作用、脂肪蓄積抑制作用(例えば、非特許文献3など)、肥満予防作用、糖尿病予防作用、コレステロール値改善作用、血糖値改善作用、血糖降下作用(例えば、特許文献4など)、高血圧予防作用、動脈硬化予防作用、体脂肪低減作用、脳卒中予防作用、糖質吸収促進作用、糖質吸収抑制作用、脂質吸収抑制作用、血行促進作用、血液流動性改善作用、毛細血管機能改善作用、血管内皮型一酸化窒素合成酵素(eNOS)の発現量を増加させる作用、NO産生能促進作用(例えば、特許文献5など)、血小板凝集改善作用、血液凝固抑制作用、血管拡張作用、免疫賦活作用、抗アレルギー作用、抗炎症作用、IL−8産生阻害作用、TNF−α産生阻害作用(例えば、特許文献6など)、リウマチ予防作用、痛風予防作用、血中尿酸値抑制作用、掻痒改善作用、肌のかゆみ抑制作用、鎮痛作用、ナチュラルキラー細胞活性化作用、風邪予防作用、抗ウイルス作用、抗菌作用、ミネラル吸収改善作用、骨強化作用、骨粗しょう症予防作用、関節痛抑制作用、関節可動域改善作用、膝関節痛改善作用、筋肉量減少抑制作用、筋肉量増大作用、筋力向上作用、持久力向上作用、サルコペニア予防作用、フレイル予防作用、便秘改善作用、認知症予防作用、老化予防作用、脳機能維持作用、神経保護作用、アルツハイマー病予防作用、虚血性心疾患改善作用、貧血予防作用、貧血改善作用、口臭予防作用、虫歯予防作用、歯周病予防作用、口腔環境改善作用、ドライシンドローム抑制/改善作用、視力低下抑制/改善作用、眼精疲労改善作用、かすみ目改善作用、抗ストレス作用、緊張緩和作用、抑うつ症状改善作用、肩こり改善作用、集中力向上作用、鎮静作用、寝起き症状改善作用、睡眠の質改善作用、寝つき改善作用、ホルモンバランス改善作用、更年期障害の改善作用、男性更年期障害の改善作用、疲労回復作用、筋肉痛抑制作用、筋肉回復作用、学習能力向上作用、胃酸調節作用、胃潰瘍予防作用、食欲調節作用、皮膚疾患改善作用、細胞増殖促進作用、消化速度調節作用、排尿機能の改善作用、耳鳴りの予防作用、耳の聞こえの予防作用、発汗調節作用、バストアップ作用、性機能亢進作用、食欲減退抑制作用、成長促進作用、膨満感改善作用、抗ガン作用(例えば、非特許文献4など)、長寿遺伝子活性化作用(例えば、非特許文献5など)、サーチュイン遺伝子の転写産物の発現増強作用、サーチュインタンパク質の発現増強作用(例えば、特許文献7など)、GAPDH遺伝子発現増強作用(例えば、特許文献8など)、グルタチオン産生促進作用(例えば、特許文献9など)、酸化防止作用、物性改善作用、乳化性改善作用、起泡性改善作用、ゲル化性改善作用、ミネラル可溶化作用、嗜好性向上作用、香味・色調・風味付与作用、口溶け改善作用、マトリックスメタロプロテアーゼ−1(MMP−1)抑制作用(例えば、特許文献10、非特許文献6など)、コラーゲン産生促進作用(例えば、特許文献11、12、非特許文献1など)があることが知られている。 Passion fruit seed extract and piceatannol have so far been nourishing and tonic, improving frailty, improving physical strength after illness, improving gastrointestinal frailty, improving anorexia, improving poor blood color, and improving coldness , Sexual function improvement action, menopause improvement action, vitality improvement action, liver function improvement action, skin beautification action, whitening action, sunburn prevention action, sunburn recovery action, prevention of pigmentation such as spots and buckwheat, melanin production suppression Action (for example, Patent Documents 1 and 2, Non-Patent Documents 1 and 2, etc.), Antioxidant action (for example, Non-Patent Document 2 etc.), Skin viscoelasticity improving action, Skin elasticity maintaining action, Transepidermal water transpiration improvement Action, stratum corneum moisture improvement effect, skin firmness improvement effect, skin dryness suppression effect, skin dullness improvement effect, skin moisture improvement effect, skin brightness (gloss) improvement effect, skin makeup improvement Action, skin sagging improvement action, wrinkle improvement action, swelling improvement action, lymphatic cavity formation promotion action, lymphatic endothelial cell proliferation promotion action (for example, Patent Document 3), renal function improvement action, diuretic action, intestinal regulation Action, anti-diarrhea action, neutral fat level improving action, fat accumulation inhibiting action (for example, Non-Patent Document 3 etc.), obesity preventing action, diabetes preventing action, cholesterol level improving action, blood sugar level improving action, hypoglycemic action (for example, , Patent Document 4), antihypertensive action, arteriosclerosis preventive action, body fat reduction action, stroke prevention action, carbohydrate absorption promotion action, carbohydrate absorption inhibition action, lipid absorption inhibition action, blood circulation promotion action, blood fluidity improvement Action, capillary function improvement action, action to increase the expression level of vascular endothelial nitric oxide synthase (eNOS), NO production ability promotion action (for example, Patent Document 5), platelet aggregation Good action, blood coagulation inhibitory action, vasodilatory action, immunostimulatory action, antiallergic action, anti-inflammatory action, IL-8 production inhibitory action, TNF-α production inhibitory action (for example, Patent Document 6 etc.), rheumatism preventive action, Gout prevention effect, blood uric acid level suppression effect, pruritus improvement effect, skin itch suppression effect, analgesic effect, natural killer cell activation effect, cold prevention effect, antiviral effect, antibacterial effect, mineral absorption improvement effect, bone strengthening effect , Osteoporosis prevention effect, joint pain suppression effect, joint range of motion improvement effect, knee joint pain improvement effect, muscle mass decrease inhibition effect, muscle mass increase effect, muscle strength improvement effect, endurance improvement effect, sarcopenia prevention effect, frail prevention Action, constipation improvement action, dementia prevention action, aging prevention action, brain function maintenance action, neuroprotection action, Alzheimer's disease prevention action, ischemic heart disease improvement action, anemia Prevention effect, anemia improvement effect, bad breath prevention effect, caries prevention effect, periodontal disease prevention effect, oral environment improvement effect, dry syndrome suppression / improvement effect, vision loss suppression / improvement effect, eye strain improvement effect, blurred vision improvement effect , Anti-stress, tension relief, depressive symptom improvement, stiff shoulder improvement, concentration improvement, sedation, wakefulness improvement, sleep quality improvement, sleep improvement, hormone balance improvement, menopause Action, male climacteric disorder improvement action, fatigue recovery action, muscle pain suppression action, muscle recovery action, learning ability improvement action, gastric acid adjustment action, gastric ulcer prevention action, appetite adjustment action, skin disease improvement action, cell proliferation promotion action, digestion Speed control action, urination function improvement action, tinnitus prevention action, ear hearing prevention action, sweat control action, bust up action, sexual function enhancement action, food Suppression of greedy decline, growth promotion, bloating improvement, anti-cancer (for example, Non-patent Document 4), longevity gene activation (for example, Non-Patent Document 5), enhanced expression of sirtuin gene transcript Action, sirtuin protein expression enhancing action (for example, Patent Document 7), GAPDH gene expression enhancing action (for example, Patent Document 8), glutathione production promoting action (for example, Patent Document 9), antioxidant action, physical property improvement Action, emulsifying property improving effect, foaming property improving effect, gelling property improving effect, mineral solubilizing effect, palatability improving effect, flavor / color tone / flavoring effect, mouth melt improving effect, matrix metalloproteinase-1 (MMP-1) ) Inhibitory action (for example, Patent Document 10, Non-patent Document 6 and the like), collagen production promoting action (for example, Patent Documents 11 and 12, Non-patent) Document 1, etc.) it is known that there is.
パッションフルーツ種子の抽出物及びピセアタンノールを含むまたは混ぜた若しくは塗った商品はこれまで、化学品、工業用のり及び接着剤、植物成長調整剤類、肥料、陶磁器用釉薬、塗装用パテ、高級脂肪酸、非鉄金属、非金属鉱物、写真材料、試験紙、工業用粉類、原料プラスチック、パルプ、カナダバルサム、コパール、サンダラック、松根油、セラック、ダンマール、媒染剤、腐蝕防止剤、防錆剤、マスチック、松脂、木材保存剤、染料、顔料、塗料、印刷インキ、謄写版用インキ、絵の具、防錆グリース、塗装用・装飾用・印刷用又は美術用の非鉄金属はく及び粉、塗装用・装飾用・印刷用又は美術用の貴金属はく及び粉、家庭用帯電防止剤、家庭用脱脂剤、さび除去剤、染み抜きベンジン、洗濯用柔軟剤、洗濯用漂白剤、かつら装着用接着剤、洗濯用でん粉のり、洗濯用ふのり、つけまつ毛用接着剤、口臭用消臭剤、動物用防臭剤、塗料用剥離剤、靴クリーム、靴墨、つや出し剤、せっけん類、歯磨き、薫料、研磨紙、研磨布、研磨用砂、人造軽石、つや出し紙、つや出し布、つけづめ、つけまつ毛、固形潤滑剤、靴油、保革油、固体燃料、液体燃料、気体燃料、工業用油、工業用油脂、ろう、ランプ用灯しん、ろうそく、医療用試験紙、もぐさ、燻蒸剤、殺菌剤、殺そ剤、殺虫剤、除草剤、防虫剤、防腐剤、医療用油紙、医療用接着テープ、衛生マスク、オブラート、ガーゼ、カプセル、眼帯、耳帯、生理帯、生理用タンポン、生理用ナプキン、生理用パンティ、脱脂綿、ばんそうこう、包帯、包帯液、胸当てパッド、綿棒、歯科用材料、おむつ、おむつカバー、はえとり紙、防虫紙、人工受精用精液、鉄及び鋼、非鉄金属及びその合金、金属鉱石、建築用又は構築用の金属製専用材料、金属製建造物組立てセット、金属製荷役用パレット、荷役用ターンテーブル、荷役用トラバーサー、金属製人工魚礁、金属製養鶏用かご、金属製の吹付け塗装用ブース、金属製セメント製品製造用型枠、金属製滑車、金属製ばね、金属製バルブ、金属製管継ぎ手、金属製フランジ、キー、コッタ、てんてつ機、金属製道路標識、金属製航路標識、金属製液体貯蔵槽、金属製工業用水槽、ガス貯蔵槽又は液化ガス貯蔵槽用のアルミニウム製の浮中ぶた、金属製液化ガス貯蔵槽、金属製ガス貯蔵槽、いかり、金属製輸送用コンテナ、かな床、はちの巣(swage blocks)、金属製金具、安全錠、鍵用金属製リング、金属製鍵、南京錠、ワイヤロープ、金網、金属製包装用容器、金属製栓、金属製ふた、金属製のネームプレート及び標札、金属製手持ち式旗ざお、金属製植物の茎支持具、金属製のきゃたつ及びはしご、金属製郵便受け、金属製帽子掛けかぎ、金属製家庭用水槽、金属製工具箱、金属製のタオル用ディスペンサー、金属製建具、金庫、金属製屋外用ブラインド、金属製立て看板、金属製人工池、金属製の可搬式家庭用温室、金属製の墓標及び墓碑用銘板、金属製靴合わせくぎ、金属製靴くぎ、金属製靴びょう、金属製靴保護金具、つえ用金属製石突き、拍車、アイゼン、カラビナ、ハーケン、金属製彫刻、貴金属、宝玉の原石、宝玉及びその模造品、キーホルダー、宝石箱、記念カップ、記念たて、身飾品、カフスボタン、貴金属製靴飾り、時計、事務用又は家庭用ののり及び接着剤、封ろう、印刷用インテル、活字、あて名印刷機、印字用インクリボン、自動印紙はり付け機、事務用電動式ステープラ、事務用封かん機、消印機、製図用具、タイプライター、チェックライター、謄写版、凸版複写機、文書細断機、郵便料金計器、輪転謄写機、マーキング用孔開型板、装飾塗工用ブラシ、紙製包装用容器、プラスチック製包装用袋、家庭用食品包装フイルム、紙製ごみ収集用袋、プラスチック製ごみ収集用袋、型紙、裁縫用チャコ、紙製のぼり、紙製旗、衛生手ふき、紙製タオル、紙製テーブルナプキン、紙製手ふき、紙製ハンカチ、荷札、印刷したくじ、紙類、文房具類、印刷物、書画、写真、写真立て、デンタルフロス、ガラス基礎製品、かいばおけ、家きん用リング、電気式歯ブラシ、化粧用具、おけ用ブラシ、金ブラシ、管用ブラシ、工業用刷毛、船舶ブラシ、家事用手袋、ガラス製包装用容器、陶磁製包装用容器、ガラス製栓、ガラス製ふた、プラスチック製の包装用瓶、鍋類、コーヒー沸かし、鉄瓶、やかん、食器類、アイスボックス、氷冷蔵庫、米びつ、食品保存用ガラス瓶、水筒、魔法瓶、調理用具、アイスペール、角砂糖挟み、くるみ割り器、こしょう入れ、砂糖入れ、ざる、塩振り出し容器、しゃもじ、じょうご、ストロー、膳、栓抜、卵立て、タルト取り分け用へら、ナプキンホルダー、ナプキンリング、鍋敷き、はし、はし箱、ひしゃく、ふるい、盆、ようじ、ようじ入れ、清掃用具及び洗濯用具、アイロン台、霧吹き、こて台、へら台、湯かき棒、浴室用腰掛け、浴室用手おけ、ろうそく消し、ろうそく立て、家庭用燃え殻ふるい、五徳、石炭入れ、火消しつぼ、ねずみ取り器、はえたたき、植木鉢、家庭園芸用の水耕式植物栽培器、じょうろ、愛玩動物用食器、愛玩動物用ブラシ、犬のおしゃぶり、小鳥かご、小鳥用水盤、洋服ブラシ、寝室用簡易便器、貯金箱、お守り、おみくじ、化学物質を充てんした保温保冷具、紙タオル取り出し用金属製箱、せっけん用ディスペンサー、観賞魚用水槽及びその附属品、トイレットペーパーホルダー、花瓶、水盤、ガラス製又は磁器製の立て看板、香炉、靴ブラシ、靴べら、靴磨き布、軽便靴クリーナー、シューツリー、コッフェル、ブラシ用牛毛・たぬきの毛・豚毛及び馬毛、船舶用オーニング、ターポリン、帆、綿繊維、麻繊維、絹繊維、毛繊維、織物用化学繊維、織物用無機繊維、衣服綿、ハンモック、布団袋、布団綿、編みひも、真田ひも、のり付けひも、よりひも、綱類、網類、布製包装用容器、わら製包装用容器、結束用ゴムバンド、雨覆い、織物製屋外用ブラインド、天幕、靴用ろう引き縫糸、ザイル、登山用又はキャンプ用のテント、ウインドサーフィン用のセイル、おがくず、カポック、かんなくず、木毛、もみがら、ろうくず、牛毛・たぬきの毛・豚毛及び馬毛、羽、糸、脱脂屑糸、織物、畳べり地、メリヤス生地、フェルト及び不織布、オイルクロス、ゴム引防水布、ビニルクロス、ラバークロス、レザークロス、ろ過布、布製身の回り品、かや、敷布、布団、布団カバー、布団側、まくらカバー、毛布、織物製テーブルナプキン、ふきん、シャワーカーテン、のぼり及び旗、織物製トイレットシートカバー、織物製椅子カバー、織物製壁掛け、カーテン、テーブル掛け、どん帳、遺体覆い、経かたびら、紅白幕、黒白幕、ビリヤードクロス、スリーピングバッグ、洋服、コート、セーター類、ワイシャツ類、寝巻き類、下着、水泳着、水泳帽、キャミソール、ティーシャツ、和服、アイマスク、エプロン、えり巻き、靴下、ゲートル、毛皮製ストール、ショール、スカーフ、足袋、足袋カバー、手袋、ネクタイ、ネッカチーフ、バンダナ、保温用サポーター、マフラー、耳覆い、ナイトキャップ、帽子、ガーター、靴下止め、ズボンつり、バンド、ベルト、靴類、靴合わせくぎ、靴くぎ、靴の引き手、靴びょう、靴保護金具、げた、草履類、仮装用衣服、運動用特殊靴、乗馬靴、ウインドサーフィン用シューズ、運動用特殊衣服、水上スポーツ用特殊衣服、漁網製作用杼、メリヤス機械用編針、電気式ヘアカーラー、針類、被服用はとめ、テープ、リボン、編みレース生地、刺しゅうレース生地、房類、組みひも、編み棒、糸通し器、裁縫箱、裁縫用へら、裁縫用指抜き、針刺し、針箱、造花の花輪、造花、腕止め、衣服用き章、衣服用バックル、衣服用バッジ、衣服用ブローチ、帯留、ボンネットピン、ワッペン、腕章、頭飾品、ボタン類、つけあごひげ、つけ口ひげ、ヘアカーラー、靴飾り、靴はとめ、靴ひも、靴ひも代用金具、人毛、たばこ、電子たばこ、喫煙用具、マッチ、生花の花輪、種子類、木、草、芝、ドライフラワー、苗、苗木、花、牧草、盆栽、蚕種、種繭、種卵、未加工のコルク、やしの葉などが知られている。 Products containing passion fruit seed extract and piceatannol mixed or painted so far have been chemicals, industrial glues and adhesives, plant growth regulators, fertilizers, ceramic glazes, paint patties, luxury Fatty acids, non-ferrous metals, non-metallic minerals, photographic materials, test papers, industrial powders, raw plastics, pulp, Canadian balsam, copal, sandalac, pine oil, shellac, danmar, mordants, corrosion inhibitors, rust inhibitors, Mastic, rosin, wood preservative, dye, pigment, paint, printing ink, photocopier ink, paint, anti-rust grease, non-ferrous metal foil and powder for painting / decoration / printing or art, painting / decoration Precious metal foil and powder for home use, printing, or art, household antistatic agent, household degreasing agent, rust remover, stain remover benzine, laundry softener, laundry bleach, wig Worn adhesive, laundry starch paste, laundry paste, false eyelash adhesive, bad breath deodorant, animal deodorant, paint release agent, shoe cream, shoe ink, polish, soap, toothpaste, cosmetics , Abrasive paper, abrasive cloth, abrasive sand, artificial pumice, polished paper, polished cloth, garnish, false eyelashes, solid lubricant, shoe oil, leather retaining oil, solid fuel, liquid fuel, gaseous fuel, industrial oil, industrial Oil, wax, lamp lantern, candle, medical test paper, moxa, fumigant, fungicide, insecticide, insecticide, herbicide, insecticide, preservative, medical oil paper, medical adhesive tape, hygiene Mask, Oblate, Gauze, Capsule, Ocular band, Ear band, Sanitary band, Sanitary tampon, Sanitary napkin, Sanitary panty, Absorbent cotton, Bandage, Bandage, Bandage liquid, Breast pad, Cotton swab, Dental material, Diaper, Diaper cover , Is Torigami, insect repellent paper, semen for artificial fertilization, iron and steel, non-ferrous metals and their alloys, metal ores, metal materials for construction or construction, metal building assembly sets, metal cargo handling pallets, cargo handling Turntable, cargo handling traverser, metal artificial reef, metal chicken cage, metal spray booth, metal cement production formwork, metal pulley, metal spring, metal valve, metal Fittings made of aluminum for pipe fittings, metal flanges, keys, cotters, levers, metal road signs, metal navigation signs, metal liquid storage tanks, metal industrial water tanks, gas storage tanks or liquefied gas storage tanks Medium lid, metal liquefied gas storage tank, metal gas storage tank, anchor, metal shipping container, kana floor, swine blocks, metal fittings, safety lock, metal ring for keys, metal key, padlock , Wire rope, wire mesh, metal packaging containers, metal stoppers, metal lids, metal name plates and tags, metal hand-held flagpoles, metal plant stem supports, metal kitas and ladders , Metal mailbox, metal hat hook, metal household water tank, metal tool box, metal towel dispenser, metal fittings, safe, metal outdoor blinds, metal stand sign, metal artificial pond , Metal portable household greenhouses, metal tombstones and tombstone nameplates, metal shoe matching nails, metal shoe nails, metal shoe caps, metal shoe guards, metal stabs for spears, spurs, crampons, carabiners, Harken, metal sculpture, precious metal, gemstones, jewelry and imitations, key chains, jewelry boxes, commemorative cups, commemorative accessories, cufflinks, precious metal shoe ornaments, watches, office or Glue and glue for garden, sealing wax, printing Intel, type, address printing machine, ink ribbon for printing, automatic stamping machine, electric stapler for office use, office sealing machine, postmarking machine, drawing tool, type Lighter, check writer, photocopier, letterpress copier, document shredder, postage meter, rotary copier, punching plate for marking, brush for decorative coating, paper packaging container, plastic packaging bag, household Food packaging film, paper garbage collection bag, plastic garbage collection bag, paper pattern, sewing chaco, paper banner, paper flag, sanitary hand towel, paper towel, paper table napkin, paper hand towel, paper Handkerchiefs, packing tags, printed lots, papers, stationery, printed materials, prints, photographs, photo stands, dental floss, basic glass products, troughs, household hood rings, electric toothbrushes, makeup Utensils, gold brush, tube brush, industrial brush, ship brush, housework gloves, glass packaging container, ceramic packaging container, glass stopper, glass lid, plastic packaging bottle, Hot pots, coffee kettles, iron bottles, kettles, dishes, ice boxes, ice refrigerators, rice bottles, glass bottles for food preservation, water bottles, thermos bottles, cooking utensils, ice buckets, sugar cube sandwiches, nutcrackers, pepper shakers, sugar canisters , Salt shaker, rice scoop, funnel, straw, straw, bottle opener, egg stand, tartlet spatula, napkin holder, napkin ring, pan spread, ladder, ladder box, dipper, sieve, tray, toothpick, toothpick , Cleaning and washing tools, ironing board, spray, trowel, spatula, poker, bathroom stool, bathroom hand rest, candle extinguisher, candle stand, Household husk sieve, Gotoku, Coal container, Fire extinguisher, Mouse remover, Flying pot, Flower pot, Hydroponic plant cultivator for home gardening, Watering can, Pet tableware, Pet brush, Dog pacifier, Small birdcage, small bird basin, clothes brush, simple toilet bowl, piggy bank, amulet, fortune, hot and cold container filled with chemicals, metal towel box for taking out paper towels, soap dispenser, aquarium for ornamental fish and its accessories Products, toilet paper holders, vases, basins, glass or porcelain signs, incense burners, shoe brushes, shoehorns, shoe polishing cloths, light shoe cleaners, shoe trees, coffels, brush bulls, raccoon dogs, pig hairs and Horse hair, marine awning, tarpaulin, sail, cotton fiber, hemp fiber, silk fiber, wool fiber, fabric chemical fiber, fabric inorganic fiber, clothing cotton, hammock Futon bag, futon cotton, braided string, Sanada string, glued string, twisted string, rope, net, cloth packaging container, straw packaging container, binding rubber band, rain cover, textile outdoor blind, awning , Shoe wax thread, zile, climbing or camping tent, windsurfing sail, sawdust, kapok, irrigation, wood hair, rice bran, wax waste, cow hair / tanuki hair / pig hair and horse hair , Feathers, yarns, defatted waste yarns, woven fabrics, tatami mats, knitted fabrics, felts and non-woven fabrics, oil cloths, rubberized waterproof cloths, vinyl cloths, rubber cloths, leather cloths, filter cloths, cloth items, cloth, mattresses, Futon, duvet cover, futon side, pillow cover, blanket, fabric table napkin, towel, shower curtain, banner and banner, fabric toilet seat cover, fabric chair coverー, Textile wall hangings, curtains, table hangings, books, corpses cover, warbler, red and white curtains, black and white curtains, billiard cloth, sleeping bags, clothes, coats, sweaters, shirts, nightclothes, underwear, swimming wear , Swimming cap, camisole, tea shirt, Japanese clothes, eye mask, apron, collar roll, socks, gaiters, fur stall, shawl, scarf, tabi, socks cover, gloves, tie, neckerchief, bandana, warmer supporter, muffler, Ear covers, night caps, hats, garters, socks, trousers, bands, belts, shoes, shoe-matching nails, shoe nails, shoe pullers, shoe caps, shoe guards, fur, sandals, fancy dress, Special sports shoes, riding shoes, windsurfing shoes, special sports clothes, water sports special clothes, fishing nets Working rods, knitting needles for knitting machines, electric hair curlers, needles, clothes stoppers, tapes, ribbons, knitted lace fabrics, embroidery lace fabrics, tufts, braids, knitting rods, threaders, sewing boxes, for sewing Spatula, needle finger for sewing, needle stab, needle box, artificial flower wreath, artificial flower, arm stopper, clothing badge, clothing buckle, clothing badge, clothing brooch, belt clip, bonnet pin, emblem, armband, headdress, button Kind, false beard, false mustache, hair curlers, shoe ornaments, shoelaces, shoelaces, shoelace substitutes, human hair, cigarettes, electronic cigarettes, smoking tools, matches, flower wreaths, seeds, trees, grass, Grass, dried flowers, seedlings, seedlings, flowers, grass, bonsai, grape seeds, seed pods, seed eggs, raw cork and palm leaves are known.
また、スチルベン系化合物が毛再生を促進することも報告されている(例えば、特許文献13など)。 It has also been reported that stilbene compounds promote hair regeneration (for example, Patent Document 13).
本発明は、パッションフルーツ種子の抽出物を有効成分とする発毛促進剤、医薬、食品および化粧品を提供することを目的とする。 An object of this invention is to provide the hair growth promoter, the pharmaceutical, foodstuffs, and cosmetics which use the extract of a passion fruit seed as an active ingredient.
本発明の一実施態様にかかる発毛促進剤、発毛促進用薬品組成物、発毛促進用食品組成物、発毛促進用化粧品組成物は、パッションフルーツ種子の抽出物を有効成分とする。上記発毛促進剤は、試薬、医薬、食品、または化粧品であってもよい。 The hair growth promoter, the hair growth promoting chemical composition, the hair growth promoting food composition, and the hair growth promoting cosmetic composition according to one embodiment of the present invention contain an extract of passion fruit seeds as an active ingredient. The hair growth promoter may be a reagent, a medicine, a food, or a cosmetic.
本発明の他の実施態様にかかる医薬は、上記発毛促進用薬品組成物を含有する。円形脱毛症、全頭脱毛症、汎発性脱毛症、蛇行性脱毛症、男性型脱毛症、女性型脱毛症、びまん性脱毛症、分娩後脱毛症、閉経後脱毛症、休止期脱毛症、成長期脱毛症、老人性脱毛症、若年性脱毛症、放射線治療による脱毛、抗がん剤治療による脱毛、薬剤性脱毛症、脂漏性脱毛症、粃糠性脱毛症、梅毒性脱毛症、膠原病や慢性甲状腺炎などの全身性疾患に伴う脱毛からなる群から選択される脱毛症の治療用医薬であってもよい。 The medicine concerning other embodiments of the present invention contains the above-mentioned pharmaceutical composition for hair growth promotion. Alopecia areata, global alopecia, generalized alopecia, serpentine alopecia, male pattern alopecia, female pattern alopecia, diffuse alopecia, postpartum alopecia, postmenopausal alopecia, resting alopecia, Growth alopecia, senile alopecia, juvenile alopecia, hair loss by radiation therapy, hair loss by anticancer drug treatment, drug-induced alopecia, seborrheic alopecia, erosive alopecia, syphilitic alopecia, It may be a medicament for the treatment of alopecia selected from the group consisting of hair loss associated with systemic diseases such as collagen disease and chronic thyroiditis.
上記発毛促進用食品組成物または上記発毛促進用化粧品組成物は、それぞれ円形脱毛症、全頭脱毛症、汎発性脱毛症、蛇行性脱毛症、男性型脱毛症、女性型脱毛症、びまん性脱毛症、分娩後脱毛症、閉経後脱毛症、休止期脱毛症、成長期脱毛症、老人性脱毛症、若年性脱毛症、放射線治療による脱毛、抗がん剤治療による脱毛、薬剤性脱毛症、脂漏性脱毛症、粃糠性脱毛症、梅毒性脱毛症、膠原病や慢性甲状腺炎などの全身性疾患に伴う脱毛からなる群から選択される脱毛症を改善するものであってもよい。 The hair growth promoting food composition or the hair growth promoting cosmetic composition comprises alopecia areata, total head alopecia, generalized alopecia, serpentine alopecia, male pattern alopecia, female pattern alopecia, Diffuse alopecia, postpartum alopecia, postmenopausal alopecia, resting alopecia, growth alopecia, senile alopecia, juvenile alopecia, hair loss by radiation therapy, hair loss by anticancer drug treatment, drug Alopecia, seborrheic alopecia, erosive alopecia, syphilitic alopecia, alopecia selected from the group consisting of hair loss associated with systemic diseases such as collagen disease and chronic thyroiditis Also good.
本発明のさらなる実施態様にかかる食品または化粧品は、それぞれ上記発毛促進用食品組成物または上記発毛促進用化粧品組成物としてもよい。上記食品が、加工食品、飼料、食品添加物、飼料添加物、補助食品またはサプリメントであってもよい。上記化粧品が、ヘアローション、ヘアトニック、ヘアオイル、ヘアクリーム、ヘアワックス、ヘアフォーム、ジェル、グリース、ポマード、チック、ヘアスプレー、ヘアウォーター、ヘアミスト、染毛剤、着色剤、脱色剤、シャンプー、リンス、トリートメント、コンディショナー、化粧水、クリーム、乳液、美容液、マスカラ、眉マスカラ、アイブロウであってもよい。 The food or cosmetic according to a further embodiment of the present invention may be the hair growth promoting food composition or the hair growth promoting cosmetic composition, respectively. The food may be processed food, feed, food additive, feed additive, food supplement or supplement. The above cosmetics are hair lotion, hair tonic, hair oil, hair cream, hair wax, hair foam, gel, grease, pomade, tic, hair spray, hair water, hair mist, hair dye, coloring agent, decoloring agent, shampoo, rinse , Treatment, conditioner, lotion, cream, milky lotion, serum, mascara, eyebrow mascara, eyebrow.
本発明によって、パッションフルーツ種子の抽出物を有効成分とする発毛促進剤、医薬、食品および化粧品を提供することができるようになった。 According to the present invention, it is possible to provide hair growth promoters, medicines, foods, and cosmetics containing an extract of passion fruit seeds as an active ingredient.
本発明の目的、特徴、利点、およびそのアイデアは、本明細書の記載により、当業者には明らかであり、本明細書の記載から、当業者であれば、容易に本発明を再現できる。以下に記載された発明の実施の形態および具体的な実施例などは、本発明の好ましい実施態様を示すものであり、例示または説明のために示されているのであって、本発明をそれらに限定するものではない。本明細書で開示されている本発明の意図並びに範囲内で、本明細書の記載に基づき、様々な改変並びに修飾ができることは、当業者にとって明らかである。 The objects, features, advantages, and ideas of the present invention will be apparent to those skilled in the art from the description of the present specification, and those skilled in the art can easily reproduce the present invention from the description of the present specification. The embodiments and specific examples of the invention described below show preferred embodiments of the present invention and are shown for illustration or explanation, and the present invention is not limited thereto. It is not limited. It will be apparent to those skilled in the art that various modifications and variations can be made based on the description of the present specification within the spirit and scope of the present invention disclosed herein.
==パッションフルーツ種子の抽出物==
本発明においてパッションフルーツ種子の抽出物は、Passiflora edulis、Passiflora alata、Passiflora amethystine、Passiflora antioquiensis、Passiflora biflora、Passiflora buonapartea、Passiflora capsularis、Passiflora cearensis、Passiflora coccinea、Passiflora cochinchinesis、Passiflora filamentosa、Passiflora herbertiana、Passiflora laurifolia、Passiflora ligularis、Passiflora lunata、Passiflora lutea、Passiflora maliformis、Passiflora mixta、Passiflora mucronata、Passiflora mollissima、Passiflora nibiba、Passiflora organensis、Passiflora pallida、Passiflora parahypensis、Passiflora pedeta、Passiflora pinnatistipula、Passiflora popenovii、Passiflora quadrangularis、Passiflora riparia、Passiflora rubra、Passiflora serrate、Passiflora tiliaefolia、Passiflora tripartite、Passiflora villosa、Passiflora warmingiiなどのパッションフルーツの種子から抽出した抽出物である。
== Passion fruit seed extract ==
In the present invention, passion fruit seed extracts are Passiflora edulis, Passiflora alata, Passiflora amethystine, Passiflora antioquiensis, Passiflora biflora, Passiflora buonapartea, Passiflora capsularis, Passiflora cearensis, Passiflora coccinea, Passiflora coassiine, Passiflora coccinea, Passiflora Passiflora ligularis, Passiflora lunata, Passiflora lutea, Passiflora maliformis, Passiflora mixta, Passiflora mucronata, Passiflora mollissima, Passiflora nibiba, Passiflora organensis, Passiflora pallida, Passiflora parahypensis, Passifloraflor pedeta , Extracts from passion fruit seeds such as Passiflora serrate, Passiflora tiliaefolia, Passiflora tripartite, Passiflora villosa, Passiflora warmingii.
パッションフルーツ種子の抽出物の形状は特に限定されず、例えば、パッションフルーツ種子を溶媒で抽出して得られる溶液、その濃縮液や希釈液などの溶液、またはいったん固化後に溶媒に溶解した溶液など(以下、抽出液は、これら全てを含む意味を有するものとする。)であってもよく、あるいは抽出液から溶媒を除去して得られるオイル、ゲルまたは固体などであってもよい。 The shape of the passion fruit seed extract is not particularly limited. For example, a solution obtained by extracting passion fruit seeds with a solvent, a solution such as a concentrated solution or a diluted solution thereof, or a solution once dissolved in a solvent after solidification ( Hereinafter, the extract has a meaning including all of these, and may be an oil, a gel, or a solid obtained by removing the solvent from the extract.
パッションフルーツ種子から抽出物を抽出する方法を以下に説明する。まず、パッションフルーツ種子をそのまま、あるいは乾燥させ、破砕、粉砕、または切断して、溶媒を添加する。破砕する前、あるいは溶媒を加える前に、凍結してもよい。 A method for extracting an extract from passion fruit seeds will be described below. First, passion fruit seeds are left as they are or dried, crushed, crushed, or cut, and a solvent is added. You may freeze before crushing or adding a solvent.
抽出に用いる溶媒の種類は、当業者であれば適切に選択することができるが、水性溶媒などの親水性溶媒または有機溶媒などの疎水性溶媒のいずれでもよく、例えば、水、メタノール、エタノール、アセトン、酢酸エチル、グリセリン、プロピレングリコール、ジプロピレングリコール、1,3−ブチレングリコール、ジメチルスルホキシド、アセトニトリル、N,N−ジメチルホルムアミド、2−プロパノール、1,4−ジオキサン、ヘキサン、クロロホルム、または、これらから選択される2以上の溶媒の混合溶媒であってもよいが、水、エタノール、または、水およびエタノールの混合溶媒であることがより好ましく、水およびエタノールの混合溶媒であることがより好ましい。 The type of solvent used for extraction can be appropriately selected by those skilled in the art, and may be either a hydrophilic solvent such as an aqueous solvent or a hydrophobic solvent such as an organic solvent, such as water, methanol, ethanol, Acetone, ethyl acetate, glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, dimethyl sulfoxide, acetonitrile, N, N-dimethylformamide, 2-propanol, 1,4-dioxane, hexane, chloroform, or these A mixed solvent of two or more solvents selected from the above may be used, but water, ethanol, or a mixed solvent of water and ethanol is more preferable, and a mixed solvent of water and ethanol is more preferable.
混合溶媒を用いる場合の、各溶媒の混合比は特に限定されないが、例えば水およびエタノールの混合溶媒を用いる場合には、水とエタノールとの体積比は、1:99〜99:1であってもよく、5:95〜50:50であることがより好ましく、10:90〜30:70であることがより好ましく、20:80であることがより好ましい。 When using a mixed solvent, the mixing ratio of each solvent is not particularly limited. For example, when using a mixed solvent of water and ethanol, the volume ratio of water to ethanol is 1:99 to 99: 1. It is more preferable that the ratio is 5:95 to 50:50, more preferable is 10:90 to 30:70, and more preferable is 20:80.
抽出に用いる溶媒は、塩を含んでいてもよく、例えばバッファーであってもよい。バッファーのpHは、投与する個体に応じて適宜設定することができ、酸性、中性、またはアルカリ性のいずれであってもよいが、pH8以下であることが好ましく、pH1.0〜pH5.0の酸性であることがより好ましく、pH3.0〜pH4.5の酸性であることがさらに好ましく、pH3.0〜pH4.0の酸性であることが特に好ましい。バッファーに用いる塩の種類は特に限定されず、例えばクエン酸塩、リンゴ酸塩、リン酸塩、酢酸塩および炭酸塩などが挙げられる。 The solvent used for extraction may contain a salt, for example, a buffer. The pH of the buffer can be appropriately set according to the individual to be administered, and may be acidic, neutral, or alkaline, but is preferably pH 8 or less, and has a pH of 1.0 to 5.0. It is more preferably acidic, more preferably acidic with a pH of 3.0 to 4.5, and particularly preferably acidic with a pH of 3.0 to 4.0. The kind of salt used for the buffer is not particularly limited, and examples thereof include citrate, malate, phosphate, acetate, and carbonate.
パッションフルーツ種子に溶媒を添加した後、超音波処理、ホモゲナイズ、圧搾粉砕などの抽出操作を行って抽出液を得ることができる。抽出液を濃縮する場合、その方法は特に限定されず、例えば、減圧、加熱など公知の方法を用いることができる。また、抽出液が水性の場合、アルコールやケトンなどの有機溶媒で抽出することにより、溶液容積を減らすことができる。抽出液から溶媒を留去して抽出物を作製する場合、例えば、減圧留去、凍結乾燥、または、スプレードライ(噴霧乾燥)によって溶媒を除去してもよい。さらに、得られた固体を適当な溶媒に溶解して、抽出液に戻してもよい。 After adding a solvent to the passion fruit seeds, an extraction solution such as ultrasonic treatment, homogenization, and press pulverization can be performed to obtain an extract. When concentrating an extract, the method is not specifically limited, For example, well-known methods, such as pressure reduction and a heating, can be used. When the extract is aqueous, the solution volume can be reduced by extracting with an organic solvent such as alcohol or ketone. When producing an extract by distilling off the solvent from the extract, the solvent may be removed, for example, by distilling off under reduced pressure, freeze drying, or spray drying (spray drying). Further, the obtained solid may be dissolved in a suitable solvent and returned to the extract.
==パッションフルーツ種子抽出物の用途==
パッションフルーツ種子抽出物を発毛促進剤として用いることができる。
== Use of passion fruit seed extract ==
Passion fruit seed extract can be used as a hair growth promoter.
本明細書において「発毛」とは、表皮の毛が増えることをいう。発毛促進の程度は、当業者に周知の方法を用いて評価することができるが、例えば、図1に示す発毛スコアに基づいて個体の発毛スコアを採点することにより評価してもよく、図5や表4に示す発毛面積スコアに基づいて個体の発毛面積スコアを採点することにより評価してもよく、表皮全体の面積のうち、毛がある表皮の面積の割合を計算することにより評価してもよい。また、毛の平均密度を測定し、その増分によって発毛促進の程度を評価してもよい。 In this specification, “hair growth” means that the hair of the epidermis increases. The degree of hair growth promotion can be evaluated using methods well known to those skilled in the art. For example, it may be evaluated by scoring an individual's hair growth score based on the hair growth score shown in FIG. Evaluation may be made by scoring the hair growth area score of an individual based on the hair growth area score shown in FIG. 5 or Table 4, and the ratio of the area of the epidermis with hair out of the total area of the epidermis is calculated. You may evaluate by. Further, the average density of hair may be measured, and the degree of hair growth promotion may be evaluated by the increment.
本明細書において「毛」とは、動物の表皮に生えた体毛を意味し、例えば頭髪、眉毛、睫毛、耳毛、鼻毛、髭、胸毛、腋毛、陰毛、脛毛などを含む。本明細書において動物は、ヒトであっても、ヒト以外の哺乳動物であっても、ヒト以外の脊椎動物であっても、よいが、具体的な動物としては、ヒト、マウス、ラット、イヌ、サルなどが例示できる。 As used herein, “hair” refers to body hair that grows on the epidermis of animals, and includes, for example, head hair, eyebrows, eyelashes, ear hairs, nose hairs, eyelashes, chest hairs, eyelashes, pubic hairs, and tibial hairs. In this specification, the animal may be a human, a mammal other than a human, or a vertebrate other than a human, and specific animals include humans, mice, rats, and dogs. And monkeys.
この発毛促進剤は、医薬、試薬などの薬品、食品、及び化粧品として利用される。以下、それぞれの利用の仕方について、詳細に述べる。 The hair growth promoter is used as a medicine, a drug such as a reagent, food, and cosmetics. Hereinafter, each usage will be described in detail.
==パッションフルーツ種子の抽出物を有効成分とする薬品==
本発明の一実施形態は、パッションフルーツ種子の抽出物を有効成分とする、発毛促進用薬品組成物である。発毛促進用薬品組成物は、試薬または医薬などの薬品の製造に利用される。この薬品は、発毛促進剤として剤形化される。
== Drugs containing passion fruit seed extract as active ingredient ==
One embodiment of the present invention is a chemical composition for promoting hair growth, comprising an extract of passion fruit seeds as an active ingredient. The chemical composition for promoting hair growth is used for the production of chemicals such as reagents or pharmaceuticals. This drug is formulated as a hair growth promoter.
この医薬は、円形脱毛症、全頭脱毛症、汎発性脱毛症、蛇行性脱毛症、男性型脱毛症、女性型脱毛症、びまん性脱毛症、分娩後脱毛症、閉経後脱毛症、休止期脱毛症、成長期脱毛症、老人性脱毛症、若年性脱毛症、放射線治療による脱毛、抗がん剤治療による脱毛、薬剤性脱毛症、脂漏性脱毛症、粃糠性脱毛症、梅毒性脱毛症、膠原病や慢性甲状腺炎などの全身性疾患に伴う脱毛症の治療薬であってもよい。また、他の疾患や用途に対する医薬をふくんでもよく、例えば、中枢神経系用薬剤、末しょう神経系用薬剤、感覚器官用薬剤、アレルギー用薬剤、循環器官用薬剤、呼吸器官用薬剤、消化器官用薬剤、ホルモン剤、泌尿生殖器用又は肛門用の薬剤、外皮用薬剤、ビタミン剤、アミノ酸剤、滋養強壮変質剤、血液用剤、代謝性薬剤、細胞賦活用薬剤、腫瘍治療用薬剤、物理的障害治療用薬剤、化学的障害治療用薬剤、抗生物質製剤、化学療法剤、生物学的製剤、寄生動物に対する薬剤、調剤用剤、診断用薬剤、治療用又は診断用アイソトープ標識物質、麻薬、生薬、動物用薬剤などとともに合剤としてもよい。 This medicine is alopecia areata, total alopecia, generalized alopecia, serpentine alopecia, male pattern alopecia, female pattern alopecia, diffuse alopecia, postpartum alopecia, postmenopausal alopecia, rest Alopecia, growth alopecia, senile alopecia, juvenile alopecia, alopecia with radiation therapy, alopecia with anticancer drug treatment, drug-induced alopecia, seborrheic alopecia, erosion alopecia, syphilis It may be a therapeutic agent for alopecia associated with systemic diseases such as alopecia areata, collagen disease and chronic thyroiditis. It may also contain drugs for other diseases and uses, such as central nervous system drugs, peripheral nervous system drugs, sensory organ drugs, allergy drugs, cardiovascular drugs, respiratory drugs, digestive drugs, etc. Organ drugs, hormonal drugs, urogenital or anal drugs, skin drugs, vitamin drugs, amino acid drugs, nourishing tonics, blood drugs, metabolic drugs, cell utilization drugs, tumor treatment drugs, physics Drugs for the treatment of chemical disorders, drugs for the treatment of chemical disorders, antibiotic preparations, chemotherapeutic agents, biological preparations, drugs for parasites, pharmaceutical preparations, diagnostic agents, therapeutic or diagnostic isotope labeling substances, narcotics, It may be combined with crude drugs and veterinary drugs.
本明細書において「男性型脱毛症(Androgenetic Alopecia: AGA)」とは、遺伝的背景によって発症するもの、および/またはジヒドロテストステロンなどの男性ホルモンが原因となって発症する疾患を意味する。 As used herein, “Androgenetic Alopecia (AGA)” means a disease that develops due to a genetic background and / or a disease that develops due to a male hormone such as dihydrotestosterone.
本明細書において「女性型脱毛症」とは、加齢に伴い女性ホルモンの分泌が減ることによって、相対的に男性ホルモンの分泌量が増加することが原因で起こる脱毛症を意味する。 As used herein, “female pattern baldness” means alopecia caused by a relatively increased secretion of male hormone due to a decrease in the secretion of female hormone with aging.
治療薬の投与経路は、例えば、経口投与、舌下投与、吸入投与、経皮投与、腹腔投与、皮下投与、筋肉内投与、静脈内投与、点鼻投与、点眼投与などが挙げられ、剤形や脱毛の重症度、脱毛が生じている部位に応じて医師などの投与者が適宜選択できるが、経口投与または経皮投与が好ましい。 The administration route of the therapeutic agent includes, for example, oral administration, sublingual administration, inhalation administration, transdermal administration, peritoneal administration, subcutaneous administration, intramuscular administration, intravenous administration, nasal administration, ophthalmic administration, etc. Depending on the severity of hair loss and the site where hair loss occurs, an administrator such as a doctor can appropriately select, but oral administration or transdermal administration is preferred.
治療薬の剤形は、投与経路や脱毛の重症度、脱毛が生じている部位に応じて医師などの投与者が適宜選択でき、例えば、経口剤、注射剤、外用剤、注入剤が挙げられる。経口剤は、錠剤、徐放錠、カプセル剤、徐放性カプセル剤、散剤、細粒剤、顆粒剤、徐放性顆粒剤、粉末、腸溶剤、液剤、ゼリー状剤、シロップ剤、トローチ、咀嚼錠、丸剤を含む。外用剤は、ローション、軟膏剤、クリーム剤、点耳剤、点眼剤、点鼻剤、吸入剤、坐剤、貼付剤を含むが、注射剤、経口剤、または外用剤が好ましい。 The dosage form of the therapeutic agent can be appropriately selected by an administrator such as a doctor according to the administration route, the severity of hair loss, and the site where hair loss occurs, and examples include oral preparations, injections, external preparations, and injections. . Oral preparations are tablets, sustained-release tablets, capsules, sustained-release capsules, powders, fine granules, granules, sustained-release granules, powders, intestinal solvents, liquids, jelly-forms, syrups, troches, Includes chewable tablets and pills. External preparations include lotions, ointments, creams, ear drops, eye drops, nasal drops, inhalants, suppositories, and patches, but injections, oral preparations, and external preparations are preferred.
治療薬の1回の投与量は、投与する個体の体重、脱毛の重症度、脱毛が生じている部位、投与経路、剤形に応じて医師などの投与者が適宜選択できる。パッションフルーツ種子の抽出物の1日の投与量は、5000mg/kg体重以下であることが好ましく、3000mg/kg体重以下であることがより好ましく、1000mg/kg体重以下であることがより好ましく、750mg/kg体重以下であることがより好ましく、500mg/kg体重以下であることがより好ましく、400mg/kg体重以下であることがより好ましく、200mg/kg体重以下であることがさらに好ましい。また、0.01mg/kg体重以上であることが好ましく、0.1mg/kg体重以上であることがより好ましく、1mg/kg以上であることがより好ましく、10mg/kg以上であることがより好ましく、50mg/kg体重以上であることがより好ましく、100mg/kg体重以上であることがさらに好ましい。 A single dose of the therapeutic agent can be appropriately selected by an administrator such as a doctor according to the body weight of the individual to be administered, the severity of hair loss, the site where hair loss occurs, the administration route, and the dosage form. The daily dose of the passion fruit seed extract is preferably 5000 mg / kg body weight or less, more preferably 3000 mg / kg body weight or less, more preferably 1000 mg / kg body weight or less, and 750 mg. / kg body weight or less is more preferable, 500 mg / kg body weight or less is more preferable, 400 mg / kg body weight or less is more preferable, and 200 mg / kg body weight or less is further preferable. Further, it is preferably 0.01 mg / kg body weight or more, more preferably 0.1 mg / kg body weight or more, more preferably 1 mg / kg or more, and more preferably 10 mg / kg or more. 50 mg / kg body weight or more, more preferably 100 mg / kg body weight or more.
==パッションフルーツ種子の抽出物を有効成分とする食品==
本発明の一実施形態は、パッションフルーツ種子の抽出物を有効成分とする、発毛促進用食品組成物である。この発毛促進用食品組成物を含有する食品は、発毛促進用に用いることができ、特に上述したような脱毛症を改善するために用いてもよい。
== Food containing an extract of passion fruit seeds as an active ingredient ==
One embodiment of the present invention is a food composition for promoting hair growth, comprising an extract of passion fruit seeds as an active ingredient. The food containing the food composition for promoting hair growth can be used for promoting hair growth, and may be used particularly for improving alopecia as described above.
この食品は、加工食品などの一般食品であってもよく、健康食品や特定保健用食品や栄養機能食品などの保健機能食品であってもよい。これらは、ヒト用であっても、ヒト以外の哺乳動物用であっても、ヒト以外の脊椎動物用であっても、ヒト以外の動物用であってもかまわない。 This food may be a general food such as a processed food, or may be a health food such as a health food, a food for specified health use, or a functional nutrition food. These may be for humans, for mammals other than humans, for vertebrates other than humans, or for animals other than humans.
ヒト用の一般食品としては、例えば、チョコレート、ビスケット、ガム、キャンディー、クッキー、グミ、打錠菓子等の菓子類;シリアル;粉末飲料、清涼飲料、乳飲料、栄養飲料、炭酸飲料、ゼリー飲料等の飲料;アイスクリーム、シャーベットなどの冷菓、食用油脂、乳製品、肉製品、加工水産物、かつお節、削り節、食用魚粉、とろろ昆布、干しのり、干しひじき、干しわかめ、焼きのり、加工野菜及び加工果実、油揚げ、凍り豆腐、こんにゃく、豆乳、豆腐、納豆、加工卵、カレー・シチュー又はスープのもと、お茶漬けのり、ふりかけ、なめ物、食用たんぱく、茶、コーヒー、ココア、氷、パン、サンドイッチ、中華まんじゅう、ハンバーガー、ピザ、ホットドッグ、ミートパイ、みそ、ウースターソース、グレービーソース、ケチャップソース、しょうゆ、食酢、酢の素、そばつゆ、ドレッシング、ホワイトソース、マヨネーズソース、焼肉のたれ、角砂糖、果糖、氷砂糖、砂糖、麦芽糖、はちみつ、ぶどう糖、粉末あめ、水あめ、ごま塩、食塩、すりごま、セロリーソルト、うま味調味料、香辛料、アイスクリームのもと、シャーベットのもと、穀物の加工品、チョコレートスプレッド、ぎょうざ、しゅうまい、すし、たこ焼き、弁当、ラビオリ、イーストパウダー、ベーキングパウダー、即席菓子のもと、パスタソース、食用酒かす、脱穀済みのえん麦、脱穀済みの大麦、食用粉類、麦芽、可食インク、黒焼き、乳幼児用粉乳、食餌療法用飲料、食餌療法用食品、乳幼児用飲料、乳幼児用食品、ビール、清涼飲料、果実飲料、飲料用野菜ジュース、ビール製造用ホップエキス、乳清飲料、泡盛、合成清酒、焼酎、白酒、清酒、直し、みりん、洋酒、果実酒、酎ハイ、中国酒、薬味酒が挙げられる。 General foods for humans include, for example, chocolates, biscuits, gums, candy, cookies, gummies, tableted confectionery, etc .; cereals; powdered drinks, soft drinks, milk drinks, nutrition drinks, carbonated drinks, jelly drinks, etc. Drinks; ice cream, sherbet and other frozen desserts, edible fats and oils, dairy products, meat products, processed marine products, dried bonito, shavings, edible fish meal, garlic kelp, dried seaweed, dried hijiki, dried seaweed, grilled seafood, processed vegetables and processed fruits , Deep-fried tofu, frozen tofu, konjac, soy milk, tofu, natto, processed eggs, curry stew or soup, green tea paste, sprinkle, tanned food, edible protein, tea, coffee, cocoa, ice, bread, sandwich, Chinese bun , Hamburger, pizza, hot dog, meat pie, miso, wooster sauce, gravy sauce, ke Chop sauce, soy sauce, vinegar, vinegar, soba sauce, dressing, white sauce, mayonnaise sauce, grilled meat sauce, sugar cubes, fructose, rock sugar, sugar, maltose, honey, glucose, powdered candy, syrup, sesame salt, salt, ground sesame, Celery salt, umami seasoning, spices, ice cream, sherbet, processed cereals, chocolate spread, gyoza, sweet sushi, sushi, takoyaki, bento, ravioli, yeast powder, baking powder, instant confectionery And pasta sauce, edible liquor, threshed oats, threshed barley, edible flour, malt, edible ink, black baked, infant formula, dietary drinks, dietary foods, infant drinks, infants Food, beer, soft drink, fruit drink, vegetable juice for beverage, Puekisu, whey beverages, awamori, synthetic sake, shochu, white sake, sake, fix, mirin, liquor, fruit wine, sake high, Chinese alcoholic beverages, include the spice liquor.
ヒト以外の動物用の一般食品としては、例えば、ペットフード、餌、釣り用餌、飼料、飼料用たんぱくが挙げられる。 Examples of general foods for animals other than humans include pet food, bait, fishing bait, feed, and feed protein.
また、食品添加物、飼料添加物、補助食品またはサプリメントなどとして剤形化された、発毛促進剤であってもよい。なお、サプリメントとは、栄養補給を主な目的とする補助食品のことで、特定保健用食品や栄養機能食品などの保健機能食品であってもよい。補助食品には、栄養補助食品や健康補助食品や機能性補助食品などが含まれる。なお、これらは、経口摂取される経口剤であってもよい。 Further, it may be a hair growth promoter formulated as a food additive, feed additive, supplementary food or supplement. Note that supplements are supplementary foods whose main purpose is nutritional supplementation, and may be health functional foods such as foods for specified health use and nutritional functional foods. Supplements include nutritional supplements, health supplements, functional supplements, and the like. These may be oral preparations that are taken orally.
食品添加物は、指定添加物、既存添加物、天然香料、一般飲食物添加物であってもよい。食品添加物としては、甘味料、人工甘味料、苦味料、酸味料、香料、強化剤、発色剤、酸化防止剤、製造用剤、着色料、増粘安定剤、防かび剤、凝固剤、乳化剤、保存料、殺菌料、調味料、漂白剤、抽出溶剤、pH調整剤、ガムベース、イーストフード、食物繊維、寒天、豆腐用凝固剤、小麦粉処理剤、被膜剤、アイスクリーム用凝固剤、家庭用食肉軟化剤、ホイップクリーム用安定剤、食品香料、食用グルテンが挙げられる。 The food additive may be a designated additive, an existing additive, a natural fragrance, or a general food additive. Food additives include sweeteners, artificial sweeteners, bitters, acidulants, fragrances, fortifiers, color formers, antioxidants, manufacturing agents, colorants, thickening stabilizers, fungicides, coagulants, Emulsifiers, preservatives, bactericides, seasonings, bleaching agents, extraction solvents, pH adjusters, gum base, yeast food, dietary fiber, agar, tofu coagulants, flour processing agents, coating agents, ice cream coagulants, household Meat softener, whipped cream stabilizer, food flavor, edible gluten.
飼料添加物としては、栄養補助用飼料添加物が挙げられる。 Examples of feed additives include feed supplements for nutritional supplementation.
本発明の食品組成物または食品は、他の食品と混ぜて用いてもよく、他の食品は、例えば、食肉、卵、食用魚介類、冷凍野菜、冷凍果実、豆、コーヒー豆、こうじ、酵母、米、ホップ、海藻類、野菜、茶の葉、糖料作物、果実、あわ、きび、ごま、そば(穀物)、とうもろこし(穀物)、ひえ、麦、籾米、もろこし、獣類、魚類、鳥類、昆虫類、漆の実が挙げられる。 The food composition or food of the present invention may be used by mixing with other foods. Examples of other foods include meat, eggs, edible seafood, frozen vegetables, frozen fruits, beans, coffee beans, koji, yeast. , Rice, hops, seaweeds, vegetables, tea leaves, sugar crops, fruits, sweet potato, acne, sesame, buckwheat (cereal), corn (cereal), mackerel, wheat, glutinous rice, corn, beast, fish, birds, Insects, lacquer fruit.
食品に含まれるパッションフルーツ種子の抽出物の含有量は、食品を摂取する個体の体重、脱毛の重症度、脱毛が生じている部位、食品の種類、食品を摂取する経路に応じて適宜選択できる。パッションフルーツ種子の抽出物の摂取量は、5000mg/kg体重以下であることが好ましく、3000mg/kg体重以下であることがより好ましく、1000mg/kg体重以下であることがより好ましく、750mg/kg体重以下であることがより好ましく、500mg/kg体重以下であることがさらに好ましい。また、0.01mg/kg体重以上であることが好ましく、0.1mg/kg体重以上であることがより好ましく、1mg/kg以上であることがより好ましく、10mg/kg以上であることがより好ましく、50mg/kg体重以上であることがより好ましく、100mg/kg体重以上であることがより好ましく、250mg/kg体重以上であることがさらに好ましい。 The content of the passion fruit seed extract contained in the food can be appropriately selected according to the body weight of the individual who ingests the food, the severity of hair loss, the site where hair loss occurs, the type of food, the route of ingesting the food . The intake of the passion fruit seed extract is preferably 5000 mg / kg body weight or less, more preferably 3000 mg / kg body weight or less, more preferably 1000 mg / kg body weight or less, and 750 mg / kg body weight. Or less, more preferably 500 mg / kg body weight or less. Further, it is preferably 0.01 mg / kg body weight or more, more preferably 0.1 mg / kg body weight or more, more preferably 1 mg / kg or more, and more preferably 10 mg / kg or more. 50 mg / kg body weight or more, more preferably 100 mg / kg body weight or more, and further preferably 250 mg / kg body weight or more.
==パッションフルーツ種子の抽出物を有効成分とする化粧品==
本発明の一実施形態は、パッションフルーツ種子の抽出物を有効成分とする、発毛促進用化粧品組成物である。この発毛促進用化粧品組成物を含有する化粧品は、発毛促進用に用いることができ、特に上述したような脱毛症を改善するために用いてもよい。
== Cosmetic product containing passion fruit seed extract as active ingredient ==
One embodiment of the present invention is a cosmetic composition for promoting hair growth, comprising an extract of passion fruit seeds as an active ingredient. A cosmetic containing the cosmetic composition for promoting hair growth can be used for promoting hair growth, and may be used particularly for improving alopecia as described above.
化粧品は、ヘアローション、ヘアトニック、ヘアオイル、ヘアクリーム、ヘアワックス、ヘアフォーム、ジェル、グリース、ポマード、チック、ヘアスプレー、ヘアウォーター、ヘアミスト、染毛剤、着色剤、脱色剤、シャンプー、リンス、トリートメント、コンディショナー、化粧水、クリーム、乳液、美容液、マスカラ、眉マスカラ、アイブロウ、などであってもよい。なお、これらは、表皮に塗布することによって用いられる塗布剤であってもよい。 Cosmetics are hair lotion, hair tonic, hair oil, hair cream, hair wax, hair foam, gel, grease, pomade, tic, hair spray, hair water, hair mist, hair dye, coloring agent, decoloring agent, shampoo, rinse, It may be a treatment, conditioner, lotion, cream, milky lotion, serum, mascara, eyebrow mascara, eyebrow, and the like. In addition, the coating agent used by apply | coating to an epidermis may be sufficient as these.
化粧品に含まれるパッションフルーツ種子の抽出物の含有割合は、化粧品を用いる個体の体重、脱毛の重症度、脱毛が生じている部位、化粧品の種類に応じて適宜選択できる。化粧品に含まれるパッションフルーツ種子の抽出物の含有割合は100%以下であることが好ましく、75%以下であることがより好ましく、50%以下であることがより好ましく、25%以下であることがより好ましく、10%以下であることがより好ましく、5%以下であることがさらに好ましい。また、0.01%以上であることが好ましく、0.1%以上であることがより好ましく、0.2%以上であることがより好ましく、0.5%以上であることがより好ましく、1%以上であることがより好ましく、2%以上であることがより好ましく、4%以上であることがさらに好ましい。 The content of the passion fruit seed extract contained in the cosmetic can be appropriately selected according to the weight of the individual using the cosmetic, the severity of hair loss, the site where hair loss occurs, and the type of cosmetic. The content of the passion fruit seed extract contained in the cosmetic is preferably 100% or less, more preferably 75% or less, more preferably 50% or less, and 25% or less. More preferably, it is 10% or less, more preferably 5% or less. Further, it is preferably 0.01% or more, more preferably 0.1% or more, more preferably 0.2% or more, and more preferably 0.5% or more. % Or more, more preferably 2% or more, and further preferably 4% or more.
(1)パッションフルーツ種子の抽出液(以下、PFS抽出液と称する)を腹腔投与したマウスにおける発毛促進について
本実施例では、PFS抽出液を含む溶液を1日2回、3日間腹腔投与し、初回投与から4日目に、マウスの背部皮膚の発毛の程度を図1の発毛スコアに基づいて採点・評価した。
(1) About hair growth promotion in mice given a peritoneally administered passion fruit seed extract (hereinafter referred to as PFS extract) In this example, a solution containing a PFS extract was administered intraperitoneally twice a day for 3 days. On the fourth day after the initial administration, the degree of hair growth on the back skin of the mice was scored and evaluated based on the hair growth score of FIG.
4週齢の雄マウス(BALB/cAJcl−nu/nu)19匹を搬入し、4日間固形飼料(AIN93G)を与えて飼育した。その後、19匹のマウスを表1に記載した4群に分けた。 19 4-week-old male mice (BALB / cAJcl-nu / nu) were carried in and fed with solid feed (AIN93G) for 4 days. Thereafter, 19 mice were divided into 4 groups described in Table 1.
基材と有効成分を混合して、以下の手順に従い投与サンプルを1日1回用時調製した。対照群には、日本薬局方 生理食塩液 大塚生食注(製造販売元:株式会社大塚製薬工場)(以下、生理食塩水と称する)と35%(v/v)エタノールを等量混合した液を投与した。
・35%(v/v)エタノール(以下、35%エタノールと称する)
無水エタノール(販売元:和光純薬工業株式会社;販売元コード:321−00025)を純水で35%(v/v)に希釈した。
・レスベラトロール溶液
レスベラトロール(東京化成工業株式会社;製品コード:R0071)を11.2mg秤量して、35%エタノールを1.49ml加え撹拌した。10分間超音波処理してレスベラトロールを溶解させた後、生理食塩水を1.5ml加え撹拌した。
・ピセアタンノール溶液
ピセアタンノール(東京化成工業株式会社;製品コード:P1928)を12mg秤量し、35%エタノールを1.49ml加え撹拌した。10分間超音波処理してピセアタンノールを溶解させた後、生理食塩水を1.5ml加え撹拌した。
・PFS抽出液を含む溶液
パッションフルーツ種子を凍結して、粉砕機(商品名:サンプルミル;型式:SK−M、協立理工株式会社)で粉砕した。粉砕したパッションフルーツ種子5gに80%(v/v)エタノール(以下、80%エタノールと称する)を50ml加え、30分間超音波処理した後、遠心して上清を回収した。沈殿に対し、50mlの80%エタノール抽出による抽出をさらに2回行い、回収した抽出液を集めて濃縮し、フリーズドライし、PFS抽出物とした。得られたPFS抽出物を60mg秤量し、35%エタノールを0.69ml加え撹拌した。10分間超音波処理した後、生理食塩水を0.75ml加えて撹拌した。
A base material and an active ingredient were mixed, and an administration sample was prepared once a day for use according to the following procedure. In the control group, Japanese Pharmacopoeia physiological saline Otsuka raw food injection (manufacturer and distributor: Otsuka Pharmaceutical Factory) (hereinafter referred to as physiological saline) and 35% (v / v) ethanol mixed in equal amounts Administered.
35% (v / v) ethanol (hereinafter referred to as 35% ethanol)
Absolute ethanol (distributor: Wako Pure Chemical Industries, Ltd .; distributor code: 321-02005) was diluted to 35% (v / v) with pure water.
-Resveratrol solution 11.2 mg of resveratrol (Tokyo Chemical Industry Co., Ltd .; product code: R0071) was weighed, and 1.49 ml of 35% ethanol was added and stirred. After resveratrol was dissolved by sonication for 10 minutes, 1.5 ml of physiological saline was added and stirred.
-Piceatannol solution 12 mg of Piceatannol (Tokyo Chemical Industry Co., Ltd .; product code: P1928) was weighed, and 1.49 ml of 35% ethanol was added and stirred. After ultrasonication for 10 minutes to dissolve piceatannol, 1.5 ml of physiological saline was added and stirred.
-Solution containing PFS extract The passion fruit seeds were frozen and pulverized with a pulverizer (trade name: sample mill; model: SK-M, Kyoritsu Riko Co., Ltd.). 50 ml of 80% (v / v) ethanol (hereinafter referred to as 80% ethanol) was added to 5 g of the pulverized passion fruit seeds, sonicated for 30 minutes, and then centrifuged to collect the supernatant. The precipitate was further extracted twice with 50 ml of 80% ethanol extraction, and the collected extract was collected and concentrated, freeze-dried, and used as a PFS extract. 60 mg of the obtained PFS extract was weighed, and 0.69 ml of 35% ethanol was added and stirred. After sonicating for 10 minutes, 0.75 ml of physiological saline was added and stirred.
サンプルを投与する当日にマウスの体重を測定し、投与量が5ml/kg体重となるように、表2に従って投与サンプルの投与量[μl]を決定した。1回目の腹腔投与の7時間後に2回目の腹腔投与を行った。各投与はいずれも30分以内に終了した。初回投与日を1日目として、3日目まで1日2回、同様にサンプルをマウスに腹腔投与した(図2)。 On the day of sample administration, the body weight of the mice was measured, and the dose [μl] of the administered sample was determined according to Table 2 so that the dose was 5 ml / kg body weight. A second abdominal administration was performed 7 hours after the first abdominal administration. Each administration was completed within 30 minutes. The sample was intraperitoneally administered to mice in the same manner twice a day until the third day, with the first administration day as the first day (FIG. 2).
投与開始から4日目に、2名の判定員が19匹のマウスそれぞれの背部皮膚を実体顕微鏡で観察し、図1の発毛スコアに基づき、各マウスの発毛スコアを採点した。図3は、2名の判定員が採点した発毛スコアの群ごとの平均値である。図3に示す通り、対照群およびRES群のマウスの発毛スコアの平均値は2.8と同じ値であった。また、PIC群のマウスの発毛スコアの平均値は3.3であり、対照群およびRES群と比べて微増した。一方、PFS抽出液群のマウスの発毛スコアの平均値は5.0であり、対照群およびRES群と比べて約1.8倍と顕著に増加した。 On the 4th day from the start of administration, two judges judged the hair growth score of each mouse based on the hair growth score of FIG. 1 by observing the back skin of each of 19 mice with a stereomicroscope. FIG. 3 is an average value for each group of hair growth scores scored by two judges. As shown in FIG. 3, the average value of the hair growth score of the mice of the control group and the RES group was the same value as 2.8. Moreover, the average value of the hair growth score of the mice in the PIC group was 3.3, which was slightly increased as compared with the control group and the RES group. On the other hand, the average value of the hair growth score of the mice in the PFS extract group was 5.0, which was significantly increased by about 1.8 times compared to the control group and the RES group.
このように、単離したピセアタンノールに比べ、PFS抽出物は、腹腔投与による顕著に高い発毛効果を有している。 Thus, compared with isolated piceatannol, the PFS extract has a significantly higher hair growth effect by intraperitoneal administration.
(2)PFS抽出液を経口投与したマウスにおける発毛促進について
本実施例では、PFS抽出液を含む溶液を1日1回6日間経口投与して、1日投与を中断するセットを1セットとする投与スケジュールを2セット行った(図4)。投与開始から14日目に、マウスの背部皮膚の発毛の程度を、図5、表4に示す3段階の発毛面積スコアを基に採点した。
(2) About hair growth promotion in mice orally administered with PFS extract In this example, a set containing a PFS extract was orally administered once a day for 6 days, and the daily administration was discontinued as one set. Two sets of administration schedules were performed (FIG. 4). On the 14th day from the start of administration, the degree of hair growth on the back skin of the mice was scored based on the three-stage hair growth area score shown in FIG.
4週齢の雄マウス(BALB/cAJcl−nu/nu)15匹のマウスを、表3に記載した3つの群に分けた。 Four 15-week-old male mice (BALB / cAJcl-nu / nu) were divided into three groups as described in Table 3.
基材である20%(v/v)マクロゴールと有効成分を混合して、以下の手順に従い投与サンプルを調製した。対照群には、基材のみを投与した。
・20%(v/v)マクロゴール(以下、20%マクロゴールと称する)
日本薬局方 マクロゴール400(製造販売元:丸石製薬株式会社)を純水で20%(v/v)に希釈した。
・PFS25抽出液
(1)と同様の方法で作製したPFS抽出液を50mg秤量し、20%マクロゴールを0.95ml加え攪拌した。その後、20分間超音波処理してPFS抽出液を溶解させた。
・PFS50抽出液
(1)と同様の方法で作製したPFS抽出液を100mg秤量し、20%マクロゴールを0.9ml加え攪拌した。その後、20分間超音波処理してPFS抽出液を溶解させた。
A 20% (v / v) macrogol as a base material and an active ingredient were mixed, and a dosing sample was prepared according to the following procedure. The control group received only the substrate.
・ 20% (v / v) macro goal (hereinafter referred to as 20% macro goal)
Japanese Pharmacopoeia Macrogol 400 (manufacturer and distributor: Maruishi Pharmaceutical Co., Ltd.) was diluted to 20% (v / v) with pure water.
-50 mg of PFS extract prepared by the same method as PFS25 extract (1) was weighed, and 0.95 ml of 20% macrogol was added and stirred. Thereafter, the PFS extract was dissolved by sonication for 20 minutes.
-100 mg of PFS extract prepared by the same method as PFS50 extract (1) was weighed, 0.9 ml of 20% macrogol was added and stirred. Thereafter, the PFS extract was dissolved by sonication for 20 minutes.
サンプルを投与する当日にマウスの体重を測定し、投与量が5ml/kg体重となるように、表2に従ってサンプルの投与量[μl]を決定した。その後、マウス用経口ゾンデを用いて、サンプルを経口投与した。 On the day of sample administration, the body weight of the mouse was measured, and the dose [μl] of the sample was determined according to Table 2 so that the dose was 5 ml / kg body weight. Thereafter, the sample was orally administered using an oral sonde for mice.
投与開始から14日目に、2名の判定員が、15匹のマウスそれぞれの背部皮膚を観察し、図5と表4に示す発毛面積スコア1〜3に基づき、各マウスの背部における発毛の程度を合議にて採点した。 On the 14th day from the start of administration, two judges determined the skin on the back of each of the 15 mice, and based on the hair growth area scores 1 to 3 shown in FIG. The degree of hair was scored by consultation.
図6は、2名の判定員が合議にて判定した発毛面積スコアの群ごとの平均値である。図6に示す通り、PFS25抽出液群のマウスの発毛面積スコアの平均値が、対照群のマウスの発毛面積スコアの平均値と比較して約1.3倍増加した。また、PFS50抽出液群のマウスの発毛面積スコアが、対照群のマウスの発毛面積スコアと比較して約1.5倍改善した。 FIG. 6 is an average value for each group of hair growth area scores determined by consultation of two judges. As shown in FIG. 6, the average value of the hair growth area score of the mice in the PFS25 extract group increased about 1.3 times compared to the average value of the hair growth area score of the mice in the control group. Moreover, the hair growth area score of the mouse | mouth of the PFS50 extract group improved about 1.5 times compared with the hair growth area score of the mouse | mouth of a control group.
このように、対照群に比べ、PFS抽出物は、経口投与による高い発毛効果を有している。 Thus, compared with the control group, the PFS extract has a high hair growth effect by oral administration.
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