JP2019176815A - Constant temperature conveyance box, conveyance rack used for constant temperature conveyance box, and constant temperature conveyance apparatus combined with the same - Google Patents

Abstract

To provide a constant temperature conveyance box for conveying an artificially cultured stem cell or tissue while maintaining a constant temperature state.SOLUTION: A constant temperature conveyance box 2 for conveying an object to be conveyed while maintaining the temperature of the object within a desired temperature range comprises: a metal heat transfer container 3 which stores the object to be conveyed in a hollow part thereof while blocking the object from outside air; an insulated container 4 which houses the heat transfer container 3; a heat transfer plate 5 which is arranged on a bottom of the insulated container 4 and equipped with a first fitting part 5c detachably fitted with a bottom surface of the heat transfer container 3; and temperature adjusting means 6 provided on a rear surface side of the heat transfer plate 5.SELECTED DRAWING: Figure 3

Description

  The present invention is capable of storing an object to be transported while maintaining aseptic conditions, is easy to maintain the object to be transported in a constant temperature state with high accuracy, and is also easy to carry. The present invention relates to a transport rack used for a transport box and a thermostatic transport device combining these.

In general, regenerative medicine is performed by transplanting a stem cell or the like artificially cultured outside the patient's body or a tissue artificially constructed from the stem cell or the like outside the patient's body into the patient's body, and the like. Defined as medical care to regenerate and restore lost human function.
Usually, both the operation of culturing stem cells collected from a patient and the operation of artificially constructing a tissue from stem cells collected from a patient are often performed in places other than medical institutions.
For this reason, when transplanting artificially cultured stem cells or body tissues to a patient, it is necessary to transport them to a medical institution that performs transplantation to the patient.
On the other hand, in order to sufficiently maintain the functions of the stem cells or body tissues cultured during transportation, temperature management and hygiene management at that time are extremely important.
As the prior art belonging to the technical field related to the present invention, the following are known.

Patent Document 1 discloses an invention relating to a culture box technology for culturing an object such as a cultured cell used in regenerative medicine while controlling the temperature so as not to destroy the biological characteristics of the object under the name “culture box”. Has been.
When the invention disclosed in Patent Document 1 is described using the reference numerals described in the document as they are, the box 4 having a heat insulating function, and the surrounding walls 5 and 6 made of aluminum alloy disposed in the box 4. A pseudo object 9 arranged inside the surrounding walls 5, 6, a temperature sensor 10 for measuring the temperature of the pseudo object 9, Peltier elements 13, 14 arranged in the box 4, and temperature control A battery 12 that supplies power to the means 13, 14, a computer 11 that controls power based on the output of the temperature sensor 10, and a gas regulator 8, and the pseudo object 9 is a culture substrate 1 a of the culture object 1. The culture object 1 and the gas regulator 8 are culture boxes that are housed in the surrounding walls 5 and 6 at least in the same specific heat.
According to the invention disclosed in Patent Document 1 described above, a lightweight culture box that can accurately maintain the temperature in a container containing a culture object such as cultured cells within a target temperature range. Can be provided.

In Patent Document 2, the name “carrying box” is used for a medical enforcement organization far away from a manufacturing facility while controlling the temperature of an object such as cultured cells used for regenerative medicine so as not to destroy the biological characteristics of the target. An invention relating to the technology of a transport box that can also transport the product is disclosed.
When the invention disclosed in Patent Document 2 is described using the reference numerals described in the document as they are, the object 1 to be conveyed is placed inside the enclosure wall 5 made of aluminum alloy disposed in the box 4 having a heat insulating function. A pseudo object 9 having at least the same specific heat as that of the culture substrate 1a is arranged, and the temperature of the pseudo object 9 is further measured, and the Peltier elements 13 and 14 installed in the box 4 are controlled according to the output value. Thus, the temperature of the pseudo object 9 is configured to be a target temperature.
According to the invention disclosed in Patent Document 2 having the above-described configuration, a lightweight transport box that can accurately maintain the temperature in a container containing a transport object such as cultured cells at a target temperature is provided. be able to.

Patent Document 3 discloses an invention related to a temperature management transport box, which is named “temperature management transport box” and accommodates an object to be transported that requires strict temperature management such as a blood product and transports it to a necessary place while controlling the temperature. It is disclosed.
The invention disclosed in Patent Document 3 has a heat-insulating container having an opening opened upward and an opening opened upward, and is mounted inside the heat-insulating container to accommodate an object to be conveyed. An electron having a heat transfer container, a heat insulating lid that opens and closes the opening of the heat insulating container supported by a hinge on the back upper end of the heat insulating container, and a Peltier element thermally connected to the heat transfer container A temperature adjusting unit, a box main body provided with a temperature sensor for controlling the temperature in the heat transfer container, and a component storage unit integrally provided adjacent to the box main body, the component storage unit, A recording / display unit having an information reading unit for reading individual information of an object to be taken in and out of the box main body unit and ID information for each operator, a display unit for displaying temperature information detected by a temperature sensor, and a heat insulating container And a lock means for automatically locking the heat insulation lid so that it does not open. The information reading section and the lock means are provided on the front side of the temperature management transport box on the operator standing position side of the component storage section. Is provided in the back side of the temperature management transport box with respect to the information reading unit.
According to the invention disclosed in Patent Document 3 having the above-described configuration, temperature management that enables management of an operator involved in taking in / out of the transported object and the removal / loading of the transported object and less movement of the operator at the time of loading / unloading the transported object. A transport box can be provided.

Patent Document 4 discloses an invention relating to a thermostatic box for controlling the temperature of a nest box of a pollinating insect such as a bumblebee under the name of "a thermostatic box for a pollinating insect such as a bumblebee".
A constant temperature box for pollinating insects such as bumblebees, which is an invention disclosed in Patent Document 4, includes a constant temperature box body for storing a nest box of pollinating insects such as bumblebees, and the inside of the constant temperature box main body of the pollinating insect. It is composed of a temperature control device storage section having a temperature control means for maintaining the optimum growth environment temperature zone, and this temperature control control device storage section is arranged on the opening side of the thermostatic box body. .
In providing a thermostatic box for pollinating insects such as bumblebees of the above configuration, not only the replacement of the nest box, the occurrence of uneven temperature inside the thermostatic box, but also the drainage of condensed water can be improved. .

Japanese Patent Laying-Open No. 2015-165789 JP2015-156822A Japanese Patent Laying-Open No. 2015-131081 Japanese Patent Laid-Open No. 2003-88

In the case of the invention disclosed in Patent Document 1, it is desirable to maintain the space for housing the culture vessel 2 in a sterile state in order to prevent contamination during the transportation of the contents of the culture vessel 2.
However, in the invention disclosed in Patent Document 1, the surrounding walls 4 and 5 accommodating the culture vessel 2 are not configured to be removable from the heat insulating outer box 4 due to its configuration. For this reason, it is necessary to sterilize the entire culture box, which is an invention product disclosed in Patent Document 1, but it is not practical to sterilize the culture box itself using an autoclave or a sterilization gas every time it is used. Absent.

In the case of the invention disclosed in Patent Document 2, it has substantially the same configuration as that of the invention disclosed in Patent Document 1, but the individual culture containers 2 accommodated in the surrounding wall 5 are individually bags 3 Since it is enclosed and accommodated in the inside, the subject which the invention disclosed by patent document 1 has does not arise.
However, if the cultured cells being transported require a gas such as oxygen for breathing, the amount of gas sealed together with the cultured cells in the bag 3 will determine the time that the cultured cells can be transported. Become. Therefore, the invention disclosed in Patent Document 2 has a problem that it is not suitable for long-term movement of cultured cells.
In view of such circumstances, a countermeasure such as pre-sealing a high-concentration gas in the bag 3 may be considered. However, in order to store the culture vessel 2 in the transport box disclosed in Patent Document 2, it is necessary to separately enclose each of them together with a high-concentration gas in the bag 3, and this operation is constantly repeated. That was extremely cumbersome.

In the case of the invention disclosed in Patent Document 3, the heat transfer container 8 connected to the temperature adjustment unit 10 is provided inside the heat insulating container 5, and the object to be conveyed is accommodated in the heat transfer container 8. It is considered that the temperature can be efficiently transmitted to the conveyance object.
However, in the case of the invention disclosed in Patent Document 3, as in the case of the invention disclosed in Patent Document 1, the heat transfer container 8 cannot be separated from the heat insulating container 5, and therefore disclosed in Patent Document 1. There is a concern that the same problem as in the case of the invention to be generated occurs.
However, in the case of the invention disclosed in Patent Document 3, since the object to be transported is double-wrapped (see FIG. 3 in Patent Document 3), there is no need to sterilize the temperature management transport box 1 itself. Seem.

  In the case of the invention disclosed in Patent Document 4, it is considered that the heat generated in the Peltier element 20 is transmitted to the plate 21 and the nest box 13 in the thermostat box body 2 can be efficiently kept warm, while the position close to the plate 21 There is a problem that a temperature difference is easily generated between the nest box 13 and the nest box 13 at a position away from the plate 21, and it is difficult to keep the object warm.

  The present invention has been made in response to such conventional problems, and its purpose is to facilitate sterilization of the container itself that accommodates the object to be conveyed and to convey the object to be conveyed while maintaining the aseptic condition. Another object of the present invention is to provide a constant temperature transfer box that can suitably prevent temperature unevenness in a transfer object during transfer, a transfer rack used for the constant temperature transfer box, and a constant temperature transfer device that combines these. .

A constant temperature transport box which is the first invention for achieving the above object is a constant temperature transport box for transporting while keeping the temperature of a transport object in a desired temperature range, which is made of metal and hollow. A heat transfer container that stores the object to be transported while being blocked from outside air, a heat insulating container that contains the heat transfer container, and a bottom of the heat transfer container, and is detachably fitted to the bottom surface of the heat transfer container And a temperature adjusting means provided on the back surface side of the heat transfer plate.
In the first invention having the above-described configuration, the heat transfer container has an action of storing the object to be transported in the hollow portion while blocking the object to be conveyed from the outside air. The outside air here means the air outside the heat transfer container, not the air outside the constant temperature transport box. Therefore, unless the heat transfer container is opened, the object to be transferred is not exposed to the outside air of the heat transfer container even when the heat transfer container is taken out from the constant temperature transfer box. Moreover, the heat insulation container has the effect | action of accommodating a heat transfer container so that attachment or detachment is possible. Furthermore, the heat transfer plate has an effect of quickly transferring heat (heat radiation or heat absorption) transmitted from the temperature adjusting means to the entire area of the heat transfer plate. In addition, the heat transfer plate has an action of being detachably fitted to and integrated with the bottom surface of the heat transfer container via the first fitting portion. The first fitting portion interposed between the heat transfer plate and the heat transfer container prevents the heat transfer container from being displaced when the heat transfer container is accommodated in the heat insulating container, and heat transfer. It has the effect of smoothing the heat transfer from the plate to the heat transfer container. Moreover, the temperature control means provided in the back surface of a heat exchanger plate has the effect | action of heating or cooling a heat exchanger plate by radiating or absorbing heat with respect to a heat exchanger plate.
In such 1st invention, the heat | fever (heat radiation or heat absorption) which arises in a temperature control means is transmitted to a heat-transfer container via a heat-transfer plate, and thereby the conveyance target accommodated in a heat-transfer container is heated or To be cooled.

The constant temperature transport box according to the second invention is the first invention described above, wherein the first temperature measuring means for measuring the temperature in the heat transfer container and the second measurement for measuring the temperature of the heat transfer plate. Heat dissipation means, a Peltier element provided on the back side of the heat transfer plate, and a heat dissipation element provided on the surface of the Peltier element on which the heat transfer plate is not joined and disposed outside the heat insulating container A temperature adjusting means comprising a fin; and a control means for controlling the Peltier element based on the measured value of the first and / or second temperature measuring means. is there.
In addition to the same action as that of the first invention described above, the second temperature measuring means constituting the temperature adjusting means measures the temperature in the heat transfer container. It has the effect of making it possible to monitor the temperature in the heat transfer container. Further, the second temperature measuring means constituting the temperature adjusting means measures the temperature of the heat transfer plate and has an effect of enabling monitoring of the state of heat dissipation or heat absorption by the Peltier element. Furthermore, the Peltier element that constitutes the temperature control means is an electronic component that utilizes the principle that heat is transferred between metals by joining different metals and flowing current therethrough. On one side of the Peltier element, A cooling (endothermic) effect is obtained, and a heat radiating (heating) effect by self-heating is exhibited on the other side. Further, when the polarity of the current to the Peltier element is reversed, the relationship between cooling and heat dissipation in the Peltier element is also reversed. For this reason, it has the effect | action of switching the heating or cooling with respect to a heat exchanger plate suitably, and enabling it to control the temperature in a heat exchanger container with high precision by providing a temperature control means with a Peltier device. Furthermore, the heat dissipating fins constituting the temperature adjusting means have an effect of dissipating heat generated from the Peltier element to the outside of the heat insulating container as necessary.
Further, the control means changes the on / off of the current to the Peltier element and changes the polarity of the current to the Peltier element based on the measurement value by the first and / or second temperature measuring means. It has the effect | action of heating or cooling a heat exchanger plate with an element.
In such a second invention, the temperature adjusting means includes the Peltier element, and the heat dissipating fins provided on the Peltier element are arranged outside the heat insulating container, so that unnecessary heat generated in the Peltier element is reduced. The heat can be reliably radiated to the outside of the heat insulating container, and the temperature inside the heat transfer container can be lowered without feeding outside air (air outside the thermostatic box) into the heat insulating container.

A constant temperature transport box according to a third aspect of the invention is the second aspect of the invention described above, characterized in that the constant temperature transport box is provided with an air passage that is formed of a cylindrical body and in which a heat radiation fin is accommodated in the hollow portion. To do.
In the third aspect of the present invention, in addition to the same action as that of the above-described second aspect of the invention, when the air passage in which the heat radiation fin is accommodated is provided in the hollow portion, the heat radiation fin is transported at a constant temperature. When cooling by the outside air with respect to the box, it has the effect | action that the flow path of the outside air which cools the fin for thermal radiation is made only in an inside of a wind path.
In this case, the provision of the air passage has the effect of efficiently supplying outside air to the fins for heat dissipation.
Further, by providing the air passage, the constant temperature transport box according to the third aspect of the invention is also clearly divided into a portion that is constantly exposed to various germs in the outside air (in the air passage) and other portions. Thereby, it has the effect | action of making the hygiene management of the constant temperature conveyance box which is 3rd invention easy.

A constant temperature transport box according to a fourth aspect of the present invention is any one of the first to third aspects described above, wherein a transport rack that holds a transport object is detachably fitted to the bottom surface of the heat transfer container. The second fitting part is provided.
According to the fourth aspect of the present invention, in addition to the same operation as the above-described first to third aspects, the second fitting portion is a transport rack for holding a transport target object in the heat transfer container. It has the effect | action of preventing the position shift at the time of accommodating.
In particular, when the transport rack is made of metal, heat is also transmitted to the transport rack via the second fitting portion. As a result, in addition to the heat transferred from the heat transfer container, the transfer target object is also heated or cooled by the heat transferred from the transfer rack.

The transport rack according to the fifth invention is made of metal and has a heat transfer container for storing the object to be transported in the hollow portion while blocking the object from outside air, and temperature adjusting means capable of heating or cooling from the bottom surface of the heat transfer container. And a transport rack that holds the transport target and is used for transporting the transport target while maintaining the temperature of the transport target in a desired temperature range, and the transport target in the heat transfer container A metal shelf plate that supports the metal plate, and at least one metal heat transfer that is provided in contact with the shelf plate and that is led to the lower surface side of the shelf plate and receives heat conduction from the bottom surface of the heat transfer container And a support.
In the fifth invention having the above-described configuration, the metal shelf board supports the object to be transported, and is transmitted to the shelf board through heat transferred from the heat transfer column and air stored in the heat transfer container. It has the effect of transferring heat to the object to be conveyed. Further, the heat transfer column has an effect of transmitting heat transmitted from the bottom of the heat transfer vessel and heat transferred to the heat transfer column via the air accommodated in the heat transfer vessel to the metal shelf. .
Therefore, according to 5th invention, it has the effect | action which transfers a heat | fever efficiently to the conveyance target object accommodated in the heat transfer container compared with the case where a conveyance rack is not provided.
Furthermore, in the fifth invention, the object to be transported is not placed directly on the bottom of the heat transfer container, but is supported through the heat transfer strut in contact with the shelf plate, and at the same time heat is transmitted, It also has the effect of suppressing rapid temperature changes.

A transport rack according to a sixth invention is the fifth invention described above, and includes a plurality of shelf boards arranged in layers and a band that binds and fixes the plurality of shelf boards. It is characterized by.
In addition to the same operation as that of the above-described fifth invention, the sixth invention having the above-described configuration can simultaneously transport a plurality of transport objects by including a plurality of shelves. It has the effect of making it. Further, the band has an action of bundling a plurality of shelf boards and fixing them together.
According to such 6th invention, it becomes possible to hold | maintain so that a conveyance target object may be clamped between the layers of shelf boards. In this case, when carrying a plurality of objects to be conveyed together, the objects to be conveyed contact or collide with each other during conveyance, or the object to be conveyed away from the shelf board is prevented from becoming difficult to transfer heat. Has an effect.

A constant temperature transport apparatus according to a seventh aspect of the present invention includes the constant temperature transport box according to any of the first to fourth aspects of the invention and the transport rack according to the fifth or sixth aspect of the invention. It is.
The seventh invention described above has an action combined with the action of the constant temperature transport box according to any of the first to fourth inventions described above and the action of the transport rack according to the fifth or sixth invention.

According to the first invention as described above, the heat (heat radiation or heat absorption) generated in the temperature adjusting means is transmitted from the heat transfer container directly to the object to be transported through the air in the heat transfer container. Furthermore, in the first invention, since the heat transfer container for storing the object to be transported is made of metal and covers the entire surface of the object to be transported, heat can be efficiently transferred from the four sides of the object to be transported. Can do.
Furthermore, in the first invention, since the heat transfer container can be separated from the heat insulating container, only the heat insulating container can be sterilized. Furthermore, since the heat transfer container is made of metal, the heat transfer container can be surely sterilized by sterilization gas or heat (autoclave or the like).
In addition, in the first invention, since the heat transfer container can be separated from the heat insulating container, only the sterilized heat transfer container is brought into the clean bench, for example, and the heat transfer container is hollow in the clean bench. The operation of storing the object to be transported in the section can be performed. In this case, since the inside of the clean bench is always kept sterile, the air in the heat transfer container is also kept sterile. As a result, both the conveyance object and the air stored in the heat transfer container can be taken out of the clean bench while being maintained in a sterile state.
Therefore, according to 1st invention, the risk that the conveyance target object accommodated in a heat-transfer container at the time of conveyance will be contaminated with various germs etc. can be made very small. Thus, when transplanting the stem cells or tissue transported using the first invention to a patient and performing regenerative medicine, the patient who has undergone transplant surgery suffers from an infectious disease, or the stem cells or tissue transplanted to the patient Can reduce the risk of malfunction due to contamination by bacteria.

  According to the second invention, in addition to the same effect as the effect of the first invention described above, the on / off of the current to the Peltier element and the change in the forward / reverse direction of the polarity of the current to the Peltier element are By performing based on the measured value of the temperature measuring means and / or the second temperature measuring means, the temperature in the heat transfer container can be controlled with high accuracy.

According to the third invention, in addition to the same effect as the above-described second invention, the air passage is provided, so that the outside air is efficiently supplied to the heat-dissipating fin and the heat-radiating fin is passed. Outside air can be efficiently discharged out of the constant temperature transport box.
Further, according to the third invention, since the part where the outside air flows in the constant temperature transport box can be limited to only the air passage, the inside of the constant temperature transport box other than the inside of the air passage is contaminated by germs in the outside air. It can prevent suitably.

In addition to the same effects as the effects of the first to third inventions described above, the fourth invention includes the second fitting portion, so that the transport rack is accommodated in the heat transfer container. In addition, it is possible to suitably prevent the displacement of the transport rack.
In particular, when the transport rack is made of metal, heat (heat radiation or heat absorption from the temperature adjusting means) can be transferred from the bottom of the heat transfer container to the transport rack, and the transport rack can also efficiently transfer the object to be transported. Can transfer heat well.

According to the fifth aspect, in addition to the heat (heat radiation or heat absorption) transmitted from the heat transfer container, the transfer object can be maintained in a desired temperature range by the heat transmitted from the transfer rack.
Moreover, it can prevent that the heat from a heat exchanger plate is directly transmitted to a conveyance target object because a conveyance target object is supported by the conveyance rack. In this case, quicker and more reliable temperature control can be realized while suppressing the occurrence of temperature unevenness in the conveyance target as compared to the case where heat is transferred from only the heat transfer container to the conveyance target.
As a result, it is preferable that the temperature of the object to be transported locally rises or falls unnecessarily, and the cultured cells that are the object to be transported die or that the intended function is impaired. Can be prevented.

According to the sixth invention, in addition to the same effect as the above-described fifth invention, it becomes easy to store and transport a plurality of objects to be transported in the heat transfer container.
In this case, since a plurality of shelf boards can be bundled and fixed with a band, a plurality of shelf boards, heat transfer columns and a plurality of conveyance objects are prevented from being scattered in the heat transfer container during the transfer. be able to. That is, according to the sixth invention, a plurality of objects to be conveyed can be stored in the heat transfer container in an organized manner.
Moreover, since a conveyance target object is clamped by the shelf board which is contacting the heat-transfer support | pillar, heat can be efficiently transmitted also from a shelf board with respect to a conveyance target object. As a result, temperature control can be performed gently and quickly and reliably on the object to be conveyed.

  7th invention has the effect combined with the effect by the constant temperature conveyance box which is one of the above-mentioned 1st thru | or 4th invention, and the effect by the conveyance rack which is 5th or 6th invention.

It is an external appearance perspective view of the constant temperature conveyance box which concerns on Example 1 of this invention. It is sectional drawing of the constant temperature conveyance box which concerns on Example 1 of this invention. It is sectional drawing in the other direction of the constant temperature conveyance box which concerns on Example 1 of this invention. It is a top view of the state which opened the cover of the outer container in the constant temperature conveyance box which concerns on Example 1 of this invention. It is a longitudinal cross-sectional view which shows an example of the conveyance target object conveyed by the constant temperature conveyance box which concerns on this invention, and the conveyance rack used for it. It is a longitudinal cross-sectional view of the conveyance rack which concerns on Example 2 of this invention holding the conveyance target object. It is a perspective view of the 1st shelf board and heat-transfer support | pillar of the conveyance rack which concern on Example 2 of this invention. It is a perspective view of the 2nd shelf board of the conveyance rack which concerns on Example 2 of this invention. It is a perspective view of the 3rd shelf board of the conveyance rack which concerns on Example 2 of this invention. It is a perspective view of the winding band of the conveyance rack which concerns on Example 2 of this invention. It is an image which shows the external appearance of the conveyance rack which concerns on Example 2 of this invention holding the conveyance target object.

  A constant temperature transport box according to an embodiment of the present invention, a transport rack used in the constant temperature transport box, and a constant temperature transport device combining these will be described in detail with reference to FIGS.

First, the constant temperature transport box according to the first embodiment of the present invention will be described with reference to FIGS. 1 to 4.
FIG. 1 is an external perspective view of a constant temperature transport box according to Embodiment 1 of the present invention. 2 is a cross-sectional view taken along line AA in FIG. 1, and FIG. 3 is a cross-sectional view taken along line BB in FIG. Further, FIG. 4 is a plan view showing a state where the cover of the outer container is opened in the constant temperature transport box according to the first embodiment of the present invention.
The constant temperature transport box 2 according to the first embodiment is a portable container for transporting while keeping the temperature of a transport target in a desired temperature range. As shown in FIGS. 2 and 3, the constant temperature transport box 2 according to the first embodiment mainly transports a transport target (for example, the transport target 33 of FIG. A metal heat transfer container 3 that can be stored while being cut off from the air outside the heat transfer container), a heat insulating container 4 that houses the heat transfer container 3, and a bottom of the heat insulating container 4. And the heat-transfer plate 5 provided with the 1st fitting part 5c detachably fitted with the bottom face of the heat-transfer container 3, and the temperature control means 6 provided in the back surface side of this heat-transfer plate 5; , Is provided.
In addition, the heat transfer container 3 in the constant temperature transport box 2 according to the first embodiment has a first fitting portion that fits with a first fitting portion 5c provided on the heat transfer plate 5 at the bottom on the outer surface thereof. 3e.
In FIGS. 2 and 3, the case where the heat transfer plate 5 is formed of a laminated body of the heat transfer plates 5a and 5b is described as an example, but the heat transfer plate 5 may be a single layer.
Further, in the constant temperature transport box 2 according to the first embodiment as described above, the metal heat transfer container 3 can be detached from the heat insulating container 4.

According to the constant temperature transport box 2 according to the first embodiment as described above, the heat transferred from the temperature adjusting means 6 to the heat transfer plate 5 due to the metal of the heat transfer container 3 (hereinafter referred to as the present specification). In the case of “heat”, it means either “radiation” or “heat absorption”), and can be quickly transmitted to the heat transfer container 3.
Moreover, since the heat transfer container 3 is an airtight container, when a conveyance target object is accommodated in the hollow part of the heat transfer container 3, heat can be transmitted to the conveyance target object from four sides of the conveyance target object. For this reason, according to the constant temperature conveyance box 2 which concerns on Example 1, a conveyance target object can be maintained in a desired temperature range, suppressing generation | occurrence | production of temperature nonuniformity.
Furthermore, in the constant temperature conveyance box 2 which concerns on Example 1, the 1st fitting part 3e in the heat-transfer container 3 and the 1st fitting part 5c in the heat-transfer plate 5 fit, and a heat-transfer plate The bottom surface of the heat transfer container 3 can be brought into close contact with the upper surface of 5.
In this case, when the heat transfer container 3 is accommodated in the heat insulating container 4, the heat transfer container 3 can be fixed on the heat transfer plate 5 without causing a positional shift. In addition, in this case, heat can be directly transferred from the heat transfer plate 5 to the heat transfer container 3. As a result, temperature control of the conveyance object accommodated in the heat transfer container 3 can be facilitated.

Furthermore, in the constant temperature transport box 2 according to the first embodiment, the heat transfer container 3 can be completely separated from the heat insulating container 4. Moreover, since the material of the heat transfer container 3 is metal, the heat transfer container 3 can be sterilized all over using an autoclave or the like, or using a sterilizing gas or the like.
The heat transfer container 3 that has been sterilized can be brought into the clean bench as it is by sealing it in a packaging container made of resin, for example, while maintaining aseptic conditions. In this case, the resin packaging container is opened in the clean bench, the sterilized heat transfer container 3 is taken out, and the object to be transported is stored in the heat transfer container 3 in the clean bench. By sealing, both the air stored in the heat transfer container 3 and the object to be transported can be surely made sterile.
Therefore, according to the constant temperature transport box 2 according to the first embodiment, it is not necessary to perform any complicated work such as packaging individual transport objects individually while maintaining aseptic conditions. As a result, according to the constant temperature transport box 2 according to the first embodiment, the transport object can be transported while maintaining the aseptic condition.

Then, each component of the constant temperature conveyance box 2 which concerns on Example 1 is demonstrated in detail.
The heat transfer container 3 according to the first embodiment includes, for example, as shown in FIGS. 2 and 3, a main body 3 b that is a hollow container having an upper opening, a lid 3 a that is covered so as to close the upper opening, A packing 3c interposed between the lid 3a and the main body 3b, and a fixture 3d (for example, a snap lock) for fixing the lid 3a to the upper opening of the main body 3b may be provided (both are selected) Components).
In this case, the conveyance object can be sealed in the heat transfer container 3.
Moreover, the form of the heat transfer container 3 does not have to be specified as shown in FIGS. 2 and 3, and the packing 3 c may not be provided as long as a sealed state can be realized without the packing 3 c. A fixture 3d having a shape other than those shown in FIGS.

Furthermore, the 1st fitting part 5c of the heat exchanger plate 5 distribute | arranged to the bottom of the heat insulation container 4 and the 1st fitting part 3e provided in the bottom face on the outer surface of the heat transfer container 3 fit. Even in this case, the heat transfer container 3 may be detached from the heat transfer plate 5 due to vibration when the heat insulating container 4 is conveyed.
Therefore, the constant temperature transport box 2 according to the first embodiment may include a fixing band 15 and a band fixture 14 for fixing the heat transfer container 3 in the heat insulating container 4 as shown in FIG. Good (both optional components).
In this case, it is possible to suitably prevent the heat transfer container 3 from being displaced in the heat insulating container 4 during the transport of the constant temperature transport box 2 according to the first embodiment.

Moreover, as shown in FIGS. 2 and 3, the temperature adjusting means 6 in the constant temperature transport box 2 according to the first embodiment is, for example, on the back surface side of the heat transfer plate 5 (the surface on which the heat transfer container 3 is not fitted). A Peltier element 8 provided; and a heat dissipating fin 9 provided on the surface of the Peltier element 8 where the heat transfer plate 5 is not joined and disposed outside the heat transfer container 3. (Both are optional components).
Furthermore, the constant temperature transport box 2 according to the first embodiment includes the first temperature measuring means 7a (see FIG. 3) for measuring the temperature in the heat transfer container 3 in addition to the above configuration, and the temperature of the heat transfer plate 5. On the basis of the second temperature measuring means 7b to be measured (see FIG. 2) and the measured value of the first temperature measuring means 7a and / or the first temperature measuring means 7a, the current on / off of the Peltier element 8 is turned on. And a control means 16 for changing the polarity of the current to the Peltier element 8 (all are optional components).
2 and 3, the first temperature measuring means 7a is connected to the first temperature measuring means connecting portion 21 shown in FIG. 4, and this first temperature measuring means connecting portion 21 is not shown. Is connected to the control means 16 (see FIG. 3) by wiring not shown.
The second temperature measuring means 7b is also connected to the control means 16 by a wiring not shown.

Moreover, when the conveyance object of the constant temperature conveyance box 2 which concerns on Example 1 is the stem cell and structure | tissue which were extract | collected from the body tissue and artificially cultured, the state where the temperature of the culture solution at the time of conveyance exceeded 40 degreeC continues long. If the cell itself is killed or its physiological activity is lost, the intended function is impaired. For this reason, in the constant temperature conveyance box 2 which concerns on Example 1, management of the upper limit temperature in the heat exchanger vessel 3 is especially important.
In view of such circumstances, in the constant temperature transport box 2 according to the first embodiment, the measured value of the temperature in the heat transfer container 3 by the first temperature measuring means 7a and the heat transfer plate 5 by the second temperature measuring means 7b. The Peltier element 8 can also be controlled based on the measured temperature value.
Thus, by controlling the Peltier element 8 based on the measured value of the first temperature measuring means 7a and / or the second temperature measuring means 7b, the temperature in the heat transfer container 3 exceeds 40 ° C. Or it can prevent suitably that the state in which the temperature in the heat-transfer container 3 exceeded 40 degreeC continues.

Furthermore, the constant temperature transport box 2 according to the first embodiment may include a fan 10 for supplying cooling air (air outside the constant temperature box) to the heat dissipating fins 9 in addition to the above configuration. (Optional component, see FIG. 2).
In this case, by controlling the fan 10 based on the measurement value of the first temperature measuring means 7a and / or the second temperature measuring means 7b, the temperature in the heat transfer container 3 is controlled more precisely and finely. be able to.
More specifically, for example, when the first temperature measuring means 7a detects that the temperature in the heat transfer container 3 has reached 40 ° C., the current to the Peltier element 8 is turned off, or the Peltier The current electrode for the element 8 is switched, and at the same time, the fan 10 is operated to lower the temperature of the heat transfer plate 5 to prevent the temperature in the heat transfer container 3 from rising further, or the Peltier element 8 The inside of the heat transfer container 3 can be cooled using the function.
As described above, the constant temperature transport box 2 according to the first embodiment includes the fan 10, and the fan 10 is further controlled based on the measurement value of the first temperature measuring means 7 a and / or the second temperature measuring means 7 b. By being controlled by 16, the temperature in the heat transfer container 3 can be finely controlled.

Furthermore, the constant temperature transport box 2 according to the first embodiment controls the heat insulating container 4 that houses the heat transfer container 3, the heat dissipating fins 9 disposed outside the heat insulating container 4, and the Peltier element 8. The control means 16 for the above and a battery 19 for operating the Peltier element 8, the control means 16 and the like may be provided in the main body 12b of the outer container 12 (all are optional components). In addition, the constant temperature transport box 2 according to the first embodiment may include a lid 12a of the outer container 12 that also serves as a lid of the heat insulating container 4 in an upper opening of the heat insulating container 4 (a selective component).
In this case, the lid 12a is rotatably fixed to a desired side portion of the opening portion of the main body 12b constituting the outer container 12 (opening portion of the heat insulating container 4) via, for example, a hinge 12c (see FIG. 2). The side of the lid 12a that does not rotate when the lid 12a is closed may be fixed to the main body 12b in a freely openable / closable manner by a fixture 12d (for example, see FIG. 2). Optional component).
In this case, each component of the constant temperature transport box 2 according to the first embodiment can be easily carried in a state of being stored in the outer container 12. Furthermore, by providing the handle 12 (optional component) on the lid 12a of the outer container 12, the constant temperature transport box 2 according to the first embodiment can be easily carried manually.

1 and 3, the constant temperature transport box 2 according to the first embodiment includes a monitor unit 18 for enabling the temperature in the heat transfer container 3 to be confirmed from the outside of the outer container 12, as shown in FIGS. 12 (optional component).
Such a monitor unit 18 is connected to the control means 16 and the battery 19 (not shown), and can display the measured temperature in the heat transfer container 3 and its transition when necessary. Further, the remaining amount of the battery 19 and the constant temperature maintenance time can be displayed as necessary. Alternatively, by providing an input means (not shown) separately in the monitor unit 18, the set temperature in the heat transfer container 3 can be changed as desired.
In this case, the user of the constant temperature transport box 2 according to the first embodiment determines whether or not the temperature in the heat transfer container 3 is properly maintained through the monitor unit 18, the remaining amount of the battery 19, or the heat transfer container 3. The set temperature inside can be easily confirmed from the outside of the outer container 12.
In addition, as shown in FIG. 4, the constant temperature transport box 2 according to the first embodiment includes a switch 17 for switching on and off the temperature adjusting means 6 in the heat insulating container 4, and a first temperature measuring means 7a as necessary. And the external memory connection part 20 for connecting the external memory for memorize | stored the measured value of the 2nd temperature measuring means 7b may be provided (all are selective components).

In addition, when the constant temperature transport box 2 according to the first embodiment is provided with the fan 10 in particular, as shown in FIGS. 2 and 3, the air passage 11 in which the heat radiation fin 9 and the fan 10 are accommodated in the hollow portion. (Optional component). Note that the air passage 11 may be arranged so as to penetrate the portion of the main body 12b of the outer container 12 where the heat insulating container 4 is not accommodated in the horizontal direction. In this case, the flow path of outside air (air outside the constant temperature box) for cooling the heat dissipating fins 9 is only in the air passage 11.
Usually, various germs that become a source of contamination of the object to be transported (stem cells or tissue cultured artificially) are present everywhere outside the constant temperature transport box 2 according to the first embodiment. In addition, when the heat insulating container 4 and a space other than the heat insulating container 4 in the constant temperature transport box 2 are connected due to wiring or the like, external germs are cooled by the fan 10 as the heat dissipating fins 9 are cooled. There is a risk of intrusion into 4. Moreover, although the constant temperature conveyance box 2 which concerns on Example 1 is comprised so that the inside of the heat-transfer container 3 can be maintained in a sterilization state as above-mentioned, the inside of the heat insulation container 4 is also a sterilization state on the characteristic of a conveyance target object. It is preferable.

In this regard, the constant temperature transport box 2 according to the first embodiment includes the air passage 11 outside the heat insulating container 4 and the heat radiation fins 9 and the fans 10 are accommodated in the air passage 11 so as to prevent contamination. The flow path of a certain outside air (air outside the thermostatic box) can be separated from the heat insulating container 4 completely only in the air passage 11. Thereby, at the time of use of the constant temperature conveyance box 2 which concerns on Example 1, the risk that parts other than the inside of the airway 11 will be contaminated with various germs can be reduced significantly.
In addition, when the constant temperature conveyance box 2 which concerns on Example 1 is provided with the air passage 11, you may provide the net | network 12e in each of the opening which makes the inlet and the exit (selective component). In this case, it is possible to suitably prevent foreign matter from entering the air passage 11 from the outside of the constant temperature transport box 2 according to the first embodiment.
In FIG. 2, the case where two fans 10 are provided in the air passage 11 is described as an example, but one fan 10 may be provided.

Moreover, when conveying a conveyance target object by the constant temperature conveyance box 2 which concerns on Example 1, a some conveyance target object may be conveyed collectively.
In this case, in order to store a plurality of objects to be transported in the heat transfer container 3 in a compact manner, the heat transfer container 3 may be provided with a transport rack (for example, see FIG. 11 shown later). Component).
On the other hand, when such a transport rack is provided in the heat transfer container 3, the transport rack may be displaced in the heat transfer container 3 during the transport of the constant temperature transport box 2 according to the first embodiment, or the transport rack may fall over. There is.
For this reason, as shown in FIGS. 2 and 3, the constant-temperature transport box 2 according to the first embodiment has a second fitting that is detachably fitted to the above-described transport rack at the bottom on the inner surface side of the heat transfer container 3. The unit 3f may be provided (optional component).
In this case, the 2nd fitting part 3f in the heat-transfer container 3 and the conveyance rack which is not illustrated can be fitted, and can be integrated so that attachment or detachment is possible. Thereby, when using the constant temperature conveyance box 2 which concerns on Example 1 in the state which accommodated the conveyance rack in the heat-transfer container 3, it can prevent suitably the position shift of the conveyance rack in the heat-transfer container 3, and a fall. it can.

Further, in particular, when the transport rack accommodated in the heat transfer container 3 is made of metal, in addition to the effect of preventing the position shift of the transport rack and the effect of preventing the fall, the heat from the bottom of the heat transfer container 3 is Can be indirectly transmitted to the object to be transported via the transport rack.
In this case, in addition to the heat from the heat transfer container 3, the transport object can be heated or cooled by heat from the transport rack holding the transport object.

Next, the transport rack 25 according to the second embodiment of the present invention will be described in detail with reference to FIGS.
The transport rack according to the second embodiment is a transport rack used for the constant temperature transport box 2 according to the first embodiment.
First, an example of a specific aspect of the conveyance target held on the conveyance rack according to the second embodiment will be described with reference to FIG.
FIG. 5 is a longitudinal sectional view showing an example of a conveyance object conveyed by the constant temperature conveyance box and the conveyance rack used therefor according to the present invention.
The conveyance object 33 of the product of the present invention is a cultured cell 39 that is cultured in a culture solution 37.
Further, such cultured cells 39 may be cultured on a culture sheet 38 that is a carrier as necessary. Further, the cultured cells 39 cultured in such a culture solution 37 are usually kept in a temperature range of 38 to 40 ° C. close to human body temperature while maintaining aseptic conditions in the petri dish 22 having an upper opening. Cultured in a dry state.

When the cultured cells 39 cultured in the petri dish 22 are transported, a lid 23 made of an elastic material is provided at the upper opening of the petri dish 22 so that the culture solution 37 does not spill from the petri dish 22. In this case, the cultured cells 39 and the culture solution 37 are sealed in the petri dish 22, and if the transport time is long, the cultured cells 39 may lack oxygen.
In view of such circumstances, it is desirable that the lid 23 provided on the petri dish 22 is provided with a ventilation film 23a capable of transmitting air while preventing the liquid from being transmitted at the center thereof.
Moreover, since the lid | cover 23 consists of elastic materials, it deform | transforms easily with external force. For this reason, when an unintended external force is applied to the lid 23, a gap may be formed between the petri dish 22 and the lid 23, and the culture solution 37 may leak out.
For this reason, an annular fixing ring 24 made of a material harder than the material constituting the lid 23 is fitted around the periphery of the lid 23 covered by the petri dish 22 to prevent the lid 23 from being deformed during conveyance. be able to.
In the present embodiment, the transport object 33 is a generic term for not only the cultured cells 39 but also the culture medium 37 and the petri dish 22, the lid 23, and the fixing ring 24 that are containers for storing them. Point to.

Next, a specific structure of the transport rack according to the second embodiment will be described with reference to FIGS.
FIG. 6 is a longitudinal sectional view of a transport rack according to the second embodiment of the present invention that holds a transport target. The same parts as those described in FIGS. 1 to 5 are denoted by the same reference numerals, and description of the configuration is omitted.
As shown in FIG. 6, the transport rack 25 according to the second embodiment is made of metal that supports, for example, the transport object 33 as shown in FIG. 5 in the heat transfer container 3 shown in FIGS. Shelf plate 26 (first shelf plate 26a, second shelf plate 26b) and the shelf plate 26 are provided in contact with the shelf plate 26 and led out to the lower surface side of the shelf plate 26, and the bottom surface of the heat transfer container 3 And at least one metal heat transfer column 31 that receives heat conduction.
In the transport rack 25 according to the second embodiment, first, heat is transmitted from the bottom surface of the heat transfer container 3 to the heat transfer column 31, and then, the heat transmitted to the heat transfer column 31 is the shelf plate 26 (first plate The heat is transmitted to the transport object 33 placed on the upper surface side of the shelf board 26 and finally transmitted to the shelf board 26a or the second shelf board 26b).
Therefore, since the heat transfer container 3 includes the transport rack 25 according to the second embodiment as described above, the transport object 33 is also generated by heat from the transport rack 25 in addition to heat from the heat transfer container 3. Can be heated or cooled.

Moreover, in the constant temperature conveyance box 2 which concerns on previous Example 1, the bottom face of the heat-transfer container 3 is directly contacting the heat-transfer plate 5 to which the Peltier element 8 is joined. For this reason, when the conveyance object 33 is directly placed on the bottom of the heat transfer container 3 in an attempt to maintain the conveyance object 33 in a desired temperature range, it is predicted that a rapid and large temperature change occurs in the conveyance object 33. . Such a rapid and large temperature change may cause problems such as a decrease in physiological activity of the cultured cell 39 that is the conveyance target 33 or a death.
Further, when the plurality of objects to be transported 33 are collectively accommodated and transported in the heat transfer container 3 and the transport rack 25 according to the second embodiment is not provided, the housing position of the transport object 33 is transmitted. It is considered that as the temperature approaches the bottom of the heat vessel 3, a rapid and large temperature change occurs in the conveyance object 33, and it is difficult to convey the individual conveyance objects 33 under the same temperature condition.

On the other hand, when the heat transfer container 3 according to the first embodiment includes the transport rack 25 according to the second embodiment, the transport object 33 is separated from the bottom of the heat transfer container 3. Can be held. In addition, since heat from the bottom of the heat transfer container 3 can be indirectly transmitted to the transfer target object 33 via the heat transfer column 31 and the shelf plate 26, conduction of heat to the transfer target object 33 is gently performed. It also has the effect that it can be done.
As a result, when a plurality of objects to be transported 33 are accommodated and transported in the heat transfer container 3, there is an effect that the degree of heat transfer to each of the objects to be transported 33 can be made uniform. As a result, it is possible to suitably suppress a difference in the temperature of the conveyance object 33 depending on the storage position of the conveyance object 33 in the heat transfer container 3.
In addition, also when the conveyance rack 25 which concerns on Example 2 is a multistage rack provided with the some shelf board 26, each by each shelf board 26 and the heat-transfer support | pillar 31 which is contacting this shelf board 26, respectively. The above-described gentle heating or cooling effect is exerted on the transport object 33.

Here, an example of the detailed structure of the transport rack 25 according to the second embodiment will be described in more detail with reference to FIGS.
FIG. 7 is a perspective view of the first shelf plate and the heat transfer column of the transport rack according to the second embodiment of the present invention. FIG. 8 is a perspective view of a second shelf board of the transport rack, and FIG. 9 is a perspective view of a third shelf board of the transport rack. Further, FIG. 10 is a perspective view of a winding band of the transport rack, and FIG. 11 is an image showing an appearance of the transport rack according to the second embodiment of the present invention holding a transport target. The same parts as those described in FIGS. 1 to 6 are denoted by the same reference numerals, and description of the configuration is omitted.
For example, as illustrated in FIG. 6, the transport rack 25 according to the second embodiment includes at least one heat transfer column 31 in an overlapping portion between the shelf boards 26 after alternately stacking the shelf boards 26 and the objects to be transported 33. May be brought into contact with each other and penetrated at other locations to be integrated.
Furthermore, the shelf plate 26 in the transport rack 25 according to the second embodiment includes a shelf plate 26 (first shelf plate 26a or second shelf plate 26b, FIGS. 7 and 8 that directly supports the object 33 to be transported. Reference) and a shelf board 26 (third shelf board 26c, see FIG. 9) used for fixing the conveyance object 33 placed on the shelf board 26.
Moreover, when the shelf board 26 and the conveyance target object 33 are laminated | stacked alternately, there exists a possibility that the transmission of the heat to the inside of these overlapping parts may worsen, and temperature may become non-uniform | heterogenous on the surface side and an inner side.

In order to deal with such a situation, in the transport rack 25 according to the second embodiment, the shelf plate 26 that supports the transport target 33 may be configured as illustrated in FIGS. 6 to 8.
Specifically, as shown in FIGS. 6 to 8, the shelf plate 26 according to the second embodiment is made of a metal-made flat plate plate 27 a or plate 27 b and a vent hole formed by cutting out the plate plate 27 a or plate 27 b. 29 and a plurality of metal support bases 28 arranged around the vent hole 29 may be used as the first shelf board 26a or the second shelf board 26b (both are optional components). ).
Further, when the first shelf plate 26 a or the second shelf plate 26 b shown in FIGS. 6 to 8 is used, the individual conveyance objects 33 are placed on the support base 28.
And when using the 1st shelf board 26a and the 2nd shelf board 26b as the shelf board 26, even if these and the conveyance target object 33 are laminated | stacked alternately, a clearance gap exists between the overlapped conveyance target objects 33. Will be formed. Then, the air heated or cooled in the heat transfer container 3 can freely enter and leave the gap.
For this reason, when the shelf board 26 is the 1st shelf board 26a or the 2nd shelf board 26b as shown in FIG. 6 thru | or FIG. 8, the conveyance target object 33 via the heat-transfer column 31 and the shelf board 26 is used. The heat is transmitted to the transport target object 33 not only from the air but also from the air flowing through the gap formed between the transport target objects 33 that overlap each other. That is, heat is transferred by the synergistic effect of both heat conduction and convection among the three principles of heat transfer.
Therefore, when the transport rack 25 according to the second embodiment includes the first shelf plate 26a and the second shelf plate 26b, each transport object 33 can be individually heated or cooled from four directions. The heating or cooling state for each conveyance object 33 can be made uniform quickly.

As described above, when the heat transfer container 3 includes the transport rack 25 according to the second embodiment, the transport object 33 can be stored in a state of being separated from the bottom of the heat transfer container 3. It is possible to prevent the heat from the hot plate 5 from being directly transmitted to the conveyance object 33.
Further, since the transport rack 25 is provided, the number of paths for indirectly transmitting heat to the transport target 33 is increased, so that heat can be transmitted to each transport target 33 gently and quickly without unevenness.
As a result, each of the objects to be conveyed 33 accommodated in the heat transfer container 3 can be maintained within a desired temperature range while suppressing a rapid and large temperature change.

7 and 8, in the first shelf plate 26a or the second shelf plate 26b, a hole 30a or a hole 30b for inserting the heat transfer column 31 into a desired position of the plate 27a or the plate 27b. Is drilled. Then, by inserting the heat transfer column 31 into the hole 30a or the hole 30b, the first shelf plate 26a or the second shelf plate 26b and the heat transfer column 31 are in contact with each other.
In addition, even though the second shelf plate 26b has the same shape as the first shelf plate 26a, the function as the transport rack 25 is not inferior, but when the plurality of first shelf plates 26a are stacked. In addition, it is necessary to insert the heat transfer column 31 through all the holes 30a each time, and the operation is extremely complicated.
For this reason, in the transport rack 25 according to the second embodiment, the second shelf 26b is used as the shelf 26 in the second and subsequent stages from the vertically lower side. The second shelf 26b is formed by cutting holes 30a arranged at the four corners of the first shelf 26a shown in FIG. 7 together with the plate 27a and forming contact sides 32 there (see FIG. 7). 8).
When such a second shelf 26b is used, when the second shelf 26b is stacked on the first shelf 26a, the second shelf 26b is transmitted to one hole 30b formed in the center of the plate 27b. Since it is only necessary to insert the thermal support 31, the installation work is extremely easy.
Further, in such a second shelf plate 26b, when the heat transfer column 31 is inserted into the hole 30b, the contact sides 32 formed at the four corners of the plate 27b are respectively disposed below the second shelf plate 26b. It abuts on the peripheral side surface of the heat transfer column 31 erected at the four corners of one shelf plate 26a. Thereby, even when there is only one heat transfer column 31 inserted through the second shelf 26b, the second shelf 26b does not rotate in the plane direction.

As a method for fixing the heat transfer column 31 to the first shelf 26a, as shown in FIG. 6, for example, the heat transfer column 31 is screwed to the main shaft 31a and the vertically lower end surface of the main shaft 31a. 31b (both are optional components).
In this case, after the main shaft 31a is inserted while being engaged with the hole 30a formed in the plate 27a, the screw 31b is attached to the vertical lower end surface of the main shaft 31a, so that heat is transferred to the first shelf 26a. The column 31 can be inserted while being fixed.
In this case, there is an advantage that the heat transfer column 31 can be detachably fixed to the first shelf 26a while reducing the number of parts of the transport rack 25 according to the second embodiment.

When the transport rack 25 is a multistage rack including a plurality of shelf plates 26 and heat transfer columns 31, there is a concern that the transport object 33 may be detached from the transport rack 25 due to vibration during transport.
Accordingly, the transport rack 25 according to the second embodiment may include a winding band 34 that bundles and fixes a plurality of stacked shelves 26 in order to avoid such troubles during transport (selective). Components, see FIGS.
Even when the winding band 34 is provided, the transport object 33 arranged at the top of the transport rack 25 according to the second embodiment is not directly or indirectly restrained by the winding band 34. There is still a concern that it may be detached from the transport rack 25.
For this reason, when the transport rack 25 according to the second embodiment includes the winding band 34, the transport object 33 disposed at the top of the transport rack 25 is placed at the top so that the transport target 33 can be reliably restrained. A third shelf 26c as shown in FIG. 9 may be provided on the transport object 33 to be arranged (optional component).
The third shelf plate 26c is composed of only the plate 27c, the vent hole 29, and the hole 30b (selective component).

As described above, when the transport rack 25 according to the second embodiment includes the first to third shelf plates 26 a to 26 c, the heat transfer column 31, and the winding band 34, the individual transport objects on the shelf plate 26. 33 can be held while being sandwiched. As a result, when carrying the constant temperature transport box 2 according to the first embodiment provided with the transport rack 25 according to the second embodiment, the transport object 33 is scattered in the heat transfer container 3 or between the transport objects 33. It can prevent suitably that temperature becomes non-uniform | heterogenous. Furthermore, in this case, the form of the transport rack 25 according to the second embodiment can be simplified, and the weight of the transport rack 25 can be reduced.
It is possible to use the first shelf plate 26a or the second shelf plate 26b instead of the third shelf plate 26c, but in this case, since the support base 28 is unnecessary, Problems such as a reduction in the number of transportable objects 33 that can be accommodated may occur.

In addition, as a specific aspect of the winding band 34 that bundles and fixes the plurality of shelf plates 26 in the transport rack 25 according to the second embodiment, for example, the one shown in FIG. 10 can be used.
As shown in FIG. 10, the winding band 34 according to the second embodiment includes, for example, an upper band 35 and a lower band 36 that are provided around the trunks of a plurality of stacked shelves 26, and these are mutually connected. It may be configured to be connectable to each other (both are optional components).
Such an upper band 35 of the winding band 34 is arranged on the vertically upper side of the laminate composed of the plurality of shelf boards 26. Further, both end portions of the upper band 35 that is made of metal and has a bent shape may be provided with snap locks 35b each provided with a loop 35a for latching.
Further, a hinge 35d (selective component) may be provided at the base of the snap lock 35b of the upper band 35 so that the angle formed by the snap lock 35b with respect to the planar direction of the upper band 35 can be changed. In this case, there is an advantage that the work of connecting the upper band 35 and the lower band 36 to form an annular shape can be facilitated.
Further, the lower band 36 is arranged on the vertically lower side of the laminated body made up of a plurality of shelf plates 26, and both end portions of the lower band 36 that is made of metal and has a bent shape are respectively formed on the upper band 35. You may provide the hook 36a for hooking on the loop 35a.
Furthermore, in the case where the heat transfer struts 31 are arranged at the scheduled positions of the winding band 34 (the upper band 35 and the lower band 36) as described above, the upper band 35 or the lower band 36 and the heat transfer strut 31 The hole 35c and the hole 36b may be provided at a position where the crosses. In this case, it is possible to prevent the heat transfer column 31 from interfering with the attachment and detachment of the winding band 34 by inserting the heat transfer column 31 into the hole 35c and the hole 36b.

Note that such a winding band 34 is provided around the body of the laminate composed of the conveyance object 33 and the shelf plate 26 (the first shelf plate 26a to the third shelf plate 26c), and these are integrated. An image showing the converted state is shown in FIG. 11 (prototype).
As described above, the transport rack 25 according to the second embodiment includes a plurality of shelf plates 26 (first shelf plate 26a to third shelf plate 26c), at least one heat transfer column 31, and a winding band 34. Can be stored in the heat transfer container 3 in a tidy state.
As a result, the conveyance object 33 and the conveyance rack 25 can be kept in close contact with each other in the heat transfer container 3 while preventing the conveyance object 33 from being scattered in the heat transfer container 3 during conveyance. The indirect heat transfer effect with respect to the conveyance target object 33 by the heat-transfer column 31 or the shelf board 26 can be heightened.

In particular, when the transport object 33 is a cultured cell 39 accommodated in the petri dish 22 as shown in FIG. 5, the opening of the petri dish 22 is sealed by the lid 23 and the fixing ring 24. If the transport rack 25 is provided with a winding band 34 as shown in FIGS. 6 and 11 during the transport, the shelf board 26 (second shelf board 26b and third shelf board 26c) and The fixing effect of the lid 23 by the fixing ring 24 is enhanced.
In this case, it is possible to suitably prevent the culture solution 37 from leaking from the petri dish 22 when the transport target 33 is transported, so that the cultured cells 39 are dried during transport or the cultured cells 39 are in a poor nutritional state. It can prevent suitably.
Therefore, according to the transport rack 25 according to the second embodiment, the physiological activity of the cultured cells 39 can be suitably maintained when transporting using the constant temperature transport box 2 according to the first embodiment.

Further, the second fitting portion 3f formed at the bottom on the inner surface side of the heat transfer container 3 of the constant temperature transfer box 2 according to the first embodiment is connected to the heat transfer column of the transfer rack 25 according to the second embodiment. When fitting the vertically lower end portion of 31, the vertically lower end portion of the heat transfer column 31 becomes the second fitting portion 40 in the transport rack 25 (see FIG. 6).
As described above, the heat transfer container 3 of the constant temperature transport box 2 according to the first embodiment and the transport rack 25 according to the second embodiment are detachably integrated via the fitting structure, so that at the time of transport. Oscillation and position shift of the transport rack 25 in the heat transfer container 3 can be suitably prevented. In addition, in this case, there is also an effect that heat can be gently and surely transmitted from the bottom of the heat transfer container 3 to the transfer target object 33 via the transfer rack 25.

Finally, the constant temperature transfer apparatus 1 according to the third embodiment will be described with reference to FIGS. 1 to 11.
The constant temperature transfer apparatus 1 according to the third embodiment of the present invention is implemented in the heat transfer container 3 of the constant temperature transfer box 2 according to the first embodiment shown in FIGS. The conveyance rack 25 according to Example 2 is provided.
The constant temperature transfer apparatus 1 according to the third embodiment has an effect that combines the effect of the constant temperature transfer box 2 according to the first embodiment and the effect of the transfer rack 25 according to the second embodiment described above. ing.

The material of the heat transfer container 3 and the transport rack 25 according to the present embodiment may be anything as long as it is metal, but is excellent in thermal conductivity, hardly corroded or deteriorated during sterilization, and is lightweight. Aluminum and aluminum alloys are particularly suitable.
Moreover, the aspect of the shelf 26 of the transport rack 25 according to the second embodiment is not necessarily specified as that illustrated in FIGS. 6 to 11 and may be arbitrarily changed according to the form of the transport target.
For example, the first shelf plate 26a and the second shelf plate 26b shown in FIGS. 6 to 8 can be used with their top and bottom inverted.
In this case, the third shelf plate 26c shown in FIG. 9 is arranged in the lowest layer in the vertical direction, and the conveyance object 33 shown in FIG. 5 is placed thereon, and the support base 28 is placed on the fixing ring 24. What is necessary is just to laminate | stack the 1st shelf board 26a or the 2nd shelf board 26b, making it contact | abut.
In this case, since the support base 28 abuts on the upper surface side of the conveyance object 33, the ventilation film 23a of the lid 23 is not blocked by the plate 27a or the plate 27b. Therefore, even if the first shelf plate 26a to the third shelf plate 26c are not provided with the vent holes 29, the intended function can be exhibited without hindrance.
In addition, when the first shelf plate 26a to the third shelf plate 26c are not provided with the vent holes 29, the contact area between the bottom surface of the petri dish 22 and the shelf plate 26 is increased, so that the heat transfer effect by the shelf plate 26 is increased. Can be increased.

  Moreover, in the constant temperature conveyance apparatus 1 which concerns on Example 3, when conveying the some conveyance target 33 in the heat transfer container 3, supporting it with the conveyance rack 25, the some conveyance target 33 of the heat transfer container 3 is carried out. It can be supported in a state separated from the bottom. In addition to this, by arranging the plurality of heat transfer columns 31 in the gaps between the plurality of conveyance objects 33, it is possible to make the heat transfer to the individual conveyance objects 33 uniform.

Further, in the transport object 33 shown in FIG. 5 above, when the culture sheet 38 has a special function or structure for facilitating the detachment of the cultured cells 39 (for example, “UpCell” (registered trademark)). Before separating the cultured cells 39 from the culture sheet 38, a pretreatment such as reducing the temperature from 38 to 40 ° C. during the culture to about 20 ° C. may be required.
In this case, only by changing the set temperature of the constant temperature transfer box 2 of the constant temperature transfer apparatus 1 according to the third embodiment, the culture cell 39 is transplanted using the constant temperature transfer box 2 while keeping the heat transfer container 3 in a sterile state. The previous pretreatment (low temperature treatment) can be performed. At that time, the constant temperature transport apparatus 1 according to the third embodiment includes the transport rack 25 according to the second embodiment, and thus can individually cool the individual transport target objects 33.
Therefore, according to the constant temperature transport apparatus 1 according to the third embodiment, the transport object 33 can be stored in the heat transfer container 3 while maintaining a sterilized state only by performing a simple operation in the clean bench. Further, pretreatment (such as low-temperature treatment) before transplantation of the cultured cells 39 can be performed without taking out the object 33 to be transported from the heat transfer container 3.
Therefore, according to the constant temperature conveyance apparatus 1 which concerns on Example 3, the cultured cell 39 can be conveyed safely and simply.

  As described above, the present invention provides a thermostatic transport box for transporting stem cells or tissues collected from a human body and artificially cultured while maintaining them in a desired temperature range, a transport rack used for the thermostatic transport box, and these. This is a combined constant temperature transfer device and can be used in the field of regenerative medicine.

  DESCRIPTION OF SYMBOLS 1 ... Constant temperature conveyance apparatus 2 ... Constant temperature conveyance box 3 ... Heat transfer container 3a ... Lid 3b ... Main body 3c ... Packing 3d ... Fixing tool 3e ... 1st fitting part 3f ... 2nd fitting part 4 ... Thermal insulation container 5 ... Heat transfer plate 5a, 5b ... Heat transfer plate 5c ... First fitting portion 6 ... Temperature adjusting means 7a ... First temperature measuring means 7b ... Second temperature measuring means 8 ... Peltier element 9 ... Radiation fin 10 ... Fan 11 ... Airway 12 ... Outer container 12a ... Lid 12b ... Main body 12c ... Hinge 12d ... Fixing tool 12e ... Net 13 ... Handle 14 ... Band fixing tool 15 ... Fixing band 16 ... Control means 17 ... Switch 18 ... Monitor unit DESCRIPTION OF SYMBOLS 19 ... Battery 20 ... External memory connection part 21 ... 1st temperature measurement means connection part 22 ... Petri dish 23 ... Cover 23a ... Air-permeable membrane 24 ... Ring for fixing 25 ... Transport rack 26 ... Shelf board 2 6a ... 1st shelf board 26b ... 2nd shelf board 26c ... 3rd shelf board 27a-27c ... Plate 28 ... Supporting base 29 ... Vent 30a, 30b ... Hole 31 ... Heat-transfer column 31a ... Main shaft 31b ... Screw 32 ... Contact side 33 ... Conveyance object 34 ... Winding band 35 ... Upper band 35a ... Loop 35b ... Snap lock 35c ... Hole 35d ... Hinge 36 ... Lower band 36a ... Hook 36b ... Hole 37 ... Culture solution 38 ... Culture sheet 39 ... cultured cell 40 ... second fitting part

Claims (7)

A constant temperature transport box for transporting the object to be transported while keeping the temperature within a desired temperature range,
A heat transfer container that is made of metal and stores the object to be transported in the hollow portion while shielding the outside from outside air;
An insulated container containing the heat transfer container;
A heat transfer plate that is disposed on the bottom of the heat insulating container and includes a first fitting portion that is detachably fitted to the bottom surface of the heat transfer container;
And a temperature adjusting means provided on the back side of the heat transfer plate. First temperature measuring means for measuring the temperature in the heat transfer container;
A second temperature measuring means for measuring the temperature of the heat transfer plate;
A Peltier element provided on the back side of the heat transfer plate, and a heat radiating element provided on the surface of the Peltier element on the side where the heat transfer plate is not joined and arranged outside the heat insulating container. A fin, and the temperature adjusting means comprising:
2. The constant temperature transport box according to claim 1, further comprising a control unit that controls the Peltier element based on a measurement value of the first and / or second temperature measuring unit.   The constant temperature transport box according to claim 2, comprising an air passage made of a cylindrical body and having the heat radiation fin accommodated in a hollow portion thereof.   4. The second fitting part for detachably fitting a transport rack that holds the transport object is provided on the bottom surface of the heat transfer container. 5. The constant temperature transport box according to item 1. A heat transfer container that is made of metal and that stores the object to be transported in the hollow portion while shielding the object from outside air, and a temperature adjusting means that can be heated or cooled from the bottom surface of the heat transfer container, It is used in a constant temperature transport box for transporting while maintaining a temperature in a desired temperature range, and is a transport rack for holding the transport object,
A metal shelf board that supports the object to be transported in the heat transfer container, and is provided in contact with the shelf board, and is led to the lower surface side of the shelf board to conduct heat from the bottom surface of the heat transfer container. And at least one metal heat transfer column. A plurality of the shelf boards arranged in layers;
The transport rack according to claim 5, further comprising a band that bundles and fixes the plurality of shelf boards.   A constant temperature conveyance apparatus comprising: the constant temperature conveyance box according to any one of claims 1 to 4; and the conveyance rack according to claim 5 or 6.