JP2019170171A - Composition for enhancing vitality under high temperature environment - Google Patents

Abstract

To provide means for coping with high temperature environment.SOLUTION: The present invention provides a composition containing lactoferrin as an active ingredient, applied for enhancing vitality under high temperature environment. The composition may be one for enhancing vitality under high temperature and high humidity environment. The composition can enhance vitality of human beings under high temperature environment. The composition may be a food and drink composition or a pharmaceutical composition. The composition may be used for human beings desiring to live more actively under high temperature environment in summer season.SELECTED DRAWING: None

Description

  The present technology relates to a composition for improving vitality in a high temperature environment.

  In recent years, high temperatures in summer have been regarded as a problem in Japan. High temperatures in summer often occur not only in urban areas such as Tokyo where the heat island phenomenon occurs, but also in areas other than urban areas. Further, in summer, not only are there many days when the maximum temperature during the day is 35 ° C or higher, but there are also many days when the minimum temperature during the night is 25 ° C or higher.

  High summer temperatures often result in physical fatigue to animals, and the physical fatigue can also induce disease. High summer temperatures cause, for example, summer heat. Summer batter exhibits various symptoms such as loss of appetite, headache, or diarrhea. It is conceivable to deal with physical fatigue or illness due to high temperatures in summer, for example by taking appropriate nutrients or drugs. For example, Patent Document 1 below describes a pharmaceutical composition for preventing or ameliorating a disease that develops in a high temperature and / or high humidity environment. The pharmaceutical composition contains dichloroacetic acid diisopropylamine and / or gluconic acid or a salt thereof.

JP2013-028596A

  High summer temperatures can have a negative effect on mood. For example, when high temperatures continue, it may feel like avoiding active activity to avoid heat. Therefore, it is considered that a better life can be brought about if such adverse effects can be dealt with. Therefore, an object of the present technology is to provide a new means for dealing with a high temperature environment.

  The present inventors have found that lactoferrin, which is a component derived from milk, has an effect of improving the vitality of humans in a high temperature environment. That is, the present technology provides the following.

[1] A composition for improving vitality in a high-temperature environment, comprising lactoferrin as an active ingredient.
[2] The composition according to [1], wherein the composition is for improving vitality in a high temperature and high humidity environment.
[3] The composition according to [1] or [2], wherein the composition is administered in an environment where the maximum daily temperature is 25 ° C or higher.
[4] The composition according to any one of [1] to [3], wherein the composition is administered in an environment having an average daily humidity of 75% or more.
[5] The composition according to any one of [1] to [4], wherein the composition is administered in an environment where the discomfort index is 75 or more.
[6] The composition according to any one of [1] to [5], wherein the vitality is evaluated by a vitality-activity factor in POMS or POMS2.
[7] The composition according to any one of [1] to [6], wherein the composition is administered so that a lactoferrin intake is 10 mg or more per day.
[8] The composition according to any one of [1] to [7], wherein the composition is for improving a summer mood state.
[9] The composition according to any one of [1] to [8], wherein the composition is a food or drink composition.
[10] The composition according to any one of [1] to [8], wherein the composition is a pharmaceutical composition.

The composition of the present technology can improve the vitality of a human in a high temperature environment. The composition of the present technology may be ingested, for example, by humans who wish to live a more active life in a hot summer environment.
In addition, the effect of this technique is not limited to the effect described here, Any effect described in this specification may be sufficient.

It is a graph which shows the result of the mood profile test | inspection regarding vitality-vitality. It is a graph which shows the result of the mood profile test | inspection regarding friendship.

  Hereinafter, preferred embodiments of the present technology will be described. However, the present technology is not limited to the following preferred embodiments, and can be freely changed within the scope of the present technology.

<Composition for improving vitality under high temperature environment>
The composition for improving vitality of the present technology contains lactoferrin as an active ingredient. The composition for improving vitality of the present technology is for improving the vitality of a subject by being administered to a subject under a high temperature environment, particularly a human under a high temperature environment. The composition of the present technology can improve the mood state or maintain a good mood state, for example, in summer when high temperature days occur frequently.
Moreover, the active ingredient of the composition of the present technology is an ingredient derived from milk that has been used for many years as a food. The said component has high safety | security to a biological body. Therefore, the composition of the present technology can be safely administered to mammals, particularly humans.

The composition of the present technology may be used to improve vitality particularly in a high temperature and high humidity environment. That is, the composition of the present technology can improve the vitality of a subject that is particularly in a high temperature and high humidity environment.
In a high temperature and high humidity environment, human vitality is particularly likely to decrease. The composition of the present technology can cope with high temperature and high humidity environment. For example, the composition of the present technology contributes to a more active life for humans in an environment of high temperature and high humidity.

In the present technology, the high temperature environment is, for example, an environment in which the daily maximum temperature is 25 ° C. or more, preferably an environment in which the daily maximum temperature is 28 ° C. or more, particularly 30 ° C. or more, more particularly 33 ° C. or more. Say.
The high temperature environment is, for example, a day when the maximum daily temperature is 25 ° C. or higher, 28 ° C. or higher, 30 ° C. or higher, or 33 ° C. or higher. It may be an environment that occurs more than a day or more than 20 days.

In the present technology, the environment with high humidity is more specifically an environment in which the average daily humidity is 75% or more, in particular, the average daily humidity is 77% or more, more particularly 80% or more. The environment.
For example, the environment where the average humidity is 75% or more, 77% or more, or 80% or more is 5 days or more, 8 days or more, 10 days or more, 15 days in January. The environment which generate | occur | produces above or 20 days or more may be sufficient.

The composition of the present technology may be administered to improve vitality in an environment with a high discomfort index. The composition of this technique can improve the vitality of the said subject by being administered to the subject in the said environment.
The discomfort index is an index representing the heat of heat. The discomfort index is represented by the following formula, for example.
Discomfort index DI = 0.81 × T + 0.01 × H × (0.99 × T-14.3) +46.3
Here, T is the dry bulb temperature (° C.), and H is the humidity (%).
In the present technology, the environment having a high discomfort index refers to an environment in which the discomfort index is 75 or more, preferably 77 or more, more preferably 80 or more, and may be an environment in which the discomfort index is 85 or more.
The environment where the discomfort index is high is, for example, the day when the highest daily discomfort index is 75 or more, 77 or more, 80 or more, or 85 or more, 1 day or more in January, 5 days or more, 8 days More than 10 days, 15 days, or 20 days or more.

  Lactoferrin is an iron-binding glycoprotein that exists in body fluids such as milk, tears, saliva, and blood. Lactoferrin is contained in the milk of mammals such as sheep, goats, pigs, mice, buffalo, camels, yaks, horses, donkeys, llamas, cows or humans. That is, the lactoferrin used in the present technology may be derived from mammalian milk. From the viewpoint of content and availability, for example, those derived from bovine or human milk are preferred. The milk may be any of colostrum, transitional milk, regular milk, and terminal milk. In the present technology, commercially available lactoferrin may be used.

  The lactoferrin used in the present technology is not limited to those derived from mammalian milk. For example, lactoferrin isolated from skim milk or whey obtained by processing the milk by a conventional method (for example, ion chromatography), recombinant lactoferrin produced from microorganisms, animal cells, or transgenic animals by genetic manipulation , Synthetic lactoferrin, or a mixture thereof. Also, lactoferrin may be non-glycosylated or glycosylated.

In the present technology, the improvement of vitality preferably does not include improvement of physical vitality. For example, the composition of the present technology is not used for dealing with physical fatigue (preventing or eliminating the fatigue) due to being in a high temperature environment. In addition, the composition of the present technology is not used for dealing with a physical disease caused by being in a high temperature environment (preventing or treating the disease).
In the present technology, the improvement of vitality includes, for example, maintaining the vitality of a target that may cause a decrease in vitality, suppressing the reduction of the vitality of the target, and improving the vitality of a target with reduced vitality. To do. By the composition of the present technology, the vitality of a target in a high temperature environment (particularly in a high temperature and high humidity environment) can be maintained, a decrease in the vitality can be suppressed, or the vitality can be improved. Thus, the subject's mood state can be improved by the composition of the present technology. The compositions of the present technology are particularly suitable for applications that increase mental vitality.
The compositions of the present technology may also be administered in combination with compositions for combating physical fatigue or illness due to high temperatures in summer. Thereby, it is possible to cope with high temperatures in summer from the physical side and from the mood side. In addition, since the vitality of the subject is improved by the composition of the present technology, recovery from physical fatigue or illness by the composition for dealing with physical fatigue or illness (for example, summer batter) can also be promoted.

In this technique, vitality may be evaluated by, for example, a “Vigor-Activity (VA)” factor which is one of POMS factors in POMS (registered trademark) or POMS2. That is, the composition of the present technology is particularly suitable for improving the vitality evaluated by the “liveness-vital” factor in POMS or POMS2.
POMS (Profile of Mood States) is a test for evaluating human mood, also called mood profile test. The test method of POMS is described in, for example, “POMS manual” and “POMS Technical Update”, and POMS may be performed as described.
POMS2 (Profile of Mood States 2nd Edition) is a test for evaluating human mood created by revising POMS. There are two types of POMS2, the POMS2 adult test and the POMS2 youth test. The test method of POMS2 is described in, for example, “POMS2 manual”. POMS2 may be performed as described herein.

The composition of the present technology is such that the daily lactoferrin intake is, for example, 10 mg or more, preferably 30 mg or more, preferably 100 mg or more, more preferably 200 mg or more, even more preferably 500 mg or more, particularly preferably 600 mg or more. It may be administered to a subject. Thereby, the effect of this technique is show | played more effectively.
In addition, the composition of the present technology may be administered to a subject such that the lactoferrin intake per day is, for example, 3000 mg or less, preferably 2500 mg or less, more preferably 2000 mg or less. Although the upper limit of lactoferrin intake may not be set in particular, any of the above values may be set as the upper limit from the viewpoint of ease of intake.
In the present technology, the lower limit value and the upper limit value of the numerical range of the lactoferrin intake per day may be selected from the values listed above. For example, according to one embodiment of the present technology, the composition of the present technology has, for example, a daily lactoferrin intake of 10 mg to 3000 mg, preferably 10 mg to 1000 mg, more preferably 100 mg to 1000 mg, more preferably 200 mg to 1000 mg, More preferably, it may be administered to a subject so as to be 500 mg to 1000 mg, and even more preferably 600 mg to 1000 mg. Alternatively, the composition of the present technology may be administered to a subject such that the daily lactoferrin intake is 200 mg to 600 mg, for example.

The composition of the present technology is preferably taken continuously. The composition of the present technology may be continuously ingested for, for example, 1 week or longer, preferably 2 weeks or longer, more preferably 3 weeks or longer, even more preferably 4 weeks or longer, particularly preferably 8 weeks or longer. Particularly preferably, the composition of the present technology may be taken daily during a period in which the administration subject is in a high temperature environment. For example, the composition of the present technology may be applied for 1 month, 2 months, 3 months, or 4 months when the temperature is high, or 2 months during the month when the temperature is high and humidity is high. It may be taken continuously (eg, every day or at predetermined intervals, such as every other day or every other day) for months, months, or months. By such continuous intake, the effects of the present technology are more effectively achieved.
In addition, the composition of the present technology may be used, for example, for 1 week or more, preferably 2 weeks or more, more preferably 3 weeks or more, even more preferably 4 weeks or more, particularly preferably 8 weeks before the period when the temperature is high. You may ingest continuously over the above. Thereby, the vitality fall when the temperature of the environment becomes high can be prevented.

  The composition of the present technology may preferably be taken before bedtime. For example, the composition of the present technology may be taken within 5 hours before bedtime, within 3 hours before bedtime, or within 1 hour before bedtime, or taken at any time between dinner and before bedtime. May be. By continuously ingesting the composition of the present technology before going to bed, the effect of the present technology is more effectively achieved. In addition, from the viewpoint of convenience, the composition of the present technology may preferably be taken orally.

  The composition of the present technology is preferably administered to a subject in the summer, for example, when the temperature during the day is high. Particularly preferably, the composition of the present technology is administered to a subject in the summer when the temperature of the daytime is high and the humidity is high. Thereby, the vitality of the object can be improved in summer, and the mood state in summer can be improved. That is, the present technology may be used to improve summer mood.

  Although the content rate of the lactoferrin in the composition of this technique may be suitably set by those skilled in the art, it is 0.01-99.9 mass% with respect to the total mass of the composition of this technique, for example, Preferably it is 0.5 The mass% is 55% by mass, more preferably 1% by mass to 50% by mass, and still more preferably 5% by mass to 45% by mass.

The compositions of the present technology may be administered to a wide range of age subjects. For example, when the subject to which the composition of the present technology is administered is a human, the composition of the present technology can be applied to a subject in an infant period (for example, 0 to 5 years old), a subject in a childhood period (for example, 6 to 12 years old), adolescence It may be administered to a subject in (for example, 13 to 17 years old) or a subject in adulthood (for example, 18 years of age or older). Particularly preferably, the composition of the present technology is administered to a subject in adulthood (eg, 18 years of age or older). The composition of the present technology can improve vitality by being administered to a subject in adulthood, and more particularly, improve “Vigor-Activity (VA)” among POMS factors. Can do.
The composition of the present technology may be administered to a non-human subject. Examples of administration subjects of the composition of the present technology include mammals other than humans. Non-human mammals include, for example, non-human primates, dogs, cats, cows, pigs, and horses.

The composition of the present technology is also suitable for improving “Friendliness (F)” among POMS factors. Therefore, the composition of the present technology may be used to improve the “friendly” factor among the POMS factors.
In addition, the composition of the present technology may be used to improve the “vigoration-activity” factor and the “friendship” factor among the POMS factors. The composition of the present technology can improve these factors in a high temperature environment, and is useful for, for example, living a more active life in a high temperature environment.

  The composition of the present technology may be used as, for example, a medicine, a food or drink, or a feed. The composition of the present technology may appropriately include an additional component included when used in these applications.

<Pharmaceutical composition>
The composition of the present technology can be used as a pharmaceutical composition. The pharmaceutical composition of the present technology may be used to improve the vitality of a subject in a high temperature environment.

  The active ingredient in the present technology is an ingredient derived from milk that has been used for many years as a food, and therefore, there is a high possibility that it can be administered with confidence regardless of the type of the patient's disease. Moreover, there is little need to worry about side effects even if administered continuously for a long period of time. Furthermore, safety is high when used in combination with other drugs. For example, along with a pharmaceutical composition for combating physical fatigue or illness caused by a subject in a high temperature environment, a pharmaceutical composition of the present technology is administered to improve the vitality of the subject. Good.

  When the composition of the present technology is used as a pharmaceutical composition, the pharmaceutical composition may be administered orally or parenterally, and can be appropriately formulated into a desired dosage form depending on the administration method. For example, in the case of oral administration, it can be formulated into solid preparations such as powders, granules, tablets and capsules; liquid preparations such as solutions, syrups, suspensions and emulsions. Moreover, in the case of parenteral administration, it can be administered, for example, through a gastric fistula.

  Moreover, when formulating, the pharmaceutical composition of the present technology may include various components such as excipients, pH adjusters, colorants, and corrigents that are commonly used for formulation. In addition, as long as the effects of the present technology are not impaired, the pharmaceutical composition of the present technology may include other known pharmaceutical ingredients. The pharmaceutical composition of the present technology can be formulated by a known method as appropriate according to the dosage form. Upon formulation, a formulation carrier may be appropriately blended to formulate.

  In addition, formulation can be appropriately performed by a known method according to the dosage form. At the time of formulation, only the active ingredient lactoferrin may be formulated, or a formulation carrier may be blended as appropriate.

  In addition, when mix | blending a formulation carrier, the lactoferrin content which is an active ingredient of this technique may be suitably selected according to a dosage form. The content ratio of the lactoferrin which is an active ingredient of this technique is 0.01-60 mass% with respect to the total mass of a pharmaceutical composition, Preferably it is 0.5 mass% -55 mass%, More preferably, it is 1 mass% -50. More preferably, it is more preferably 5% by mass to 45% by mass.

The administration period of the pharmaceutical composition of the present technology may be appropriately determined according to a period in which improvement of vitality is required. For example, the pharmaceutical composition of the present technology may be continuously (eg, daily, or over a period of, for example, 1 week or more, preferably 2 weeks or more, more preferably 3 weeks or more, even more preferably 4 weeks or more, particularly preferably 8 weeks or more). For example, every other day or every other day at a predetermined interval).
The pharmaceutical compositions of the present technology may be administered to subjects of a wide range of ages. That is, the composition of the present technology can be used for subjects in early childhood (eg, 0-5 years), subjects in childhood (eg, 6-12 years), subjects in adolescence (eg, 13-17 years), or It may be administered to a subject in adulthood (eg 18 years of age or older). Particularly preferably, the composition of the present technology is administered to a subject in adulthood (eg, 18 years of age or older).
When ingesting the pharmaceutical composition of the present technology, the present technology is such that the intake of lactoferrin is, for example, 10 mg to 3000 mg, preferably 10 mg to 1000 mg, more preferably 100 mg to 1000 mg, even more preferably 200 mg to 600 mg per day. Of the pharmaceutical composition may be ingested.

  In addition, as the preparation carrier, various organic or inorganic carriers and bases can be used depending on the dosage form. Ingredients used for formulating the composition of the present technology include, for example, excipients, binders, disintegrants, lubricants, stabilizers, and flavoring agents.

  Examples of the excipient include sugar derivatives such as reduced maltose, lactose, sucrose, glucose, mannitol and sorbit; starch derivatives such as corn starch, potato starch, α-starch, dextrin and carboxymethyl starch; crystalline cellulose, hydroxy Cellulose derivatives such as propylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, carboxymethylcellulose calcium; gum arabic; dietary fiber; dextrin; dextran; pullulan; silicate derivatives such as light anhydrous silicic acid, synthetic aluminum silicate, magnesium magnesium metasilicate; Phosphate derivatives such as calcium carbonate; carbonate derivatives such as calcium carbonate; sulfate derivatives such as calcium sulfate.

  Examples of the binder include gelatin, polyvinyl pyrrolidone, macrogol and the like in addition to the above excipients.

  Examples of the disintegrant include, in addition to the above excipients, chemically modified starch or cellulose derivatives such as croscarmellose sodium, carboxymethyl starch sodium, and crosslinked polyvinylpyrrolidone.

  As the lubricant, for example, talc; stearic acid; stearic acid metal salts such as calcium stearate and magnesium stearate; colloidal silica; waxes such as pea gum and geirow; boric acid; glycol; carboxylic acids such as fumaric acid and adipic acid Carboxylic acid sodium salts such as sodium benzoate; sulfates such as sodium sulfate; leucine; lauryl sulfates such as sodium lauryl sulfate and magnesium lauryl sulfate; silicic acids such as anhydrous silicic acid and silicic acid hydrate; starch derivatives and the like; And hardened oils such as rapeseed hardened oil.

  Examples of the stabilizer include paraoxybenzoates such as methyl paraben and propyl paraben; alcohols such as chlorobutanol, benzyl alcohol and phenylethyl alcohol; benzalkonium chloride; acetic anhydride; sorbic acid and the like.

  Examples of the flavoring agent include sweeteners, acidulants, and fragrances.

<Food &Drink>
The composition of the present technology may be a food or drink composition. The food / beverage composition of this technique may be used in order to improve the vitality of the object in a high temperature environment.

Examples of the food and beverage composition of the present technology include beverages such as soft drinks and milk beverages, or concentrated concentrates of the beverages and powders used for preparing the beverages; dairy products such as processed milk and fermented milk; Formula milk for use; enteral nutrition; functional foods.
Moreover, as an example of the food / beverage product composition of the present technology, for example, beverages such as carbonated beverages, nutritional beverages, fruit beverages, or concentrated concentrates of the beverages and powders used to prepare the beverages; for example, ice cream, ice sherbet , And frozen confectionery such as shaved ice; noodles such as buckwheat noodle, udon, harusame, gyoza rind, sweet husk, Chinese noodles and instant noodles; candy, gum, chocolate, tablet confectionery, snack confectionery, biscuit, jelly, jam, Confectionery such as cream and baked confectionery; marine or livestock processed foods such as kamaboko, ham and sausage; fats and oils such as salad oil, tempura oil, margarine, mayonnaise, shortening, whipped cream and dressings; Seasonings such as sauces and sauces; Flop, mention may be made of stew, salad, prepared foods, pickles, and the cooked food, such as bread. Liquid and tablet-like supplements may be sufficient as the food-drinks composition of this technique, for example.

  These foods and drinks may be produced by methods known to those skilled in the art. In these methods for producing foods and beverages, the time and method for adding lactoferrin may be appropriately selected by those skilled in the art.

Moreover, the food-drinks composition of this technique can be provided or sold as the food-drinks by which the health use regarding a vitality improvement or the health use regarding a vitality improvement effect was displayed, for example.
The “display” act includes all acts for informing the consumer of the use, and if it is an expression that can recall or analogize the use, the purpose of the display, the content of the display, and Regardless of the object or medium to be displayed, all of them fall under the “display” act of this technology.
The food / beverage product composition of the present technology may be labeled with, for example, “for adults”, “for improving the vitality in summer”, or “for not losing heat”.

  The “display” is preferably performed by an expression that allows the consumer to directly recognize the use. Specifically, it is the act of transferring, displaying, importing, displaying, or importing products that are related to food or drinks or packaging that describes the use, advertisements related to products, price lists, or transaction documents. Examples include an act of describing and displaying the above uses, distributing them, or providing the information by using electromagnetic (Internet etc.) methods by describing the above uses in the content.

  The display content is preferably a display approved by the government or the like (for example, a display that is approved based on various systems determined by the government and is performed in a mode based on such approval). Moreover, it is preferable to attach such display contents to advertising materials at sales sites such as packaging, containers, catalogs, pamphlets, POP (Point of purchase advertising), and other documents.

  In addition, the “labeling” shall mean products such as health foods, functional foods, enteral nutrition foods, special purpose foods, health functional foods, foods for specified health use, nutritional functional foods, and quasi drugs. Is displayed. As a more specific example of a display, a display approved by the Consumer Affairs Agency, for example, a display approved by a food system for specific health use or a similar system may be mentioned. Examples of indications approved by the Consumer Affairs Agency include, for example, indications for specified health foods, indications for conditional specified health foods, indications that affect the structure and function of the body, and indications for reducing disease risk Can be mentioned. More specifically, indications as foods for specified health (especially indications for health use) as defined in the Enforcement Regulations of the Health Promotion Act (April 30, 2003, Ministry of Health, Labor and Welfare Ordinance No. 86) and A similar display is a typical example.

  Content of the lactoferrin contained in the food / beverage products of this technique may be suitably selected by those skilled in the art. The content rate of the lactoferrin which is an active ingredient of this technique is 0.01-60 mass% with respect to the total mass of food-drinks composition, Preferably it is 0.5 mass% -55 mass%, More preferably, it is 1 mass%- It is still more preferable that it is 50 mass%, More preferably, it is 5 mass%-45 mass%.

The intake period of the food and drink according to the present technology may be appropriately determined according to a period in which improvement of vitality is required. For example, the food and drink of the present technology may be continuously (for example, every day, or more than 8 weeks, preferably 2 weeks or more, more preferably 3 weeks or more, even more preferably 4 weeks or more, particularly preferably 8 weeks or more). For example, it may be taken at predetermined intervals such as every other day or every other day).
When ingesting the food / beverage product composition of the present technology, the lactoferrin intake is, for example, 10 mg to 3000 mg, preferably 10 mg to 1000 mg, more preferably 100 mg to 1000 mg, even more preferably 200 mg to 600 mg per day. Technical food and beverage compositions may be ingested.

The present technology also provides the following methods and products.
[1]
A method of using lactoferrin for producing a composition for improving vitality in a high temperature environment.
[2]
Lactoferrin for improving vitality in high temperature environments.
[3]
A method of improving vitality in a high-temperature environment by administering lactoferrin.

  Hereinafter, the present technology will be described in more detail using examples, but the present technology is not limited to these examples.

[Test Example 1]
(1) Sample preparation Each raw material was mixed at the blending ratio shown in Table 1 and tableted by a conventional method to produce three types of tablets having a weight per tablet of 250 mg. That is, a control sample containing no lactoferrin, test sample A containing 33.3 mg lactoferrin per tablet, and test sample B containing 100 mg lactoferrin per tablet were obtained.

(2) Test method A randomized, double-blind, placebo-controlled parallel group comparison test was performed using the above samples to examine the effect of lactoferrin intake on summer mood. The test was conducted as follows.
That is, 300 healthy adults in Nobeoka City, Miyazaki Prefecture, who agreed to participate in this study, took a control sample after the 4-week pre-observation period (hereinafter sometimes referred to as “control group”). And a group taking test sample A (hereinafter sometimes referred to as “test group A”) and a group taking test sample B (hereinafter sometimes referred to as “test group B”) at random. Allocated.
The subjects in each group took 6 tablets of the control sample, test sample A or test sample B once a day for 12 weeks from June to September 2017 before going to bed. That is, test group A ingested 200 mg lactoferrin per day, and test group B ingested 600 mg lactoferrin per day.
In order to evaluate the temporary mood state before and 12 weeks after ingestion, a “POMS2 adult shortened version” test, which is a mood profile test, was performed, and these total scores were calculated according to the Japanese manual. Converted to score score.

  Table 2 shows data relating to temperature, humidity, and discomfort index from June to September 2017 in Nobeoka City, Miyazaki Prefecture, where this test was conducted.

(3) Statistical analysis The blinded results were reviewed before key opening. Those who did not meet the pre-determined analysis criteria (that is, those whose test sample intake rate was less than 70%, those who received combination prohibition treatment, those who received prohibited drugs or foods) and data after randomization Analysis was done except for those who did not. The number of subjects to be analyzed was n = 95 for the control group, n = 85 for the test group A, and n = 85 for the test group B. For each group, an average value (arithmetic mean) of T score scores was calculated.

(4) Results The results of the above-described statistical analysis on the results of the examination by “POMS2 adult shortened version” are shown in the following Table 3 and FIGS.

  As shown in Table 3 and FIG. 1, among the POMS factors, in the control group, there was no significant change in the value between the pre-intake period and the 12th week in the control group. In groups A and B, the score was higher at 12 weeks than before ingestion. In particular, the test group B had a significantly higher score at the 12th week than the control group.

  In addition, as shown in Table 3 and FIG. 2, among the POMS factors, regarding the “Friendship (F)”, in the control group, the value was greatly reduced in the 12th week compared to before the intake, whereas in the test group A, The numerical value only slightly decreased at 12 weeks compared to before intake, and in Test Group B, the score at 12 weeks was higher than before intake. In particular, the test group B had a significantly higher score at the 12th week than the control group.

  In addition to the above two factors, the POMS factor further includes the following five factors: “anger-hostility (AH)”, “confused-embarrassed (CB)”, “depression-depression (DD)”, There are “Fatigue-Apathy (FI)” and “Tension-Anxiety (TA)”. In the above test, these five factors were similarly examined and statistically analyzed. As a result, for these five factors, there was no remarkable change in numerical values between the control group and the test group.

  From the above results, it can be seen that ingestion of lactoferrin is effective for improving the vitality of a subject in a high temperature environment. Moreover, when the lactoferrin intake was 600 mg per day, the vitality-improving effect of lactoferrin was exerted more strongly than when the lactoferrin intake was 200 mg per day. It is considered that the greater the intake of lactoferrin, the higher the vitality-improving action by lactoferrin. In particular, when the intake of lactoferrin is about 600 mg per day, it is considered that a particularly strong activity-improving action is exhibited.

In addition, from the above results, lactoferrin intake is evaluated not only by the mood state of “POI-Vitality (VA)” among POMS factors, but also by “Friendship (F)” of subjects in a high temperature environment. It turns out that it is effective also in improving the mood state made.

Claims (10)

  A composition for improving vitality in a high-temperature environment, comprising lactoferrin as an active ingredient.   The composition according to claim 1, wherein the composition is for improving vitality in a high temperature and high humidity environment.   The composition according to claim 1 or 2, wherein the composition is administered in an environment where the maximum daily temperature is 25 ° C or higher.   The composition according to any one of claims 1 to 3, wherein the composition is administered in an environment having an average daily humidity of 75% or more.   The composition according to any one of claims 1 to 4, wherein the composition is administered in an environment having a discomfort index of 75 or more.   The composition according to any one of claims 1 to 5, wherein the vitality is evaluated by a vitality-activity factor in POMS or POMS2.   The composition according to any one of claims 1 to 6, wherein the composition is administered so that a lactoferrin intake is 10 mg or more per day.   The composition according to any one of claims 1 to 7, wherein the composition is for improving a summer mood state.   The composition as described in any one of Claims 1-8 whose said composition is a food-drinks composition. The composition according to any one of claims 1 to 8, wherein the composition is a pharmaceutical composition.