JP2019119705A - Oral composition for improving touch feeling including adlay extract - Google Patents

Abstract

To provide a novel application of adlay extract.SOLUTION: There is provided the oral composition for improving touch feeling including adlay extract.SELECTED DRAWING: None

Description

  The present invention relates to an oral composition and the like for improving the feel of the skin, which comprises a cottonseed extract.

  Hatomugi usually use threshed grains for food, but studies have also been made on effective use of the hut shell, thin skin, astringent skin etc. obtained at the time of threshing. It is described that an extract obtained by enzymatic treatment of thin skin, astringent skin and the like is effective for treatment of a tumor and the like. In addition, one aspect of the adlay extract described in Patent Document 1 is commercially available from Agrilink Technology, Inc. as adlay CRD extract. In addition, development has also been carried out for liquid compositions that contain a stable extract of castor bean extract (Patent Document 2).

Patent No. 3590042 JP, 2014-090675, A

  An object of the present invention is to provide a novel use of a mint extract.

The inventors of the present invention found that oral intake of Hatomugi extract can improve the touch feeling and the cosmetic paste, and further improvement has been made to complete the present invention.
The present invention includes, for example, the subject matter described in the following sections.
Item 1.
An oral composition for improving the feeling of touch, which comprises an eggplant extract.
Item 2.
Item 2. The oral composition according to item 1, which is for improving the feel of facial skin.
Item 3.
The oral composition according to any one of Items 1 and 2, which is used for continuous administration or intake for at least 4 weeks.
Item 4.
The oral composition according to any one of Items 1 to 3, which is a liquid composition.
Item 5.
The oral composition according to any one of Items 1 to 4, which is a pharmaceutical composition or a food composition.

  With the oral composition for improving the feeling of touch according to the present invention, the feeling of feeling is improved and the cosmetic paste is improved, so that makeup can be facilitated.

An example of a typical static friction measurement waveform is shown. The measurement result of static friction appearance distance is shown. The measurement results of the static friction coefficient are shown. The measurement results of the average dynamic friction coefficient are shown. The measurement result of the total water content of a water load test is shown. The measurement result of the water retention ability of a water load test is shown. The example of the typical waveform obtained by the measurement of Cutometer is shown. The result of the re-deformability (R1) obtained from the waveform obtained by the measurement of the Cutometer is shown. The result of the net elasticity (R5) obtained from the waveform obtained by the measurement of the Cutometer is shown. The result of the skin volume fraction obtained from the shadow image of a replica is shown. The result of the skin texture maximum depth obtained from the shadow image of the replica is shown. The result of the texture maximum width of the skin obtained from the shadow image of the replica is shown. We show tallying result of "skin condition" by questionnaire. We show count result of "skin firmness" by questionnaire. We show tallying result of "skin texture, smoothness" by questionnaire. We show count result of "feel of skin touch" by questionnaire. We show tallying result of "goodness of makeup paste" by questionnaire.

  Hereinafter, each embodiment of the present invention will be described in more detail.

  The oral composition for improving the feel included in the present invention contains a mint extract.

  The Hatomugi extract used in the present invention is the Hatomugi extract described in Patent Document 1 (Japanese Patent No. 3590042), and more specifically, it is obtained by centrifugally filtering at least the enzyme-treated product of the husk shell, skin and astringent skin. It is a cottonseed extract obtained by concentrating the obtained supernatant fraction (by further drying according to the purpose). Therefore, the Hatomugi extract can be said to be a Hatomugi enzyme-treated extract. The enzymes used for the enzyme treatment are as described in the patent document 1, and include diastase, takadiastase, α-amylase, β-amylase, glucoamylase, etc., pectinase, β-dalcosidase, cellulase, hemicellulase, xylanase etc. Various enzymes are mentioned. That is, the enzyme used for the said enzyme process is an enzyme which cut | disconnects the alpha-1, 4 bond or alpha-1, 6 bond between each sugar molecule which comprises polysaccharides (for example, starch, cellulose, pectin etc.). At the time of enzyme treatment, a suitable solvent such as water can be used, for example. In addition, the cottonseed extract to be used in the present invention may contain a cottonseed extract treated with a cottonseed extract obtained from at least one selected from a hut shell, thin skin and astringent skin. Therefore, other cottonseed extract may be included, for example, a cotton bean enzyme-treated extract obtained by similarly treating other parts (for example, grains, stems, etc.) other than the husk shell, thin skin and astringent skin is further included Or may contain hot water extract of castor bean. Preferably, the cottonseed extract of the present invention mainly comprises a cotton bean enzyme-treated extract obtained from at least one selected from husk shell, thin skin and astringent skin. A commercial item can also be used as a Hatomugi extract used for this invention mentioned above, for example, a Hatomugi CRD extract (made by Agrilink Technology, Inc.) can be used especially suitably. No particular limitation is imposed on the hazemoth extract contained in the oral composition for improving blur according to the present invention, but about 1000 to 20000 mg is preferable, about 3000 to 15000 mg is more preferable, and about 5000 to 10000 mg is more preferable. .

  "Feeling feel" refers to the touch received from the feel felt by the finger or the skin, especially when the finger is placed on the skin and the finger is slipped, and "good feel" in the present application means a homogeneous feeling. And feel a smooth impression without feeling stuck. Factors involved in the touch include the state of unevenness of the skin surface, the amount of moisture and moisture retention of the skin surface, and the degree of elasticity and shape restoration of the skin, and their combined action is The relative evaluation can be made by measuring the static friction coefficient or the dynamic friction coefficient of the In general, skin with a small degree of unevenness on the skin surface, uniform presence of unevenness, high elasticity, and high shape restoration property has less variation in static friction coefficient and dynamic friction coefficient on the skin surface, Since the average value also decreases, it is considered to have a "good touch feeling". Further, in particular, when makeup is performed on the skin of the face, the difference in skin condition is slightly felt, but in general, the skin having a good touch feeling has a good makeup paste. For the evaluation of makeup paste, for example, the state of unevenness of the skin surface is the spreadability of the cosmetic when applying foundation which is a cosmetic containing a powder in particular, adhesion of the cosmetic composition to the skin per unit area It is easy to affect the difference of the amount (application amount) and the uniformity of the adhesion amount, and it is easy to greatly affect the final cosmetic perfection. Therefore, in people who do daily makeup, the feeling of making up the makeup affects the ease of making up and finishing of the makeup, so it has become a very anxious point, and women who are regularly doing up As we evaluate each time, there are many people who are able to make a quick evaluation regarding the feeling of touch and the paste of makeup. Therefore, sensory evaluation is extremely important as a comprehensive evaluation of "feel".

  The oral composition for improving the feeling of touch according to the present invention is not particularly limited, but it is preferable that the daily dosage be continuously administered or taken. The duration is preferably at least 2 weeks, more preferably at least 4 weeks. The appropriate daily administration or intake of the oral composition for improving the feeling of touch according to the present invention is not particularly limited, but for example, an amount containing about 2000 mg to about 40 000 mg of adlay extract per adult day Preferably, an amount of about 6000 to 300000 mg is more preferable, and an amount of about 10000 to 20000 mg is more preferable. By continuing administration or intake of the oral composition for improving the feel according to the present invention, even if administration or intake is interrupted, the skin improvement effect can be sustained and / or enhanced even when administration or intake is interrupted.

  The oral composition for improving the feeling of touch according to the present invention may be a solid composition or a liquid composition, but is preferably a liquid composition. When it is set as a liquid composition, a poplar bean extract can be stably contained in a liquid composition by referring the description of patent document 2 (Unexamined-Japanese-Patent No. 2014-090675).

    In addition, the oral composition for improving the feeling of touch according to the present invention may contain other components other than the poplar extract, as long as the effects of the present invention are not impaired. Other components include, for example, bases, carriers, additives, etc. which are usually used for pharmaceuticals, food additives or foods. Moreover, the component as described in the patent document 2 (Unexamined-Japanese-Patent No. 2014-090675) mentioned above is mentioned preferably.

  The oral composition for improving touch feeling of the present invention can be suitably used, for example, as a pharmaceutical composition or a food composition.

  When the oral composition for improving the feeling of touch according to the present invention is used as a pharmaceutical composition, other ingredients include pharmaceutically acceptable carriers, carriers, and / or additives (eg, solvents, dispersants, emulsifiers) , Buffers, stabilizers, excipients, binders, binders, disintegrants, lubricants, etc.). The administration mode is preferably transdermal administration or oral administration, and more preferably oral administration. The said pharmaceutical composition can be prepared by a conventional method.

  When the oral composition for improving the feeling of touch according to the present invention is used as a food composition, as other ingredients, food hygiene acceptable bases, carriers, additives, and other ingredients that can be used as food Materials can be exemplified. For example, flavors, preservatives, flavoring agents, sweetening agents and the like can be mentioned, and more specifically, for example, as flavoring agents and sweetening agents, citric acid, ascorbic acid, erythorbic acid, vitamin E and its derivatives, lemon, etc. And citrus fruits, organic acids such as citric acid and salts thereof, erythritol, xylitol, glucose, sucrose, isomerized sugar, licorice extract, aspartame, sucrose, acesulfame cam, and the like. In addition, the form of the oral composition for improving darkness is not particularly limited, and can be used, for example, as a beverage, and more specifically, for example, processed foods, health foods (nutrition functional foods, functional display foods, foods for specified health use Etc.), supplements, food for the sick (including hospital food, sick food, nursing care food, etc.) and the like. These can be prepared by conventional methods. In particular, when prepared as a health food (a nutritive function food, a functional indication food, a food for specified health, etc.) or a supplement, it may be prepared, for example, in the form of a drink to facilitate continuous intake. Although preferred, it is not particularly limited thereto.

  In the present specification, the term "comprising" also includes "consisting essentially of" and "consisting of" (The term "comprising" includes "consisting essentially of" and "consisting of.").

  Hereinafter, the present invention will be described more specifically, but the present invention is not limited to the following examples.

Preparation of test oral composition (test composition) To the adjustment solution prepared by stirring water and thickening agent using a high-pressure homogenizer and applying an appropriate viscosity, castwood CRD extract, citric acid, flavor etc. are added again and homo The mixture was mixed and dispersed uniformly by a mixer to prepare a liquid composition containing 8000 mg of the wax extract per 30 ml. Each bottle was filled with 30 ml of the liquid composition, and used as a test composition in the following study.

Drinking test test oral composition (test composition) The test composition was consumed once a day for four weeks to 22 test subjects (22 women aged 27 to 43). The test design was a single-blind test, and various tests were carried out immediately before and at the end of drinking (4 weeks after drinking), which may be described as 0 w and 4 w. In addition, since the implementation period was from the end of July to the end of August, maintain the condition of each person's daily life as much as possible during the test period, and avoid excessive sunburn such as sea bathing and outdoor activities. And esthetics were the conditions for the subjects. The evaluation site was the inner part of the left and right forearm, and the evaluation test was friction count measurement (static, dynamic), water load measurement, elasticity measurement, two-dimensional image analysis by replica collection, and questionnaire. As statistical analysis, data following normal distribution adopts Dunnett's multiple comparison test after repeated measures analysis of variance, and data not following normal distribution is subjected to Bonferroni correction after Wilcoxon's signed rank test, just before drinking And a test of significant difference at the end of drinking (immediately after 4 weeks drinking) was adopted. In Bonferroni's correction, the value obtained by dividing the significance level by the number of pairs to be compared (this time 0.016) was used as the correction significance level. For statistical analysis, statistical software "SPSS version 18.0 for Windows (SPSS Japan Inc.)" was used.

Friction count measurement (static, dynamic)
The measurement site was a site at a distance of about one third from the wrist side toward the elbow direction at the inner side of the left forearm. As a measuring instrument, a static friction measuring apparatus TL-201 (manufactured by Trinity Lab Co., Ltd.) is used, and as a measuring condition, load (20 g), measuring speed (10 mm / sec), measuring distance (20 mm), number of times of measurement (1 time) was adopted. A typical waveform obtained as a measurement result is shown in FIG. The static friction coefficient appears at a large peak appearing at the beginning of the graph of FIG. 1, and the distance until this peak appears is related to the viscoelasticity of the skin and is said to be an index related to so-called "skin firmness". Moreover, the average dynamic friction count used the average value of the dynamic friction count currently measured in the site | part (10-12 mm of 0-20 mm of measurement ranges) most measured value was stable by the pre test. The obtained results are shown in FIG. 2, the static friction count in FIG. 3, and the average dynamic friction count in FIG.

  As shown in FIG. 2, while the distance was significantly shortened in the test group, the placebo group showed almost the same value. As shown in FIG. 3, the test group had a large increase whereas the placebo group only showed approximately the same static friction count. Also, as shown in FIG. 4, the mean kinetic friction coefficient tended to decrease slightly in the test group, while it tended to increase in the placebo group. From the above, considering the summer test that is susceptible to sunlight in daily life, the skin tension tends to recover in the test group, and the friction coefficient tends to increase in the placebo, while it is almost the same in the test group. From the same level, it was found that continuous drinking of the test composition for 4 weeks shows the effect of preventing the deterioration of the skin's slip characteristics.

The water loading measurement site was a site at a distance of about one third from the wrist side toward the elbow direction at the inner side of the left forearm. As a measuring instrument, CorneoMeter CM-825 (made by Courage + Khazaka electronic GmbH) was used. The measurement method first measures the moisture of the measurement site, then drops 20 μl of ion-exchanged water on the measurement site, and after leaving for 10 seconds, gently presses the cotton to remove moisture and measures the moisture immediately after removing the cotton Did. Furthermore, moisture measurement was repeatedly performed for up to 120 seconds every 30 seconds from the measurement immediately after (total 5 times measurement). The measurement results were expressed by determining the total amount of water given to the measurement site and the amount of change of the water (water holding ability). The total water content given to the measurement site was expressed as a value obtained by subtracting the skin water content measurement value before dripping of water from the skin water content measurement value immediately after cotton removal, and the change amount of water (water retention capacity) was measured repeatedly. The average value of the four skin moisture content measurement values after 30 seconds after cotton removal and 120 seconds after was expressed as a percentage divided by the skin moisture content measurement value immediately after cotton removal. The obtained results are shown in FIG. 5 for the total water content and in FIG. 6 for the water retention ability.

  As shown in FIG. 5, the total amount of water given to the skin at the measurement site is almost the same in both groups, and although the water holding ability shows a difference in absolute value, the change rate of water holding ability over time Were almost the same.

The elasticity measurement measurement site was a site at a distance of about one third from the wrist side toward the elbow direction on the inner side of the left forearm and a site shifted about 2 cm in the shoulder direction from the position of the water load test. As a measuring instrument, Cuto Meter MPA-580 (made by Courage + Khazaka electronic GmbH) was used. The measurement conditions were a suction pressure of 200 hPa, a suction time of 5 seconds, an open time of 2 seconds, and a suction number of once. The measurement was carried out a total of four times with shifting so that the portions do not overlap, and the average value was taken as the measured value. A typical waveform obtained as a measurement result is shown in FIG. In FIG. 7, numerical values on the vertical axis corresponding to positions indicated by R1 and R5 are respectively set as an R1 parameter and an R5 parameter. The R1 parameter represents the ability to reshape the shape changed by suction to the shape before suction (re-deformability), and the R5 parameter represents elasticity (a value closer to 1.0 indicates higher elasticity). The obtained results are shown in FIG. 8 for the R1 parameter and in FIG. 9 for the R5 parameter.

  As shown in FIG. 8, the re-deformability of the skin was unchanged with the placebo, but tended to improve in the test group. Also, as shown in FIG. 9, the elasticity of the skin did not change with the placebo, but showed a tendency to decrease in the test group.

Two-dimensional image analysis by replica collection

The replica collection site was a site at a distance of about one third from the wrist side toward the elbow direction on the inner side of the right forearm. As a measurement instrument, ASA-03 RXD (manufactured by Asahi BioMed) was used. The replica was collected by applying silicone to the measurement site and peeling after drying. The range of the replica used for evaluation was an area of 5 mm × 5 mm. When light was irradiated from an oblique direction of 30 ° to the evaluation part of the collected replica, the shadows appearing on the replica were photographed 180 ° from each of which were photographed from two directions to obtain two shadow images. A recess (groove-like structure) having a depth of 130 μm or less was defined as “Ki” in a part obtained from the analysis of these two shadow images, and the numerical values of various parameters in this shadow image were measured. "Kime"
The sum of the volume of the groove recognized as H, the maximum depth and the maximum width are shown in FIG. 10, FIG. 11 and FIG. 12 respectively.

  As shown in FIG. 10, the total volume was increased in the test group, but no change was observed in the placebo group. On the other hand, as changes in texture, as shown in FIGS. 11 and 12, both the maximum depth and the maximum width increased by about 2 μm in the placebo group, but were suppressed to about 7-8 μm in the test group The From these results, in the placebo group, the texture groove tends to be large and deep, and the number of textures is reduced because the total volume is not changed. On the other hand, in the test group, changes in the width and depth of the texture are suppressed as compared to the placebo, and the total volume is increased, so that the number of textures is significantly reduced or not maintained. It was found that “fineness” was maintained.

Questionnaire survey was conducted on the actual condition of skin condition for subjects after drinking for 4 weeks. The evaluation items are "skin condition", "skin firmness", "skin texture / smoothness", "skin feel" and "makeup paste", and 0 is "the worst condition", 0 We performed 10 in 10 steps of "the best condition" evaluation. The results are shown in FIGS. Improvement was seen in all evaluation items after 4 weeks of continuous drinking. In particular, significant differences were found in the "skin tone", "skin firmness" and "skin texture / smoothness" in the test group, and significant tendencies in the "skin feel", but any item in the placebo group There was no significant trend either.

Claims (5)

An oral composition for improving the feeling of touch, which comprises an eggplant extract. Item 2. The oral composition according to item 1, which is for improving the feel of facial skin. The oral composition according to any one of Items 1 and 2, which is used for continuous administration or intake for at least 4 weeks. The oral composition according to any one of Items 1 to 3, which is a liquid composition. The oral composition according to any one of Items 1 to 4, which is a pharmaceutical composition or a food composition.

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