JP2019099575A - Quantitative injection type aerosol product for insect pest control and insect pest controlling method - Google Patents

Abstract

To provide a quantitative injection type aerosol product for insect pest control less in stimulation feeling, hardly contaminating a spray object, capable of diffusion a hardly volatilization insecticidal compound to a wide range uniformly, and exhibiting excellent insect pest controlling effect, and an insect pest controlling method.SOLUTION: There is provided a quantitative injection type aerosol product for insect pest control in which an aerosol composition consisting of a stock solution containing a hardly volatilization insecticidal compound with vapor pressure of less than 1×10mmHg (25°C), and a propellant is filled, the stock solution is contained at 40 vol.% or less in the aerosol composition, and injection amount per 1 time is 0.1 to 1.0 mL.SELECTED DRAWING: None

Description

  The present invention relates to a metered dose aerosol product for pest control and a pest control method. More specifically, the present invention is a quantitative injection-type pest control device that exhibits less irritability, is less likely to contaminate the spray target, and can uniformly diffuse the fugitive insecticidal compound over a wide area and exhibits excellent pest control effect The present invention relates to aerosol products and pest control methods.

  For example, insect repellents and aerosol products for controlling insect pests are known which have a volatile insecticidal compound such as transfluthrin as a main component and naturally volatilize such an insecticidal compound to obtain an insecticidal effect (for example, Patent Documents 1 to 4) 2). Also, aerosol products and pump products are known in which the amount of spray is increased so that the insecticide compounds can be spread as widely as possible. Furthermore, an aerosol product for controlling insect pests is known, which is composed mainly of a non-volatile insecticidal compound.

Japanese Patent Laid-Open No. 2003-73203 JP, 2010-280633, A

  However, when a volatile insecticidal compound such as transfluthrin is used in the pest control methods described in Patent Documents 1 and 2, the possibility that the user may aspirate by volatilizing the volatile insecticidal compound at the time of spraying. There is. In this case, the user may feel irritating. In addition, when the spray amount is increased (for example, more than 1 mL per time), the floor, clothes, and the like may be contaminated (such as liquid stains) in the vicinity of the sprayed position. Furthermore, the aerosol products containing the fugitive insecticidal compounds are not sufficiently diffusive, and their methods of use are limited, for example, they are sprayed to hit pests such as cockroaches or sprayed to their habitat, It has not been applied to clothing and the like housed in a narrow space such as a closet.

  The present invention has been made in view of such conventional problems, and is less irritating, is capable of uniformly diffusing the non-volatile insecticidal compound in a wide range, and is uniformly non-volatile insecticidal compound to the spray target It is an object of the present invention to provide a quantitative spray type aerosol product for controlling insect pests and a method for controlling insect pests, which are less likely to cause local contamination by adhering a

  The present inventors earnestly studied about conditions for solving the above-mentioned subject, and acquired the following knowledge. That is, the irritability is enhanced by injecting an aerosol composition comprising a predetermined amount of undiluted solution containing a non-volatile insecticidal compound exhibiting a predetermined vapor pressure and a propellant, by adjusting the amount of injection once to a specific amount, It is less likely to cause local contamination and can exhibit excellent pest control effect by uniformly diffusing the non-volatile insecticidal compound in a wide range and uniformly adhering the non-volatile insecticidal compound to the object to be sprayed. And completed the present invention. That is, the following constitutions are mainly included in the quantitative spray type aerosol product for pest control and pest control method of the present invention for solving the above problems.

(1) An aerosol composition comprising a stock solution containing a fugitive insecticidal compound having a vapor pressure of less than 1 × 10 ⁻⁵ mmHg (25 ° C.) and a propellant is charged, and the stock solution is contained in the aerosol composition And the controlled-injection type aerosol product for pest control which is contained so that it may be 40 volume% or less, and the injection amount per time is 0.1-1.0 mL.

  (2) The controlled-spray aerosol product for pest control according to (1), wherein the fugitive insecticidal compound comprises phenothrin or permethrin.

  (3) The controlled spray aerosol product for pest control according to (1) or (2), which is used for a narrow space in which clothes are stored.

(4) Consists of a stock solution containing a fugitive insecticidal compound having a vapor pressure of less than 1 × 10 ⁻⁵ mmHg (25 ° C.) and a propellant, wherein the stock solution is contained in the aerosol composition at 40% by volume or less The pest control method which injects the aerosol composition which is carried out so that the injection amount per time may be 0.1-1.0 mL.

  According to the present invention, it is less irritating, can diffuse the low-volatile insecticide compound uniformly over a wide area, and is less likely to cause local contamination by causing the low-volatile insecticide compound to adhere uniformly to the object to be sprayed. It is possible to provide a quantitative spray type aerosol product for controlling pests and a method for controlling pests, which exhibit excellent pest control effects.

FIG. 1 is a schematic view of an experimental apparatus for explaining a method of confirming the repellent effect on ticks.

<Quantitative spray type aerosol products for pest control>
A quantitative spray type aerosol product for pest control according to one embodiment of the present invention (hereinafter also referred to as an aerosol product) comprises a stock solution containing a fugitive insecticidal compound having a vapor pressure of less than 1 × 10 ⁻⁵ mmHg (25 ° C.) An aerosol container filled with an aerosol composition comprising a propellant, a valve mechanism attached to the aerosol container, a stem mechanism attached to the valve mechanism, a stem mechanism and a valve mechanism, and spraying the aerosol composition And an injection button having an injection hole formed therein. The stock solution is contained in the aerosol composition so as to be 40% by volume or less. The aerosol product of the present embodiment is adjusted to 0.1 to 1.0 mL of injection amount per time. Each configuration will be described below. In addition, the aerosol product of the present embodiment is adjusted such that the kind of nonvolatile volatile insecticidal compound, the content of the undiluted solution, and the injection amount per aerosol composition become the above-mentioned specific kind and range. It is characterized by Therefore, other configurations (for example, the shape of the aerosol product, other components and blending amounts, various physical properties such as internal pressure of the container, etc.) may be within the above range, and are not particularly limited. Therefore, in the following detailed description, the kind of the non-volatile insecticidal compound, the content of the undiluted solution, and the injection amount per time of the aerosol composition are adjusted to be the above-mentioned specific kind and range Other than the above, all are examples.

(Stock solution)
The stock solution contains a fugitive insecticidal compound having a vapor pressure of less than 1 × 10 ⁻⁵ mmHg (25 ° C.). The vapor pressure of the nonvolatile insecticide compound may be less than 1 × 10 ⁻⁵ mmHg (25 ° C.), preferably 5 × 10 ⁻⁶ mmHg (25 ° C.) or less, and 1 × 10 ⁻⁶ mmHg ( It is more preferable that it is 25 degrees C or less. When the vapor pressure of the fugitive insecticidal compound is less than 1 × 10 ⁻⁵ mmHg (25 ° C.), the aerosol product tends to maintain the pest control effect for a long period of time after being attached to the object to be sprayed.

  The nonvolatile insecticidal compound is not particularly limited as long as it exerts a pest control effect. Examples of non-volatile insecticidal compounds include insecticidal compounds such as pyrethroid compounds, carbamate compounds, neonicotinoid compounds, chitin synthesis inhibitory compounds, juvenile hormone-like compounds and the like. These fugitive insecticidal compounds may be used in combination.

The pyrethroid compound is not particularly limited as long as the vapor pressure is less than 1 × 10 ⁻⁵ mmHg (25 ° C.). Examples of pyrethroid compounds include phenothrin (vapor pressure: 1.43 × 10 ⁻⁷ mmHg (21 ° C.)), permethrin (vapor pressure: 5.18 × 10 ⁻⁸ mmHg (25 ° C.)), bifenthrin (vapor pressure) : 1.34 x 10 ^-8 mmHg (25 ° C), cyfluthrin (vapor pressure: 1.5 x 10 ^-10 mmHg (20 ° C)), cypermethrin (vapor pressure: 1.7 x 10 ^-9 mmHg (20 C)), cypophothrin (vapor pressure: 9.0 × 10 ⁻⁷ mmHg (20 ° C.)), and the like. Among these, it is preferable that the pyrethroid-based compound contains phenothrin or permethrin because of its high insecticidal effect. The vapor pressure of phenothrin, cyfluthrin, cypermethrin, and cypenothrin is less than 1 × 10 ⁻⁵ mmHg at 25 ° C.

The carbamate compound is not particularly limited as long as the vapor pressure is less than 1 × 10 ⁻⁵ mmHg (25 ° C.). Examples of carbamate compounds include carbaryl (vapor pressure: 1.36 × 10 ⁻⁶ mmHg (25 ° C.)) and the like.

The neonicotinoid compound is not particularly limited as long as the vapor pressure is less than 1 × 10 ⁻⁵ mmHg (25 ° C.). Examples of neonicotinoid compounds include dinotefuran (vapor pressure: 1.3 × 10 ⁻⁸ mmHg (25 ° C.)), imidacloprid (vapor pressure: 3.0 × 10 ⁻¹² mmHg (25 ° C.), etc. Be

The chitin synthesis inhibitory compound is not particularly limited as long as the vapor pressure is less than 1 × 10 ⁻⁵ mmHg (25 ° C.). Examples of chitin synthesis inhibitory compounds include diflubenzuron (vapor pressure: 9.0 × 10 ⁻¹⁰ mmHg (25 ° C.)) and the like.

The juvenile hormone-like compound is not particularly limited as long as the vapor pressure is less than 1 × 10 ⁻⁵ mmHg (25 ° C.). Examples of juvenile hormone-like compounds include pyriproxyfen (vapor pressure: 9.8 × 10 ⁻⁸ mmHg (23 ° C.)) and the like. In addition, the vapor pressure of pyriproxyfen is less than 1 × 10 ⁻⁵ mmHg at 25 ° C.

  By using these insecticidal compounds as the fugitive insecticidal compounds, for example, clothing insect pests such as iga and koiga, etc., cockroaches such as snails, cockroaches, cockroaches, cockroaches, cockroaches, cockroaches and cockroaches, spiders, centipedes, ants, ants, Insect pests such as mistletoe, worm bug, larch bug, termite, caterpillar, tick, flea, bed bug, lice, and scallop, mosquito pests such as mosquito, fly, bee, bee, bug, cuttlefish, bug beetle, bark beetle etc can be suitably controlled .

  The content of the nonvolatile insecticide compound is not particularly limited. The content of the nonvolatile volatile insecticidal compound can be appropriately adjusted depending on the type of the nonvolatile volatile insecticidal compound. If an example is given, it is preferable that it is 30 w / v% or more in a undiluted | stock solution, and, as for content of a non-volatile insecticidal compound, it is more preferable that it is 40 w / v% or more. On the other hand, the content of the fugitive insecticidal compound may be 100 w / v% in the stock solution. When the content of the fugitive insecticidal compound is less than 30 w / v%, the aerosol product may not sufficiently exert a desired insecticidal effect or may not be easily diffused widely.

The stock solution may optionally contain a volatile insecticide compound in addition to the above-mentioned nonvolatile compound. Examples of volatile volatile compounds include pyrethroid compounds and organic phosphorus compounds. The pyrethroid compound of the volatile insecticide compound is, for example, profluthrin (vapor pressure: 7.72 × 10 ⁻⁵ mmHg (25 ° C.)), enpentrin (vapor pressure: 1.05 × 10 ⁻⁴ mmHg (23.5 ° C.) Can be mentioned. Examples of the organophosphorus compound of the volatile insecticide compound include dichlorvos (vapor pressure: 1.20 × 10 ⁻² mmHg (20 ° C.)).

  Moreover, in the case where the volatile volatile compound is contained, the content of the volatile volatile compound is not particularly limited. The content of the volatile insecticide compound can be appropriately adjusted depending on the type of the volatile insecticide compound. If an example is given, it is preferable that it is 1 w / v% or more in a undiluted | stock solution, and, as for content of a volatile volatile insecticidal compound, it is more preferable that it is 5 w / v% or more. On the other hand, the content of the volatile insecticide compound is preferably 30 w / v% or less, more preferably 20 w / v% or less in the stock solution. When the content of the volatile insecticide compound is in the above-mentioned range, the aerosol product has the advantage of being less irritating and easily spread over a wide area.

  The stock solution may optionally contain a solvent in addition to the above-mentioned sparingly insecticidal compound. A solvent may be contained to appropriately dissolve the above-mentioned non-volatile insecticidal compound so as to be easily mixed with the propellant in the aerosol container or to facilitate handling of the stock solution at the time of production.

  The solvent is not particularly limited. Examples of the solvent include ethanol, isopropyl alcohol (IPA), isopropyl myristate (IPM), liquid paraffin, kerosene and the like. Among these, the solvent is preferably ethanol, IPA, or IPM from the viewpoint that the solvent is easy to dissolve the non-volatile insecticidal compound, is inexpensive, and is easy to handle.

  When the solvent is contained, the content of the solvent is not particularly limited. The content of the solvent in the stock solution is preferably 1% by volume or more, more preferably 5% by volume or more, and still more preferably 10% by volume or more. On the other hand, the content of the solvent in the undiluted solution is preferably 99% by volume or less, more preferably 90% by volume or less. When the content of the solvent is less than 1% by volume, the aerosol product may not be able to sufficiently dissolve the fugitive insecticidal compound depending on the kind of the fugitive insecticidal compound. On the other hand, when the content of the solvent exceeds 99% by volume, the aerosol product may have a reduced content of the nonvolatile volatile insecticidal compound, and it may be difficult to obtain a sufficient pest control effect.

  The stock solution may contain optional components in addition to the above-mentioned sparingly insecticidal compound and the above-mentioned solvent optionally contained. Optional components include, for example, various perfumes; antibacterial agents; nonionic, anionic or cationic surfactants; antioxidants such as butylhydroxytoluene; stabilizers such as citric acid and ascorbic acid; and inorganic substances such as talc and silicic acid Powders, deodorants, pigments and the like can be mentioned.

(Propellant)
The propellant is the content that is pressure-filled into the aerosol container with the stock solution. The propellant is injected from the injection port of the injection button described later together with the undiluted solution by operating a valve mechanism described later. At the same time, the propellant imparts a propulsive force at the time of spraying the stock solution, and atomizes the aerosol composition and diffuses it into space.

  The type of propellant is not particularly limited. As a propellant, liquefied gas, compressed gas, etc. are mentioned, for example. Examples of liquefied gas include liquefied petroleum gas, aliphatic hydrocarbons having 3 to 5 carbon atoms such as propane, normal butane, isobutane, normal pentane, and isopentane, and trans-1,3,3,3-tetrafluoroprop-1- Examples thereof include hydrofluoroolefins such as ene and trans-2,3,3,3-tetrafluoroprop-1-ene, dimethyl ether and mixtures thereof. Examples of the compressed gas include nitrogen gas, carbon dioxide gas, nitrous oxide gas, compressed air and the like.

  In the present embodiment, the propellant is preferably contained in the aerosol composition so as to be 95% by volume or less, more preferably 80% by volume or less. The propellant is preferably contained in the aerosol composition to be 60% by volume or more, and more preferably 65% by volume or more.

  In the present embodiment, the stock solution may be contained in the aerosol composition so as to be 40% by volume or less, and preferably 35% by volume or less. The stock solution is preferably contained in the aerosol composition so as to be 5% by volume or more, and more preferably 10% by volume or more. When the content of the undiluted solution is less than 5% by volume in the aerosol composition, the aerosol composition tends to have a low content of the fugitive insecticidal compound and a sufficient pest control effect can not be obtained.

  The internal pressure of the aerosol container at 25 ° C. is preferably 0.2 MPa or more, and more preferably 0.25 MPa or more in the state in which the stock solution and the propellant are filled. The internal pressure of the aerosol container at 25 ° C. is preferably 0.8 MPa or less, more preferably 0.7 MPa or less. When the internal pressure of the aerosol container is less than 0.2 MPa, the aerosol composition may drip off from the injection port after spraying, and the diffusivity of the fugitive insecticidal compound may be deteriorated. On the other hand, when the internal pressure of the aerosol container exceeds 0.8 MPa, the aerosol composition may leak from the aerosol container.

  Returning to the entire aerosol product description, the aerosol product containing the above-described stock solution and propellant is pressure-filled into the aerosol container. The aerosol container is not particularly limited. As an example, the aerosol container is a substantially cylindrical pressure-resistant container having an opening at the top. The opening is a filling port for filling the aerosol composition, and after being filled with the stock solution, it is closed by a valve mechanism described later.

  The material of the aerosol container is not particularly limited. Examples of the material of the aerosol container include metals such as aluminum and tin, synthetic resins such as polyethylene terephthalate, and pressure resistant glass.

  The valve mechanism is a mechanism for removing the aerosol composition filled in the aerosol container, and is attached to the opening of the aerosol container to close the opening. Further, in the valve mechanism of the present embodiment, a metering chamber for temporarily storing the aerosol composition removed from the aerosol container is formed. The volume of the metering chamber corresponds to the volume of the aerosol composition sprayed by one injection. The volume of the metering chamber of the present embodiment is 0.1 to 1.0 mL.

  The stem mechanism is a portion attached to the valve mechanism, and an internal passage is formed for sending the stock solution and the propellant taken into the valve mechanism to the injection button described later. The internal passage is suitably opened and closed by the stem rubber of the stem mechanism.

  The injection button is a member for injecting the undiluted solution taken in from the aerosol container via the stem mechanism by the valve mechanism together with the propellant. The injection button is formed with an injection hole for injecting the aerosol composition.

  The number, size and shape of the injection ports are not particularly limited. The number of the injection holes may be one, or two or more, for example. Moreover, it is preferable that the dimension (injection hole diameter) of a nozzle is 0.4-0.7 mm. The shape (cross-sectional shape) of the injection port may be circular, oval, square, or various irregular shapes.

  In the aerosol product of the present embodiment, when the user operates the injection button, the stem mechanism and the valve mechanism are operated, and the inside of the aerosol container communicates with the outside. As a result, a predetermined amount of the aerosol composition in the aerosol container is taken out from the aerosol container in accordance with the pressure difference between the inside and the outside of the aerosol container, and is jetted from the injection hole of the jet button.

  The aerosol composition sprayed by the aerosol product of this embodiment preferably has an injection force of 2.0 gf or more at 25 ° C., more preferably 5.0 gf or more at a position 30 cm away from the injection port. . The aerosol composition preferably has an injection force of 14.0 gf or less at 25 ° C., more preferably 10.0 gf or less, at a position 30 cm away from the injection port. When the jetting force is less than 2.0 gf, the jetted aerosol composition is unlikely to be diffused widely. On the other hand, when the injection force exceeds 14.0 gf, when the injected aerosol composition is injected in the application space, a large amount of the non-volatile insecticidal compound adheres to the wall of the space, etc., and the adhesion to the spray target is small. Tend to be The aerosol product of the present embodiment is easy to diffuse the fugitive insecticidal compound uniformly over a wide range by adjusting the injection force to be in the above range. The jet force of the jetted aerosol composition is, for example, perpendicular to the flat plate surface toward the center of the circular plate of φ60 mm attached to a digital force gauge (DS2-2N, manufactured by Imada Co., Ltd.). Thus, it can be calculated by measuring the maximum value when the aerosol composition is jetted from a distance of 30 cm. In the present embodiment, the method of adjusting the injection force is not particularly limited. Such injection force may be appropriately adjusted depending on the type of aerosol composition, internal pressure, number of injection ports, shape, and the like.

  The aerosol product of the present embodiment is adjusted so that the injection amount per injection is 0.1 to 1.0 mL. Preferably, the injection amount per injection is adjusted to be 0.1 to 0.4 mL. If the injection amount per injection is less than 0.1 mL, the injected aerosol composition may not be uniformly diffused, and a sufficient pest control effect may not be obtained. On the other hand, when the injection amount per injection exceeds 1.0 mL, the injected aerosol composition is likely to cause contamination of the injection target. The method for adjusting the injection amount per injection is not particularly limited. The injection amount per injection can be adjusted, for example, by appropriately adjusting the capacity of the metering chamber in the valve mechanism, the time during which the inside of the aerosol container communicates with the outside when the injection button is operated, and the like.

  The aerosol product of the present embodiment comprises an aerosol composition comprising a predetermined amount of a stock solution containing the above-mentioned non-volatile insecticidal compound exhibiting a predetermined vapor pressure and a propellant, in a single injection amount of 0.1 to 1.0 mL. By adjusting and spraying, it is less irritating, less likely to contaminate the target to be sprayed, and it is possible to uniformly diffuse the fugitive insecticidal compound over a wide area, and achieve excellent pest control effect. . In addition, it is more preferable to make the injection quantity per time into 0.4 mL or less at the point which is hard to contaminate a sprayed object.

  The method for producing the aerosol product of the present embodiment is not particularly limited. In one example, the aerosol product is filled with an aerosol container with a stock solution, a valve mechanism provided with a metering chamber is used to close the opening of the aerosol container, a propellant is pressurized and loaded through the stem mechanism, and then the spray button Can be manufactured by attaching The injection button is exemplified by a trigger button, a push-down button, and the like.

  The application site of the aerosol product of the present embodiment is not particularly limited. The aerosol product of this embodiment may be applied to the desired space to control pests. Applicable places include, for example, clothing storage space (clothes case, drawer, wardrobe, closet, walk-in closet, closet, etc.), clearance between various furniture and home appliances and floor or wall, shoe box, suitcase, bathroom Etc. can be mentioned. Among these, the aerosol product of the present embodiment can be suitably used for a narrow space for housing clothes, such as a closet. When used in such confined spaces, the aerosol product can spray the aerosol composition uniformly over a wide area, for example, in a closet. Also, the aerosol product may uniformly adhere the low volatility compound in the aerosol composition to the garment. Therefore, the wall surface of the closet and the clothes are prevented from being attached locally with a high concentration of the non-volatile compounds, and are not easily contaminated. In this case, clothes and the like are less likely to cause stains and the like. In the present embodiment, the narrow space refers to a semi-sealed or sealed space having a volume of about 50 liters to 18000 liters (about 4.5 mats). The aerosol product of the present embodiment has a small liquid stain on the object to be sprayed and is excellent in the diffusibility in space, particularly when used in a narrow space having a volume of 50 L to 2500 L. If the volume of the application site is less than 50 L, the concentration of the drug in such space tends to be high, and the liquid stain on the object to be sprayed tends to occur. On the other hand, when the volume of the application site exceeds 18000 L, convection of the air flow by spraying is difficult to occur, and the drug is not easily sprayed uniformly on the spray target. In addition, excessive spraying of the chemical for uniform application tends to cause liquid stains.

  Further, the aerosol product is not particularly limited as long as it can be sprayed so that the aerosol product can be dispersed uniformly in a wide range, but preferably it is sprayed obliquely upward. When spraying in an obliquely upward direction, it is preferable that the angle at the time of spraying be 0 to 75 degrees in the obliquely upward direction from the horizontal direction.

As described above, according to the aerosol product of the present embodiment, there is little irritation, it is difficult to contaminate the spray target, and the fugitive insecticidal compound can be diffused uniformly over a wide range, and can be adhered to the spray target. For example, the aerosol product of the present embodiment can attach 5 mg / m ² or more of the fugitive insecticidal compound to an object to be sprayed (for example, a closet, clothes, etc.) by a single injection. As a result, an excellent pest control effect is exhibited for a long time.

<Pest control method>
The pest control method according to one embodiment of the present invention comprises a stock solution containing a fugitive insecticidal compound having a vapor pressure of less than 1 × 10 ⁻⁵ mmHg (25 ° C.) and a propellant, and the stock solution is 40 in the aerosol composition. In this method, the aerosol composition contained so as to have a volume percentage or less is injected so that the injection amount per injection becomes 0.1 to 1.0 mL.

  In carrying out the pest control method of the present embodiment, the aerosol composition and the aerosol product may be the same as those described in the above embodiment.

  In the present embodiment, the number of injections may be one. According to the pest control method of the present embodiment, the stock solution contains a hardly volatile compound. Therefore, the user is less likely to feel a sensation. In addition, since the hardly volatile compound can be sprayed uniformly over a wide range, it is difficult to contaminate the object to be sprayed (for example, floor surface, clothes, etc.), and easily maintain excellent pest control effect. According to the pest control method of the present embodiment, the desired effect can be obtained even if the number of injections is one, but the number of injections may be two or more depending on the size of the space.

  Hereinafter, the present invention will be more specifically described by way of examples. The present invention is not limited to these examples.

Example 1
4.24 g of phenothrin (4 mL) as a bulk substance is filled in an aerosol container with a diameter of 35 mm and a height of 68 mm, and a valve (0.2 cc metering valve) attached, and then the blending ratio (volume ratio) of the stock solution and the propellant is A 16 mL volume of propellant (liquefied petroleum gas specific gravity: 0.55 g / mL) was pressurized to 20:80, and an injection button was attached to produce an aerosol product. The internal pressure (25 ° C.) of this aerosol product was 0.49 MPa. By using this aerosol product, 42.4 mg of drug substance is injected at a time.

(Example 2)
We weighed 3.00 g of permethrin and made up to 6 mL with 99.5% ethanol. The mixture solution obtained was used as a stock solution, and 14 mL of a propellant (liquefied petroleum gas specific gravity: 0.56 g / mL) was added so that the blending ratio (volume ratio) of the stock solution and the propellant would be 30:70. An aerosol product was produced in the same manner as in Example 1. The internal pressure (25 ° C.) of this aerosol product was 0.39 MPa. By using this aerosol product, 30.0 mg of drug substance is injected at one time.

(Example 3)
3.18 g of phenothrin (3 mL) as a bulk substance is filled in the same aerosol container as in Example 1 and a valve (0.1 cc metering valve) is attached, and then the blending ratio (volume ratio) of the undiluted solution to the propellant is 17 mL of a propellant (liquefied petroleum gas specific gravity: 0.56 g / mL) was pressure-filled to 15: 85, and an injection button was attached to produce an aerosol product. The internal pressure (25 ° C.) of this aerosol product was 0.39 MPa. By using this aerosol product, 15.9 mg of drug substance is injected at one time.

(Example 4)
3.00 g phenothrin was weighed and made up to 6 mL with 99.5% ethanol. The mixture solution obtained was used as a stock solution, and 14 mL of a propellant (liquefied petroleum gas specific gravity: 0.56 g / mL) was added so that the blending ratio (volume ratio) of the stock solution and the propellant would be 30:70. An aerosol product was made in the same manner as Example 1. The internal pressure (25 ° C.) of this aerosol product was 0.39 MPa. By using this aerosol product, 30.0 mg of drug substance is injected at one time.

(Example 5)
4.24 g of phenothrin (4 mL) as a bulk substance is filled in an aerosol container with a diameter of 35 mm and a height of 68 mm, and a valve (1.0 cc metering valve) attached, and then the blending ratio (volume ratio) of the stock solution and the propellant is 16 mL of propellant (liquefied petroleum gas specific gravity: 0.56 g / mL) was pressure-filled to 20:80, and an injection button was attached to produce an aerosol product. The internal pressure (25 ° C.) of this aerosol product was 0.39 MPa. By using this aerosol product, the drug substance is sprayed at 212.0 mg per dose.

(Comparative example 1)
1.93 g of phenothrin was weighed and made up to 4 mL with 99.5% ethanol. The obtained mixed solution is used as a stock solution, filled in an aerosol container with a diameter of 35 mm and a height of 68 mm, and a valve (2.2 cc metering valve) attached, and the blending ratio (volume ratio) of the stock solution and the propellant is 20:80. Then, 16 mL of a propellant (liquefied petroleum gas specific gravity: 0.56 g / mL) was pressurized and charged, and an injection button was attached to produce an aerosol product. The internal pressure (25 ° C.) of this aerosol product was 0.39 MPa. By using this aerosol product, the drug substance is sprayed at 212.3 mg per dose.

(Comparative example 2)
Bulk material used 5.55 g of transfluthrin (4 mL, vapor pressure: 4.12 × 10 ^-5 mmHg (25 ° C)) and 16 mL of propellant (liquefied petroleum gas specific gravity: 0.56 g / mL) An aerosol product was produced in the same manner as in Example 1. The internal pressure (25 ° C.) of this aerosol product was 0.39 MPa. By using this aerosol product, the drug substance is sprayed at 55.5 mg per dose.

(Comparative example 3)
3.00 g of phenothrin was weighed and made up to 15 mL with 99.5% ethanol. The resulting mixed solution was used as a stock solution, and 5 mL of a propellant (liquefied petroleum gas specific gravity: 0.56 g / mL) was added so that the blending ratio (volume ratio) of the stock solution and the propellant would be 75:25. An aerosol product was made in the same manner as Example 1. The internal pressure (25 ° C.) of this aerosol product was 0.39 MPa. By using this aerosol product, 30.0 mg of drug substance is injected at one time.

  About the obtained aerosol products of Examples 1 to 5 and Comparative Examples 1 to 3, the diffusibility of the aerosol composition, the feeling of irritation, the liquid stain on the clothes, and the jet force were evaluated by the following method. The results are shown in Table 1.

<Diffusion of Aerosol Composition>
In a stainless steel chest A (size: width 64 cm, depth 60 cm, height 130 cm, volume: approx 500 L), a sheep blanket (10 cm × 10 cm piece) 27 cm from the front, 11 cm from the left and right sides, 15 cm or 95 cm from the top surface It hung a total of four pieces in the position of, and sprayed each aerosol product once in the horizontal direction. Twenty-four hours after spraying, the content of the drug adhering to the cloth was analyzed by gas chromatography, the average of the analysis values of four cloths was calculated, and the diffusivity was evaluated according to the following evaluation criteria. See Table 1 for aerosol spray conditions. In addition, regarding Example 4, the diffusivity was also evaluated with respect to a stainless steel chest B (size: width 85 cm, depth 133 cm, height 191 cm, volume: about 2159 L). The number of injections of the aerosol composition at that time was 4 times, and all the injections were performed from a fixed position.
(Evaluation criteria)
○: The average value of the drug adhesion per 4 cloths was 5 mg / m ² or more.
X: The average drug adhesion amount per four cloths was less than 5 mg / m ² .

<Evaluation of feeling of stimulation>
Hang a piece of cotton cloth (JIS L 0803 compliant item, 5 cm x 5 cm piece) in the center of stainless steel chest A (size: width 64 cm, depth 60 cm, height 130 cm, volume: approx 500 L) from a distance of 20 cm from the cloth The aerosol products of Examples 1 to 5 and Comparative Examples 1 to 3 were jetted once, and the feeling of irritation felt when the cloth sprayed with the aerosol was attached to the skin was evaluated according to the following evaluation criteria.
(Evaluation criteria)
○: I did not feel a stimulus.
X: I felt stimulation.

Liquid stains on clothing
Hang a piece of silk cloth (JIS L 0803 compliant product, with 6 hooks, 5 cm x 5 cm piece) at the center of stainless steel chest A (size: width 64 cm, depth 60 cm, height 130 cm, volume: about 500 L), 20 cm from the cloth The aerosol products of Examples 1 to 5 and Comparative Examples 1 to 3 were sprayed once from a distance, and the degree of liquid stain (contamination) of the cloth was evaluated according to the following evaluation criteria.
(Evaluation criteria)
○: no liquid stain (contamination) occurred.
Δ: Almost no liquid stain (contamination) occurred.
X: Liquid stain (contamination) occurred.

<Injection force>
When the aerosol composition is jetted from a distance of 30 cm perpendicular to the flat surface toward the center of the circular flat plate with a diameter of 60 mm attached to a digital force gauge (DS2-2N, manufactured by Imada Co., Ltd.) The maximum value of was measured. The measurement was performed three times at 25 ° C., and the average value was taken as the injection force (gf).

  As shown in Table 1, the aerosol products of Examples 1 to 5 all had excellent diffusivity. From this, an excellent pest control effect can be expected. These aerosol products can inhibit the hatching of iga eggs etc. with respect to the clothing accommodated in accommodation space, such as a chest, for example. In addition, these aerosol products were not irritating, and almost no liquid stains occurred on the object to be sprayed (the cloth in the stainless steel closet). The aerosol product of Example 4 also had excellent diffusivity in the diffusivity test using a stainless steel bag B (volume: about 2159 L). Thereby, an excellent pest control effect can be expected.

On the other hand, when the aerosol product of Comparative Example 1 in which the injection amount per injection exceeded 1.0 mL was sprayed into a narrow space such as a stainless steel closet, liquid stains were generated on the cloth to be sprayed. In addition, when the aerosol product of the comparative example 1 was sprayed not into the narrow space but into the space having a larger volume, it was confirmed that the liquid stain did not occur on the cloth. In addition, the aerosol product of Comparative Example 2 in which transflutrin having a vapor pressure of more than 1 × 10 ⁻⁵ mmHg (25 ° C.) was compounded felt irritation. Furthermore, the aerosol product of Comparative Example 3 in which the stock solution was blended in excess of 40% by volume was inferior in diffusion, and liquid stains were generated on the cloth to be sprayed.

<Letal effects against clothing pests / unpleasant pests>
Using the aerosol product of Example 4 described above, the lethal effects on clothing pests and unpleasant pests (garbage eggs, worm larvae, moth adults, cutworms, bark beetles and tobacco beetles) were confirmed by the following test methods.

(Test method)
Test insects are placed in a plastic cup (diameter 8 cm, height 4 cm, volume about 200 mL) or glass petri dish under 25 ° C., humidity 70% environment, stainless steel case A (dimension: width 64 cm, depth 60 cm, height) 130 cm, volume: about 500 L) placed at the center of the bottom surface. The aerosol product of Example 4 was sprayed once from the center of the width direction (location 32 cm from the left and right) and at a height of 65 cm (horizontal direction with respect to iga (Iga eggs, iga larvae, iga adults) And 45 ° from the horizontal direction to the other test insects)). Two hours after treatment, the number of kills of the moth (Giga eggs, moth larvae, moth adults) is counted, and after one day of treatment, the number of kills of the beetles, bark beetles and tobacco beetles are counted, and the respective mortality (%) Was calculated. The test was performed twice and compared to the untreated area where the aerosol product was not used. The results are shown in Table 2.

(Test insect)
Imaginum eggs: about 20. Iga larvae (about 30 days old): about 10: Imaginum adults: about 20. Bugs: about 20. bark beetles: about 10 tobacco beetles: about 10

  As shown in Table 2, according to the aerosol product of the present invention, a high mortality rate was shown for all clothing pests and unpleasant pests. Thereby, it was shown that the aerosol product of the present invention exhibits an excellent pest control effect.

(Example 6)
As a drug substance, 1.2 g of phenothrin and 0.3 g of profluthrin were weighed, and made up to 3 mL with 99.5% ethanol. The obtained mixed solution was used as a stock solution. The resulting undiluted solution is filled in an aerosol container with a diameter of 35 mm and a height of 68 mm, and after a valve (0.2 cc metering valve) is attached, the blending ratio (volume ratio) of undiluted solution and propellant is 15: 85 A propellant ((liquefied petroleum gas: specific gravity: 0.55 g / mL) was pressure-charged to 17 mL, and an injection button (injection hole 0.6 mm) was attached to produce an aerosol product. The internal pressure (25 ° C.) of this aerosol product was 0.49 MPa. By using this aerosol product, phenothrin is injected at 12 mg per dose and profluthrin is injected at 3 mg per dose.

  The aerosol product of Example 6 was used to conduct a confirmation test of repellent effects on ticks and a confirmation test of lethal effects on clothing pests and unpleasant pests according to the following method.

<Repellent effect against ticks>
FIG. 1 is a schematic view of an experimental apparatus for explaining a method of confirming the repellent effect on ticks. As shown in FIG. 1, in a petri dish 1 having a diameter of 15 cm, black paper 2 of 9 cm square and four cotton cloths of 3.5 cm square are arranged in order from the bottom of petri dish 1 Then, 2 cm square black paper 4 was placed at the center of each cotton cloth 3 and food (fresh medium 5) was placed on each black paper 4. Among the cotton cloths 3a to 3d, the cotton cloth 3a and the cotton cloth 3c were sprayed with the contents using the aerosol product of Example 6 according to the following method. As a result, the four cotton cloths 3a to 3d are alternately disposed with those treated with the aerosol product of Example 6 and those not treated. In addition, about 500 to 1000 test insects (Pinkworm mites) were placed almost equally in the four places on the outside of the black paper 2. Let stand at 25 ° C, 75% RH overnight and count the test insects crawling up in the treated area (cotton cloth 3a and cotton cloth 3c) and the non-treated area (cotton cloth 3b and cotton cloth 3d). The repellent rate (%) against ticks was calculated by the calculation formula. The test was performed three times. The results of repellent rate and average repellent rate (%) against the obtained ticks are shown in Table 3.
Repellent rate against ticks (%)
= (The number of crawling ticks in the untreated zone-the number of crawling ticks in the treated district) / (The number of crawling ticks in the untreated zone) × 100

(Method of processing contents into cotton cloth)
With respect to the above-mentioned cotton cloth 3a and cotton cloth 3c placed at the center of the bottom of the space (size: width 85 cm, depth 133 cm, height 191 cm, volume: about 2159 L), the aerosol product produced in Example 6 The jet was applied once from the position of 70 cm high at the center (at 42.5 cm from the left and right) and in the horizontal direction. After 2 hours, cotton cloth was used for the above test.

  As shown in Table 3, it was confirmed that the aerosol product of the present invention exhibits an excellent repellent effect on ticks.

<Letal effects against clothing pests / unpleasant pests>
Using the aerosol product of Example 6 above, the lethal effects on clothing pests and unpleasant pests (garworm larvae, moth adults, spiny beetles, spiny beetles, bark beetles and tobacco beetles) were confirmed by the following test methods.

(Test method)
Test insects are placed in a plastic cup (diameter 8 cm, height 4 cm, volume about 200 mL) or glass petri dish under 25 ° C., humidity 70% environment, stainless steel case A (dimension: width 64 cm, depth 60 cm, height) 130 cm, volume: about 500 L) placed at the center of the bottom surface. The aerosol product of Example 6 was sprayed once at an angle of 45 ° upward from the horizontal direction from the position of 100 cm in height at the center of the width direction (place 32 cm from the left and right). Two hours and one day after treatment, the number of lethality of each clothing pest and unpleasant pest was counted, and the mortality rate (%) was calculated. The test was performed twice and compared to the untreated area where the aerosol product was not used. The results are shown in Table 4. In Table 4, numerical values without parentheses indicate results after 2 hours, and numerical values in parentheses indicate results after 1 day.

(Test insect)
Larvae (about 30 days old): about 10: Adults of about 10: about 10 headworms of about 10: about 10 headed beetles: about 20: bark beetles: about 10 tobacco beetles: about 10

  As shown in Table 4, according to the aerosol product of the present invention, all clothing pests and unpleasant pests showed a high mortality rate after one day at the latest. Thereby, it was shown that the aerosol product of the present invention exhibits an excellent pest control effect.

1 petri dish 2 black paper 3a to 3d cotton cloth 4 black paper 5 fresh medium P1 to P4

Claims (4)

An aerosol composition comprising a stock solution comprising a fugitive insecticidal compound having a vapor pressure of less than 1 × 10 ⁻⁵ mmHg (25 ° C.) and a propellant;
The stock solution is contained in the aerosol composition so as to be 40% by volume or less,
The fixed quantity spray type aerosol product for pest control whose injected quantity per time is 0.1-1.0 mL.   The pest control controlled injection aerosol product according to claim 1, wherein the fugitive insecticidal compound comprises phenothrin or permethrin.   The pest control metered dose aerosol product according to claim 1 or 2, which is used for a narrow space in which clothes are accommodated. An aerosol composition comprising a stock solution containing a fugitive insecticidal compound having a vapor pressure of less than 1 × 10 ⁻⁵ mmHg (25 ° C.) and a propellant, wherein the stock solution is contained at 40 vol% or less in the aerosol composition. The pest control method which injects a thing so that the injection amount per time may be 0.1-1.0 mL.

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