WO2015105128A1 - Bed bug repellent, bed bug repellent composition, and bed bug repelling method - Google Patents

Bed bug repellent, bed bug repellent composition, and bed bug repelling method Download PDF

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WO2015105128A1
WO2015105128A1 PCT/JP2015/050278 JP2015050278W WO2015105128A1 WO 2015105128 A1 WO2015105128 A1 WO 2015105128A1 JP 2015050278 W JP2015050278 W JP 2015050278W WO 2015105128 A1 WO2015105128 A1 WO 2015105128A1
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bed bug
bed
silicon dioxide
dioxide powder
repellent
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PCT/JP2015/050278
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French (fr)
Japanese (ja)
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隆太 宮地
耕作 野▲崎▼
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アース製薬株式会社
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Priority to CN201580003986.0A priority Critical patent/CN105899075A/en
Priority to JP2015556820A priority patent/JPWO2015105128A1/en
Publication of WO2015105128A1 publication Critical patent/WO2015105128A1/en

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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds

Definitions

  • the present invention relates to a bed bug control agent, a bed bug control composition, and a bed bug control method.
  • repellents containing N, N-diethyltoluamide (DEET) and the like are known as means for protecting themselves from blood-sucking pests such as bed bugs (see, for example, Patent Document 1 below).
  • bedbugs have a high growth rate and are resistant to hunger, and can survive for months to up to a year or more without being fed. Therefore, repelling bed bugs is not enough, and it is desired to kill them.
  • bed bugs are mainly active at night, and during the day they are not visible to the back of carpets, tatami rims, furniture (bed frame, chiffon, etc.), baseboard support, closets, wall gaps, etc. Because it lives in indoor dark places, it is difficult to identify the habitat and to contact a sufficient amount of insecticide. Therefore, it is difficult to completely eliminate bed bugs with insecticides.
  • a method using a pesticide containing an insecticidal component such as a pyrethroid compound may be considered.
  • an insecticidal component such as a pyrethroid compound
  • the development of resistance is a problem for insecticidal components such as pyrethroid compounds.
  • the present invention has been made in view of the above problems, and an object of the present invention is to provide a bed bug repellent, a bed bug repellent composition, and a bed bug repelling method capable of controlling bed bugs without using insecticidal components. .
  • the bed bug repellent according to the present invention is made of silicon dioxide powder having an oil absorption of 35 mL / 100 g or more.
  • bed bugs can be controlled without using an insecticidal component.
  • the reason why such an effect is obtained in the present invention is unknown in detail, but the present inventors presume as follows. That is, when the bed bug repellent according to the present invention comes into contact with bed bugs, body surface components such as fatty acids and waxes on the body surface of bed bugs are taken away by the silicon dioxide powder. Therefore, it is presumed that the barrier function of the body surface of the bed bug is lost, and the bed bug cannot hold water necessary for survival. And by using the silicon dioxide powder which has the predetermined oil absorption amount of this invention, it is estimated that the body surface component of bed bug can be taken away efficiently and bed bug can be exterminated.
  • the bed bug control composition according to the present invention contains the bed bug control agent. According to the bed bug control composition according to the present invention, the bed bug can be controlled without using an insecticidal component, like the bed bug control agent according to the present invention.
  • the bed bug extermination method according to the present invention is an extermination method in which silicon dioxide powder having an oil absorption amount of 35 mL / 100 g or more is brought into contact with bed bugs.
  • the bed bug can be controlled without using an insecticidal component, like the bed bug control agent according to the present invention.
  • bed bugs can be controlled without using an insecticidal component. Therefore, there is no fear of developing resistance to the insecticidal component, and bed bugs that are already resistant to the insecticidal component can be exterminated.
  • use for bed bug control of the silicon dioxide powder whose oil absorption amount is 35 mL / 100g or more can be provided.
  • ADVANTAGE OF THE INVENTION According to this invention, use for bed bug control of the composition containing the silicon dioxide powder whose oil absorption is 35 mL / 100g or more can be provided.
  • the bed bug repellent according to the present embodiment is made of silicon dioxide (also referred to as silica or anhydrous silicic acid) powder having an oil absorption of 35 mL / 100 g or more.
  • the oil absorption amount of the silicon dioxide powder is preferably 40 mL / 100 g or more, more preferably 90 mL / 100 g or more, and further preferably 110 mL / 100 g or more, from the viewpoint of improving bed bug extermination efficiency. Further, if the oil absorption amount is 150 mL / 100 g or more, high removal efficiency can be obtained even under high humidity conditions, and if the oil absorption amount is 200 to 300 mL / 100 g, it is high over a long period even under high humidity conditions. Exterminating efficiency is obtained. If the oil absorption of the silicon dioxide powder is 500 mL / 100 g or less, a sufficient bed bug control effect can be easily obtained.
  • the oil absorption of the silicon dioxide powder may be 1000 mL / 100 g or less, 500 mL / 100 g or less, or 400 mL / 100 g or less.
  • the oil absorption of the silicon dioxide powder can be measured by a method based on, for example, JIS K5101, ASTM D2414, ISO4656.
  • the silicon dioxide powder is preferably amorphous from the viewpoint of easy control of oil absorption and specific surface area.
  • the silicon dioxide powder may aggregate to form aggregated particles.
  • the average particle diameter of the silicon dioxide powder (mainly aggregated particles) can be measured, for example, by a Coulter counter method (Coulter multisizer method).
  • the average particle diameter of the silicon dioxide powder is preferably 2 ⁇ m or more from the viewpoint that the powder is sufficiently in contact with bed bugs and easily takes away body surface components such as wax from the body surface of bed bugs.
  • the average particle diameter of the silicon dioxide powder is preferably 2 ⁇ m or more, more preferably 10 ⁇ m or more, and even more preferably 20 ⁇ m or more from the viewpoint of being difficult to disperse when sprayed with a pesticide.
  • the average particle diameter of the silicon dioxide powder is preferably 500 ⁇ m or less from the viewpoint of excellent fluidity of the disinfectant and handling properties during processing. In addition, if the average particle size is 20 ⁇ m or less, it is easy to enter the body mass of bed bugs.
  • the average particle size is preferably 90 ⁇ m or more from the viewpoint of facilitating adhesion to the entire body surface of bed bugs and improving the removal efficiency.
  • the silicon dioxide powder is preferably porous.
  • the specific surface area of the silicon dioxide powder is preferably 50 m 2 / g or more, and more preferably 200 m 2 / g or more, from the viewpoint of improving bed bug extermination efficiency.
  • the specific surface area of the silicon dioxide powder is preferably 800 m 2 / g or less, 500 meters 2 / g or less is more preferable.
  • the specific surface area of the silicon dioxide powder may be 1000 m 2 / g or less. When the specific surface area exceeds 1000 m 2 / g, the strength of the silicon dioxide powder is lowered, and the crushed powder rises during use, and the usability may deteriorate.
  • the specific surface area of the silicon dioxide powder can be measured, for example, by a method based on the BET method or ISO 5794-1.
  • the bed bug repellent composition according to the present embodiment contains a bed bug repellent composed of silicon dioxide powder having an oil absorption of 35 mL / 100 g or more and an optional component other than the bed repellent repellent.
  • the content of the bed bug repellent is preferably 0.1% by mass or more based on the total mass of the bed bug repellent composition from the viewpoint of improving the bed repellent efficiency. 1 mass% or more is more preferable.
  • the content of the bed bug control agent is preferably 1% by mass or more based on the whole stock solution.
  • the content of the bed bug repellent is preferably 1% by mass or more based on the whole preparation, and more preferably 5% by mass or more from the viewpoint of improving the control efficiency of bed bugs.
  • 20 mass% or more is more preferable.
  • the content of the bed bug repellent is preferably 0.4% by mass or more based on the whole preparation from the viewpoint of improving the fluidity and operability of the preparation.
  • the bed bug control composition according to the present embodiment can be used as various preparations, and a liquid or solid carrier may be used.
  • the bed bug control composition according to the present embodiment can be formulated as, for example, a liquid agent, a gel agent, a sol agent, a granule agent, a tablet, an aerosol agent, a sheet agent, and a coating agent.
  • Examples of the method of formulating using a carrier and the like include, for example, a method of mixing the bed bug repellent according to the present embodiment with a solid carrier, a liquid carrier, a gaseous carrier and the like, and the bed bug repellent according to the present embodiment as a solid carrier.
  • a method of molding after mixing is mentioned. Only one type of carrier may be used, or two or more types may be used.
  • the bed bug control composition may be supported on a solid carrier and then dispersed in a liquid carrier.
  • solid carriers used for formulation include inorganic powders (metals such as calcium carbonate, calcium silicate, sodium sulfate, zeolite, talc, clay, bentonite, quartzite, feldspar, acid clay, diatomite powder, pumice powder, etc.
  • Wood powder wheat flour, resin powder (thermoplastic resin such as polypropylene, polyethylene, polyamide, polyethylene terephthalate; copolymer polyamide; copolymer thermoplastic resin, etc.), organic powder such as corn starch, silk powder, iron powder And metal powders such as aluminum powder and copper powder.
  • the bed bug repellent may be dispersed in a powder having a particle size similar to that of the bed bug repellent, or the bed bug repellent may be supported on a powder having a particle size larger than that of the bed bug repellent.
  • liquid carrier examples include water, alcohols such as ethanol and isopropanol; fatty acid esters such as isopropyl myristate; esters such as propylene carbonate; hydrocarbons such as normal paraffin, isoparaffin and naphthene; HFC-245fa, Asahiklin AE-3000 Hydrofluorocarbon solvents such as Asahiklin AC-6000 (manufactured by Asahi Glass Co., Ltd.); hydrofluoroether solvents such as HFO-1233zd, HFO-1234yf, HFO-1234ze, Novec7000 (manufactured by Sumitomo 3M Limited) Can be mentioned.
  • alcohols such as ethanol and isopropanol
  • fatty acid esters such as isopropyl myristate
  • esters such as propylene carbonate
  • hydrocarbons such as normal paraffin, isoparaffin and naphthene
  • HFC-245fa Asahiklin AE-3000
  • Examples of the method for treating the liquid carrier in which the bed bug repellent is dispersed include a method of coating using an applicator such as a brush, a method of spraying using a hand pump, and a method of directly spraying from a container. .
  • an applicator such as a brush
  • a method of spraying using a hand pump and a method of directly spraying from a container.
  • a surfactant, a thickener or the like may be added.
  • gaseous carrier examples include butane gas, chlorofluorocarbon gas, alternative chlorofluorocarbon gas, liquefied petroleum gas (LPG), dimethyl ether, nitrogen gas, and carbon dioxide gas.
  • LPG liquefied petroleum gas
  • the bed bug repellent may be directly dispersed in the gaseous carrier, and the bed bug repellent is dispersed.
  • the liquid carrier may be jetted after mixing with the gaseous carrier.
  • the bed bug control composition according to the present embodiment may contain an optional component as long as the effect of the bed bug control agent according to the present embodiment is not hindered.
  • the optional component include an insecticidal component, an attracting component, a surfactant, an antioxidant, an antiseptic, an anticorrosive agent, and a coloring agent.
  • silicon dioxide powder having an oil absorption of less than 35 mL / 100 g may be used.
  • the bed bug control composition which concerns on this embodiment can control bed bugs, without using an insecticidal component, the bed bug control composition does not need to contain an insecticidal component.
  • Insecticidal components include, for example, pesticide chrysanthemum extract, natural pyrethrin, praretrin, imiprotorin, phthalthrin, allethrin, bifenthrin, resmethrin, phenothrin, ciphenothrin, permethrin, cypermethrin, etofenprox, cyfluthrin, deltamethrin, bifenthrin, fenvalerate, fenvalerate, fenproperate , Empensulin, silafluophene, transfluthrin, metofluthrin, profluthrin and other pyrethroid insecticides; fenitrothion, diazinon, marathon, pyridafenthion, prothiophos, oxime, chlorpyrifos, dichlorvos and other organophosphorus insecticides; Carbamate insecticides; oxadia
  • the insecticidal component Only one type may be used as the insecticidal component, or two or more types may be used.
  • the content of the insecticidal component is, for example, 0.1 to 50% by mass based on the total mass of the bed bug control composition.
  • the attracting component those conventionally used for pest control can be widely used.
  • the attraction component include vegetable or animal diets such as proteins, carbohydrates, and lipids; aromatic components derived from natural products and prepared, pheromones, amino acids, nucleic acids, oils and fats, hexenals, octynals, and other unsaturated aldehydes; butyric acid Organic acids such as
  • an attracting component only one type may be used or two or more types may be used.
  • the content of the attracting component is, for example, 0.01 to 50% by mass based on the total mass of the bed bug extermination composition.
  • the bed bug extermination method according to the present embodiment is an extermination method in which silicon dioxide powder having an oil absorption amount of 35 mL / 100 g or more is brought into contact with bed bugs.
  • the silicon dioxide powder may be sprayed toward the bed bug, or the silicon dioxide powder may be spread over the habitat of the bed bug.
  • the silicon dioxide powder may be brought into contact with the bed bug using the bed bug elimination composition according to the present embodiment. It may be sprayed in advance on a place where the bed bug is lurking or in the vicinity thereof, on the action range of the bed bug, and may be brought into contact with the bed bug at the time of activities such as nighttime.
  • Application rate of the silicon dioxide powder in the bed bugs removal method according to the present embodiment (spraying concentration), from the viewpoint of sufficient disinfection effect can be easily obtained, 0.125 g / m 2 or more preferably, 0.3 g / m 2 or more Is more preferable, and 0.5 g / m 2 or more is still more preferable.
  • the amount of silicon dioxide powder sprayed is preferably 200 g / m 2 or less in the case of local use that prevents invasion or colonization for the purpose of preventing the expansion of the habitat of bed bugs (preventive treatment). (Insecticide), 100 g / m 2 or less is preferable from the viewpoint of obtaining a sufficient extermination effect.
  • application amount is 200 g / m 2 or less, it is possible to prevent wasteful dispersion of the preparation around the treated portion, and a sufficient extermination effect can be obtained even for bed bugs with high habitat density.
  • application rate of the silicon dioxide powder is preferably 40 g / m 2 or less, to suppress the waste of the drug is effectively disinfected viewpoint from 20 g / m 2 or less to more preferred.
  • Bed bugs tend to be active in high-temperature and high-humidity environments and have high resistance to drugs.
  • bed bugs can be exterminated even in an environment at a temperature of 25 ° C. and a humidity of 50% or more (for example, a mortality rate of 80% or more after 48 hours).
  • the bed bug can be exterminated even in a high humidity environment at 75 ° C. and humidity of 75% (for example, mortality rate of 80% or more after 168 hours).
  • Test 1 Various powders shown in Table 1 below were prepared as specimens.
  • Sunsphere is manufactured by AGC S-Itech Co., Ltd.
  • God Ball is manufactured by Suzuki Yushi Kogyo Co., Ltd.
  • Ad Solider is manufactured by Freund Sangyo Co., Ltd.
  • Polonex is manufactured by Maruo Calcium Co., Ltd. Is manufactured by Tomita Pharmaceutical Co., Ltd.
  • the waist-high petri dish was placed in a plastic case having an outer dimension of 310 mm (width) ⁇ 434 mm (depth) ⁇ 143 mm (height).
  • the lid of the plastic case was sealed with rubber packing.
  • the humidity in the case was adjusted to 50% using concentrated glycerin.
  • five bed bugs (Chiba series, permethrin resistance of 10,000 times or more) were tested on the petri dish, and the bed bugs were continuously brought into contact with the specimen. After testing the bed bugs, the number of lethal heads was observed over time, and the lethality was calculated. The same test was repeated again to calculate the lethality of a total of 10 bed bugs and evaluate the control effect.
  • Table 1 The results are shown in Table 1.
  • Test 2 Various powders shown in Table 2 below were prepared as specimens.
  • OSC is manufactured by Oriental Silica Corporation
  • Toxeal is manufactured by Oriental Silica Corporation.
  • the lethality of bed bugs was evaluated in the same manner as in Test 1 except that the test environment was changed to a temperature of 25 ° C. and a humidity of 60%. For comparison, an evaluation was also performed when no silicon dioxide powder was sprayed. The results are shown in Table 2.
  • Test 3 Various silicon dioxide powders shown in Table 3 below were prepared as specimens.
  • the fine seal is manufactured by Oriental Silica Corporation.
  • the lethality of bed bugs was evaluated in the same manner as in Test 1 except that the test environment was changed to a temperature of 25 ° C. and a humidity of 75%. The results are shown in Table 3.
  • Adsolider 101 (Freund Sangyo Co., Ltd.) was prepared as a silicon dioxide powder.
  • the application rate is about 0.125 g / m 2 (about 2.3 cm 3 / m 2 ), about 0.3 g / m 2 (about 5.5 cm 3 / m 2 ), about 0.5 g / m 2 (about 9. 2cm 3 / m 2) and about 1.0 g / m 2 (about 18.3cm 3 / m 2) example except for the change to 1-6 (application rate: about 3.0 g / m 2, temperature 25 ° C.
  • the mortality of bed bugs was calculated in the same manner as in the case of humidity 50%, and the control effect was evaluated. For comparison, an evaluation was also performed when no silicon dioxide powder was sprayed. The results are shown in Table 4.
  • the bed bug was transferred to a clean plastic cup, and the plastic cup was allowed to stand in a sealed container in an environment of a temperature of 25 ° C. and a humidity of 50%.
  • the mortality was evaluated by observing the number of lethal animals after 24 and 48 hours. The same test was repeated three times, and the lethality of a total of 30 bed bugs was calculated to evaluate the control effect.
  • an aerosol containing 105 mL of stock solution and 345 mL of propellant per 450 mL was used.
  • the constituent components of the stock solution the components shown in Table 5 were used.
  • Toxeal NP manufactured by Oriental Silica Corporation
  • Adsolider 101 manufactured by Freund Sangyo Co., Ltd.
  • the liquid carrier normal paraffin (manufactured by Sanko Chemical Co., Ltd., trade name: neothiozole) was used.
  • the amount of silicon dioxide powder sprayed was about 0.6 g / m 2 .
  • Test 7 Affix the filter paper on the entire bottom surface of the glass waist petri dish ( ⁇ 9cm x height 6.5cm) so that there is no gap between the bedbugs and the petri dish, Processed.
  • silicon dioxide powder was used as a specimen, and the amount of silicon dioxide powder sprayed was about 3.0 g / m 2 (about 55 cm 3 / m 2 ).
  • Adsolider 101 manufactured by Freund Sangyo Co., Ltd.
  • Toxeal NP manufactured by Oriental Silica Corporation
  • permethrin insecticidal component
  • permethrin insecticidal component
  • the petri dish was allowed to stand overnight (for 12 hours or more) in a plastic airtight container, and then five bed bugs (Chiba, permethrin-resistant 10,000) The test was continuously carried out for 12 hours. Thereafter, the bed bug was transferred to a clean plastic cup, and the plastic cup was allowed to stand in a sealed container in an environment of a temperature of 25 ° C. and a humidity of 50%. The lethality was evaluated by observing the number of lethal heads after 24 hours. The same test was repeated again to evaluate the lethality of a total of 10 bed bugs. Moreover, it replaced with the resistant bed bug and tested the sensitive bed bug (Teikyo University system), and performed the same evaluation. The results are shown in Table 6.
  • Test 8 About 3.0 g of a specimen (water dispersing agent) was dropped on the main surface (15 cm ⁇ 15 cm) of the plywood so as to be uniform throughout, and then left to stand overnight (25 ° C., 12 hours or more). Next, five bed bugs (Chiba-based, permethrin resistance of 10,000 times or more) are placed on the sample processing surface of the plywood board in a plastic sealed container (sealed container with packing) in an environment of temperature 25 ° C. and humidity 50%. After the test, it was covered with a plastic cup ( ⁇ 6 cm, height 3.5 cm), and bed bugs were forcibly contacted with the specimen for 1 hour.
  • a plastic sealed container sealed container with packing
  • the bed bug was transferred to a clean plastic cup, and the plastic cup was allowed to stand in a sealed container in an environment of a temperature of 25 ° C. and a humidity of 50%.
  • the lethality was evaluated by observing the number of lethal heads after 24 hours. The same test was repeated three times, and the lethality of a total of 15 bed bugs was calculated to evaluate the control effect.

Abstract

Provided is a bed bug repellent composed of a silicon dioxide powder having an oil absorption of 35 mL/100g or more. Also provided is a bed bug repellent composition comprising the bed bug repellent. Also provided is a bed bug repelling method wherein the bed bug is contacted with the silicon dioxide powder having an oil absorption of 35 mL/100g or more.

Description

トコジラミ駆除剤、トコジラミ駆除用組成物及びトコジラミ駆除方法Bed bug control agent, bed bug control composition, and bed bug control method
 本発明は、トコジラミ駆除剤、トコジラミ駆除用組成物及びトコジラミ駆除方法に関する。 The present invention relates to a bed bug control agent, a bed bug control composition, and a bed bug control method.
 従来、トコジラミ等の吸血害虫から身を守る手段として、N,N-ジエチルトルアミド(DEET)等を含有する忌避剤が知られている(例えば、下記特許文献1参照)。しかしながら、トコジラミは増殖率が高いこと、及び、飢餓に強く、摂食しなくても数ヶ月から最長で1年間以上も生き延びられることから、生存させておくと生息域が拡大してしまう。そのため、トコジラミを忌避するだけでは充分とは言えず、致死させて駆除することが望まれている。さらに、トコジラミは、主に夜間に活動的となり、日中は、カーペットの裏、畳の縁、家具(ベッドフレーム、タンス等)の中、巾木添い、押入れ、壁の隙間などの人目につかない屋内の暗所に生息していることから、生息域を特定すること、及び、充分な量の殺虫剤に接触させることが難しい。そのため、トコジラミを殺虫剤により完全に駆除することは困難である。 Conventionally, repellents containing N, N-diethyltoluamide (DEET) and the like are known as means for protecting themselves from blood-sucking pests such as bed bugs (see, for example, Patent Document 1 below). However, bedbugs have a high growth rate and are resistant to hunger, and can survive for months to up to a year or more without being fed. Therefore, repelling bed bugs is not enough, and it is desired to kill them. In addition, bed bugs are mainly active at night, and during the day they are not visible to the back of carpets, tatami rims, furniture (bed frame, chiffon, etc.), baseboard support, closets, wall gaps, etc. Because it lives in indoor dark places, it is difficult to identify the habitat and to contact a sufficient amount of insecticide. Therefore, it is difficult to completely eliminate bed bugs with insecticides.
特開平8-198708号公報Japanese Patent Laid-Open No. 8-198708
 トコジラミを駆除するに際しては、ピレスロイド系化合物等の殺虫成分を含む駆除剤を用いる手法が考えられる。しかしながら、ピレスロイド系化合物等の殺虫成分に対しては、抵抗性の発達が問題となっている。また、より高い安全性を期待して、このような殺虫成分を用いることなくトコジラミを駆除することが求められている。 In the control of bed bugs, a method using a pesticide containing an insecticidal component such as a pyrethroid compound may be considered. However, the development of resistance is a problem for insecticidal components such as pyrethroid compounds. In addition, in view of higher safety, there is a demand for extermination of bed bugs without using such insecticidal components.
 本発明は、上記課題に鑑みてなされたものであり、殺虫成分を用いることなくトコジラミを駆除することが可能なトコジラミ駆除剤、トコジラミ駆除用組成物及びトコジラミ駆除方法を提供することを目的とする。 The present invention has been made in view of the above problems, and an object of the present invention is to provide a bed bug repellent, a bed bug repellent composition, and a bed bug repelling method capable of controlling bed bugs without using insecticidal components. .
 本発明に係るトコジラミ駆除剤は、吸油量が35mL/100g以上である二酸化ケイ素粉末からなる。 The bed bug repellent according to the present invention is made of silicon dioxide powder having an oil absorption of 35 mL / 100 g or more.
 本発明に係るトコジラミ駆除剤によれば、殺虫成分を用いることなくトコジラミを駆除することができる。本発明においてこのような効果が得られる原因は詳細には不明であるが、本発明者らは、以下のように推測している。すなわち、本発明に係るトコジラミ駆除剤がトコジラミに接触すると、トコジラミの体表面の脂肪酸、ワックス等の体表成分が、二酸化ケイ素粉末により奪われる。そのため、トコジラミの体表表面のバリア機能が失われ、トコジラミが生存に必要な水分を保持することができなくなると推測される。そして、本発明の所定の吸油量を有する二酸化ケイ素粉末を用いることにより、トコジラミの体表成分を効率よく奪うことができ、トコジラミを駆除することができると推測される。 According to the bed bug control agent according to the present invention, bed bugs can be controlled without using an insecticidal component. The reason why such an effect is obtained in the present invention is unknown in detail, but the present inventors presume as follows. That is, when the bed bug repellent according to the present invention comes into contact with bed bugs, body surface components such as fatty acids and waxes on the body surface of bed bugs are taken away by the silicon dioxide powder. Therefore, it is presumed that the barrier function of the body surface of the bed bug is lost, and the bed bug cannot hold water necessary for survival. And by using the silicon dioxide powder which has the predetermined oil absorption amount of this invention, it is estimated that the body surface component of bed bug can be taken away efficiently and bed bug can be exterminated.
 本発明に係るトコジラミ駆除用組成物は、上記トコジラミ駆除剤を含有する。本発明に係るトコジラミ駆除用組成物によれば、本発明に係るトコジラミ駆除剤と同様に、殺虫成分を用いることなくトコジラミを駆除することができる。 The bed bug control composition according to the present invention contains the bed bug control agent. According to the bed bug control composition according to the present invention, the bed bug can be controlled without using an insecticidal component, like the bed bug control agent according to the present invention.
 本発明に係るトコジラミ駆除方法は、吸油量が35mL/100g以上である二酸化ケイ素粉末をトコジラミに接触させる駆除方法である。本発明に係るトコジラミ駆除方法によれば、本発明に係るトコジラミ駆除剤と同様に、殺虫成分を用いることなくトコジラミを駆除することができる。 The bed bug extermination method according to the present invention is an extermination method in which silicon dioxide powder having an oil absorption amount of 35 mL / 100 g or more is brought into contact with bed bugs. According to the bed bug control method according to the present invention, the bed bug can be controlled without using an insecticidal component, like the bed bug control agent according to the present invention.
 本発明によれば、殺虫成分を用いることなくトコジラミを駆除することができる。そのため、殺虫成分に対する抵抗性の発達を招く恐れが無く、既に殺虫成分に対する抵抗性を有するトコジラミを駆除することもできる。また、本発明によれば、吸油量が35mL/100g以上である二酸化ケイ素粉末のトコジラミ駆除への使用を提供できる。本発明によれば、吸油量が35mL/100g以上である二酸化ケイ素粉末を含有する組成物のトコジラミ駆除への使用を提供できる。 According to the present invention, bed bugs can be controlled without using an insecticidal component. Therefore, there is no fear of developing resistance to the insecticidal component, and bed bugs that are already resistant to the insecticidal component can be exterminated. Moreover, according to this invention, use for bed bug control of the silicon dioxide powder whose oil absorption amount is 35 mL / 100g or more can be provided. ADVANTAGE OF THE INVENTION According to this invention, use for bed bug control of the composition containing the silicon dioxide powder whose oil absorption is 35 mL / 100g or more can be provided.
実施例における試験方法を説明するための図面である。It is drawing for demonstrating the test method in an Example.
 以下、本発明の実施形態について詳細に説明する。 Hereinafter, embodiments of the present invention will be described in detail.
(トコジラミ駆除剤)
 本実施形態に係るトコジラミ駆除剤は、吸油量が35mL/100g以上である二酸化ケイ素(シリカ、無水ケイ酸とも言う)粉末からなる。
(Budgeticide)
The bed bug repellent according to the present embodiment is made of silicon dioxide (also referred to as silica or anhydrous silicic acid) powder having an oil absorption of 35 mL / 100 g or more.
 二酸化ケイ素粉末の吸油量は、トコジラミの駆除効率が向上する観点から、40mL/100g以上が好ましく、90mL/100g以上がより好ましく、110mL/100g以上が更に好ましい。さらに、吸油量が150mL/100g以上であれば、高湿度条件であっても高い駆除効率が得られ、吸油量200~300mL/100gであれば、高湿度条件であっても長期間に亘り高い駆除効率が得られる。二酸化ケイ素粉末の吸油量が500mL/100g以下であれば、充分なトコジラミ駆除効果が容易に得られる。二酸化ケイ素粉末の吸油量は、1000mL/100g以下であってもよく、500mL/100g以下であってもよく、400mL/100g以下であってもよい。吸油量が1000mL/100gを超えると、二酸化ケイ素粉末の強度が低くなり、使用時に砕けた粉末が舞い上がる等して使用感が悪くなる場合がある。二酸化ケイ素粉末の吸油量は、例えばJIS K5101、ASTM D2414、ISO4656に準拠した方法により測定することができる。 The oil absorption amount of the silicon dioxide powder is preferably 40 mL / 100 g or more, more preferably 90 mL / 100 g or more, and further preferably 110 mL / 100 g or more, from the viewpoint of improving bed bug extermination efficiency. Further, if the oil absorption amount is 150 mL / 100 g or more, high removal efficiency can be obtained even under high humidity conditions, and if the oil absorption amount is 200 to 300 mL / 100 g, it is high over a long period even under high humidity conditions. Exterminating efficiency is obtained. If the oil absorption of the silicon dioxide powder is 500 mL / 100 g or less, a sufficient bed bug control effect can be easily obtained. The oil absorption of the silicon dioxide powder may be 1000 mL / 100 g or less, 500 mL / 100 g or less, or 400 mL / 100 g or less. When the amount of oil absorption exceeds 1000 mL / 100 g, the strength of the silicon dioxide powder is lowered, and the crushed powder rises during use, and the usability may deteriorate. The oil absorption of the silicon dioxide powder can be measured by a method based on, for example, JIS K5101, ASTM D2414, ISO4656.
 二酸化ケイ素粉末は、吸油量及び比表面積を制御し易い観点から、非晶性であることが好ましい。二酸化ケイ素粉末は、粉末同士が凝集して凝集粒子を形成する場合がある。二酸化ケイ素粉末(主に凝集粒子)の平均粒子径は、例えば、コールターカウンター法(コールターマルチサイザー法)で測定することができる。二酸化ケイ素粉末の平均粒子径は、粉末が充分にトコジラミに接触してトコジラミの体表からワックス等の体表成分を奪い易い観点から、2μm以上が好ましい。また、二酸化ケイ素粉末の平均粒子径は、駆除剤散布時に飛散しにくい観点から、2μm以上が好ましく、10μm以上がより好ましく、20μm以上が更に好ましい。処理時のハンドリング性が向上する観点から、90μm以上が好ましい。平均粒子径が90μm以上であると、ハンドリング性が向上し、トコジラミ駆除剤のみでの処理が容易となる。二酸化ケイ素粉末の平均粒子径は、駆除剤の流動性及び処理時のハンドリング性に優れる観点から、500μm以下が好ましい。また、平均粒子径が20μm以下であれば、トコジラミの体節に入り込み易い。平均粒子径は、トコジラミの体表全体へ付着し易くなり駆除効率が向上する観点から、90μm以上が好ましい。 The silicon dioxide powder is preferably amorphous from the viewpoint of easy control of oil absorption and specific surface area. The silicon dioxide powder may aggregate to form aggregated particles. The average particle diameter of the silicon dioxide powder (mainly aggregated particles) can be measured, for example, by a Coulter counter method (Coulter multisizer method). The average particle diameter of the silicon dioxide powder is preferably 2 μm or more from the viewpoint that the powder is sufficiently in contact with bed bugs and easily takes away body surface components such as wax from the body surface of bed bugs. In addition, the average particle diameter of the silicon dioxide powder is preferably 2 μm or more, more preferably 10 μm or more, and even more preferably 20 μm or more from the viewpoint of being difficult to disperse when sprayed with a pesticide. 90 μm or more is preferable from the viewpoint of improving handling during processing. When the average particle size is 90 μm or more, the handling property is improved and the treatment with the bed bug repellent alone is facilitated. The average particle diameter of the silicon dioxide powder is preferably 500 μm or less from the viewpoint of excellent fluidity of the disinfectant and handling properties during processing. In addition, if the average particle size is 20 μm or less, it is easy to enter the body mass of bed bugs. The average particle size is preferably 90 μm or more from the viewpoint of facilitating adhesion to the entire body surface of bed bugs and improving the removal efficiency.
 二酸化ケイ素粉末は多孔質であることが好ましい。二酸化ケイ素粉末の比表面積は、トコジラミの駆除効率が向上する観点から、50m/g以上が好ましく、200m/g以上がより好ましい。二酸化ケイ素粉末の比表面積は、800m/g以下が好ましく、500m/g以下がより好ましい。二酸化ケイ素粉末の比表面積は、1000m/g以下であってもよい。比表面積が1000m/gを超えると、二酸化ケイ素粉末の強度が低くなり、使用時に砕けた粉末が舞い上がる等して使用感が悪くなる場合がある。二酸化ケイ素粉末の比表面積は、例えば、BET法、ISO5794-1に準拠した方法により測定することができる。 The silicon dioxide powder is preferably porous. The specific surface area of the silicon dioxide powder is preferably 50 m 2 / g or more, and more preferably 200 m 2 / g or more, from the viewpoint of improving bed bug extermination efficiency. The specific surface area of the silicon dioxide powder is preferably 800 m 2 / g or less, 500 meters 2 / g or less is more preferable. The specific surface area of the silicon dioxide powder may be 1000 m 2 / g or less. When the specific surface area exceeds 1000 m 2 / g, the strength of the silicon dioxide powder is lowered, and the crushed powder rises during use, and the usability may deteriorate. The specific surface area of the silicon dioxide powder can be measured, for example, by a method based on the BET method or ISO 5794-1.
(トコジラミ駆除用組成物)
 本実施形態に係るトコジラミ駆除用組成物は、吸油量が35mL/100g以上である二酸化ケイ素粉末からなるトコジラミ駆除剤と、当該トコジラミ駆除剤以外の任意成分とを含有している。
(Combination for bed bugs)
The bed bug repellent composition according to the present embodiment contains a bed bug repellent composed of silicon dioxide powder having an oil absorption of 35 mL / 100 g or more and an optional component other than the bed repellent repellent.
 本実施形態に係るトコジラミ駆除用組成物において、トコジラミ駆除剤の含有量は、トコジラミの駆除効率が向上する観点から、トコジラミ駆除用組成物の全質量を基準として、0.1質量%以上が好ましく、1質量%以上がより好ましい。トコジラミ駆除用組成物がエアゾール剤である場合、トコジラミ駆除剤の含有量は原液全体を基準として1質量%以上が好ましい。トコジラミ駆除剤が固体担体に保持されている場合、トコジラミ駆除剤の含有量は、製剤全体を基準として、1質量%以上が好ましく、トコジラミの駆除効率が向上する観点から、5質量%以上がより好ましく、20質量%以上が更に好ましい。家具の隙間等への局所的な処理で駆除する場合、トコジラミ駆除剤の含有量は、製剤の流動性及び操作性が向上する観点から、製剤全体を基準として0.4質量%以上が好ましい。 In the bed bug repellent composition according to this embodiment, the content of the bed bug repellent is preferably 0.1% by mass or more based on the total mass of the bed bug repellent composition from the viewpoint of improving the bed repellent efficiency. 1 mass% or more is more preferable. When the bed bug control composition is an aerosol agent, the content of the bed bug control agent is preferably 1% by mass or more based on the whole stock solution. When the bed bug repellent is held on a solid carrier, the content of the bed bug repellent is preferably 1% by mass or more based on the whole preparation, and more preferably 5% by mass or more from the viewpoint of improving the control efficiency of bed bugs. Preferably, 20 mass% or more is more preferable. In the case of extermination by local treatment of furniture gaps and the like, the content of the bed bug repellent is preferably 0.4% by mass or more based on the whole preparation from the viewpoint of improving the fluidity and operability of the preparation.
 本実施形態に係るトコジラミ駆除用組成物は、各種製剤として用いることができ、液体又は固体等の担体などを用いてもよい。本実施形態に係るトコジラミ駆除用組成物は、例えば、液剤、ゲル剤、ゾル剤、粒剤、顆粒剤、錠剤、エアゾール剤、シート剤、塗工剤等として製剤化することができる。担体等を用いて製剤化する方法としては、例えば、本実施形態に係るトコジラミ駆除剤を固体担体、液体担体、ガス状担体等と混合する方法、本実施形態に係るトコジラミ駆除剤を固体担体と混合した後に成型加工する方法が挙げられる。担体は、1種類のみを用いてもよく、2種類以上を用いてもよい。また、トコジラミ駆除用組成物を固体担体に担持させた後に、液体担体に分散させる等してもよい。 The bed bug control composition according to the present embodiment can be used as various preparations, and a liquid or solid carrier may be used. The bed bug control composition according to the present embodiment can be formulated as, for example, a liquid agent, a gel agent, a sol agent, a granule agent, a tablet, an aerosol agent, a sheet agent, and a coating agent. Examples of the method of formulating using a carrier and the like include, for example, a method of mixing the bed bug repellent according to the present embodiment with a solid carrier, a liquid carrier, a gaseous carrier and the like, and the bed bug repellent according to the present embodiment as a solid carrier. A method of molding after mixing is mentioned. Only one type of carrier may be used, or two or more types may be used. Further, the bed bug control composition may be supported on a solid carrier and then dispersed in a liquid carrier.
 製剤化の際に用いられる固体担体としては、例えば、炭酸カルシウム、ケイ酸カルシウム、硫酸ナトリウム、ゼオライト、タルク、クレー、ベントナイト、珪石、長石、酸性白土、珪藻土粉末、軽石粉末等の無機粉末(金属粉末を除く);木粉、小麦粉、樹脂パウダー(ポリプロピレン、ポリエチレン、ポリアミド、ポリエチレンテレフタレート等の熱可塑性樹脂;共重合ポリアミド;共重合熱可塑性樹脂など)、コーンスターチ、シルク粉末等の有機粉末;鉄粉、アルミ粉末、銅粉末等の金属粉末が挙げられる。トコジラミ駆除剤と同程度の粒子径の粉末にトコジラミ駆除剤を分散させてもよく、トコジラミ駆除剤よりも粒子径の大きな粉末にトコジラミ駆除剤を担持させてもよい。 Examples of solid carriers used for formulation include inorganic powders (metals such as calcium carbonate, calcium silicate, sodium sulfate, zeolite, talc, clay, bentonite, quartzite, feldspar, acid clay, diatomite powder, pumice powder, etc. Wood powder, wheat flour, resin powder (thermoplastic resin such as polypropylene, polyethylene, polyamide, polyethylene terephthalate; copolymer polyamide; copolymer thermoplastic resin, etc.), organic powder such as corn starch, silk powder, iron powder And metal powders such as aluminum powder and copper powder. The bed bug repellent may be dispersed in a powder having a particle size similar to that of the bed bug repellent, or the bed bug repellent may be supported on a powder having a particle size larger than that of the bed bug repellent.
 液体担体としては、例えば、水、エタノール、イソプロパノール等のアルコール;ミリスチン酸イソプロピル等の脂肪酸エステル;炭酸プロピレン等のエステル;ノルマルパラフィン、イソパラフィン、ナフテン等の炭化水素;HFC-245fa、アサヒクリンAE-3000、アサヒクリンAC-6000(旭硝子株式会社製)等のハイドロフルオロカーボン系溶媒;HFO-1233zd、HFO-1234yf、HFO-1234ze、Novec7000(住友スリーエム株式会社製)等のハイドロフルオロエーテル系のフッ素系溶媒が挙げられる。トコジラミ駆除剤を分散させた液体担体を処理する方法としては、例えば、刷毛等のアプリケーターを用いて塗工する方法、ハンドポンプ等を用いて噴霧する方法、容器から直接散布処理する方法が挙げられる。液体担体中に二酸化ケイ素粉末を分散させるために、界面活性剤、増粘剤等を添加してもよい。 Examples of the liquid carrier include water, alcohols such as ethanol and isopropanol; fatty acid esters such as isopropyl myristate; esters such as propylene carbonate; hydrocarbons such as normal paraffin, isoparaffin and naphthene; HFC-245fa, Asahiklin AE-3000 Hydrofluorocarbon solvents such as Asahiklin AC-6000 (manufactured by Asahi Glass Co., Ltd.); hydrofluoroether solvents such as HFO-1233zd, HFO-1234yf, HFO-1234ze, Novec7000 (manufactured by Sumitomo 3M Limited) Can be mentioned. Examples of the method for treating the liquid carrier in which the bed bug repellent is dispersed include a method of coating using an applicator such as a brush, a method of spraying using a hand pump, and a method of directly spraying from a container. . In order to disperse the silicon dioxide powder in the liquid carrier, a surfactant, a thickener or the like may be added.
 ガス状担体としては、例えば、ブタンガス、フロンガス、代替フロンガス、液化石油ガス(LPG)、ジメチルエーテル、窒素ガス、炭酸ガスが挙げられる。動力散布機又はベンチュリー機構を利用した噴霧器、ハンドポンプ、又は、局所処理用の噴霧器を用いて、ガス状担体にトコジラミ駆除剤を直接分散させて処理してもよく、トコジラミ駆除剤を分散させた液体担体をガス状担体と混合した後に噴射してもよい。 Examples of the gaseous carrier include butane gas, chlorofluorocarbon gas, alternative chlorofluorocarbon gas, liquefied petroleum gas (LPG), dimethyl ether, nitrogen gas, and carbon dioxide gas. Using a sprayer using a power spreader or a venturi mechanism, a hand pump, or a sprayer for local treatment, the bed bug repellent may be directly dispersed in the gaseous carrier, and the bed bug repellent is dispersed. The liquid carrier may be jetted after mixing with the gaseous carrier.
 本実施形態に係るトコジラミ駆除用組成物は、本実施形態に係るトコジラミ駆除剤の効果を妨げない範囲において、任意成分を含有してもよい。任意成分としては、例えば、殺虫成分、誘引成分、界面活性剤、酸化防止剤、防腐剤、誤食防止剤、着色剤が挙げられる。任意成分として、吸油量が35mL/100g未満である二酸化ケイ素粉末を用いてもよい。なお、本実施形態に係るトコジラミ駆除用組成物では、殺虫成分を用いることなくトコジラミを駆除することができることから、トコジラミ駆除用組成物は、殺虫成分を含有していなくてもよい。 The bed bug control composition according to the present embodiment may contain an optional component as long as the effect of the bed bug control agent according to the present embodiment is not hindered. Examples of the optional component include an insecticidal component, an attracting component, a surfactant, an antioxidant, an antiseptic, an anticorrosive agent, and a coloring agent. As an optional component, silicon dioxide powder having an oil absorption of less than 35 mL / 100 g may be used. In addition, since the bed bug control composition which concerns on this embodiment can control bed bugs, without using an insecticidal component, the bed bug control composition does not need to contain an insecticidal component.
 殺虫成分としては、例えば、除虫菊エキス、天然ピレトリン、プラレトリン、イミプロトリン、フタルスリン、アレスリン、ビフェントリン、レスメトリン、フェノトリン、シフェノトリン、ペルメトリン、サイパーメスリン、エトフェンプロックス、シフルスリン、デルタメスリン、ビフェントリン、フェンバレレート、フェンプロパトリン、エムペンスリン、シラフルオフェン、トランスフルトリン、メトフルトリン、プロフルトリン等のピレスロイド系殺虫剤;フェニトロチオン、ダイアジノン、マラソン、ピリダフェンチオン、プロチオホス、ホキシム、クロルピリホス、ジクロルボス等の有機リン系殺虫剤;カルバリル、プロポクスル、メソミル、チオジカルブ等のカーバメート系殺虫剤;メトキサジアゾン等のオキサジアゾール系殺虫剤;フィプロニル等のフェニルピラゾール系殺虫剤;アミドフルメト等のスルホンアミド系殺虫剤;ジノテフラン、イミダクロプリド、ニテンピラム等のネオニコチノイド系殺虫剤;クロルフェナピル等のピロール系殺虫剤が挙げられる。殺虫成分として、1種類のみを用いてもよく、2種類以上を用いてもよい。殺虫成分を用いる場合、殺虫成分の含有量は、トコジラミ駆除用組成物の全質量を基準として例えば0.1~50質量%である。 Insecticidal components include, for example, pesticide chrysanthemum extract, natural pyrethrin, praretrin, imiprotorin, phthalthrin, allethrin, bifenthrin, resmethrin, phenothrin, ciphenothrin, permethrin, cypermethrin, etofenprox, cyfluthrin, deltamethrin, bifenthrin, fenvalerate, fenvalerate, fenproperate , Empensulin, silafluophene, transfluthrin, metofluthrin, profluthrin and other pyrethroid insecticides; fenitrothion, diazinon, marathon, pyridafenthion, prothiophos, oxime, chlorpyrifos, dichlorvos and other organophosphorus insecticides; Carbamate insecticides; oxadiazo such as methoxadiazone System insecticide; phenylpyrazole insecticides such as fipronil; sulfonamide insecticides such as amidoflumet; dinotefuran, imidacloprid, neonicotinoid insecticides such as nitenpyram; pyrrole insecticides such as chlorfenapyr like. Only one type may be used as the insecticidal component, or two or more types may be used. When the insecticidal component is used, the content of the insecticidal component is, for example, 0.1 to 50% by mass based on the total mass of the bed bug control composition.
 誘引成分としては、害虫防除用に従来用いられているものを広く採用することができる。誘引成分としては、例えば、タンパク質、炭水化物、脂質等の植物性又は動物性の食餌;天然物由来及び調合された芳香成分、フェロモン、アミノ酸、核酸、油脂、ヘキセナール、オクチナール等の不飽和アルデヒド;酪酸等の有機酸が挙げられる。誘引成分として、1種類のみを用いてもよく、2種類以上を用いてもよい。誘引成分を用いる場合、誘引成分の含有量は、トコジラミ駆除用組成物の全質量を基準として例えば0.01~50質量%である。 As the attracting component, those conventionally used for pest control can be widely used. Examples of the attraction component include vegetable or animal diets such as proteins, carbohydrates, and lipids; aromatic components derived from natural products and prepared, pheromones, amino acids, nucleic acids, oils and fats, hexenals, octynals, and other unsaturated aldehydes; butyric acid Organic acids such as As an attracting component, only one type may be used or two or more types may be used. When the attracting component is used, the content of the attracting component is, for example, 0.01 to 50% by mass based on the total mass of the bed bug extermination composition.
(トコジラミ駆除方法)
 本実施形態に係るトコジラミ駆除方法は、吸油量が35mL/100g以上である二酸化ケイ素粉末をトコジラミに接触させる駆除方法である。本実施形態に係るトコジラミ駆除方法では、二酸化ケイ素粉末をトコジラミに向けて散布してもよく、二酸化ケイ素粉末をトコジラミの生息場所に散布してもよい。本実施形態に係るトコジラミ駆除方法では、本実施形態に係るトコジラミ駆除用組成物を用いて、二酸化ケイ素粉末をトコジラミに接触させてもよい。トコジラミが潜んでいる場所又はその周辺、トコジラミの行動範囲等に予め散布しておき、夜間等の活動時にトコジラミに接触させてもよい。
(How to control bed bugs)
The bed bug extermination method according to the present embodiment is an extermination method in which silicon dioxide powder having an oil absorption amount of 35 mL / 100 g or more is brought into contact with bed bugs. In the bed bug extermination method according to the present embodiment, the silicon dioxide powder may be sprayed toward the bed bug, or the silicon dioxide powder may be spread over the habitat of the bed bug. In the bed bug elimination method according to the present embodiment, the silicon dioxide powder may be brought into contact with the bed bug using the bed bug elimination composition according to the present embodiment. It may be sprayed in advance on a place where the bed bug is lurking or in the vicinity thereof, on the action range of the bed bug, and may be brought into contact with the bed bug at the time of activities such as nighttime.
 本実施形態に係るトコジラミ駆除方法において二酸化ケイ素粉末の散布量(散布濃度)は、充分な駆除効果が容易に得られる観点から、0.125g/m以上が好ましく、0.3g/m以上がより好ましく、0.5g/m以上が更に好ましい。二酸化ケイ素粉末の散布量は、トコジラミの生息域拡大を防ぐ目的での侵入又は定着を阻止する局所用法の場合(予防的処理)、200g/m以下が好ましく、生息域への局所用法の場合(殺虫)、充分な駆除効果が容易に得られる観点から、100g/m以下が好ましい。散布量が200g/m以下であれば、処理部分周辺への製剤の無駄な飛散を防ぐことができ、生息密度の高いトコジラミに対しても充分な駆除効果が得られる。屋内の床面全面に処理する場合、二酸化ケイ素粉末の散布量は、40g/m以下が好ましく、薬剤の無駄を抑えて効率的に駆除する観点から20g/m以下がより好ましい。 Application rate of the silicon dioxide powder in the bed bugs removal method according to the present embodiment (spraying concentration), from the viewpoint of sufficient disinfection effect can be easily obtained, 0.125 g / m 2 or more preferably, 0.3 g / m 2 or more Is more preferable, and 0.5 g / m 2 or more is still more preferable. The amount of silicon dioxide powder sprayed is preferably 200 g / m 2 or less in the case of local use that prevents invasion or colonization for the purpose of preventing the expansion of the habitat of bed bugs (preventive treatment). (Insecticide), 100 g / m 2 or less is preferable from the viewpoint of obtaining a sufficient extermination effect. If the application amount is 200 g / m 2 or less, it is possible to prevent wasteful dispersion of the preparation around the treated portion, and a sufficient extermination effect can be obtained even for bed bugs with high habitat density. When processing on the floor over the entire surface of the indoor, application rate of the silicon dioxide powder is preferably 40 g / m 2 or less, to suppress the waste of the drug is effectively disinfected viewpoint from 20 g / m 2 or less to more preferred.
 トコジラミは、高温多湿の環境下において、活発に活動し薬剤等に対する抵抗力が高い傾向がある。これに対し、本実施形態に係るトコジラミ駆除方法では、例えば、温度25℃、湿度50%以上の環境においてもトコジラミを駆除可能(例えば48時間後において80%以上の致死率)であり、温度25℃、湿度75%の高湿度環境においてもトコジラミを駆除可能(例えば168時間後において80%以上の致死率)である。 ト Bed bugs tend to be active in high-temperature and high-humidity environments and have high resistance to drugs. In contrast, in the bed bug extermination method according to the present embodiment, for example, bed bugs can be exterminated even in an environment at a temperature of 25 ° C. and a humidity of 50% or more (for example, a mortality rate of 80% or more after 48 hours). The bed bug can be exterminated even in a high humidity environment at 75 ° C. and humidity of 75% (for example, mortality rate of 80% or more after 168 hours).
 以下、実施例により本発明を具体的に説明する。但し、本発明は下記の実施例のみに限定されるものではない。 Hereinafter, the present invention will be specifically described by way of examples. However, the present invention is not limited to the following examples.
(試験1)
 下記表1に示す各種粉末を検体として準備した。表1中、サンスフェアはAGCエスアイテック株式会社製であり、ゴッドボールは鈴木油脂工業株式会社製であり、アドソリダーはフロイント産業株式会社製であり、ポロネックスは丸尾カルシウム株式会社製であり、フローライトは富田製薬株式会社製である。
(Test 1)
Various powders shown in Table 1 below were prepared as specimens. In Table 1, Sunsphere is manufactured by AGC S-Itech Co., Ltd., God Ball is manufactured by Suzuki Yushi Kogyo Co., Ltd., Ad Solider is manufactured by Freund Sangyo Co., Ltd., and Polonex is manufactured by Maruo Calcium Co., Ltd. Is manufactured by Tomita Pharmaceutical Co., Ltd.
 ガラス製腰高シャーレ(Φ9cm×高さ6.5cm)の底面に、トコジラミの入り込む隙間がシャーレとの間にできないように、ろ紙を底面全体に貼った後、底面全体に均一になるように検体約0.35cmを散布した(散布量:嵩比重90mL/5g(0.056g/mL)のアドゾリダー101では約3.0g/m(約55cm/m))。次に、温度25℃、湿度50%の環境において、シャーレを密閉容器内に一晩(12時間以上)静置した。腰高シャーレは、外形寸法が310mm(幅)×434mm(奥行き)×143mm(高さ)のプラスチック製のケース内に静置した。プラスチック製のケースの蓋をゴムパッキンで密封した。ケース内の湿度は、濃グリセリンを用いて50%に調整した。そして、シャーレに5頭のトコジラミ(千葉系、ペルメトリン抵抗性1万倍以上)を供試して継続的にトコジラミを検体に強制接触させた。トコジラミを供試した後に経時的に致死頭数を観察して致死率を算出した。同様の試験を再度繰り返し、計10頭のトコジラミの致死率を算出し、防除効果を評価した。結果を表1に示す。 Apply a filter paper on the entire bottom surface of the glass waist petri dish (Φ9cm x height 6.5cm) so that no gaps for bed bugs can be made between the petri dish and the sample to be uniform over the entire bottom surface. 0.35 cm 3 was sprayed (spraying amount: about 3.0 g / m 2 (about 55 cm 3 / m 2 ) in Adzolider 101 having a bulk specific gravity of 90 mL / 5 g (0.056 g / mL)). Next, the petri dish was allowed to stand overnight (12 hours or more) in a sealed container in an environment of a temperature of 25 ° C. and a humidity of 50%. The waist-high petri dish was placed in a plastic case having an outer dimension of 310 mm (width) × 434 mm (depth) × 143 mm (height). The lid of the plastic case was sealed with rubber packing. The humidity in the case was adjusted to 50% using concentrated glycerin. Then, five bed bugs (Chiba series, permethrin resistance of 10,000 times or more) were tested on the petri dish, and the bed bugs were continuously brought into contact with the specimen. After testing the bed bugs, the number of lethal heads was observed over time, and the lethality was calculated. The same test was repeated again to calculate the lethality of a total of 10 bed bugs and evaluate the control effect. The results are shown in Table 1.
Figure JPOXMLDOC01-appb-T000001
Figure JPOXMLDOC01-appb-T000001
 表1から明らかなように、吸油量が35mL/100g以上である二酸化ケイ素粉末を用いた場合には、48時間後において90%以上の致死率が達成されることが確認された。このように、48時間後において80%以上の致死率という充分な駆除効果が得られている。 As is clear from Table 1, when silicon dioxide powder having an oil absorption of 35 mL / 100 g or more was used, it was confirmed that a lethality of 90% or more was achieved after 48 hours. Thus, a sufficient extermination effect of a mortality rate of 80% or more is obtained after 48 hours.
(試験2)
 下記表2に示す各種粉末を検体として準備した。表2中、OSCはオリエンタル・シリカ・コーポレーション製であり、トクシールはオリエンタル・シリカ・コーポレーション製である。試験環境を温度25℃、湿度60%に変更したことを除き試験1と同様にトコジラミの致死率を評価した。比較のため、二酸化ケイ素粉末を散布しない場合の評価も行った。結果を表2に示す。
(Test 2)
Various powders shown in Table 2 below were prepared as specimens. In Table 2, OSC is manufactured by Oriental Silica Corporation, and Toxeal is manufactured by Oriental Silica Corporation. The lethality of bed bugs was evaluated in the same manner as in Test 1 except that the test environment was changed to a temperature of 25 ° C. and a humidity of 60%. For comparison, an evaluation was also performed when no silicon dioxide powder was sprayed. The results are shown in Table 2.
Figure JPOXMLDOC01-appb-T000002
Figure JPOXMLDOC01-appb-T000002
 表2から明らかなように、実施例では、72時間後において100%の致死率が達成されることが確認された。このように、72時間後において80%以上の致死率が得られている。このように、湿度60%の高湿度条件下であっても充分な駆除効果が得られている。 As is clear from Table 2, in the examples, it was confirmed that 100% mortality was achieved after 72 hours. Thus, a mortality rate of 80% or more is obtained after 72 hours. Thus, a sufficient extermination effect is obtained even under high humidity conditions of 60% humidity.
(試験3)
 下記表3に示す各種二酸化ケイ素粉末を検体として準備した。表3中、ファインシールはオリエンタル・シリカ・コーポレーション製である。試験環境を温度25℃、湿度75%に変更したことを除き試験1と同様にトコジラミの致死率を評価した。結果を表3に示す。
(Test 3)
Various silicon dioxide powders shown in Table 3 below were prepared as specimens. In Table 3, the fine seal is manufactured by Oriental Silica Corporation. The lethality of bed bugs was evaluated in the same manner as in Test 1 except that the test environment was changed to a temperature of 25 ° C. and a humidity of 75%. The results are shown in Table 3.
Figure JPOXMLDOC01-appb-T000003
Figure JPOXMLDOC01-appb-T000003
 表3から明らかなように、実施例では、168時間後において80%以上の致死率が達成されることが確認された。このように、湿度75%という非常に高湿度条件下においても充分な駆除効果が得られている。 As is apparent from Table 3, in the examples, it was confirmed that a mortality rate of 80% or more was achieved after 168 hours. Thus, a sufficient extermination effect is obtained even under a very high humidity condition of 75% humidity.
(試験4)
 二酸化ケイ素粉末としてアドソリダー101(フロイント産業株式会社製)を準備した。散布量を約0.125g/m(約2.3cm/m)、約0.3g/m(約5.5cm/m)、約0.5g/m(約9.2cm/m)及び約1.0g/m(約18.3cm/m)に変更したことを除き実施例1-6(散布量:約3.0g/m、温度25℃、湿度50%)と同様にトコジラミの致死率を算出し、防除効果を評価した。比較のため、二酸化ケイ素粉末を散布しない場合の評価も行った。結果を表4に示す。
(Test 4)
Adsolider 101 (Freund Sangyo Co., Ltd.) was prepared as a silicon dioxide powder. The application rate is about 0.125 g / m 2 (about 2.3 cm 3 / m 2 ), about 0.3 g / m 2 (about 5.5 cm 3 / m 2 ), about 0.5 g / m 2 (about 9. 2cm 3 / m 2) and about 1.0 g / m 2 (about 18.3cm 3 / m 2) example except for the change to 1-6 (application rate: about 3.0 g / m 2, temperature 25 ° C. The mortality of bed bugs was calculated in the same manner as in the case of humidity 50%, and the control effect was evaluated. For comparison, an evaluation was also performed when no silicon dioxide powder was sprayed. The results are shown in Table 4.
Figure JPOXMLDOC01-appb-T000004
Figure JPOXMLDOC01-appb-T000004
 表4から明らかなように、実施例では、いずれの散布量においても48時間後において80%以上の致死率が達成されることが確認された。このように、トコジラミに対して直接処理することができない場合において、活動期に接触する程度の低濃度の薬剤であっても充分な駆除効果が得られることがわかる。このことから、薬剤の届きにくい隙間に生息するトコジラミに対しても、充分な駆除効果が得られると期待される。 As is clear from Table 4, in the Examples, it was confirmed that a lethality of 80% or more was achieved after 48 hours at any application amount. Thus, it can be seen that in the case where the treatment for bed bugs cannot be performed directly, even with a drug at a low concentration that is in contact with the active period, a sufficient extermination effect can be obtained. For this reason, it is expected that a sufficient extermination effect can be obtained even for bed bugs that live in gaps where the drug is difficult to reach.
(試験5)
 全体に均一になるようにベニヤ板の主面(15cm×15cm)に各検体(エアゾール剤)を約2.7g噴射した後、一晩(25℃、12時間以上)静置した。次に、温度25℃、湿度50%の環境のプラスチック製の密閉容器内(パッキン付の密閉容器)において10頭のトコジラミ(千葉系、ペルメトリン抵抗性1万倍以上)をベニヤ板の検体処理面に供試した後、プラスチックカップ(φ6cm、高さ3.5cm)で覆い、トコジラミを検体に1時間強制接触させた。その後、トコジラミを清潔なプラスチックカップに移し、プラスチックカップを温度25℃、湿度50%の環境の密閉容器内に静置した。24時間後及び48時間後の致死頭数を観察して致死率を評価した。同様の試験を3回繰り返し、計30頭のトコジラミの致死率を算出し、防除効果を評価した。
(Test 5)
About 2.7 g of each specimen (aerosol) was sprayed onto the main surface (15 cm × 15 cm) of the plywood so as to be uniform throughout, and then left still overnight (25 ° C., 12 hours or more). Next, in a sealed plastic container (sealed container with packing) in an environment of temperature 25 ° C and humidity 50%, 10 bed bugs (Chiba-based, permethrin resistance 10,000 times or more) are applied to the specimen processing surface of the plywood board. After the test, it was covered with a plastic cup (φ6 cm, height 3.5 cm), and bed bugs were forcibly contacted with the specimen for 1 hour. Thereafter, the bed bug was transferred to a clean plastic cup, and the plastic cup was allowed to stand in a sealed container in an environment of a temperature of 25 ° C. and a humidity of 50%. The mortality was evaluated by observing the number of lethal animals after 24 and 48 hours. The same test was repeated three times, and the lethality of a total of 30 bed bugs was calculated to evaluate the control effect.
 検体としては、450mLあたり原液105mL及び噴射剤345mLを含むエアゾール剤を用いた。原液の構成成分としては、表5に示す成分を用いた。二酸化ケイ素粉末として、トクシールNP(オリエンタル・シリカ・コーポレーション製)及びアドソリダー101(フロイント産業株式会社製)を用いた。液状担体としては、ノルマルパラフィン(三光化学工業株式会社製、商品名:ネオチオゾール)を用いた。100mLあたり液化石油ガス(LPG0.15MPa,20℃)52.2mLと、DME(ジメチルエーテル)47.8mLとを含む噴射剤を用いた(ガス構成(質量比:20℃):DME/LPG0.15MPa=49.5/50.5)。二酸化ケイ素粉末の散布量は、約0.6g/mであった。結果を表5に示す。 As a specimen, an aerosol containing 105 mL of stock solution and 345 mL of propellant per 450 mL was used. As the constituent components of the stock solution, the components shown in Table 5 were used. Toxeal NP (manufactured by Oriental Silica Corporation) and Adsolider 101 (manufactured by Freund Sangyo Co., Ltd.) were used as the silicon dioxide powder. As the liquid carrier, normal paraffin (manufactured by Sanko Chemical Co., Ltd., trade name: neothiozole) was used. A propellant containing 52.2 mL of liquefied petroleum gas (LPG 0.15 MPa, 20 ° C.) and 47.8 mL of DME (dimethyl ether) per 100 mL was used (gas configuration (mass ratio: 20 ° C.): DME / LPG 0.15 MPa = 49.5 / 50.5). The amount of silicon dioxide powder sprayed was about 0.6 g / m 2 . The results are shown in Table 5.
Figure JPOXMLDOC01-appb-T000005
Figure JPOXMLDOC01-appb-T000005
(試験6)
 図1に示す20cm×27cmの試験領域の中央に、全体に均一になるように5cm×20cmの帯状に二酸化ケイ素粉末(アドソリダー101、フロイント産業株式会社製)を散布(散布量:約3.0g/m(約55cm/m))して処理領域Aを形成した。処理領域Aを挟む二つの無処理領域B1,B2のうちの無処理領域B1に、トコジラミは狭い暗所を好むことから、トコジラミの潜伏場所となり得る5cm×5cmの黒紙Cを設置した。温度25℃、湿度50%の環境において、黒紙Cを設置していない無処理領域B2にトコジラミ(千葉系、ペルメトリン抵抗性1万倍以上)を10頭供試し、24時間後の致死頭数を観察した。トコジラミは、無処理領域B2から処理領域Aを経由して無処理領域B1へ移動した。同様の試験を2回繰り返し、計20頭のトコジラミの致死率を評価した結果、致死率は100%であった。
(Test 6)
In the center of the test area of 20 cm × 27 cm shown in FIG. 1, silicon dioxide powder (Adsolider 101, manufactured by Freund Sangyo Co., Ltd.) is sprayed in a strip shape of 5 cm × 20 cm so as to be uniform throughout (spreading amount: about 3.0 g) / M 2 (about 55 cm 3 / m 2 )) to form a treatment area A. In the untreated area B1 of the two untreated areas B1 and B2 between which the treated area A is sandwiched, a white paper C of 5 cm × 5 cm, which can be a hiding place for bed bugs, was placed because the bed bug prefers a narrow dark place. In an environment with a temperature of 25 ° C and a humidity of 50%, 10 bed bugs (Chiba-based, permethrin resistance of 10,000 times or more) were tested in the untreated area B2 where no black paper C was installed. Observed. The bed bug moved from the non-processing area B2 to the non-processing area B1 via the processing area A. The same test was repeated twice, and the mortality rate of a total of 20 bedbugs was evaluated. As a result, the mortality rate was 100%.
 このように、トコジラミに対して直接薬剤を処理することができない場合にも、潜伏場所の周辺に処理することで充分な駆除効果が得られることがわかる。さらに、潜伏場所(暗所)へ向かう間に薬剤に曝露されることで、潜伏場所に辿りついた場合にも、その場で致死することから生息域の拡大及び侵入を防ぐことができる。 Thus, it can be seen that even when the drug cannot be processed directly against bed bugs, a sufficient extermination effect can be obtained by processing around the latent place. Furthermore, by being exposed to the drug while heading to the latent place (dark place), even when the latent place is reached, it can be lethal on the spot, thereby preventing the expansion and invasion of the habitat.
(試験7)
 ガラス製腰高シャーレ(Φ9cm×高さ6.5cm)の底面に、トコジラミが入り込む隙間がシャーレとの間にできないように、ろ紙を底面全体に貼った後、底面全体に均一になるように検体を処理した。実施例では、検体として二酸化ケイ素粉末を用い、二酸化ケイ素粉末の散布量は約3.0g/m(約55cm/m)であった。二酸化ケイ素粉末として、アドソリダー101(フロイント産業株式会社製)及びトクシールNP(オリエンタル・シリカ・コーポレーション製)を用いた。比較例では、検体としてペルメトリン(殺虫成分)を用い、ペルメトリンをアセトンに溶解してろ紙に含浸させた。ペルメトリンの処理量は100mg/m(0.63mg/シャーレ)であった。
(Test 7)
Affix the filter paper on the entire bottom surface of the glass waist petri dish (Φ9cm x height 6.5cm) so that there is no gap between the bedbugs and the petri dish, Processed. In the examples, silicon dioxide powder was used as a specimen, and the amount of silicon dioxide powder sprayed was about 3.0 g / m 2 (about 55 cm 3 / m 2 ). As the silicon dioxide powder, Adsolider 101 (manufactured by Freund Sangyo Co., Ltd.) and Toxeal NP (manufactured by Oriental Silica Corporation) were used. In the comparative example, permethrin (insecticidal component) was used as a specimen, and permethrin was dissolved in acetone and impregnated in filter paper. The amount of permethrin treated was 100 mg / m 2 (0.63 mg / dish).
 次に、温度25℃、湿度50%の環境において、シャーレをプラスチック製の密閉容器内に一晩(12時間以上)静置した後、シャーレに5頭のトコジラミ(千葉系、ペルメトリン抵抗性1万倍以上)を供試して継続的にトコジラミを検体に12時間強制接触させた。その後、トコジラミを清潔なプラスチックカップに移し、プラスチックカップを温度25℃、湿度50%の環境の密閉容器にて静置した。24時間後の致死頭数を観察して致死率を評価した。同様の試験を再度繰り返し、計10頭のトコジラミの致死率を評価した。また、抵抗性トコジラミに代えて感受性トコジラミ(帝京大系)を供試して同様の評価を行った。結果を表6に示す。 Next, in a 25 ° C. and 50% humidity environment, the petri dish was allowed to stand overnight (for 12 hours or more) in a plastic airtight container, and then five bed bugs (Chiba, permethrin-resistant 10,000) The test was continuously carried out for 12 hours. Thereafter, the bed bug was transferred to a clean plastic cup, and the plastic cup was allowed to stand in a sealed container in an environment of a temperature of 25 ° C. and a humidity of 50%. The lethality was evaluated by observing the number of lethal heads after 24 hours. The same test was repeated again to evaluate the lethality of a total of 10 bed bugs. Moreover, it replaced with the resistant bed bug and tested the sensitive bed bug (Teikyo University system), and performed the same evaluation. The results are shown in Table 6.
Figure JPOXMLDOC01-appb-T000006
Figure JPOXMLDOC01-appb-T000006
 表6から明らかなように、実施例では、抵抗性トコジラミ及び感受性トコジラミのいずれに対しても24時間後において100%の致死率が達成されていることが確認され、充分な駆除効果が得られることが確認された。 As is apparent from Table 6, in the Examples, it was confirmed that a lethality rate of 100% was achieved after 24 hours for both resistant and susceptible bed bugs, and a sufficient extermination effect was obtained. It was confirmed.
(試験8)
 全体に均一になるようにベニヤ板の主面(15cm×15cm)に検体(水分散剤)を約3.0g滴下した後、一晩(25℃、12時間以上)静置した。次に、温度25℃、湿度50%の環境のプラスチック製の密閉容器内(パッキン付の密閉容器)において5頭のトコジラミ(千葉系、ペルメトリン抵抗性1万倍以上)をベニヤ板の検体処理面に供試した後、プラスチックカップ(φ6cm、高さ3.5cm)で覆い、トコジラミを検体に1時間強制接触させた。その後、トコジラミを清潔なプラスチックカップに移し、プラスチックカップを温度25℃、湿度50%の環境の密閉容器内に静置した。24時間後の致死頭数を観察して致死率を評価した。同様の試験を3回繰り返し、計15頭のトコジラミの致死率を算出し、防除効果を評価した。
(Test 8)
About 3.0 g of a specimen (water dispersing agent) was dropped on the main surface (15 cm × 15 cm) of the plywood so as to be uniform throughout, and then left to stand overnight (25 ° C., 12 hours or more). Next, five bed bugs (Chiba-based, permethrin resistance of 10,000 times or more) are placed on the sample processing surface of the plywood board in a plastic sealed container (sealed container with packing) in an environment of temperature 25 ° C. and humidity 50%. After the test, it was covered with a plastic cup (φ6 cm, height 3.5 cm), and bed bugs were forcibly contacted with the specimen for 1 hour. Thereafter, the bed bug was transferred to a clean plastic cup, and the plastic cup was allowed to stand in a sealed container in an environment of a temperature of 25 ° C. and a humidity of 50%. The lethality was evaluated by observing the number of lethal heads after 24 hours. The same test was repeated three times, and the lethality of a total of 15 bed bugs was calculated to evaluate the control effect.
 検体の構成成分としては、表7に示す成分を用いた。二酸化ケイ素粉末として、アドソリダー101(フロイント産業株式会社製)を用いた。液状担体としては、水及びエタノールを用いた。二酸化ケイ素粉末の散布量は、約3.0g/mであった。結果を表7に示す。 The components shown in Table 7 were used as the constituent components of the specimen. Adsolider 101 (Freund Sangyo Co., Ltd.) was used as the silicon dioxide powder. Water and ethanol were used as the liquid carrier. The amount of silicon dioxide powder sprayed was about 3.0 g / m 2 . The results are shown in Table 7.
Figure JPOXMLDOC01-appb-T000007
Figure JPOXMLDOC01-appb-T000007
 表7から明らかなように、水、エタノール等の液体担体中に物理的な力で分散させたトコジラミ駆除剤を用いる場合であっても、充分な駆除効果が得られている。 As is clear from Table 7, even when a bed bug disinfectant dispersed with a physical force in a liquid carrier such as water or ethanol is used, a sufficient disinfecting effect is obtained.
 A…処理領域、B1,B2…無処理領域、C…黒紙。 A: Processing area, B1, B2: No processing area, C: Black paper.

Claims (3)

  1.  吸油量が35mL/100g以上である二酸化ケイ素粉末からなる、トコジラミ駆除剤。 Bed bug repellent consisting of silicon dioxide powder with an oil absorption of 35 mL / 100 g or more.
  2.  請求項1に記載のトコジラミ駆除剤を含有する、トコジラミ駆除用組成物。 A bed bug control composition comprising the bed bug control agent according to claim 1.
  3.  吸油量が35mL/100g以上である二酸化ケイ素粉末をトコジラミに接触させる、トコジラミ駆除方法。
     
    The bed bug extermination method of bringing a silicon dioxide powder having an oil absorption of 35 mL / 100 g or more into contact with bed bugs.
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