JP2019099534A - Hair growth agent and hair growth method - Google Patents
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本発明は、頭部の毛髪の生育を促進する発毛剤、および、その発毛剤を用いた発毛方法に関するものである。 The present invention relates to a hair growth agent for promoting the growth of hair on the head, and a hair growth method using the hair growth agent.
従来から脱毛症や薄毛症を予防・改善して毛髪の生育を促進する発毛剤、育毛剤の開発が望まれており、高齢化が進み、人々が多くのストレスを抱える現代社会においては、年齢、性別にかかわらず、その要望が一段と高くなっている。これまでにも様々な発毛剤が開発されており、それらの中で代表的なものとしては、脱毛症の原因物質であるテストステロン５α−リダクターゼの活性を阻害する阻害剤が知られている（特許文献１）。また、色々な植物抽出物を成分とする発毛剤も開発されている（特許文献２）。 In the past, development of hair growth agents and hair growth agents that promote hair growth by preventing and improving alopecia and thinning hair has been desired, and in the modern society where aging progresses and people are stressed a lot, Regardless of age and gender, the demand is even higher. Various hair growth agents have been developed so far, and among them, typical inhibitors are known which inhibit the activity of testosterone 5α-reductase which is a causative agent of alopecia ( Patent Document 1). Moreover, the hair growth agent which uses various plant extracts as a component is also developed (patent document 2).
しかしながら、テストステロン５α−リダクターゼ阻害剤は、化学的に合成されるものであるため、その副作用が懸念される。一方、植物抽出物を成分とする発毛剤は、安全性は高いものの、十分な発毛効果が得られるには至っていない。 However, since the testosterone 5α-reductase inhibitor is chemically synthesized, its side effects are of concern. On the other hand, although the hair growth agent which uses a plant extract as a component is highly safe, a sufficient hair growth effect has not been obtained yet.
本発明の目的は、上記従来の発毛剤、育毛剤の問題点を解消し、安全性が高く、副作用を誘発する虞れがない上、発毛効果が高く、安価かつ容易に製造可能な発毛剤を提供することにある。また、その発毛剤を用いた効率的な発毛方法を提供することにある。 The object of the present invention is to solve the problems of the above conventional hair growth agents and hair growth agents, to be highly safe, to have no possibility of inducing side effects, to have a high hair growth effect, inexpensive and easy to manufacture It is in providing a hair growth agent. Another object of the present invention is to provide an efficient hair growth method using the hair growth agent.
かかる本発明の内、請求項１に記載された発明は、頭部の毛髪の生育を促進する発毛剤であって、界面活性剤中に０．１質量％以上１０質量％未満の臭素酸Ｎａを添加したことを特徴とするものである。 Among the present inventions, the invention described in claim 1 is a hair growth promoter for promoting the growth of hair on the head, comprising 0.1 mass% or more and less than 10 mass% of bromate acid in the surfactant. It is characterized in that Na is added.
請求項２に記載された発明は、請求項１に記載された発明において、前記界面活性剤が、硫酸系の界面活性剤を主成分とするものであることを特徴とするものである。 The invention described in claim 2 is characterized in that, in the invention described in claim 1, the surfactant contains a sulfuric acid-based surfactant as a main component.
請求項３に記載された発明は、請求項１、または請求項２に記載された発明において、前記界面活性剤が、プロポリスを含有したものであることを特徴とするものである。 The invention described in claim 3 is characterized in that, in the invention described in claim 1 or claim 2, the surfactant contains propolis.
請求項４に記載された発明は、頭部の毛髪の生育を促進する発毛方法であって、請求項１〜３のいずれかに記載された発毛剤を頭皮および毛髪に塗布して泡立てて所定の時間だけ放置する発毛剤塗布処理と、頭皮の内の脱毛あるいは薄毛部位に引張あるいは押圧による刺激を与える刺激付与処理と、前記刺激付与処理後の毛髪を、臭素酸Ｎａを含有しない第二界面活性剤を用いて洗い流す余剰分除去処理とを有することを特徴とするものである。 The invention described in claim 4 is a hair growth method for promoting the growth of hair on the head, wherein the hair growth agent according to any one of claims 1 to 3 is applied to the scalp and the hair for foaming. The hair growth agent application treatment which is left standing for a predetermined time, the stimulation giving treatment which gives stimulation by tension or pressure to the hair loss or thin hair part in the scalp, and the hair after the stimulation giving treatment does not contain sodium bromate It is characterized in that it has an excess content removing process to be washed out using a second surfactant.
請求項５に記載された発明は、請求項４に記載された発明において、前記第二界面活性剤が、プロポリスを含有したものであることを特徴とするものである。 The invention described in claim 5 is characterized in that, in the invention described in claim 4, the second surfactant contains propolis.
本発明に係る発毛剤は、性別を問わず幅広い年齢層の人に対して良好な発毛・育毛効果を奏する上、使用に際して頭皮の荒れや紅斑、発赤を招来する等の副作用がなく、安全性に優れている。また、本発明に係る発毛方法によれば、性別を問わず幅広い年齢層の人に対して短期間の内に効率的に、かつ、安全に発毛・育毛を促すことが可能となる。 The hair growth agent according to the present invention exerts good hair growth and hair growth effects on people of a wide range of age groups regardless of gender, and has no side effects such as rough skin, erythema and redness upon use. It is excellent in safety. Further, according to the hair growth method of the present invention, it is possible to promote hair growth and hair growth efficiently and safely in a short period of time for persons of a wide age group regardless of gender.
以下、本発明に係る発毛剤および発毛方法の一実施形態について詳細に説明する。なお、以下の説明においては、各成分の含有量、添加量に関する“〜”は、原則的に、左側の数値以上右側の数値未満を意味するものとする。 Hereinafter, an embodiment of a hair growth agent and a hair growth method according to the present invention will be described in detail. In addition, in the following description, "-" regarding content of each component and addition amount shall mean more than the numerical value of the left side and less than the numerical value of the right side.
本発明に係る発毛剤は、界面活性剤中に所定量の臭素酸Ｎａを添加したことを特徴としている。臭素酸Ｎａを添加する界面活性剤としては、非イオン界面活性剤、アニオン界面活性剤、カチオン界面活性剤、両性界面活性剤等の各種の界面活性剤を、単独で、あるいは２種以上を混合して用いることができる。 The hair growth agent according to the present invention is characterized in that a predetermined amount of sodium bromate is added to the surfactant. As surfactants to which sodium bromate is added, various surfactants such as nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, etc. may be used alone or in combination of two or more. Can be used.
非イオン界面活性剤としては、ポリオキシエチレンアルキルエーテル、ポリオキシエチレン脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ポリオキシエチレングリセリン脂肪酸エステル、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンソルビトール脂肪酸エステル等を挙げることができる。 As nonionic surfactants, polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, Polyoxyethylene sorbitol fatty acid ester etc. can be mentioned.
また、アニオン系界面活性剤としては、ラウリル硫酸Ｎａ、ラウレス硫酸Ｎａ等の高級アルコール系界面活性剤、炭素数が１４〜１６のオレフィンスルホン酸Ｎａ等のαオレフィン系界面活性剤、ココイルグルタミン酸Ｎａ、ラウロイルグルタミン酸Ｎａ、ラウロイルアラニンＮａ、ココイルメチルアラニンＮａ、ラウロイルサルコシンＮａ、ココイルサルコシンＮａ等のアミノ酸系界面活性剤、ココイルメチルタウリンＮａ、ラウロイルメチルタウリンＮａ等のタウリン系界面活性剤、ココイル加水分解コラーゲンＮａ等のタンパク質由来系界面活性剤、スルホコハク酸ラウリル２Ｎａ等のスルホコハク酸系界面活性剤、オレイン酸Ｎａ、ラウレス‐３酢酸Ｎａ等の石けん系界面活性剤、ＰＥＧ−ヤシ油脂肪酸アミドＭＥＡ硫酸Ｎａ等のアミドエーテル硫酸系界面活性剤等を挙げることができる。 Further, as the anionic surfactant, higher alcohol surfactants such as sodium lauryl sulfate and sodium laureth sulfate, α-olefin surfactants such as sodium olefin sulfonate having 14 to 16 carbon atoms, sodium cocoyl glutamate, Amino acid surfactants such as lauroyl glutamic acid Na, lauroyl alanine Na, cocoyl methyl alanine Na, lauroyl sarcosine Na, cocoyl sarcosine Na, etc. Taurine surfactants such as cocoyl methyl taurine Na, lauroyl methyl taurine Na, cocoly hydrolyzed collagen Na Such as protein derived surfactants, sulfosuccinic acid surfactants such as 2Na lauryl sulfosuccinate, soap surfactants such as sodium oleate and sodium laureth-3 acetate, PEG-coconut fatty acid amide MEA sodium sulfate etc A And the like Doeteru sulfate surfactant.
一方、カチオン界面活性剤としては、第四級アンモニウム塩、第一級〜第三級脂肪アミン塩、トリアルキルベンジルアンモニウム塩、アルキルピリジニウム塩、２−アルキル−１−アルキル−１−ヒドロキシエチルイミダゾリニウム塩、Ｎ，Ｎ−ジアルキルモルフォルニウム塩、ポリエチレンポリアミン脂肪酸アミド塩等を挙げることができる。 On the other hand, as cationic surfactants, quaternary ammonium salts, primary to tertiary fatty amine salts, trialkylbenzyl ammonium salts, alkyl pyridinium salts, 2-alkyl-1-alkyl-1-hydroxyethyl imidazoles And salts thereof, such as sodium salts, N, N-dialkylmorpholinium salts, polyethylene polyamine fatty acid amide salts and the like.
また、両性界面活性剤としては、ラウラミドプロピルベタイン、ココアン酢酸Ｎａ、コカミドプロピルベタイン等のベタイン系界面活性剤、ラウラミノジプロピオン酸Ｎａ等のアミノ酸系界面活性剤等を挙げることができる。 Examples of amphoteric surfactants include betaine surfactants such as lauramidopropyl betaine, sodium cocoan acetate, cocamidopropyl betaine, and amino acid surfactants such as sodium lauraminodipropionate.
本発明の発毛剤には、上記した各種の界面活性剤を好適に用いることができるが、それらの中でも、ラウリル硫酸Ｎａ、ラウレス硫酸Ｎａ、ＰＥＧ−ヤシ油脂肪酸アミドＭＥＡ硫酸Ｎａ等の硫酸塩を有する硫酸系の界面活性剤（アニオン系界面活性剤）、ココイルグルタミン酸Ｎａ、ラウロイルグルタミン酸Ｎａ、ラウロイルアラニンＮａ、ココイルメチルアラニンＮａ、ラウロイルサルコシンＮａ、ココイルサルコシンＮａ、ラウラミノジプロピオン酸Ｎａ等のアミノ酸系界面活性剤、ラウラミドプロピルベタイン、ココアン酢酸Ｎａ、コカミドプロピルベタイン等のベタイン系界面活性剤を主成分とするもの（すなわち、質量割合で全体の概ね８０％以上が硫酸系の界面活性剤であるもの）を用いると、発毛効果がより顕著なものとなるので好ましく、硫酸系の界面活性剤を用いると、特に好ましい。なお、被処置者が敏感な皮膚を有している場合には、界面活性剤として、硫酸系のものよりもアミノ酸系のものやベタイン系のものを用いるのが好ましい。 Among the various surfactants described above can be suitably used in the hair growth agent of the present invention, and among them, sulfates such as sodium lauryl sulfate, sodium laureth sulfate, PEG-coconut fatty acid amide MEA sulfate sodium and the like Sulfuric acid-based surfactants (anionic surfactants), cocoyl glutamate Na, lauroyl glutamate Na, lauroyl alanine Na, cocoyl methyl alanine Na, lauroyl sarcosine Na, cocoyl sarcosine Na, sodium lauroaminodipropionate, etc. Based on a betaine-based surfactant such as a surfactant based on laurylamidopropyl betaine, sodium cocoan acetate or cocamidopropyl betaine (that is, 80% or more of the surfactant based on sulfuric acid based on weight ratio) ), The hair growth effect is more pronounced In Preferably, the use of surfactants sulfuric acid are particularly preferred. When the treated person has sensitive skin, it is preferable to use an amino acid-based one or a betaine-based one as the surfactant rather than a sulfuric acid-based one.
本発明に係る発毛剤は、上記した界面活性剤中に所定量の臭素酸Ｎａを添加する必要がある。臭素酸Ｎａの添加量は、界面活性剤に対して０．１質量％以上１０質量％未満とする必要がある。臭素酸Ｎａの添加量が０．１質量％未満であると、良好な発毛作用が得られないので好ましくなく、反対に、臭素酸Ｎａの添加量が１０質量％を上回ると、頭皮への刺激が強くなる上、不経済となるので好ましくない。臭素酸Ｎａの添加量は、１質量％以上８質量％未満であるとより好ましく、３質量％以上６質量％未満であると特に好ましい。 In the hair growth agent according to the present invention, it is necessary to add a predetermined amount of sodium bromate to the above-mentioned surfactant. The addition amount of sodium bromate needs to be 0.1% by mass or more and less than 10% by mass with respect to the surfactant. It is not preferable that the addition amount of sodium bromate is less than 0.1% by mass because a good hair growth effect can not be obtained, and conversely, when the addition amount of sodium bromate is more than 10% by mass, it is not preferable to the scalp. It is not preferable because the stimulus becomes strong and uneconomical. The addition amount of sodium bromate is more preferably 1% by mass or more and less than 8% by mass, and particularly preferably 3% by mass or more and less than 6% by mass.
また、本発明に係る発毛剤には、プロポリスを含有させることができる。当該プロポリス（Propolis）とは、植物が分泌した種々の物質をミツバチが採集して営巣に用いる粘着性の物質のことであり、所謂、蜂ヤニのことである。かかるプロポリスを発毛剤に含有させることによって、臭素酸Ｎａとの相互的な作用によりきわめて良好な発毛効果を発現させることが可能になる上、皮膚への刺激を低減することが可能となる。本発明に係る発毛剤には、このプロポリスの固形分濃度が１０％〜３０％の抽出溶液（エタノール溶液等）を、０．５〜１５．０質量％含有させるのが好ましく、１．０〜５．０質量％含有させるのがより好ましく、２．０〜４．０質量％含有させるのが特に好ましい（したがって、固形分濃度としては、０．０５質量％〜４．５質量％含有させるのが好ましく、０．１質量％〜１．５質量％含有させるのがより好ましく、０．２質量％〜１．２質量％含有させるのが特に好ましい）。また、プロポリスの抽出溶液としては、固形分濃度が約２０％の抽出溶液を用いるのが、発毛剤の安定性の面から好ましい。 In addition, the hair growth agent according to the present invention can contain propolis. The propolis (Propolis) is a sticky substance which bees collect and use for nesting by various substances secreted by plants, and is a so-called bee clover. By including such propolis in a hair growth agent, it becomes possible to express a very good hair growth effect by interaction with sodium bromate, and it is also possible to reduce skin irritation. . The hair growth agent according to the present invention preferably contains 0.5 to 15.0% by mass of an extraction solution (ethanol solution etc.) having a solid content concentration of 10% to 30% of this propolis, 1.0 It is more preferable to contain -5.0% by mass, and it is particularly preferable to contain 2.0 to 4.0% by mass (thus, as a solid content concentration, to contain 0.05% by mass to 4.5% by mass) Is preferably contained in an amount of 0.1% by mass to 1.5% by mass, particularly preferably 0.2% by mass to 1.2% by mass). Further, as a propolis extraction solution, it is preferable to use an extraction solution having a solid content concentration of about 20% from the viewpoint of the stability of the hair growth agent.
加えて、本発明に係る発毛剤には、必要に応じて、各種のアルコールや発酵アルコール、グリコール類（ブチルグリコール等）、植物から抽出したエキス、防腐剤、香料、粘度調整剤、ＰＨ調整剤等を添加することも可能である。 In addition, in the hair growth agent according to the present invention, various alcohols and fermented alcohols, glycols (such as butyl glycol), extracts extracted from plants, preservatives, fragrances, viscosity modifiers, pH adjustment, as necessary. It is also possible to add an agent or the like.
本発明に係る発毛剤は、頭皮および毛髪に塗布して使用するものであり、その使用方法は特に限定されないが、頭皮および毛髪に塗布して泡立てて所定の時間だけ放置する発毛剤塗布処理と、頭皮の内の脱毛あるいは薄毛部位に引張あるいは押圧による刺激を与える刺激付与処理と、刺激付与処理後の毛髪を、臭素酸Ｎａを含有しない界面活性剤（第二界面活性剤）を用いて洗い流す余剰分除去処理とを有する方法を採用すると、発毛効果が一段と顕著なものとなるので好ましい。 The hair growth agent according to the present invention is used by applying to the scalp and the hair, and the method of use is not particularly limited. However, the hair growth agent is applied to the scalp and the hair and foamed and left for a predetermined time. Treatment, stimulation treatment to give stimulation by tension or pressure to hair loss or thin hair part in the scalp, and hair after stimulation treatment using Na bromate free surfactant (second surfactant) It is preferable to adopt a method having an excess removal process to wash away the hair, since the hair growth effect becomes more remarkable.
上記した余剰分除去処理で使用する第二界面活性剤としては、上記した非イオン界面活性剤、アニオン界面活性剤、カチオン界面活性剤、両性界面活性剤等の各種の界面活性剤を、単独で、あるいは２種以上を混合して用いることができるが、アミノ酸系の界面活性剤（すなわち、ココイルグルタミン酸Ｎａ、ラウロイルグルタミン酸Ｎａ、ラウロイルアラニンＮａ、ココイルメチルアラニンＮａ、ラウロイルサルコシンＮａ、ココイルサルコシンＮａ等のアニオン系界面活性剤や、ラウラミノジプロピオン酸Ｎａ等の両性界面活性剤）を用いると、発毛効果がより顕著なものとなるので好ましい。 As the second surfactant to be used in the above-mentioned surplus removal processing, various surfactants such as the above-mentioned nonionic surfactant, anionic surfactant, cationic surfactant, amphoteric surfactant and the like may be used alone. Or two or more of them can be used in combination, but amino acid-based surfactants (ie, cocoyl glutamate Na, lauroyl glutamate Na, lauroyl alanine Na, cocoyl methyl alanine Na, lauroyl sarcosine Na, cocoyl sarcosine Na, etc. It is preferable to use an anionic surfactant or an amphoteric surfactant such as sodium lauraminodipropionate because the hair growth effect is more remarkable.
さらに、余剰分除去処理で使用する第二界面活性剤が、プロポリスを含有したものであると、発毛効果が一段と顕著なものとなり、皮膚への刺激がより低減されるので好ましい。第二界面活性剤には、プロポリスの固形分濃度が１０％〜３０％の抽出溶液（エタノール溶液等）を、０．５〜１５．０質量％含有させるのが好ましく、１．０〜５．０質量％含有させるのがより好ましく、２．０〜４．０質量％含有させるのが特に好ましい（したがって、固形分濃度としては、０．０５質量％〜４．５質量％含有させるのが好ましく、０．１質量％〜１．５質量％含有させるのがより好ましく、０．２質量％〜１．２質量％含有させるのが特に好ましい）。また、プロポリスの抽出溶液としては、固形分濃度が約２０％の抽出溶液を用いるのが、第二界面活性剤の安定性の面から好ましい。 Furthermore, it is preferable that the second surfactant used in the excess removal treatment contains propolis, since the hair growth effect becomes more remarkable and the skin irritation is further reduced. The second surfactant preferably contains 0.5 to 15.0% by mass of an extraction solution (ethanol solution or the like) having a solid content concentration of 10% to 30% of propolis, and 1.0 to 5%. 0% by mass is more preferable, and 2.0 to 4.0% by mass is particularly preferable. Therefore, as a solid content concentration, 0.05% by mass to 4.5% by mass is preferably contained. It is more preferable to contain 0.1 mass% to 1.5 mass%, and it is particularly preferable to contain 0.2 mass% to 1.2 mass%. In addition, it is preferable from the viewpoint of the stability of the second surfactant to use an extraction solution with a solid content concentration of about 20% as the extraction solution of propolis.
加えて、上記した刺激付与処理において、頭皮の内の脱毛あるいは薄毛部位に引張あるいは押圧により刺激を与える方法は、施術者の手によって直接的に頭皮に刺激を与えるものに限定されず、吸引具、ブラシや針等の道具を用いて頭皮に刺激を与えるものや、電子機器を利用して、所定の周期で断続的に頭皮に刺激を与えるもの等でも良い。 In addition, in the above-described stimulation treatment, the method of stimulating the hair loss or thinning area in the scalp by pulling or pressing is not limited to the method of directly stimulating the scalp with the hands of the practitioner, and a suction tool The brush may be one that stimulates the scalp using a tool such as a brush or a needle, or one that stimulates the scalp intermittently at a predetermined cycle using an electronic device.
以下、実施例によって本発明に係る発毛剤および発毛方法についてより詳細に説明するが、本発明は、かかる実施例の態様に何ら限定されるものではなく、本発明の趣旨を逸脱しない範囲で、適宜変更することが可能である。また、実施例における物性、特性の評価方法は以下の通りである。なお、下記の各官能評価においては、被験者１０名分の各評価結果の平均的な段階（◎，○，△，×）を最終的な評価結果とした。 EXAMPLES Hereinafter, the hair growth agent and the hair growth method according to the present invention will be described in more detail by way of examples, but the present invention is not limited to the embodiments of such examples at all and does not deviate from the scope of the present invention. It is possible to make appropriate changes. Moreover, the evaluation method of the physical property in an Example and a characteristic is as follows. In each sensory evaluation described below, the average stage (◎, ,, Δ, x) of each evaluation result for 10 subjects was taken as the final evaluation result.
＜発毛効果＞
頭部に脱毛部分、薄毛部分を有する被験者１０名に対して、３０日間にわたって、毎日、下記のａ〜ｄの手順による発毛処置を施した。
ａ．実施例あるいは比較例の発毛剤を、被験者の頭部の脱毛部分あるいは薄毛の部分の頭皮および毛髪に塗布する。
ｂ．塗布した発毛剤を、施術者の手によって泡立てた後に、約５分間放置する。
ｃ．発毛剤を塗布して放置した脱毛あるいは薄毛部分を、施術者の手によって約２分間にわたって断続的に押圧することによって、頭皮に刺激を与える。
ｄ．第二界面活性剤を利用して、脱毛部分あるいは薄毛の部分を含めた頭髪全体を洗い流す（すなわち、第二界面活性剤 約１０ｇを頭髪全体に塗布し、約１分間にわたって頭髪に馴染ませた後に、約４０℃の湯で洗い流す）。
Hair growth effect
Ten subjects having a hair loss portion and a thin hair portion on their heads were subjected to hair growth treatment according to the following a to d procedure daily for 30 days.
a. The hair growth agent of the example or the comparative example is applied to the scalp and the hair of the hair removal part or the thin part of the head of the subject.
b. After lathering with the hands of the practitioner, the applied hair regrowth agent is left for about 5 minutes.
c. The scalp is irritated by intermittently pressing the hair removal or thinning portions left with the hair growth agent by the hands of the practitioner for about 2 minutes.
d. Using the second surfactant, wash out the entire hair, including the hair loss area or the thin hair area (ie, apply about 10 g of the second surfactant to the entire hair and adapt it to the hair for about 1 minute) Wash with hot water at about 40 ° C).
そして、上記の如く発毛処置を施した後の発毛状態を、拡大鏡（１０倍）を利用して観察し、下記の３段階で官能評価した。
◎：きわめて顕著な発毛（新たな毛髪の生育）が認められた（１０本以上／１ｃｍ２）
○：顕著な発毛が認められた（５本以上１０本未満／１ｃｍ２）。
△：若干の発毛が認められた（１本以上５本未満／１ｃｍ２）。
×：発毛が認められない。
Then, the hair growth state after the hair growth treatment as described above was observed using a magnifying glass (10 ×), and sensory evaluation was performed in the following three stages.
:: extremely remarkable hair growth (new hair growth) was observed (10 or more per cm 2 )
○: Remarkable hair growth was observed (5 or more and less than 10/1 cm 2 ).
Δ: Some hair growth was observed (1 or more and less than 5/1 cm 2 ).
X: Hair growth is not recognized.
＜頭皮への刺激＞
上記した発毛処置を施した後の被験者の頭皮の状態を、拡大鏡（１０倍）を利用して観察し、下記の３段階で官能評価した。
○：頭皮の変化（発毛処理前後の変化）が認められない。
△：わずかな肌荒れや紅斑・発赤が認められる。
×：肌荒れや紅斑・発赤が明確に認められる。
<Stimulation to the scalp>
The condition of the subject's scalp after the hair growth treatment described above was observed using a magnifying glass (10 ×), and sensory evaluation was performed in the following three steps.
○: Change in scalp (change before and after hair growth treatment) is not observed.
:: slight skin roughness, erythema and redness are observed.
X: Rough skin, erythema and redness are clearly recognized.
［実施例１］
下記の各成分を混合・攪拌することによって、発毛剤を調製した。
＜発毛剤の成分＞
・グリセリン：６０質量％
・香料：０．２質量％
・界面活性剤（ラウリル硫酸Ｎａ（アニオン系界面活性剤））：４．０質量％
・臭素酸Ｎａ：４．５質量％
・プロポリス（固形分濃度２０％のエタノール抽出液）： １．５質量％（固形分０．３質量％）
・分散剤：６．０質量％
・精製水：残余量
Example 1
A hair growth agent was prepared by mixing and stirring the following components.
<Components of hair growth agent>
-Glycerin: 60% by mass
-Perfume: 0.2% by mass
-Surfactant (Na lauryl sulfate (anionic surfactant)): 4.0% by mass
-Bromate Na: 4.5% by mass
-Propolis (20% solids concentration ethanol extract): 1.5 mass% (solid content 0.3 mass%)
Dispersant: 6.0% by mass
・ Purified water: residual amount
また、下記の各成分を混合・攪拌することによって、第二界面活性剤を調製した。
＜第二界面活性剤の成分＞
・グリセリン：６０質量％
・プロポリス（固形分濃度２０％のエタノール抽出液）： １．０質量％（固形分０．２質量％）
・香料：０．２質量％
・界面活性剤（味の素(株)製 アミソフト（登録商標）（Ｌ−グルタミン酸およびヤシ油脂肪酸由来のアミノ酸系アニオン界面活性剤）：４．０質量％
・分散剤：６．０質量％
・精製水：残余量
Moreover, the 2nd surfactant was prepared by mixing and stirring each following component.
<Component of second surfactant>
-Glycerin: 60% by mass
-Propolis (20% solids concentration ethanol extract): 1.0 mass% (solid content 0.2 mass%)
-Perfume: 0.2% by mass
-Surfactant (Ajinomoto Co., Ltd. product Amisoft (registered trademark) (amino acid based anionic surfactant derived from L-glutamic acid and coconut oil fatty acid): 4.0% by mass
Dispersant: 6.0% by mass
・ Purified water: residual amount
そして、それらの発毛剤、第二界面活性剤を用いて、上記の如き発毛処置を３０日間にわたって治験者に施し、発毛効果、皮膚への刺激について評価した。評価結果を発毛剤、第二界面活性剤の組成とともに表１に示す。 Then, using the hair growth agent and the second surfactant, the hair growth treatment as described above was applied to the examiner for 30 days, and the hair growth effect and skin irritation were evaluated. The evaluation results are shown in Table 1 together with the composition of the hair growth agent and the second surfactant.
［実施例２］
第二界面活性剤を調製する際に、プロポリスを加えなかった以外は、実施例１と同様にして、第二界面活性剤を得た。そして、実施例１と同じ発毛剤、および、得られた第二界面活性剤を用いて、上記の如き発毛処置を３０日間にわたって治験者に施し、発毛作用、皮膚への刺激について評価した。評価結果を発毛剤、第二界面活性剤の組成とともに表１に示す。
Example 2
A second surfactant was obtained in the same manner as in Example 1 except that propolis was not added when preparing the second surfactant. Then, using the same hair growth agent as Example 1 and the obtained second surfactant, the above-mentioned hair growth treatment is applied to the examiner for 30 days, and the hair growth effect and skin irritation are evaluated. did. The evaluation results are shown in Table 1 together with the composition of the hair growth agent and the second surfactant.
［実施例３］
発毛剤を調製する際に、界面活性剤をラウロイルグルタミン酸Ｎａ（アミノ酸系界面活性剤）に変更した以外は、実施例１と同様にして、発毛剤を得た。また、第二界面活性剤を調製する際に、プロポリスを加えなかった以外は、実施例１と同様にして、第二界面活性剤を得た。そして、それらの発毛剤および第二界面活性剤を用いて、上記の如き発毛処置を３０日間にわたって治験者に施し、発毛作用、皮膚への刺激について評価した。評価結果を発毛剤、第二界面活性剤の組成とともに表１に示す。
[Example 3]
A hair growth agent was obtained in the same manner as in Example 1, except that the surfactant was changed to lauroyl glutamic acid Na (an amino acid surfactant) when preparing the hair growth agent. Further, a second surfactant was obtained in the same manner as in Example 1 except that propolis was not added when preparing the second surfactant. Then, using the hair growth agent and the second surfactant, the hair growth treatment as described above was applied to the subject for 30 days, and the hair growth effect and skin irritation were evaluated. The evaluation results are shown in Table 1 together with the composition of the hair growth agent and the second surfactant.
［実施例４］
発毛剤を調製する際に、界面活性剤をオレフィンスルホン酸Ｎａ（炭素数＝１４〜１６）に変更した以外は、実施例１と同様にして、発毛剤を得た。そして、その発毛剤および実施例１と同じ第二界面活性剤を用いて、上記の如き発毛処置を３０日間にわたって治験者に施し、発毛作用、皮膚への刺激について評価した。評価結果を発毛剤、第二界面活性剤の組成とともに表１に示す。
Example 4
A hair growth agent was obtained in the same manner as in Example 1, except that the surfactant was changed to an olefin sulfonic acid Na (carbon number = 14 to 16) when the hair growth agent was prepared. Then, using the hair growth agent and the same second surfactant as in Example 1, the above-described hair growth treatment was applied to the subject for 30 days, and the hair growth effect and skin irritation were evaluated. The evaluation results are shown in Table 1 together with the composition of the hair growth agent and the second surfactant.
［実施例５］
発毛剤および第二界面活性剤を調製する際に、いずれにもプロポリスを加えなかった以外は、実施例１と同様にして、第二界面活性剤を得た。そして、実施例１と同じ発毛剤、および、得られた第二界面活性剤を用いて、上記の如き発毛処置を３０日間にわたって治験者に施し、発毛作用、皮膚への刺激について評価した。評価結果を発毛剤、第二界面活性剤の組成とともに表１に示す。
[Example 5]
A second surfactant was obtained in the same manner as Example 1, except that no propolis was added to any of the hair growth agent and the second surfactant. Then, using the same hair growth agent as Example 1 and the obtained second surfactant, the above-mentioned hair growth treatment is applied to the examiner for 30 days, and the hair growth effect and skin irritation are evaluated. did. The evaluation results are shown in Table 1 together with the composition of the hair growth agent and the second surfactant.
［比較例１］
発毛剤を調製する際に、界面活性剤に臭素酸Ｎａを加えなかった以外は、実施例１と同様にして、発毛剤を得た。そして、その発毛剤および実施例１と同じ第二界面活性剤を用いて、上記の如き発毛処置を３０日間にわたって治験者に施し、発毛作用、皮膚への刺激について評価した。評価結果を発毛剤、第二界面活性剤の組成とともに表１に示す。
Comparative Example 1
When preparing a hair growth agent, a hair growth agent was obtained in the same manner as in Example 1 except that sodium bromate was not added to the surfactant. Then, using the hair growth agent and the same second surfactant as in Example 1, the above-described hair growth treatment was applied to the subject for 30 days, and the hair growth effect and skin irritation were evaluated. The evaluation results are shown in Table 1 together with the composition of the hair growth agent and the second surfactant.
表１から、実施例１〜５の発毛剤を用いて治験者に発毛処置を施した場合には、頭皮にダメージを与えることなく、顕著な発毛効果が得られていることが分かる。また、硫酸系の界面活性剤中に臭素酸Ｎａおよびプロポリスを含有させた発毛剤を用いて発毛処置を施した場合には、きわめて顕著な発毛効果が得られていることが分かる。さらに、プロポリスを加えた発毛剤、第二界面活性剤によって発毛処置を施した場合には、頭皮へのダメージがより小さくなることが分かる。一方、臭素酸Ｎａを加えていない比較例１の発毛剤（界面活性剤）を用いて治験者に発毛処理を施した場合には、顕著な発毛効果が得られず、頭皮へのダメージが大きいことが分かる。 It can be seen from Table 1 that, when hair growth treatment was performed on the trial subjects using the hair growth agents of Examples 1 to 5, a remarkable hair growth effect was obtained without damaging the scalp. . It can also be seen that when the hair growth treatment is carried out using a hair growth agent containing Na bromate and propolis in a sulfuric acid surfactant, a very remarkable hair growth effect is obtained. Furthermore, it can be seen that when hair growth treatment is performed with a propolis-added hair growth agent and a second surfactant, damage to the scalp becomes smaller. On the other hand, when the subject is treated with hair growth using the hair growth agent (surfactant) of Comparative Example 1 to which sodium bromate is not added, no remarkable hair growth effect is obtained, and It turns out that the damage is large.
本発明の発毛剤は、上記の如く、優れた効果を奏するものであるので、脱毛症、薄毛症を改善するための化成品として好適に用いることができる。 Since the hair growth agent of the present invention exerts an excellent effect as described above, it can be suitably used as a chemical product for improving alopecia and thinning hair.
Claims (5)
界面活性剤中に０．１質量％以上１０質量％未満の臭素酸Ｎａを添加したことを特徴とする発毛剤。 Hair growth agent that promotes hair growth on the head,
A hair growth agent characterized in that 0.1 mass% or more and less than 10 mass% of sodium bromate is added to a surfactant.
請求項１〜請求項３のいずれかに記載された発毛剤を頭皮および毛髪に塗布して泡立てて所定の時間だけ放置する発毛剤塗布処理と、
頭皮の脱毛あるいは薄毛部位に引張あるいは押圧による刺激を与える刺激付与処理と、
前記刺激付与処理後の毛髪を、臭素酸Ｎａを含有しない第二界面活性剤を用いて洗い流す余剰分除去処理とを有することを特徴とする発毛方法。 A hair growth method for promoting head hair growth, comprising:
A hair growth agent application process in which the hair growth agent according to any one of claims 1 to 3 is applied to the scalp and hair, lathered, and left for a predetermined time.
Stimulation treatment which gives stimulation by tension or pressure to the hair loss or thin hair part of the scalp,
A method for hair growth characterized by having an excess component removal treatment of washing away the hair after the stimulation treatment with a second surfactant which does not contain sodium bromate.
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Citations (7)
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|---|---|---|---|---|
| JPS63201113A (en) * | 1987-02-16 | 1988-08-19 | Baiotetsuku Heaa:Kk | Hair growing and restoring method |
| JPH0853327A (en) * | 1994-06-10 | 1996-02-27 | Toshihiro Matsumoto | Hair tonic composed of allantoin or its derivative |
| JPH10279439A (en) * | 1997-03-31 | 1998-10-20 | Kureha Chem Ind Co Ltd | Trichogenous agent |
| US20050166338A1 (en) * | 2003-06-04 | 2005-08-04 | Amparo Arango | Kit for promoting the growth of human hair and its method of use |
| JP2006335698A (en) * | 2005-06-03 | 2006-12-14 | Toshio Inomata | Hair tonic |
| JP2007302575A (en) * | 2006-05-09 | 2007-11-22 | Milbon Co Ltd | Method for improving state of scalp |
| JP2014058471A (en) * | 2012-09-18 | 2014-04-03 | Yamada Bee Farm Corp | TESTOSTERONE-5α-REDUCTASE INHIBITOR |
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- 2017-12-07 JP JP2017235179A patent/JP7095981B2/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63201113A (en) * | 1987-02-16 | 1988-08-19 | Baiotetsuku Heaa:Kk | Hair growing and restoring method |
| JPH0853327A (en) * | 1994-06-10 | 1996-02-27 | Toshihiro Matsumoto | Hair tonic composed of allantoin or its derivative |
| JPH10279439A (en) * | 1997-03-31 | 1998-10-20 | Kureha Chem Ind Co Ltd | Trichogenous agent |
| US20050166338A1 (en) * | 2003-06-04 | 2005-08-04 | Amparo Arango | Kit for promoting the growth of human hair and its method of use |
| JP2006335698A (en) * | 2005-06-03 | 2006-12-14 | Toshio Inomata | Hair tonic |
| JP2007302575A (en) * | 2006-05-09 | 2007-11-22 | Milbon Co Ltd | Method for improving state of scalp |
| JP2014058471A (en) * | 2012-09-18 | 2014-04-03 | Yamada Bee Farm Corp | TESTOSTERONE-5α-REDUCTASE INHIBITOR |
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