JP2019098156A - Biomagnetism measurement device, biological information measurement device, and biomagnetism measurement method - Google Patents

Abstract

To provide a biomagnetism measurement device, a biological information measurement device, and a biomagnetism measurement method which can accurately and easily superimpose an image diagnostic result and a biomagnetism measurement result.SOLUTION: One embodiment of a biomagnetism measurement device 100 comprises: a frame 3 on which a subject S is placed; a biomagnetism detecting unit 2 which can detect biomagnetism of the subject S; a supporting unit 4 which supports a detection target part T of biomagnetism of the subject S; a radiation detecting unit 6 provided below the supporting unit 4; and a position changing unit 7 capable of changing a relative position of the biomagnetism detecting unit 2 and the detection target part T. The supporting unit 4 has a surface shape following the surface of the biomagnetism detecting unit 2.SELECTED DRAWING: Figure 4

Description

  The present invention relates to a biomagnetic measurement device, a biological information measurement device, and a biomagnetic measurement method.

  A biomagnetic measuring device that measures weak biomagnetism generated from the heart, spinal cord, peripheral nerves, etc. of a subject has a function to detect magnetism generated by weak current accompanying excitation of cells constituting these organs. , And is an important technology for diagnosis of heart disease, neurological disease and the like. The information obtained from biomagnetic measurement is displayed superimposed on the morphological image obtained by the image diagnostic apparatus. As an imaging diagnostic apparatus, a simple X-ray apparatus, a magnetic resonance imaging (MRI) diagnostic apparatus, or the like is used. Usually, a morphological image is taken at a place different from biomagnetic measurement.

  However, since the object moves between the diagnostic imaging apparatus and the biomagnetic measurement apparatus, it is extremely difficult to superimpose the measurement results with high accuracy. For example, when the subject moves between the radiation irradiation apparatus and the biomagnetic measurement apparatus, the trunk (spine) of the subject bends or bends in the front-rear direction or the left-right direction, or the joints of the four limbs of the subject bend Since it is stretched, it is extremely difficult to precisely match the position information of the object by the diagnostic imaging apparatus with the position of the object at the time of examination with the biomagnetic measurement apparatus.

  The present invention has been made in view of the above circumstances, and it is a biomagnetic measuring device, a biological information measuring device, and a biomagnetic measuring method capable of easily superposing an image diagnostic result and a biomagnetic measurement result with good accuracy. Intended to provide.

  One aspect of a biomagnetic measurement apparatus includes a gantry on which a subject is mounted, a biomagnetic detection unit capable of detecting biomagnetism of the subject, and a support part for supporting a biomagnetic detection target part of the subject. A radiation detection unit provided below the support unit; and a position change unit capable of changing a relative position between the biomagnetism detection unit and the detection target site, the support unit being the biomagnetism detection unit It has a surface shape that conforms to the surface of.

  According to the present invention, the diagnostic imaging result and the biomagnetic measurement result can be superimposed easily with high accuracy.

It is a block diagram (the 1) which shows the structure of the biomagnetism measuring apparatus which concerns on 1st Embodiment. It is a block diagram (the 2) which shows the structure of the biomagnetism measuring apparatus which concerns on 1st Embodiment. It is a block diagram (the 3) which shows the structure of the biomagnetism measuring apparatus which concerns on 1st Embodiment. It is a block diagram (the 4) which shows the structure of the biomagnetism measuring apparatus which concerns on 1st Embodiment. It is a sectional view showing the composition of a biomagnetism detection part. It is a figure which shows the function of a position change part. It is a block diagram (the 1) which shows the structure of the biomagnetism measuring apparatus which concerns on 2nd Embodiment. It is a block diagram (the 2) which shows the structure of the biomagnetism measuring apparatus which concerns on 2nd Embodiment. It is a block diagram (the 3) which shows the structure of the biomagnetism measuring apparatus which concerns on 2nd Embodiment. It is a block diagram (the 4) which shows the structure of the biomagnetism measuring apparatus which concerns on 2nd Embodiment. It is a block diagram (the 1) which shows the structure of the biomagnetism measuring apparatus which concerns on 3rd Embodiment. It is a block diagram (the 2) which shows the structure of the biomagnetism measuring apparatus which concerns on 3rd Embodiment. It is a block diagram (the 3) which shows the structure of the biomagnetism measuring apparatus which concerns on 3rd Embodiment. It is a block diagram (the 4) which shows the structure of the biomagnetism measuring apparatus which concerns on 3rd Embodiment. It is a flowchart which shows the biomagnetism measuring method using the biomagnetism measuring device which concerns on 1st Embodiment. It is a figure which shows the example of the measurement result which piled up the biometric information measurement result and the plain X-ray image. It is a figure which shows the state from which the detachable bridge part was removed. It is a flowchart which shows the biomagnetism measuring method using the biomagnetism measuring device which concerns on 2nd Embodiment. It is a flow chart which shows the biomagnetism measuring method using the biomagnetism measuring device concerning a 3rd embodiment.

  Hereinafter, the embodiments of the present invention will be described in detail, but the present invention is not limited to the following embodiments at all, and can be implemented with appropriate modifications within the scope of the object of the present invention. .

First Embodiment
First, the first embodiment will be described. 1 to 4 are configuration diagrams showing the configuration of the biomagnetic measurement apparatus 100 according to the first embodiment. 1 and 2 show the configuration when biomagnetic measurement is performed, and FIGS. 3 and 4 show the configuration when radiation imaging is performed. FIG. 1 and FIG. 3 are views seen from above the head of the subject, and FIG. 2 and FIG. 4 are views seen from the side of the subject. As shown in FIGS. 1 to 4, the biomagnetic measurement apparatus 100 includes a biomagnetic detection unit 2 capable of detecting the biomagnetism of the subject S and a gantry 3 on which the subject S is placed. The biomagnetic measurement apparatus 100 further includes a bridge 4 above the biomagnetic detection unit 2. The bridge portion 4 is, for example, detachably attached to the gantry 3. The bridge portion 4 may be fixed to the gantry 3. In addition, a radiation irradiation apparatus 5 is provided above the gantry 3 so as to irradiate the measurement region T of the subject S. The biomagnetic measurement apparatus 100 further includes a position change unit 7 that raises and lowers the gantry 3 and the bridge 4 and a radiation detector 6 provided below the bridge 4. The bridge part 4 is an example of a support part. For example, the biomagnetism detection unit 2 is attached to the mounting unit 12 for the biomagnetism detection unit 2 provided below the bridge portion 4, and the radiation detector 6 is for the radiation detector 6 provided below the bridge portion 4 Is mounted on the mounting portion 16 of the

  Hereinafter, the biomagnetism detection unit 2, the gantry 3, the bridge unit 4, the radiation irradiation apparatus 5, the radiation detector 6 and the position change unit 7 will be respectively described.

[Biomagnetic detection unit 2]
FIG. 5 is a cross-sectional view showing the configuration of the biomagnetic detection unit 2. As shown in FIG. 5, the biomagnetism detection unit 2 includes a magnetic sensor array in which a plurality of magnetic sensors 21 for detecting biomagnetism are arranged in an array. The plurality of magnetic sensors 21 are held in an insulating container 22 having a temperature control mechanism.

(Magnetic sensor 21)
The magnetic sensor 21 detects biomagnetism generated from the subject. Specifically, examples of the magnetic sensor 21 include a superconducting quantum interference device (SQUID), an optically pumped atomic magnetometer (OPAM), and the like. These SQUID sensors and optically pumped atomic magnetic sensors have detection sensitivities that can detect extremely weak biomagnetism of about 10 ^-18 T.

  Generally, as shown in FIG. 5, a plurality of magnetic sensors 21 are arranged in an array in a heat insulation container 22 having a temperature control mechanism. The signal of each magnetic sensor 21 is sent to the calculation unit 23 and converted into biomagnetic information. By having a plurality of magnetic sensors 21, it is possible not only to obtain a large amount of biomagnetic information but also to obtain more detailed biological information by two-dimensional mapping of the measured magnetic information. In addition, when the magnetic sensor 21 operates even at normal temperature, the temperature control mechanism and the heat insulating container 22 become unnecessary. The number of magnetic sensors 21 and the arrangement method are not particularly limited, and may be appropriately set according to the measurement area T of the subject S.

  The detection signal detected by the magnetic sensor 21 is sent to the calculation unit 23. The arithmetic unit 23 generates biomagnetic information from the signal detected by the magnetic sensor 21, converts it into image information, and displays and outputs the information to a display device or the like.

(Temperature control mechanism)
The temperature control mechanism is a mechanism for adjusting the temperature of the magnetic sensor 21 to a predetermined temperature suitable for the magnetic sensor 21 to operate, and may be a known cooling device or heating device. For example, in the case where the magnetic sensor 21 is a SQUID sensor, the magnetic sensor 21 is operated near absolute zero in order for the magnetic sensor 21 to realize the superconducting state. In the present embodiment, the heat insulating container 22 plays a part of the function of the temperature control mechanism.

(Insulated container 22)
For example, as shown in FIG. 5, the heat insulation container 22 includes an inner tank 221 and an outer tank 222, accommodates a plurality of magnetic sensors 21 in the inner tank 221, and a space between the inner tank 221 and the outer tank 222. Is a vacuum, and a refrigerant such as liquid helium is supplied into the inner tank 221. Thereby, in the biomagnetism detection unit 2, the temperature is controlled to a temperature suitable for operating the magnetic sensor 21.

  The shape of the heat insulation container 22 is not particularly limited, but the surface facing the subject S (hereinafter, referred to as a tip surface 22a) has a shape along the body surface of the measurement region T of the subject S. Preferably, it may be flat or curved. For example, as shown in FIG. 1 and FIG. 2, when performing biomagnetic measurement by placing the neck of the subject S against the biomagnetic detection unit 2, the shape of the distal end surface 22a is a curved shape according to the arc of the cervical cord Is preferred.

  In addition, the heat insulation container 22 is not limited to the vacuum heat insulation container shown in FIG. 5, You may be comprised from a foam material etc. FIG. The heat insulating container 22 is preferably made of a nonmagnetic material having low permeability. By the heat insulation container 22 being comprised by nonmagnetic material, even if the heat insulation container 22 vibrates, it can suppress that the influence by the fluctuation | variation of environmental magnetism reaches the magnetic sensor 21. FIG. Examples of nonmagnetic materials include plastic materials such as acrylic resin, inorganic materials such as silica and alumina, nonferrous metals such as copper, brass, aluminum and titanium, and composite materials thereof.

[Mount 3]
The shape of the gantry 3 is not particularly limited as long as the gantry S can hold and hold the subject S. For example, as shown in FIGS. 1 to 4, a head for positioning the head of the subject S There is also a case where the gantry 3 is configured by a plurality of separate gantrys such as the gantry for division 31 and the gantry for storage 32 for positioning the trunk. The biomagnetic detection unit 2 is disposed between the head mount 31 and the body mount 32 and is provided to face the measurement area T of the subject S.

  It is preferable that the member which comprises the mount frame 3 be comprised with the nonmagnetic material with low magnetic permeability. Since the gantry 3 is made of a nonmagnetic material, even if the subject S vibrates, it is possible to suppress the influence of the fluctuation of the environmental magnetism on the magnetic sensor 21. Examples of nonmagnetic materials include plastic materials such as acrylic resin, inorganic materials such as silica and alumina, copper, brass, nonferrous metals such as aluminum and titanium, and composite materials thereof, as in the case of the heat insulating container 22. Since the gantry 3 supports a part or all of the subject S, load resistance, impact resistance and the like are required. Therefore, it is desirable to be composed of metal parts or engineering plastics having high mechanical strength.

[Bridge part 4]
The bridge portion 4 has a surface shape that follows the surface of the biomagnetism detection unit 2, and is provided so as to cover the biomagnetism detection unit 2. The bridge portion 4 is preferably formed along the shape of the distal end surface 22 a of the biomagnetism detection portion 2 so that a gap can not be formed between the bridge portion 4 and the biomagnetism detection portion 2 in close contact therewith. It should be made with high precision. The reason why it is preferable to be formed along the shape of the surface of the biomagnetic detection unit 2 and to be formed without a gap is to shorten the distance between the subject S and the magnetic sensor 21 as much as possible. This is to measure the biomagnetic signal from the subject S as a larger signal. The reason is that the biomagnetic field has a very weak signal, and if the distance between the subject S and the magnetic sensor 21 is short, a larger signal can be expected. For example, the signal of the biomagnetic field may decay in inverse proportion to the square or cube of the distance.

  The distance between the spinal cord (biomagnetic field source) of the subject S and the magnetic sensor 21 is about 70 mm. Therefore, even if there is a slight deviation, the influence on the measurement is not so great. Therefore, the shape "following the surface shape of the bridge portion 4" includes not only the shape of the surface of the biomagnetism detection portion 2 completely matching, but also the case where the surface shape substantially matches. It is more preferable that the shapes completely match.

  Moreover, according to the shape of the front end surface 22a of the biomagnetism detection unit 2, a planar shape or a curved shape can be taken. Since the bridge portion 4 moves up and down with the subject S placed thereon, it is desirable that the bridge portion 4 have mechanical strength sufficient to withstand the load of the subject S. The cross-sectional thickness of the bridge portion 4 is preferably 1 mm to 20 mm depending on the structure and strength of the material. As an example, when the bridge portion 4 is made of polycarbonate, it can be about 5 mm in the part facing the subject S in FIG. 2 and about 20 mm in the parts supporting the part facing the subject S. When the bridge portion 4 is made of glass fiber reinforced plastic (GFRP), the cross-sectional thickness of the bridge portion 4 is about 1 mm to 3 mm in a portion facing the subject S in FIG. In the part of the both ends which support the part which opposes S, it can be about 5 mm-10 mm.

  It is preferable that the member which comprises the bridge part 4 is comprised with a nonmagnetic material with low magnetic permeability. Since the bridge portion 4 is made of a nonmagnetic material, even if the subject S vibrates, it is possible to suppress that the magnetic sensor 21 is affected by the fluctuation of the environmental magnetism. Examples of nonmagnetic materials include plastic materials such as acrylic resin, inorganic materials such as silica and alumina, nonferrous metals such as copper, brass, aluminum and titanium, and composite materials thereof as well as the heat insulating container 22 and the frame 3. Be The bridge portion 4 can be manufactured by cutting, bending, injection molding or the like of a material.

[Position change unit 7]
The position change unit 7 raises and lowers the gantry 3 and the bridge 4 synchronously. The raising and lowering mechanism may be manual or electric, and in particular, an electric raising and lowering mechanism using a hydraulic cylinder and an electric pump is useful. For raising and lowering the gantry 3, the entire gantry 3 may be raised and lowered, or only a part of the gantry 3, for example, the top plate of the gantry 3 may be raised and lowered.

  The head mount 31 and the body mount 32 may be fixed to each other via the bridge 4. In this case, the position changing unit 7 can raise and lower the head mount 31 and the body mount 32 in synchronization in an integrated manner. The bridge portion 4 may be connected to any one of the head mount 31 and the body mount 32, and the position change unit 7 may be connected to the bridge 4, the head mount 31, and the body mount 32 respectively. May be raised and lowered independently. When the relative positions of the bridge 4, the head mount 31, and the trunk mount 32 change, for example, as shown in FIG. 6A, only the trunk mount 32 is lowered, as shown in FIG. As shown to (b), the adhesiveness of measurement area | region T of the test object S and the bridge part 4 can be improved. After lowering only the trunk support 32, the bridge 4 or the head support 31 or both of them may be moved up and down for fine adjustment.

[Irradiation apparatus 5]
The radiation irradiation apparatus 5 can use a well-known thing, as long as it can irradiate the radiation which can be emitted to a biological body. In the present invention, "radiation" is not limited to the simple X-rays generally used, but is a beam generated by particles (including photons) emitted by radioactive decay, such as alpha rays, beta rays, gamma rays, etc. In addition to these, it is a comprehensive concept including beams having the same or higher energy than these, such as particle beams and cosmic rays. In view of the high versatility, it is preferable to use simple X-rays as radiation.

[Radiation detector 6]
The radiation detector 6 is mounted on the mounting unit 16 in a state in which the gantry 3 and the bridge portion 4 are lifted and a gap is formed between the bridge portion 4 and the biomagnetic detection unit 2. The radiation detector 6 acquires the radiation R transmitted through the measurement area T of the subject S as a morphological image which is digital image data.

  The signal detected by the radiation detector 6 is sent to the calculation unit. The arithmetic unit generates a morphological image from the signal detected by the radiation detector 6, converts it into image information, and displays and outputs it on the display device.

  For example, a flat panel detector (hereinafter referred to as FPD) can be used for the radiation detector 6. In FPD, a so-called direct conversion method in which charge is generated by the detection element according to the dose of the irradiated radiation and converted to an electric signal, and the irradiated radiation is converted to electromagnetic waves of other wavelengths such as visible light by a scintillator or the like. After the conversion, there is a so-called indirect method in which a charge is generated by a photoelectric conversion element such as a photodiode according to the energy of the converted and irradiated electromagnetic wave and converted into an electric signal.

  In addition, a so-called imaging plate (hereinafter referred to as IP) in which a film coated with a stimulable phosphor powder is housed in a casing called cassette can be suitably used. The radiation transmitted through the measurement region T of the subject S is irradiated to the imaging plate, and the energy of the radiation is stored in the stimulable phosphor. Thereafter, the imaging plate is irradiated with laser light of a specific wavelength by the reading device, and the light quantity is read by the scanner to obtain a morphological image as digital image data.

  In the biomagnetism measuring apparatus 100 configured as described above, biomagnetism measurement using the biomagnetism detection unit 2 and imaging of a simple X-ray image using the radiation irradiation apparatus 5 and the radiation detector 6 are performed. Either may be done first. Although the heights of the gantry 3 and the bridge portion 4 are different between the state shown in FIGS. 1 and 2 and the states shown in FIGS. 3 and 4, the movement of the gantry 3 and the bridge portion 4 is as follows. Is performed by the position change unit 7.

  Biomagnetic measurement is performed in the state shown in FIGS. 1 and 2. That is, in a state where the bridge 4 is in close contact with the biomagnetic detection unit 2, the measurement region T of the subject S is supported on the bridge 4, and the other part of the subject S is mounted on the gantry 3, The magnetic detection unit 2 measures biomagnetism in the measurement area T.

  The imaging of the plain X-ray image is performed in the state shown in FIG. 3 and FIG. That is, in a state where the position change unit 7 raises the gantry 3 and the bridge portion 4 synchronously while the object S is placed, radiation is emitted from the radiation irradiating device 5 and the radiation transmitted through the measurement area T is radiation Detector 6 detects. In this state, a gap exists between the biomagnetism detection unit 2 and the bridge portion 4, the radiation detector 6 is mounted on the mounting portion 16 in the gap, and the measurement region T of the subject S on the bridge portion 4. Is supported, and the other part of the subject S is placed on the gantry 3. After taking a simple X-ray image, the radiation detector 6 is removed from the mounting unit 16 and the position changing unit 7 synchronously lowers the gantry 3 and the bridge unit 4.

  According to the biomagnetism measurement apparatus 100 according to the present embodiment, measurement of biomagnetism using the biomagnetism detection unit 2 and acquisition of a morphological image using the radiation detector 6 are performed while maintaining the posture of the subject S. be able to. Therefore, the biomagnetic detection result obtained from the biomagnetic detection unit 2 and the morphological image which is digital image data of the simple X-ray image obtained from the radiation detector 6 can be accurately superimposed.

  In the biomagnetic measurement apparatus 100, the radiation detector 6 can be removed for biomagnetic measurement. Therefore, regardless of whether FPD or IP is used as the radiation detector 6, the influence of the radiation detector 6 on biomagnetic measurement can be eliminated. When comparing FPD and IP, FPD, which does not require an indirect reading device, is preferred because of its ease and simplicity of processing. Since commercially available FPDs contain many magnetic materials in control electronics, batteries and the like, it is extremely preferable to remove them in biomagnetic measurement. Further, since a commercially available FPD is flat, it is difficult to superimpose measurement results with excellent accuracy when used in combination with the biomagnetic detection unit 2 having a curved end surface 22a. That is, since the shape of the measurement area T of the subject S is different between the case where it is on the plane of the FPD and the case where it is on the curved tip surface 22a of the biomagnetic detection unit 2, it is different from the morphological image obtained by the FPD. This is different from the form of the measurement area T on the tip end surface 22a. Therefore, when the conventional biomagnetic measurement apparatus is used, a deviation easily occurs between the morphological image captured using the FPD and the biomagnetic measurement result obtained from the biomagnetic detection unit 2. On the other hand, such deviation can be eliminated by using the biomagnetic measurement device 100 according to the present embodiment.

  In order to further improve the overlay accuracy of the biomagnetic measurement result obtained from the biomagnetic detection unit 2 and the morphological image obtained from the radiation detector 6, detection is possible with both the radiation detector 6 and the biomagnetic detection unit 2 It is preferred to use a marker. An electromagnetic coil is mentioned as an example of such a marker. The cable of the coil unit included in the electromagnet coil is reflected on the radiation detector 6, and the biomagnetism detection unit 2 detects the magnetic field generated by the electric signal supplied to the electromagnet coil. By superimposing the detection results such that the positions of markers such as the electromagnet coil and the like coincide with each other, more accurate superposition can be performed. The electromagnet coil may be embedded in the bridge portion 4. When the electromagnet coil is attached to the surface of the bridge portion 4, the electromagnet coil may be in contact with the subject S, but by embedding in the bridge portion 4, physical interference with the subject S can be suppressed. It is.

  The mounting unit 12 and the mounting unit 16 contribute to holding of the relative position between the biomagnetic detection unit 2 and the radiation detector 6. By holding the relative positions of the biomagnetism detection unit 2 and the radiation detector 6, even if no position specifying means such as markers for specifying mutual position information is provided, the biomagnetism detection unit 2 can obtain the position information. The biomagnetic detection result and the morphological image obtained from the radiation detector 6 can be accurately superimposed. However, one or both of the mounting portion 12 and the mounting portion 16 may not be provided.

  The size of the radiation detector 6 is not particularly limited, and may be a size corresponding to the measurement area T of the subject S. The radiation detector 6 is preferably smaller than the radiation area of the radiation irradiated from the radiation irradiation device 5, and the relative distance between the radiation irradiation device 5 and the subject S can also be appropriately adjusted.

  In the present embodiment, FPD and IP are illustrated as the radiation detector 6 and a simple X-ray apparatus is illustrated as the radiation irradiating apparatus 5, but a computed tomography (CT) apparatus or the like may be suitably used. it can. The CT apparatus is an apparatus for scanning radiation onto a subject, processing the transmitted radiation dose on a computer, and imaging the internal structure of the subject, so to say, a diagnostic apparatus having a so-called radiation detector and a radiation irradiation apparatus. It is.

Second Embodiment
Next, a second embodiment will be described. 7 to 10 are configuration diagrams showing the configuration of a biomagnetic measurement device 200 according to the second embodiment. 7 and 8 show the configuration when biomagnetic measurement is performed, and FIGS. 9 and 10 show the configuration when radiation imaging is performed. FIGS. 7 and 9 are views from above the head of the subject, and FIGS. 8 and 10 are views from the side of the subject. As shown in FIGS. 7 to 10, the biomagnetic measurement apparatus 200 includes a position change unit 207 in place of the position change unit 7 in the first embodiment. In addition, the radiation irradiating device 5 is provided not right above the biomagnetic detection unit 2 in the vertical direction, but at a position away from immediately above the vertical direction. The other configuration is the same as that of the first embodiment.

  While the position change unit 7 raises and lowers the gantry 3 and the bridge portion 4, the position change unit 207 synchronously moves the gantry 3 and the bridge portion 4 in the horizontal direction. The horizontal movement mechanism may be manual or motorized. For example, various known horizontal movement mechanisms such as bearings, rollers, belt conveyors, guide rails, slide rails, linear movement pushers, ball screw linear movement mechanisms, or a combination thereof can be used. With respect to the movement of the gantry 3, the entire gantry 3 may be moved, or a part of the gantry 3, for example, only the top plate of the gantry 3 may be moved. Thus, in the second embodiment, the moving directions of the gantry 3 and the bridge portion 4 are different from those of the first embodiment.

  In the biomagnetic measurement apparatus 200 configured as described above, biomagnetic measurement using the biomagnetic detection unit 2 and imaging of a simple X-ray image using the radiation irradiation apparatus 5 and the radiation detector 6 are performed. Either may be done first. Although the positions of the gantry 3 and the bridge portion 4 are different between the state shown in FIGS. 7 and 8 and the states shown in FIGS. 9 and 10, the movement of the gantry 3 and the bridge portion 4 here, the body side direction The horizontal movement is performed by the position change unit 207.

  Biomagnetic measurement is performed in the state shown in FIGS. 7 and 8. That is, as in the first embodiment, the bridge portion 4 is in close contact with the biomagnetic detection portion 2, the measurement region T of the subject S is supported on the bridge portion 4, and the other portion of the subject S is a gantry. The biomagnetism detection unit 2 measures the biomagnetism of the measurement region T in the state of being placed on the surface 3.

  Imaging of a plain X-ray image is performed in the state shown in FIGS. That is, radiation is emitted from the radiation irradiating device 5 in a state in which the position change unit 207 moves the gantry 3 and the bridge portion 4 to the position directly below the radiation irradiating device 5 in synchronization with the object S placed thereon. The radiation detector 6 detects the radiation transmitted through T. In this state, there is a space below the bridge portion 4 in which the radiation detector 6 is mounted on the mounting portion 16 and the measurement region T of the subject S is supported on the bridge portion 4. The other part of is mounted on the gantry 3. After taking a simple X-ray image, the radiation detector 6 is removed from the mounting unit 16, and the position changing unit 207 synchronizes the gantry 3 and the bridge unit 4 and horizontally moves them to their original positions.

  When the position change unit 207 includes a caster attached to the gantry 3, the gantry 3 is separated from the biomagnetic detection unit 2 while maintaining the posture of the subject, and moved to another room where, for example, a CT apparatus or an MRI diagnostic apparatus is installed. Then, a detailed image may be taken there. In addition, the CT apparatus or the MRI apparatus may be brought in and the image may be taken on the spot. When a CT apparatus is used, the CT apparatus functions as the radiation irradiating apparatus 5 and the radiation detector 6.

Third Embodiment
Next, a third embodiment will be described. 11 to 14 are configuration diagrams showing the configuration of a biomagnetic measurement apparatus 300 according to the third embodiment. 11 and 12 show the configuration when biomagnetic measurement is performed, and FIGS. 13 and 14 show the configuration when radiation imaging is performed. FIGS. 11 and 13 are views from above the head of the subject, and FIGS. 12 and 14 are views from the side of the subject. As shown in FIGS. 11 to 14, the biomagnetic measurement apparatus 300 includes a position change unit 307 instead of the position change unit 7 in the first embodiment. In addition, the radiation irradiating device 5 is provided not right above the biomagnetic detection unit 2 in the vertical direction, but at a position away from immediately above the vertical direction. Furthermore, the bridge portion 4 is provided not on the biomagnetism detection portion 2 but below the radiation irradiating device 5 in the vertical direction. The mounting unit 16 and the radiation detector 6 are also provided below the radiation irradiating device 5 in the vertical direction. The other configuration is the same as that of the first embodiment.

  While the position change unit 7 and the position change unit 207 move the gantry 3 and the bridge unit 4, the position change unit 307 moves the subject S in the horizontal direction. For example, when the movable top plate is provided on the gantry 3, the position changing unit 307 horizontally moves the subject S by moving the top plate on which the subject S is placed while the main body of the gantry 3 is fixed. It can be done. Moreover, if it is possible to move in the horizontal direction while maintaining the posture of the subject S, for example, a cloth or a film is provided as the position changing unit 307 between the gantry 3 and the subject S, and The subject S may be moved by causing the object S to move.

  In the biomagnetic measurement apparatus 300 configured as described above, biomagnetic measurement using the biomagnetic detection unit 2 and imaging of a simple X-ray image using the radiation irradiation apparatus 5 and the radiation detector 6 are performed. Either may be done first. Although the position of the subject S is different between the state shown in FIGS. 11 and 12 and the states shown in FIGS. 13 and 14, movement of the subject S, here horizontal movement in the lateral direction of the body, This is performed by the position change unit 307.

  Biomagnetic measurement is performed in the state shown in FIG. 11 and FIG. That is, the biomagnetic detection unit 2 performs biomagnetism of the measurement region T in a state where the measurement region T of the subject S is in close contact with the biomagnetic detection unit 2 and the other part of the subject S is mounted on the gantry 3. measure.

  The imaging of the plain X-ray image is performed in the state shown in FIGS. 13 and 14. That is, in a state in which the position change unit 307 moves the subject S to the position directly below the radiation irradiating apparatus 5, radiation is emitted from the radiation irradiating apparatus 5, and the radiation detector 6 detects the radiation transmitted through the measurement area T. In this state, there is a space below the bridge portion 4 in which the radiation detector 6 is mounted on the mounting portion 16 and the measurement region T of the subject S is supported on the bridge portion 4. The other part of is mounted on the gantry 3. After the simple X-ray image is taken, the radiation detector 6 is removed from the mounting unit 16, and the position changing unit 307 horizontally moves the subject S to the original position.

  Also by the third embodiment, the same effect as that of the second embodiment can be obtained. In addition, since the bridge portion 4 is disposed offset from immediately above the biomagnetic detection portion 2, biomagnetic measurement can be performed with high accuracy without removing the bridge portion 4.

<Biomagnetic measurement method using biomagnetic measurement apparatus 100>
Next, a biomagnetic measurement method using the biomagnetic measurement device 100 will be described. FIG. 15 is a flowchart showing a biomagnetic measurement method using the biomagnetic measurement device 100. In this biomagnetic measurement method, radiography and biomagnetic measurement of the spinal cord of the subject (human) S are performed.

  First, the subject S is placed in a supine position on the gantry 3 and stands by at a position where the spinal cord of the subject S comes directly above the biomagnetic detection unit 2 (step S100).

  Next, radiation imaging is performed (step S200). Specifically, an examiner such as a medical radiographer operates the position changing unit 7 to synchronously raise the gantry 3 and the bridge portion 4 with the object S placed thereon (step S211). Thereafter, the examiner inserts the radiation detector 6 into the mounting portion 16 in the gap formed between the bridge portion 4 and the biomagnetic detection portion 2 and operates the operation portion for the radiation irradiating device 5 to perform radiation Radiation is irradiated from the irradiation device 5 toward the subject S, and a simple X-ray image of the subject S is captured by the radiation detector 6 (step S212). Thereafter, the radiation detector 6 is removed from the mounting unit 16, and the position change unit 7 is operated to synchronously lower the gantry 3 and the bridge unit 4 while the object S is placed thereon (step S213).

  Next, biomagnetic measurement is performed (step S300). Specifically, the spinal cord evoked magnetic field which is the detection result from the biomagnetic detection unit 2 is acquired.

  The measurement result (biological information measurement result) of the spinal cord-induced magnetic field acquired in step S300 is superimposed on the simple X-ray image acquired in step S200 and displayed on the display device. FIG. 16 shows an example of the measurement result obtained by superposing the human biological information measurement result and the plain X-ray image. As can be understood from FIG. 16, it is possible to obtain biological information obtained by superimposing the simple X-ray image of the spinal cord and the spinal cord-induced magnetic field map with good accuracy by one measurement.

  In this method, radiographic imaging is performed before biomagnetic measurement, but biomagnetic measurement may be performed before radiographic imaging. However, when the bridge portion 4 is removable from the gantry 3, after the radiation image photographing, as shown in FIG. 17, the bridge portion 4 can be removed and biomagnetic measurement can be performed. Since the distance between the measurement area T and the magnetic sensor 21 of the biomagnetic detection unit 2 can be shortened by removing the bridge portion 4, the observed magnetic field signal also becomes large, and the accuracy of biomagnetic measurement is enhanced. Can be expected. As described above, in consideration of improvement in the accuracy of biomagnetic measurement by removing the bridge portion 4, it is preferable to perform radiographic imaging before biomagnetic measurement.

<Biomagnetic Measurement Method Using Biomagnetic Measurement Device 200>
Next, a biomagnetic measurement method using the biomagnetic measurement device 200 will be described. FIG. 18 is a flowchart showing a biomagnetic measurement method using the biomagnetic measurement device 200. The biomagnetic measurement method using the biomagnetic measurement apparatus 200 differs from the biomagnetic measurement method using the biomagnetic measurement apparatus 100 in the content of radiation image capturing. That is, when radiation imaging is performed (step S200), first, the examiner operates the position changing unit 207 to move the gantry 3 and the bridge portion 4 in the horizontal direction in synchronization with the object S placed thereon. (Step S221). Thereafter, the examiner inserts the radiation detector 6 into the mounting portion 16 in the space under the bridge portion 4 formed by the bridge portion 4 moving from above the biomagnetic detection portion 2, and the radiation irradiating device 5 Then, radiation is irradiated toward the subject S, and a simple X-ray image of the subject S is taken by the radiation detector 6 (step S222). Thereafter, the radiation detector 6 is removed from the mounting unit 16, and the position changing unit 207 is operated to synchronize the gantry 3 and the bridge unit 4 and move them horizontally to the original position (step S223). The other processing is the same as the biomagnetic measurement method using the biomagnetic measurement device 100.

  Also in this method, radiation imaging is performed before biomagnetic measurement, but biomagnetic measurement may be performed before radiation imaging. However, in consideration of improvement of the accuracy of biomagnetic measurement by removing the bridge portion 4, it is preferable to perform radiation image capturing before biomagnetic measurement.

<Biomagnetic measurement method using biomagnetic measurement apparatus 300>
Next, a biomagnetic measurement method using the biomagnetic measurement apparatus 300 will be described. FIG. 19 is a flowchart showing a biomagnetic measurement method using the biomagnetic measurement apparatus 300. The biomagnetic measurement method using the biomagnetic measurement apparatus 300 differs from the biomagnetic measurement method using the biomagnetic measurement apparatus 100 or 200 in the content of radiation image capturing. That is, when radiation imaging is performed (step S200), first, the examiner operates the position changing unit 307 to move the subject S in the horizontal direction (step S231). At this time, the bridge 4 supports the measurement area T. Thereafter, the examiner inserts the radiation detector 6 into the mounting portion 16 in the space under the bridge portion 4 and irradiates radiation from the radiation irradiating device 5 toward the subject S, and the radiation detector 6 The simple X-ray image of S is taken (step S232). Thereafter, the radiation detector 6 is removed from the mounting unit 16, and the position changing unit 307 is operated to move the subject S in the horizontal direction to the original position (step S233). The other processing is the same as the biomagnetic measurement method using the biomagnetic measurement device 100.

  Also in this method, radiation imaging is performed before biomagnetic measurement, but biomagnetic measurement may be performed before radiation imaging. Further, in the biomagnetic measurement apparatus 300, since the bridge portion 4 is disposed offset from immediately above the biomagnetic detection portion 2, biomagnetic measurement can be performed with high accuracy without removing the bridge portion 4.

  The measurement area T of the subject S is not limited to the spinal cord, chest, etc., and may be other parts, organs, etc., such as the brain. The distal end surface 22a of the biomagnetism detection unit 2 preferably has a shape closely attached to the body surface of the measurement region T, and the bridge portion 4 has a surface shape conforming to the distal end surface 22a.

DESCRIPTION OF SYMBOLS 2 biomagnetic detection part 3 mount frame 4 bridge part 5 radiation irradiation apparatus 6 radiation detector 7, 207, 307 position change part 12 mounting part 16 mounting part 31 head mount frame 32 trunk mount frame 100, 200, 300 biomagnetic measurement Device S object R radiation T measurement area

JP, 2009-172175, A JP, 2016-221184, A International Publication No. 2017/150207 International Publication No. 2007/099697

Claims (15)

A gantry on which the subject is placed;
A biomagnetic detection unit capable of detecting the biomagnetism of the subject;
A support portion for supporting a detection target site of biomagnetism of the subject;
A radiation detection unit provided below the support unit;
A position change unit capable of changing a relative position between the biomagnetism detection unit and the detection target site;
Have
The biomagnetic measurement device according to claim 1, wherein the support portion has a surface shape that follows the surface of the biomagnetic detection portion.   The biomagnetic measurement apparatus according to claim 1, wherein the position changing unit moves the subject and the gantry while fixing the position of the biomagnetic detection unit.   The biomagnetic measurement apparatus according to claim 1, wherein the position changing unit moves the subject and the support while fixing the position of the biomagnetic detection unit. The position changing unit moves the subject, the gantry, and the support vertically upward.
The biomagnetic measurement device according to any one of claims 1 to 3, wherein the radiation detection unit is disposed in a gap formed between the biomagnetic detection unit and the support unit.   The biomagnetic measurement device according to any one of claims 1 to 3, wherein the position changing unit moves the subject in the horizontal direction while fixing the position of the biomagnetic detection unit.   The biomagnetism measurement device according to any one of claims 1 to 5, wherein the gantry includes a plurality of gantrys classified by region.   The biomagnetism measurement device according to claim 6, wherein the support portion is disposed between the plurality of the part-by-part stand.   The biomagnetic measurement device according to any one of claims 1 to 7, wherein the support portion is detachably held by the gantry. A biomagnetism measuring apparatus for detecting biomagnetism of a detection target site of a subject and capturing a radiation image,
A biomagnetic measurement apparatus characterized in that the detection of the biomagnetism and the imaging of the radiation image are performed by moving the subject to different positions while maintaining its posture. A gantry on which the subject is placed;
A first biological information detection unit capable of detecting the first biological information of the subject;
A support portion for supporting a detection target portion of the first biological information of the subject;
A second biological information detection unit provided below the support unit and capable of detecting second biological information different from the first biological information;
A position change unit capable of changing a relative position between the first biological information detection unit and the detection target site;
Have
The biological information measuring device according to claim 1, wherein the support portion has a surface shape that follows the surface of the first biological information detection portion. The first biological information does not include information on the form of the subject,
The biological information measuring device according to claim 10, wherein the second biological information includes a morphological image of the subject. Taking a radiation image of a detection target site of a subject using a radiation detection unit;
Detecting biomagnetism of the detection target site using a biomagnetism detection unit;
Between the imaging of the radiation image and the detection of the biomagnetism, changing the relative position between the biomagnetism detection unit and the detection target site while maintaining the posture of the subject;
A biomagnetism measuring method characterized by having.   The biomagnetic measurement method according to claim 12, further comprising the step of removing the radiation detection unit from between the detection target site and the biomagnetic detection unit before the step of detecting the biomagnetism.   13. The apparatus according to claim 12, wherein the radiation image is captured while the subject is placed on a gantry and the detection target portion is supported by a support having a surface shape that follows the surface of the biomagnetic detection unit. The biomagnetism measuring method as described in 13.   The biomagnetic measurement method according to claim 14, further comprising the step of removing the support portion from between the detection target site and the biomagnetic detection unit before the step of detecting the biomagnetism.