JP2019048802A - Oral biofilm removing agent and composition for oral cavity containing the same - Google Patents

Abstract

To provide: an oral biofilm removing agent which exhibits an excellent oral biofilm removal effect; and a composition for oral cavity, which contains this oral biofilm removing agent.SOLUTION: An oral biofilm removing agent is composed of (A) one or more selected from among polyoxyethylene lauryl ethers having an average number of moles of added ethylene oxides of 10-25 moles and polyoxyethylene alkyl ethers having an average number of moles of added ethylene oxides of 7-17 moles and a C14-16 alkyl group, and (B) one or more selected from among acyl sarcosine salts and acyl taurine salts, with the mass ratio (A)/(B) being 0.1-3; and a composition for oral cavity contains this oral biofilm removing agent. The composition for oral cavity additionally contains (C) a propylene glycol alginate ester.SELECTED DRAWING: None

Description

  The present invention relates to an oral biofilm remover that provides an excellent oral biofilm removal effect, and an oral composition containing the same.

  In recent years, the periodontal disease and its reserve forces have become significant, and care of periodontal pockets, particularly sterilization of oral biofilms, has become important. Since intraoral pathogenic bacteria such as caries causative bacteria and periodontitis bacteria cause oral diseases, it is important to sterilize and remove them. However, biofilms are composed of co-aggregates of various oral bacteria and extracellular polysaccharides, and it is not easy to kill or remove the biofilm as compared to floating bacteria in the oral cavity. In order to remove the biofilm in the oral cavity, not only the physical method by brushing with a toothbrush but also a chemical method capable of removing the biofilm which can not reach the brush is useful.

  As a chemical removal method, it is known to use protease, dextranase, mutanase, or the like of an enzyme that degrades exopolysaccharide, but the effect is hard to say that it is sufficient. In JP-A-46449, sodium chondroitin sulfate is used in combination, and further, a specific nonionic surfactant is blended to improve the plaque formation suppressing effect. Moreover, the present applicant pays attention to the penetration bactericidal action to biofilms, such as isopropyl methyl phenol which is a non-ionic bactericidal agent, and the composition for liquid oral cavity which is excellent in the penetration bactericidal power to a biofilm is patent documents 2-5 It proposed in (Unexamined-Japanese-Patent No. 2009-256228, international publication 2007/148551, Unexamined-Japanese-Patent No. 2006-182663, international publication No. 2006/067967). However, since a biofilm may be formed in the periodontal pocket deep part which is hard to remove, the further improvement of the biofilm removal effect was desired.

In addition, surfactants are known to have a cleansing effect, and although they were recognized to have a slight plaque removing effect from the viewpoint of their infiltration and interface cleaning effects, the sole use of surfactants It is not recognized at present that there is a sufficient biofilm removal effect.
The applicants of the present invention have made a biofilm remover using an anionic surfactant α-olefin sulfonate or alkyl sulfoacetate as described in Patent Documents 6 and 7 (WO 2015/008823 and WO 2015/008824). Proposed to Patent Document 8 (Japanese Patent Application Laid-Open No. 2007-326831) proposes an oral stain-removing agent composed of a specific polyoxyethylene alkyl ether.

By the way, in the composition for oral cavity, especially the composition for liquid oral cavity such as mouthwash, the feeling of use such as taste and smell at the time of use in the oral cavity leads to continuous use, and the appearance of the preparation is stable and the occurrence of bitterness Although it is important in terms of quality to be retained, it is likely to be deteriorated by the influence of the compounding ingredients.
In liquid oral compositions, nonionic surfactants are generally used as surfactants, and polyoxyethylene hydrogenated castor oil having a relatively good taste and high solubilizing power is generally used. Toothpaste contains various nonionic surfactants, but when it is added to a liquid oral composition, it gives unpleasant taste and smell, and some have insufficient solubility in water. Such nonionic surfactants tend to be avoided in particular to be actively adopted in a mouthwash and their use has been limited.

  Patent documents 9, 10 (patent 5720697, patent 5729252) are nonionic interfaces selected from propylene glycol alginate and isopropyl methyl phenol, and a specific polyoxyethylene hydrogenated castor oil and polyoxyethylene alkyl ether. The composition for oral cavity which has the tooth surface adhesion inhibitory effect and the bactericidal effect of the periodontopathogenic bacteria which mix | blended combining the active agent is proposed. In Patent Document 9, a specific composition example is toothpaste, while Patent Document 10 shows an example of a liquid preparation, wherein the polyoxyethylene alkyl ether has 16 or more carbon atoms of an alkyl group and an average added mole of ethylene oxide. More than 20 are used. Patent Document 11 (Japanese Patent Publication 2009-520802) proposes an oral care composition in which an undesirable taste of an essential oil containing menthol is masked by an alginic acid derivative of seaweed extract, and is a polyoxyacid having a nonionic surfactant. A mouthwash formulated with an ethylene polyoxypropylene block copolymer is described in the examples.

JP, 2009-46449, A JP, 2009-256228, A WO 2007/148551 JP, 2006-182663, A WO 2006/067967 International Publication No. 2015/008823 International Publication No. 2015/008824 JP, 2007-326831, A Patent No. 5720697 gazette Patent No. 5729252 Japanese Patent Application Publication No. 2009-520802 Unexamined-Japanese-Patent No. 2003-292426

  The present invention has been made in view of the above circumstances, and an object of the present invention is to provide an oral biofilm removal agent which provides an excellent oral biofilm removal effect, and an oral composition containing the same.

  As a result of intensive investigations to achieve the above object, the present inventors disperse and remove an oral biofilm when a specific nonionic surfactant is used in combination with a specific anionic surfactant in a specific ratio. It has been found that the above-mentioned excellent effects and effects can be exhibited, and by combining the above-mentioned specific surfactant combination system in the composition for oral cavity, it is possible to impart an excellent oral biofilm removal effect, and the present invention has been completed.

Anionic surfactant alone does not have a sufficient biofilm removing effect, and the biofilm removing action by the acyl sarcosine salt or the acyl taurine salt of the anionic surfactant is at a very weak level. Moreover, the biofilm removal effect is hardly recognized in the nonionic surfactant, and generally, when the nonionic surfactant is used in combination with the anionic surfactant, the biofilm of the anionic surfactant etc. is obtained. It was thought that there was a tendency for the effects of However, in the present invention, the average addition mole number of (A) ethylene oxide is 10 to 25 moles, and the average addition mole number of polyoxyethylene lauryl ether and ethylene oxide is 7 to 17 moles, and the carbon number of the alkyl group is 14 to When one or more selected from polyoxyethylene alkyl ethers of 16 and one or more selected from (B) acyl sarcosine salts and acyl taurine salts are used in combination, (A) / (B) In the range of 0.1 to 3 as a mass ratio, surprisingly, the two surfactants act synergistically to remove the biofilm attached to the tooth surface, particularly the periodontal pathogenic biofilm and disperse it It is possible to impart an unexpected effect of enhancing the effect of removing and removing, and providing an excellent biofilm removing effect.
Therefore, in the present invention, the combination of the specific nonionic surfactant and the anionic surfactant, which are the components (A) and (B), exhibits a particularly remarkable action and effect.
In addition, patent document 12 (Unexamined-Japanese-Patent No. 2003-292426) is an improvement of the antimicrobial effect by suppression of container adsorption of a nonionic antimicrobial agent, The toothpaste or liquid toothpaste of the Example (Example 12 or 13) Only contains lauroyl sarcosine sodium and polyoxyethylene alkyl ether together with a non-ionic antimicrobial agent. On the other hand, the present invention is the removal of the oral biofilm by the combined use system of the surfactant, and the composition for the liquid oral cavity containing no abrasive and no nonionic antibacterial agent or bactericidal agent. Also, an excellent biofilm removal effect can be obtained (see Examples described later).

  Furthermore, in the present invention, when a specific amount of (C) alginic acid propylene glycol ester is further added in addition to the components (A) and (B), the off-flavors and odors peculiar to the component (A) in the composition for liquid oral cavity, in particular. Can be sufficiently suppressed, the taste and smell give particularly good good feeling in use, and also the appearance stability can be well maintained.

More specifically, when the component (A), which is the above-mentioned specific nonionic surfactant, is simply blended into a liquid preparation such as a mouthwash, a peculiar off-tasting odor is felt after being used and exhaled in the oral cavity. Although the feeling of use may be impaired, by adding the component (C) to the components (A) and (B), the peculiar off-tastes and odors peculiar to the component (A) can be sufficiently suppressed, and the feeling of use can be improved. It was possible to obtain a good preparation. In addition, the polyoxyethylene alkyl ether tends to have poor solubility in water as the average addition mole number of ethylene oxide or carbon number of the alkyl group decreases, and the increase of propylene glycol alginate causes insufficient dissolution. However, in the present invention, by adding the component (C), the liquid preparation is prevented from generating occurrences even after storage for 1 month at high temperature (50 ° C.), and while maintaining the appearance stability well, It was also possible to give the above-mentioned excellent usability.
Propylene glycol alginate is known as a caking additive for toothpastes, but in the present invention, particularly in the composition for liquid oral cavity, the component (C) specifically suppresses the off-flavor from the component (A). In addition, it exerts an unexpected effect, for example, can exert an exceptional effect which can not be obtained when sodium carboxymethylcellulose known as a cellulose-based binder is used in place of the component (C). it can.

Accordingly, the present invention provides the following oral biofilm removal agent and an oral composition containing the same.
[1]
(A) Polyoxyethylene lauryl ether having an average addition mole number of ethylene oxide of 10 to 25 moles and polyoxyethylene having an average addition mole number of ethylene oxide of 7 to 17 moles and an alkyl group having 14 to 16 carbon atoms One or more selected from alkyl ethers,
(B) The oral biofilm removal agent which consists of 1 type, or 2 or more types chosen from an acyl sarcosine salt and an acyl taurine salt, and (A) / (B) is 0.1-3 in mass ratio.
[2]
The oral biofilm removal agent as described in [1] whose (A) / (B) is 0.1-2 as mass ratio.
[3]
Component (A) is selected from polyoxyethylene lauryl ether in which the average addition mole number of ethylene oxide is 15 to 25 moles and polyoxyethylene cetyl ether in which the average addition mole number of ethylene oxide is 10 to 15 moles [1. ] Or the oral biofilm removal agent as described in [2].
[4]
The oral biofilm remover according to any one of [1] to [3], wherein the component (B) is selected from an acyl sarcosine salt and an acyl taurine salt in which the carbon number of the acyl group is 10 to 18.
[5]
The composition for oral cavity containing the oral biofilm removal agent in any one of [1]-[4].
[6]
The composition for oral cavity as described in [5] which contains 0.05-0.6 mass% of (A) component, and 0.05-0.5 mass% of (B) components.
[7]
Furthermore, the composition for oral cavity as described in [5] or [6] which contains 0.05-0.5 mass% of (C) alginic acid propylene glycol ester.
[8]
Furthermore, the composition for oral cavity as described in [7] which contains 3-15 mass% of 1 type, or 2 or more types selected from (D) glycerol and sugar alcohol.
[9]
The composition for oral cavity in any one of [5]-[8] which is a composition for liquid oral cavity which does not contain an abrasive.
[10]
The composition for oral cavity as described in [9] which is a mouthwash.

  ADVANTAGE OF THE INVENTION According to this invention, the oral biofilm removal agent which provides the outstanding oral biofilm removal effect, and the oral composition containing this can be provided. In the present invention, even a biofilm formed in the deep part of the periodontal pocket can be dispersed and removed, or the bactericidal agent can be expected to enhance the bactericidal action on the biofilm, and is particularly effective for preventing or suppressing periodontal disease. It can be used for

Hereinafter, the present invention will be described in more detail. The oral biofilm remover of the present invention comprises (A) polyoxyethylene lauryl ether having an average added mole number of ethylene oxide (hereinafter abbreviated as E.O.) of 10 to 25 moles and E.I. O. And one or more selected from polyoxyethylene alkyl ethers having 7 to 17 moles of an alkyl group having 14 to 16 carbon atoms and (B) an acyl sarcosine salt and an acyl taurine salt It consists of a seed or more, (A) / (B) is 0.1-3 as a mass ratio, and a combined use system of such (A) and (B) components is used as an active ingredient.
In this case, although it can be used as an oral biofilm removal agent which consists only of these active ingredients, the other composition is further blended and the composition for oral cavity which contains (A) and (B) ingredient as an active ingredient of oral biofilm removal. It can be prepared as

The component (A) is E.I. O. Polyoxyethylene lauryl ether having a molar ratio of 10 to 25; O. Is selected from polyoxyethylene alkyl ethers having 7 to 17 moles and having 14 to 16 carbon atoms in the alkyl group. As the above-mentioned polyoxyethylene alkyl ether having 14 to 16 carbon atoms in the alkyl group, polyoxyethylene cetyl ether and polyoxyethylene myristyl ether can be used. These can be used singly or in combination of two or more.
Here, the polyoxyethylene lauryl ether E.I. O. Is 10 to 25 moles, preferably 15 to 20 moles, from the viewpoint of the oral biofilm removal effect (hereinafter abbreviated as BF removal effect). In addition, the polyoxyethylene alkyl ether E having a carbon number of 14 to 16 in the alkyl group may be E.I. O. Is 7 to 17 moles, preferably 10 to 15 moles, more preferably 15 moles in terms of the BF removal effect. E. O. The BF removal effect is excellent when each is in the above range, and the BF removal effect is inferior when the lower limit value is not satisfied or the upper limit value is exceeded.
From the viewpoint of the BF removal effect, the component (A) is particularly selected from the above-mentioned E.I. O. Polyoxyethylene lauryl ether and polyoxyethylene cetyl ether, particularly polyoxyethylene cetyl ether, from the viewpoint of tastelessness when contained in the mouth.

  As the component (A), specifically, EMALEX 710, 712, 715, 720, 725, 107, 110, 112, 115, 117 and the like manufactured by Nippon Emulsion Co., Ltd. can be used.

Component (B) is selected from acyl sarcosine salts and acyl taurine salts of anionic surfactants, and one or more may be used.
The acyl group of the acyl sarcosine salt preferably has 10 to 18 carbon atoms, more preferably 10 to 14 carbon atoms. The acyl group of the acyl taurine salt preferably has 10 to 18 carbon atoms, more preferably 10 to 14 carbon atoms. These salts include alkali metal salts such as sodium and potassium, alkaline earth metal salts, organic amine salts and the like.
Specifically, as acyl sarcosine salt, lauroyl sarcosine sodium, cocoyl sarcosine sodium, myristoyl sarcosine sodium, palmitoyl sarcosine sodium, stearoyl sarcosine sodium, etc., as acyl taurine salt, lauroyl methyl taurine sodium, cocoyl methyl taurine sodium, myristoyl methyl taurine sodium , Palmitoyl methyl taurine sodium, stearoyl methyl taurine sodium and the like. Among them, sodium lauroyl sarcosine and sodium lauroyl methyl taurine are preferable, and sodium lauroyl sarcosine is particularly preferable from the viewpoint of no taste.

  As the component (B), for example, Sialpon SLP (Lauroyl Sarcosine sodium) manufactured by Kawaken Fine Chemicals Co., Ltd. for acyl sarcosine salt, NIKKOL LMT (Lauroyl methyl taurine sodium) manufactured by Nikko Chemicals Co., Ltd. for acyl taurine salt etc. It can be used.

  The mass ratio (A) / (B) indicating the blending ratio of the component (A) to the component (B) is 0.1 to 3 as a mass ratio, preferably 0.1 to 2 and more preferably 0.1 to 2 It is 1. When the mass ratio of (A) / (B) is in the above range, an excellent BF removal effect can be obtained. In the case of less than 0.1 and in the case of more than 3, the effect of removing BF is inferior in any case.

  The oral biofilm remover of the present invention can be blended into the composition for oral cavity, but in particular, since the biofilm removal effect can be obtained regardless of the abrasive, the content of the abrasive is small or the abrasive is not contained. It can be suitably blended in the composition for oral cavity. Furthermore, it can be suitably formulated into a liquid or gel oral composition. The liquid oral composition can be prepared and applied to a mouthwash, liquid dentifrice, mouth freshener and the like, but a mouthwash is particularly preferable.

  In this case, the component (A) can be blended in an amount such that the mass ratio of (A) / (B) falls within the above range. The preferable blending amount of the component (A) is 0.05% (% by mass, the same applies hereinafter) or more, particularly 0.1% or more of the whole composition, and 0.6% or less, particularly 0.5% or less Is good. If it is 0.05% or more, the BF removal effect is sufficiently excellent, and if it is 0.6% or less, the synergetic effect on the BF removal of both components (A) and (B) is sufficiently exhibited.

  The preferable blending amount of the component (B) is 0.05% or more, particularly 0.1% or more, and preferably 0.5% or less, particularly 0.3% or less of the whole composition. If it is 0.05% or more, the BF removal effect is sufficiently excellent, and if it is 0.5% or less, irritation and off-flavor in the oral cavity can be suppressed and a good feeling of use can be maintained.

In the present invention, surfactants other than the above, particularly nonionic surfactants other than the component (A), such as sucrose fatty acid ester, polyglycerin fatty acid ester, alkyl glycosides, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, Alkyl dimethylamine oxide, an anionic surfactant other than the component (B), for example, a water-soluble salt of a higher alkyl sulfuric acid ester such as sodium lauryl sulfate, a higher fatty acid monoglyceride sulfonic acid having 10 to 18 carbon atoms of a fatty acid group The water-soluble salt and paraffin sulfonic acid may be blended within a range that does not affect the BF removal effect, but they may be blended and 0%.
When the nonionic surfactant other than the component (A) is blended, the blending amount is preferably such that the total blended amount of the nonionic surfactant including the component (A) is 1% or less of the entire composition. . From the viewpoint of the BF removal effect, it is preferable not to mix (0%).
When an anionic surfactant other than the component (B) is blended, the total amount of the anionic surfactant including the component (B) is 2% or less, particularly 1% or less of the entire composition. The range is good. From the viewpoint of the BF removal effect, it is preferable not to mix (0%). Moreover, as for the compounding quantity of anionic surfactant other than (B) component, less than the same quantity of the compounding quantity of (B) component is preferable.

  Further, (C) alginic acid propylene glycol ester can be added to the composition for oral cavity of the present invention. By adding the component (C), the off-tases and off-flavors peculiar to the above-mentioned nonionic surfactants can be further suppressed, and the appearance stability can be further improved.

(C) Alginic acid propylene glycol ester, when combined with component (A), acts as an inhibitor of off-flavors and off-flavors derived from component (A).
Alginic acid propylene glycol ester is an ester made by introducing a propylene glycol group to a carboxyl group to increase the acid resistance and salt resistance of a natural polysaccharide alginic acid unique to brown algae represented by kelp and wakame. What is commercialized under trade names such as Duck Lloyd of Food Chemifa, Kimiroid of Kimica Co., Ltd., and Kelp acid can be used.

  The alginic acid backbone of alginic acid propylene glycol ester is composed of D-mannuronic acid [M] linked to β-1,4 bond and L-guluronic acid [G] linked to α-1,4 bond. The quantitative ratio (M / G ratio, molar ratio) of D-mannuronic acid to L-guluronic acid is preferably more than 1.0 from the viewpoint of appearance stability after high temperature storage, and the upper limit is 2 or less It is. When the M / G ratio is 1.0 or less, negoli may occur during high temperature storage, and the appearance stability may not be secured, and those exceeding 2 are not commercially available.

  When synthesizing alginic acid propylene glycol ester from alginic acid by esterification, the degree of substitution of the carboxyl group, ie, the degree of esterification, changes depending on the reaction conditions. The higher the degree of esterification, the higher the effect of suppressing off-tastes and off-flavors. The degree of esterification of the carboxyl group is preferably 70% or more, and more preferably 70 to 95%. An esterification degree of 70% or more is particularly preferable in terms of appearance stability. No esterification degree of more than 95% is commercially available.

  From the viewpoint of appearance stability, the viscosity of a 1% aqueous solution at 20 ° C. (same below) is 10 to 150 mPa · s, particularly 10 to 60 mPa · s, from the viewpoint of appearance stability. It is preferably in the range of s. Those less than 10 mPa · s are not commercially available. When the viscosity is 150 mPa · s or less, the appearance stability can be satisfactorily secured.

For example, the following commercial products can be used.
Alginic acid propylene glycol ester Brand name Kelp acid 503: 1% aqueous solution viscosity 18 mPa · s (rotor No. 1, 60 rpm), M / G ratio = 1.3, degree of esterification = 80% / Kimica Co., Ltd. Brand name Kimiroid BF: 1% aqueous solution viscosity 20 mPa · s (rotor No. 1, 60 rpm), M / G ratio = 1.3, degree of esterification = 80% / made by Kimika Co., Ltd. trade name Kimiroid LLV: 1% aqueous solution viscosity 24 mPa · s (rotor No. 1, 60 rpm), M / G ratio = 1.3, degree of esterification = 80% / made by Kimica Co., Ltd. trade name Kimiloid NLS-K: 1% aqueous solution viscosity 55 mPa · s (rotor No. 1 , 60 rpm), M / G ratio = 1.3, degree of esterification = 80% / (made by Kimica Co., Ltd.) Brand name Kimiroid LV: 1% aqueous solution viscosity 90 mPa · s (rotor No. .1, 30 rpm), M / G ratio = 1.3, degree of esterification = 80% / made by Kimica Co., Ltd. trade name Kimiroid MV: 1% aqueous solution viscosity 148 mPa · s (rotor No. 1, 30 rpm), M / G ratio = 1.3, degree of esterification = 80% / manufactured by Kimika Co., Ltd. trade name Duck Lloyd LF: 1% aqueous solution viscosity 21 mPa · s (rotor No. 1, 60 rpm), M / G ratio = 0.8, Esterification degree = 75% / made by Food Chemifa trade name Duck Lloyd PF: 1% aqueous solution viscosity 51 mPa · s (rotor No. 1, 60 rpm), M / G ratio = 0.8, degree of esterification = 75% / Made by Food Chemifa Co., Ltd.

In addition, the said viscosity is a value measured by BL type | mold viscosity meter, and, specifically, it is a measured value by the following method (following same).
Viscosity measurement method (Kimiloid and kelp acid manufactured by Kimica Co., Ltd.)
In a 300 mL tall beaker, 297 g of purified water is taken, and 3.0 g of propylene glycol alginate is added to dissolve completely while stirring with a stirrer or three one motor. Next, after standing for 1 hour in a constant temperature water bath at 20 ° C., the viscosity after 1 minute is accurately measured using a BL type viscometer.
Viscosity meter: Tokyo Keiki Co., Ltd., BL type viscometer measurement conditions ・ When 1% aqueous solution viscosity is 10 to 80 mPa · s: Rotor No. 1, rotational speed 60rp
m
· In the case where the 1% aqueous solution viscosity exceeds 80 mPa · s and is 160 mPa · s or less: 1, 30 rpm
In the case where the 1% aqueous solution viscosity exceeds 160 mPa · s and is 400 mPa · s or less: 2, rotation speed 60rpm
· When the 1% aqueous solution viscosity exceeds 400 mPa · s and is 800 mPa · s or less: 2, rotation speed 30rpm
· When the 1% aqueous solution viscosity exceeds 800 mPa · s and is 1,600 mPa · s or less: Rotor No. 1 3, rotation speed 60rpm
Measurement time: 1 minute viscosity measurement method (Duck Lloyd manufactured by Food Chemifa Co., Ltd.)
4 g of propylene glycol alginate is collected and placed in a 600 mL beaker, and 396 g of purified water is added little by little while stirring with a stir bar. First dissolve well with a small amount of water, and when it has dissolved to some extent, add the entire amount of water. After swelling for 1 hour, the mixture is stirred for 1 minute at 12,000 rpm with a high-speed stirrer (homomixer). The solution is placed in a 300 mL tall beaker and allowed to stand in a 20 ° C. water bath. When the foam rises and the color of the solution in the beaker becomes clear, remove the upper foam with a spoonful or the like. Put a thermometer into a beaker, confirm that the test solution has reached 20 ° C, and measure the viscosity.
Viscometer: Tokyo Keiki Co., Ltd., BL type viscometer rotor: No. 1
Rotation speed: 60 rpm
Measurement time: 1 minute

  The amount of propylene glycol ester (C) blended is 0.05 to 0.5% of the whole composition, preferably 0.07 to 0.3%, from the viewpoint of the suppressing effect on the off-flavor and off-flavors and the appearance stability. It is. If the content is less than 0.05%, the effect of suppressing off-flavors and offensive odors is poor. If it exceeds 0.5%, the stability of the appearance is deteriorated due to the insufficient dissolution of the component (C).

In addition, when mix | blending (C) component, (A) component is the same as that of the above-mentioned, and C14-C16 polyoxyethylene alkyl ether of said alkyl group is polyoxyethylene cetyl ether, poly Oxyethylene myristyl ether can be used. The component (A) may be used singly or in combination of two or more. O. The number of carbon atoms in the alkyl group is preferably 7 to 16 and the number of carbon atoms in the alkyl group is 14 to 16. Among them, polyoxyethylene alkyl ether is preferable, and polyoxyethylene cetyl ether is more preferable.
Here, the above-mentioned polyoxyethylene lauryl ether E.I. O. Is 10 to 25 moles, preferably 15 to 25 moles. In addition, the polyoxyethylene alkyl ether E having a carbon number of 14 to 16 in the alkyl group may be E.I. O. Is 7 to 17 moles, and in particular, 10 to 17 moles are preferable from the viewpoint of the appearance stability. E. O. When each is in the above-mentioned range, the off-flavors and off-flavors are sufficiently suppressed, the feeling of use is better, and the appearance stability becomes better even after high-temperature storage. E. O. If it is too small, the appearance stability may be deteriorated.
The compounding amount of the component (A) is preferably 0.05 to 0.3%, more preferably 0.07 to 0.25% of the whole composition, in terms of the suppressing effect of the off-flavor and the offensive odor and the appearance stability. . Appearance stability is more excellent in it being 0.05% or more. If it is 0.3% or less, the off-flavors and off-flavors after the discharge are sufficiently suppressed, and the feeling of use is further improved.

  In the present invention, one or more selected from (D) glycerin and a sugar alcohol can be further blended. When the component (D) is blended together with the component (C), the effect of suppressing the off-tastes and offensive odors by the component (C) is further improved.

  Examples of the component (D) include glycerin, xylitol as a sugar alcohol, erythritol, maltitol, sorbitol and mannitol. Among them, glycerin and xylitol are preferable from the viewpoint of the improvement of the inhibitory effect on the off-flavor and off-flavor. These can be used alone or in combination of two or more in view of the effects. A commercial item can be used for (D) component.

  As for the compounding quantity of (D) component, 3-15% of the whole composition is preferable. Within this range, the suppressing effect of the off-flavor and off-flavor is more excellent. The amount of glycerin is preferably 2 to 10% of the whole composition when at least glycerin is blended within the range of the above-mentioned blending amount, and when at least a sugar alcohol, particularly xylitol is blended, The blending amount is preferably 1 to 5% of the whole composition. It is particularly preferable to use glycerin and a sugar alcohol in combination.

  In the present invention, appropriate known components can be blended as necessary in addition to the above components, depending on the dosage form and purpose of use of the composition for oral cavity. In the liquid oral composition, specifically, a wetting agent, a thickening agent, a preservative, a preservative, a sweetener, a coloring agent, a pH adjuster, a flavor, an active ingredient and the like are blended. In the present invention, the content of the abrasive in the composition is preferably 0 to 10%, and more preferably 0 to 5%, because it is preferable to use a low content or no content of the abrasive. In particular, it is preferable as a composition for oral cavity which does not contain an abrasive. Abrasives are usually not formulated into mouthrinses.

  The wetting agent may, for example, be a sugar alcohol such as sorbitol, xylitol or erythritol, glycerin, ethylene glycol, polyethylene glycol having an average molecular weight of 100 to 500, preferably 190 to 420 (average molecular weight described in Quasi-drug raw material standard 2006, hereinafter the same) And other polyhydric alcohols. When the component (D) is blended, the component (D) also acts as a wetting agent, and therefore the wetting agent may not be blended in addition to the component (D). It is also possible to blend a polyhydric alcohol such as propylene glycol, ethylene glycol and polyethylene glycol having the above-mentioned specific average molecular weight. The total content of wetting agents is usually from 1 to 50%, in particular from 3 to 50%.

  Examples of the thickener include those other than the component (C), for example, cellulose-based compounds such as sodium carboxymethyl cellulose and gums such as xanthan gum. The compounding amount is usually 0 to 3%.

Examples of preservatives include p-oxybenzoic acid esters, benzoic acid or sodium salts thereof. As the sweetening agent, sodium saccharin, stevioside and the like can be mentioned.
Examples of the colorant include water-soluble dyes having high safety such as Blue No. 1, Green No. 3, Yellow No. 4, Red No. 105 and the like.

  In the present invention, it is preferable to adjust the pH at 25 ° C. to 5.5 to 8.0, and a combination of sodium dihydrogenphosphate and sodium monohydrogenphosphate as a pH adjuster in this vicinity, or citric acid and citric acid Sodium acid can also be added in combination.

As a spice, various spice ingredients, an essential oil, etc. are mentioned. For example, menthol, carvone, anethole, cineole, methyl salicylate, cinnamic aldehyde, eugenol, 3-1-mentoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N- Substituted-paramenthane-3-carboxamide, pinene, octylaldehyde, citral, plegon, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, Undecalactone, hexanal, isoamyl alcohol, hexenol, dimethyl sulfide, cyclotene, furfural, trimethylpyrazine, ethyl lactate Flavor components such as methyl lactate, ethyl thioacetate, peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil , Coriander oil, mandarin oil, lime oil, lavender oil, rosemary oil, laurel oil, chamomile oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, Natural flavors such as jasmine oil, iris concrete, absolute peppermint, absolute rose, orange flower, and flavors processed with these natural flavors (pre-cut, pre-cut, fractionated, liquid-liquid extraction, etc.) Strawberry flavor, apple flavor, Nana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavors, such as blended fragrance such as tropical fruit flavors, and the like.
The blending amount of the perfume is usually 0.00001 to 2% of the whole composition.

  As an active ingredient, a nonionic bactericidal agent such as isopropylmethylphenol, a cationic bactericidal agent such as cetyl pyridinium chloride, an anti-inflammatory agent, a fluorine-containing compound, an enzyme, vitamins and the like can be used within the scope of the present invention. An effective amount may be added.

In the composition for oral cavity of the present invention, purified water is used as a solvent, and a lower monohydric alcohol such as ethanol may be blended. The content of the lower monohydric alcohol, particularly ethanol, may be 10% or less, particularly 5% or less of the whole composition, or 0% without blending.
In the present invention, the liquid oral composition having a low ethanol concentration and substantially containing no ethanol has good appearance stability.

  EXAMPLES The present invention will be specifically described below by showing Examples, Comparative Examples, and Formulation Examples, but the present invention is not limited to the following Examples. In the following examples,% indicates% by mass unless otherwise specified.

Example I, Comparative Example I
The composition for a liquid oral cavity (mouthwashing agent) of the composition shown to Table I-1-I-3 was prepared by the conventional method, these were used as a test composition, and the following method evaluated. The results are shown in Tables I-1 to I-3. In the table, POE is an abbreviation of polyoxyethylene, and the numbers in parentheses are the average added mole number of ethylene oxide (the same applies hereinafter).

<Method for evaluating periodontal pathogenic biofilm dispersion effect (BF removal effect)>
(1) Method of preparing model periodontopathogenic biofilm 4 hours with human non-stimulating saliva obtained by filtering a hydroxyapatite (HA) plate (made by Asahi Optical Co., Ltd.) with a diameter of 7 mm and a thickness of 3.5 mm with a 0.45 μm filter The treated medium is used as a model biofilm preparation carrier, and the culture solution is prepared by dissolving 30 g of Trypticase Soy Broth (manufactured by Difco) in 1 L of purified water, 5 mg / L of hemin (manufactured by Sigma), vitamin K What added 1 mg / L (made by Wako Pure Chemical Industries, Ltd.) was used. The oral bacteria used for preparation of the model biofilm were all purchased from the American Type Culture Collection (ATCC), and Streptococcus gordonii strain ATCC 51656 and Actinomyces naes Landi strain ATCC 51655 as oral bacteria, porphys as pathogenic bacteria. Lomonas gingivalis strain ATCC 33277 was used. These three bacterial strains are each inoculated into the above-mentioned culture solution at 2 × 10 ⁷ cfu / mL (clony forming units / mL), and together with the saliva-treated HA carrier at 37 ° C. under anaerobic conditions (80 vol% nitrogen, 10 vol Continuous culture (the replacement rate of the culture solution was 10 vol%) was carried out with% carbon dioxide and 10 vol% hydrogen to form a model biofilm of a mixture of three species on the HA surface.

(2) Evaluation of dispersion effect on model biofilm 1 mL of the test composition was added to the formed model biofilm, and left still for 3 minutes. Then, it was rinsed with 1 mL of phosphate buffered saline (PBS, manufactured by Wako Pure Chemical Industries, Ltd.) to remove the dispersed biofilm by the addition of the test composition. The biofilm that remained undispersed was placed in a test tube (diameter 13 mm × 100 mm) to which 2 mL of the same buffer (PBS) was added, and forcedly dispersed by sonication (200 μA, 10 seconds). The turbidity (OD) at a wavelength of 550 nm of this dispersion was measured, and the amount of remaining biofilm not dispersed in the sample was measured.
The biofilm dispersion effect of a test composition calculated | required the biofilm dispersion rate with respect to control by the formula shown below, and determined the biofilm dispersion effect according to the following reference | standard from this dispersion rate.
As a control, PBS was used.
Biofilm dispersion rate (%) =
{(Control turbidity-test composition treatment turbidity) / control turbidity} × 100
Judgment criteria of biofilm dispersion effect ◎: biofilm dispersion rate of 50% or more ○: biofilm dispersion rate of 35% to less than 50% Δ: biofilm dispersion rate of 20% to 35% ×: biofilm dispersion rate Less than 20%

  The BF removal effect of Comparative Examples 6 to 9 in which the inappropriate POE alkyl ether is used in combination with the component (B) shown in Table I-3 is lower than that of Comparative Example 1 using the component (B) alone. The

Example II
The liquid oral cavity composition (mouthwashing agent) of the composition shown to Table II-1 and II-2 was prepared by the conventional method, and the following method evaluated. The results are shown in Tables II-1 and II-2.
In addition, when the composition for liquid oral cavity shown to Table II-1 and II-2 was evaluated by the method similar to the above, it was excellent in the BF removal effect.

<Method of evaluating the suppression effect of the off-flavor and off-flavor>
Five test panelists contained 10 mL of the sample (liquid oral composition) in the mouth, were mouthwashed for 20 seconds, and the absence of offensive off-flavors was evaluated according to the following five-point rating criteria. From the average score of 5 persons, according to the following judgment criteria, it was judged by ◎, ◎, 、, △, x.
Rating criteria for the absence of off-flavor and off-flavor:
5 points: no offensive offensive odor 4 points: hardly offensive offensive odor 3 points: offensive offensive odor was slightly, but there was no problem 2 points: offside offensive odor was slightly 1 point: off flavoring offensive odor Judgment criteria for no off-flavor and off-flavor:
◎: Average point 4.5 or more :: Average point 3.5 or more and less than 4.5 points ○: Average point 2.5 or more and less than 3.5 points Δ: Average point 1.5 or more 2.5 points Less than ×: Less than 1.5 points on average

<Method for evaluating appearance stability>
The sample (liquid oral composition) is filled with 450 mL of a clear and colorless PET (polyethylene terephthalate) container (manufactured by Yoshino Kogyosho) filled with 500 mL, and stored in a 50 ° C. thermostat for 1 month. Lack of the eye was visually evaluated according to the following four-point scale. Three samples were evaluated, and based on the average point, according to the following determination criteria, it determined by (double-circle), (circle), (triangle | delta), and x.
Scoring criteria for poorness:
4 points: There was no nigori 3 points: There was almost no nigori 2 points: There was a little nigrily 1 point: There was a considerable nigori Judgment criteria of non-nigori
A: Average point 3.5 or more and 4.0 or less ○: Average point 3.0 or more and less than 3.5 points Δ: Average point 2.0 or more and less than 3.0 points ×: Average point 2.0 Less than

The details of the component (C) used are shown below.
(C) Component (Alginate Propylene Glycol Ester)
APG1
Brand name: Kimiroid BF, manufactured by Kimika Co., Ltd. 1% aqueous solution viscosity 20 mPa · s (rotor No. 1, 60 rpm),
M / G ratio = 1.3, degree of esterification = 80%
APG2
Brand name: Kelp acid 503, manufactured by Kimika Co., Ltd. 1% aqueous solution viscosity 18 mPa · s (rotor No. 1, 60 rpm),
M / G ratio = 1.3, degree of esterification = 80%
The viscosity of the component (C) was measured by the same method using the BL viscometer described above.

Formulation Example 1 Mouthwash (A) POE (15) Myristyl Ether 0.2%
(B) lauroyl sarcosine sodium 0.2
Glycerin 10
Purified water
100.0% in total
(A) / (B) mass ratio; 1

[Preparation Example 2] Mouthwash (A) POE (15) Myristyl ether 0.1%
(B) lauroyl sarcosine sodium 0.1
(C) Alginic acid propylene glycol ester (APG1) 0.1
POE (60) hydrogenated castor oil 0.3
Fragrance 0.2
(D) Glycerin 2.0
(D) Xylitol 4.0
Propylene glycol 2.0
Ethanol 4.0
Citric acid 0.05
Sodium citrate 0.3
Purified water
100.0% in total
(A) / (B) mass ratio; 1

Claims (10)

(A) Polyoxyethylene lauryl ether having an average addition mole number of ethylene oxide of 10 to 25 moles and polyoxyethylene having an average addition mole number of ethylene oxide of 7 to 17 moles and an alkyl group having 14 to 16 carbon atoms One or more selected from alkyl ethers,
(B) The oral biofilm removal agent which consists of 1 type, or 2 or more types chosen from an acyl sarcosine salt and an acyl taurine salt, and (A) / (B) is 0.1-3 in mass ratio.   The oral biofilm removal agent according to claim 1, wherein (A) / (B) is 0.1 to 2 as a mass ratio.   The component (A) is selected from polyoxyethylene lauryl ether in which the average addition mole number of ethylene oxide is 15 to 25 moles, and polyoxyethylene cetyl ether in which the average addition mole number of ethylene oxide is 10 to 15 moles. The oral biofilm removal agent according to 1 or 2.   The oral biofilm removal agent according to any one of claims 1 to 3, wherein the component (B) is selected from an acyl sarcosine salt and an acyl taurine salt in which an acyl group has 10 to 18 carbon atoms.   The composition for oral cavity containing the oral biofilm removal agent of any one of Claims 1-4.   The composition for oral cavity of Claim 5 which contains 0.05-0.6 mass% of (A) component, and 0.05-0.5 mass% of (B) components.   The composition for oral cavity according to claim 5 or 6, further comprising (C) 0.05 to 0.5% by mass of propylene glycol ester of alginic acid.   Furthermore, the composition for oral cavity of Claim 7 which contains 3-15 mass% of 1 type, or 2 or more types selected from (D) glycerol and sugar alcohol.   The composition for oral cavity according to any one of claims 5 to 8, which is a liquid oral composition containing no abrasive.   The composition for oral cavity according to claim 9, which is a mouthwash.