JP2019032328A5 - - Google Patents
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- JP2019032328A5 JP2019032328A5 JP2018161024A JP2018161024A JP2019032328A5 JP 2019032328 A5 JP2019032328 A5 JP 2019032328A5 JP 2018161024 A JP2018161024 A JP 2018161024A JP 2018161024 A JP2018161024 A JP 2018161024A JP 2019032328 A5 JP2019032328 A5 JP 2019032328A5
- Authority
- JP
- Japan
- Prior art keywords
- drug
- amino acid
- acid sequence
- active
- depression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 238000000034 method Methods 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 7
- 239000012190 activator Substances 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 241000283984 Rodentia Species 0.000 claims 3
- 230000002964 excitative effect Effects 0.000 claims 3
- 230000001537 neural effect Effects 0.000 claims 3
- 210000002569 neuron Anatomy 0.000 claims 3
- 238000003556 assay Methods 0.000 claims 2
- 230000006399 behavior Effects 0.000 claims 2
- 210000002472 endoplasmic reticulum Anatomy 0.000 claims 2
- 230000008172 membrane trafficking Effects 0.000 claims 2
- 108091005462 Cation channels Proteins 0.000 claims 1
- 108010035848 Channelrhodopsins Proteins 0.000 claims 1
- 102000034573 Channels Human genes 0.000 claims 1
- 230000007357 depressive behavior Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000012048 forced swim test Methods 0.000 claims 1
- 210000002442 prefrontal cortex Anatomy 0.000 claims 1
- 210000001609 raphe nuclei Anatomy 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261613231P | 2012-03-20 | 2012-03-20 | |
| US61/613,231 | 2012-03-20 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015501753A Division JP6396883B2 (ja) | 2012-03-20 | 2013-03-13 | うつ病の非ヒト動物モデルおよびその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019032328A JP2019032328A (ja) | 2019-02-28 |
| JP2019032328A5 true JP2019032328A5 (enExample) | 2019-05-09 |
Family
ID=49223208
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015501753A Expired - Fee Related JP6396883B2 (ja) | 2012-03-20 | 2013-03-13 | うつ病の非ヒト動物モデルおよびその使用方法 |
| JP2018161024A Ceased JP2019032328A (ja) | 2012-03-20 | 2018-08-30 | うつ病の非ヒト動物モデルおよびその使用方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015501753A Expired - Fee Related JP6396883B2 (ja) | 2012-03-20 | 2013-03-13 | うつ病の非ヒト動物モデルおよびその使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20150040249A1 (enExample) |
| EP (1) | EP2827707A4 (enExample) |
| JP (2) | JP6396883B2 (enExample) |
| CN (1) | CN104270942B (enExample) |
| AU (2) | AU2013235517B2 (enExample) |
| CA (1) | CA2867567A1 (enExample) |
| WO (1) | WO2013142196A1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9238150B2 (en) | 2005-07-22 | 2016-01-19 | The Board Of Trustees Of The Leland Stanford Junior University | Optical tissue interface method and apparatus for stimulating cells |
| US8926959B2 (en) | 2005-07-22 | 2015-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
| US10052497B2 (en) | 2005-07-22 | 2018-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
| US20070053996A1 (en) | 2005-07-22 | 2007-03-08 | Boyden Edward S | Light-activated cation channel and uses thereof |
| US9274099B2 (en) | 2005-07-22 | 2016-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Screening test drugs to identify their effects on cell membrane voltage-gated ion channel |
| WO2008086470A1 (en) | 2007-01-10 | 2008-07-17 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
| WO2008101128A1 (en) | 2007-02-14 | 2008-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | System, method and applications involving identification of biological circuits such as neurological characteristics |
| WO2008106694A2 (en) | 2007-03-01 | 2008-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Systems, methods and compositions for optical stimulation of target cells |
| US10035027B2 (en) | 2007-10-31 | 2018-07-31 | The Board Of Trustees Of The Leland Stanford Junior University | Device and method for ultrasonic neuromodulation via stereotactic frame based technique |
| US10434327B2 (en) | 2007-10-31 | 2019-10-08 | The Board Of Trustees Of The Leland Stanford Junior University | Implantable optical stimulators |
| SG189813A1 (en) | 2008-04-23 | 2013-05-31 | Univ Leland Stanford Junior | Systems, methods and compositions for optical stimulation of target cells |
| JP5890176B2 (ja) | 2008-05-29 | 2016-03-22 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | セカンドメッセンジャーを光制御するためのセルライン、システム、および方法 |
| AU2009260029B2 (en) | 2008-06-17 | 2016-03-17 | The Board Of Trustees Of The Leland Stanford Junior University | Methods, systems and devices for optical stimulation of target cells using an optical transmission element |
| US9101759B2 (en) | 2008-07-08 | 2015-08-11 | The Board Of Trustees Of The Leland Stanford Junior University | Materials and approaches for optical stimulation of the peripheral nervous system |
| NZ602416A (en) | 2008-11-14 | 2014-08-29 | Univ Leland Stanford Junior | Optically-based stimulation of target cells and modifications thereto |
| JP5866332B2 (ja) | 2010-03-17 | 2016-02-17 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 感光性イオンを通過させる分子 |
| EP3486253A1 (en) | 2010-11-05 | 2019-05-22 | The Board of Trustees of The Leland Stanford Junior University | Light-activated chimeric opsins and methods of using the same |
| CN103491770B (zh) | 2010-11-05 | 2016-06-08 | 斯坦福大学托管董事会 | 稳定阶跃函数视蛋白及其使用方法 |
| US9992981B2 (en) | 2010-11-05 | 2018-06-12 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic control of reward-related behaviors |
| WO2012061681A1 (en) | 2010-11-05 | 2012-05-10 | The Board Of Trustees Of The Leland Stanford Junior University. | Control and characterization of memory function |
| CN106106368A (zh) | 2010-11-05 | 2016-11-16 | 斯坦福大学托管董事会 | 光控cns功能障碍 |
| CA2817175C (en) | 2010-11-05 | 2019-09-24 | The Board Of Trustees Of The Leland Stanford Junior University | Upconversion of light using lanthanide-doped nanoparticles for use in optogenetic methods |
| US8696722B2 (en) | 2010-11-22 | 2014-04-15 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic magnetic resonance imaging |
| EP3524676A1 (en) | 2011-12-16 | 2019-08-14 | The Board of Trustees of The Leland Stanford Junior University | Opsin polypeptides and methods of use thereof |
| ES2628006T3 (es) | 2012-02-21 | 2017-08-01 | Circuit Therapeutics, Inc. | Composiciones para el tratamiento de trastornos neurogénicos del suelo pélvico |
| US10974064B2 (en) | 2013-03-15 | 2021-04-13 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic control of behavioral state |
| US9636380B2 (en) | 2013-03-15 | 2017-05-02 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic control of inputs to the ventral tegmental area |
| WO2014179331A2 (en) | 2013-04-29 | 2014-11-06 | The Board Of Trustees Of The Leland Stanford Junior University | Devices, systems and methods for optogenetic modulation of action potentials in target cells |
| CA2921221A1 (en) | 2013-08-14 | 2015-02-19 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for controlling pain |
| WO2015156862A2 (en) * | 2014-01-16 | 2015-10-15 | Arizona Board Of Regents On Behalf Of Arizona State University | Integrated high-resolution untethered flexible neural implant |
| EP3122761B1 (en) | 2014-03-28 | 2019-03-06 | The Board of Trustees of The Leland Stanford Junior University | Engineered light-activated anion channel proteins and methods of use thereof |
| WO2016209654A1 (en) | 2015-06-22 | 2016-12-29 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and devices for imaging and/or optogenetic control of light-responsive neurons |
| WO2017015395A1 (en) * | 2015-07-21 | 2017-01-26 | The Board Of Trustees Of The Leland Stanford Junior University | Carbon fiber optrodes for magnetic resonance imaging compatible optogenetics |
| US11294165B2 (en) | 2017-03-30 | 2022-04-05 | The Board Of Trustees Of The Leland Stanford Junior University | Modular, electro-optical device for increasing the imaging field of view using time-sequential capture |
| KR102412194B1 (ko) * | 2018-11-13 | 2022-06-23 | 한국과학기술연구원 | 자폐 스펙트럼 장애의 치료방법, 자폐 스펙트럼 장애 모니터링용 마우스, 및 자폐 스펙트럼 장애 예방 또는 치료용 후보물질의 스크리닝 방법 |
| CN114903006B (zh) * | 2021-02-09 | 2024-08-02 | 中国科学院脑科学与智能技术卓越创新中心 | 一种非人灵长类动物物质成瘾模型的构建方法与应用 |
| CN113558010A (zh) * | 2021-07-19 | 2021-10-29 | 重庆师范大学 | 斑马鱼抑郁模型的建立及吗拉贝胺抗抑郁活性的测定方法 |
| CN113584032B (zh) * | 2021-08-20 | 2023-08-29 | 深圳市恩辑生物科技有限公司 | 一种迷你启动子pAPP及其应用 |
| CN114711192B (zh) * | 2022-04-13 | 2022-11-29 | 中国科学院西北高原生物研究所 | 一种长效抑郁症动物模型的构建试剂盒及构建方法 |
| CN115104575B (zh) * | 2022-07-08 | 2025-02-11 | 华中科技大学 | 一种酒精性抑郁动物模型的建立方法及其应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2251838C2 (ru) * | 1999-07-15 | 2005-05-20 | Рисерч Дивелопмент Фаундейшн | Способ получения неприродной трансгенной мыши с дефицитом гена рецептора 2 кортиколиберина и ее использование |
| US7674463B1 (en) * | 1999-07-15 | 2010-03-09 | Research Development Foundation | Method of inhibiting angiogenesis by administration of a corticotropin releasing factor receptor 2 agonist |
| US20040034882A1 (en) * | 1999-07-15 | 2004-02-19 | Vale Wylie W. | Corticotropin releasing factor receptor 2 deficient mice and uses thereof |
| TW201206425A (en) * | 2004-05-18 | 2012-02-16 | Brni Neurosciences Inst | Treatment of depressive disorders |
| US9274099B2 (en) * | 2005-07-22 | 2016-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Screening test drugs to identify their effects on cell membrane voltage-gated ion channel |
| WO2008106694A2 (en) * | 2007-03-01 | 2008-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Systems, methods and compositions for optical stimulation of target cells |
| NZ602416A (en) * | 2008-11-14 | 2014-08-29 | Univ Leland Stanford Junior | Optically-based stimulation of target cells and modifications thereto |
| KR101036338B1 (ko) * | 2009-03-27 | 2011-05-23 | 경상대학교산학협력단 | Ｔｒｅｓｋ 유전자를 과발현하는 형질전환 동물 및 이의 제조방법 |
| JP2011030565A (ja) * | 2009-07-06 | 2011-02-17 | Yokohama City Univ | 社会的隔離モデル動物 |
| US20110072525A1 (en) * | 2009-09-22 | 2011-03-24 | Effat Emamian | Compositions and methods for the treatment of psychiatric and neurological disorders |
| CN102233071B (zh) * | 2010-04-21 | 2013-02-06 | 中国中医科学院广安门医院 | 一种用于治疗抑郁症的中药组合物及其制备方法 |
| US8957028B2 (en) * | 2010-11-13 | 2015-02-17 | Massachusetts Institute Of Technology | Red-shifted opsin molecules and uses thereof |
| CN102634450A (zh) * | 2012-03-01 | 2012-08-15 | 东南大学 | 基于生物芯片的抗抑郁药物疗效风险评估系统及其应用 |
-
2013
- 2013-03-13 US US14/385,331 patent/US20150040249A1/en not_active Abandoned
- 2013-03-13 WO PCT/US2013/030893 patent/WO2013142196A1/en not_active Ceased
- 2013-03-13 CN CN201380022721.6A patent/CN104270942B/zh not_active Expired - Fee Related
- 2013-03-13 EP EP13765207.9A patent/EP2827707A4/en not_active Withdrawn
- 2013-03-13 CA CA2867567A patent/CA2867567A1/en not_active Abandoned
- 2013-03-13 AU AU2013235517A patent/AU2013235517B2/en not_active Ceased
- 2013-03-13 JP JP2015501753A patent/JP6396883B2/ja not_active Expired - Fee Related
-
2018
- 2018-08-30 JP JP2018161024A patent/JP2019032328A/ja not_active Ceased
-
2019
- 2019-01-17 AU AU2019200310A patent/AU2019200310A1/en not_active Abandoned
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