JP2019011304A - Spray type agent for easy administration - Google Patents

Abstract

To provide a spray type agent for easy administration that masks pharmaceutical tastes and odors, and can mask collectively plural doses as well as one dose.SOLUTION: A agent for easy administration is prepared by mixing a sweetener, a flavoring agent, a flavor, a coloring agent or the like with a solvent or powder for dispersion, and charging the mixture into a spray type container. Such an agent can mask tastes and odors just by spraying.

Description

The present invention masks the bitterness, odor, etc. of pharmaceuticals by spraying at home or medical institutions, making it easy to take even those who are difficult to take mainly due to taste and odor It relates to the agent.

Usually, it is common to use water or white hot water for internal medicine. However, drugs that have a bitter taste among powdered and pulverized tablets give strong discomfort to the patient. Therefore, especially for infants and elderly people with impaired cognitive function, parents, caregivers, or healthcare workers It is a work that requires a lot of labor. Therefore, these drugs are often administered by mixing them with food, beverages, etc., or using other easy-to-use agents such as jelly (for example, see Patent Document 1).

Moreover, each pharmaceutical company is trying bitterness masking uniquely by the request | requirement from a medical field, etc. (for example, refer patent document 2).

However, the method of mixing with jelly or the like requires labor to adjust immediately before taking, and the bitterness masking method performed at each pharmaceutical company or the like often requires sophisticated and large-scale equipment and technology.

Japanese Patent No. 4647493 JP2013-127209A

The subject of the present invention is that all people, including infants and the elderly whose cognitive function has declined, need advanced and large-scale equipment and technology when they need to take medicines with tastes and odors that do not taste like bitterness. In addition, it is to provide an easy-to-use agent that can be masked not only for one dose but also for a plurality of doses simultaneously by spraying and can be stored for 3 hours or more.

In order to solve the above-mentioned problems, the present inventor has found that sweeteners, taste-masking agents (including bitterness-inhibiting substances), mouth fresheners, fragrances, pigments, coloring agents, oils and fats and preparations that can be added to foods or pharmaceuticals. By filling a liquid or powder containing at least one of the raw materials into a container of 1000 mL or less and spraying it as an aerosol or non-aerosol type spray, no advanced or large-scale equipment or technology is required. And found out that it can mask the taste or odor of medicines and supplements.

In addition, methanol, ethanol, propanol, isopropanol, acetone as solvents for dissolving sweeteners, flavoring agents, mouth fresheners, fragrances, pigments, colorants, oils and fats, and raw materials for formulation, and attaching them to pharmaceutical products to be masked In addition, by using a volatile liquid containing 1% or more of one or more selected from benzyl alcohol, the substances other than the solvent cover the drug, and although it is simple, the effect close to the coating by the spray drying method is obtained. It is done.

This effect makes it possible to obtain a pharmaceutical product that is masked in taste or odor and dried to such an extent that it can be packaged within at least 10 minutes immediately after spraying of the ready-to-use agent. In other words, not only the patient himself or his / her caregiver can mask each time when taking the medicine, but also a medical worker can mask multiple times at a medical institution including a pharmacy. Therefore, it is desirable to use these solvents unless there is a special reason.

In addition, the sweeteners that play a central role in bitterness masking are sugar: sugar, glucose, maltose, fructose, lactose, sugar alcohols: sorbitol, mannitol, maltitol, reduced starch syrup, reduced palatinose, xylitol, erythritol, non-sugar sweeteners : Stevia, glycyrrhizin, aspartame, acesulfame K, saccharin, saccharin sodium, saccharin calcium, sucralose, and neotame, these sweeteners are often added to pharmaceuticals and manifest their medicinal effects Therefore, it is suitable for this easy-to-use agent.

The effects of the present invention are reduction of discomfort during taking by masking the taste and odor of pharmaceuticals, and simplification of the pharmaceutical preparation process for patients, guardians, medical workers, and the like.

The easy-to-use agent according to the present invention is at least any of sweeteners, flavoring agents (including bitterness-inhibiting substances), mouth fresheners, fragrances, pigments, coloring agents, fats and oils, and raw materials for preparations that can be added to foods or pharmaceuticals. A container with a spray function is filled with a mixture of a masking component consisting of one kind and a solvent or powder for dispersing the masking component and adhering it to a pharmaceutical product.

The masking component contained in the easy-to-use agent according to the present invention is not particularly limited as long as it can be added to food or medicine and can mask unpleasant taste and odor of the medicine, In consideration of the effect on the drug efficacy, the solubility in alcohols used as volatile solvents, and the calorie intake by the user, it is desirable to add high-intensity sweeteners such as saccharin Na and aspartame, and fragrances.

Moreover, in order to improve masking property, the fats and oils or polymer | macromolecule which does not inhibit spraying and drying can also be mix | blended.

Furthermore, in order to improve the visibility of masking, it is preferable to mix | blend a pigment | dye and a coloring agent.

The solvent contained in the easy-to-use agent according to the present invention is preferably a solvent that is highly volatile and hardly remains when taking medicines, but even if it remains, it may harm the health of the user. Must not be. For this reason, it is preferable to use ethanol as a main solvent which is easy to ensure safety except for allergic symptoms and is easily available commercially.

The form and style of the container with a spray function are not particularly limited as long as it fulfills the above-described function, but it is preferable to use an aerosol type from the viewpoint of the amount, momentum, and hygiene of the contents to be ejected.

Moreover, since a medical institution including a general household and a pharmacy is assumed as a place to be used, the capacity is preferably 50 to 500 mL in consideration of convenience.

In order to produce the ready-to-use agent according to the present invention as a spray, a known method can be used. For example, there is a method in which a solution or powder in which a masking component or the like is uniformly dispersed is filled in an aerosol container, an aerosol valve is attached, and after clinching, a gas usually used for an aerosol agent such as liquefied petroleum gas is filled.

Examples of the present invention will be described below, but the present invention is not limited to the following examples.

Saccharin Na is added to 50 mL of Japanese Pharmacopoeia absolute ethanol at room temperature to make a saturated solution. Subsequently, food color containing commercially available food yellow No. 4 and food blue No. 1 is added to make a saturated solution. Next, the filtrate obtained by natural filtration was filled into a household pump spray spray to obtain an easy-to-use agent of this example.

-Preparation of sample 10 g of the easy-to-use agent prepared while mixing appropriately with a spatula was sprayed in two portions on 1 g of commercially available wheat flour. When the mixture was mixed with a spatula for about 1 minute after spraying, it was dried to such an extent that it would be sufficient for a sachet in a pharmacy, so this was used as a sample.

-When the sample after observation and result adjustment was placed in two places on the tongue, a strong sweetness was felt.
In addition, after spraying, the white flour turned slightly green and the color tone was uniform. The fluidity increased and the adhesion to paper and polyethylene bags decreased.
Furthermore, when this sample was packaged with a medicine wrapping paper or a polyethylene bag and allowed to stand for 3 days and observed, no changes were found in sweetness, appearance, fluidity and adhesion.

Claims (4)

Liquid or powder containing at least one of sweeteners, flavoring agents (including bitterness-inhibiting substances), mouth fresheners, fragrances, pigments, coloring agents, fats and oils, and pharmaceutical raw materials that can be added to foods or pharmaceuticals An easy-to-use agent which is an aerosol or non-aerosol-type propellant in which the body is filled in a container of 1000 mL or less, and can mask the taste or odor of pharmaceuticals, supplements by spraying. 2. The volatile liquid containing 1% or more of one or more selected from methanol, ethanol, propanol, isopropanol, acetone and benzyl alcohol as a solvent and carrier for inclusions. Taking agent. Sweeteners are sugar: sugar, glucose, maltose, fructose, lactose, sugar alcohol: sorbitol, mannitol, maltitol, reduced starch syrup, reduced palatinose, xylitol, erythritol, non-sugar sweeteners: stevia, glycyrrhizin, aspartame, acesulfame K The saccharin, saccharin sodium, saccharin calcium, sucralose and neotame are selected from one or two or more ready-to-use agents according to claims 1 and 2. A liquid or powder prepared for the purpose of filling the easy-to-use agent according to any one of claims 1 to 3.