JP2018538267A5 - - Google Patents
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- Publication number
- JP2018538267A5 JP2018538267A5 JP2018526144A JP2018526144A JP2018538267A5 JP 2018538267 A5 JP2018538267 A5 JP 2018538267A5 JP 2018526144 A JP2018526144 A JP 2018526144A JP 2018526144 A JP2018526144 A JP 2018526144A JP 2018538267 A5 JP2018538267 A5 JP 2018538267A5
- Authority
- JP
- Japan
- Prior art keywords
- aqueous solution
- acid
- bilastin
- concentration
- organic carboxylic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000007864 aqueous solution Substances 0.000 claims 11
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 6
- 150000001735 carboxylic acids Chemical class 0.000 claims 5
- KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 claims 4
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 4
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 claims 3
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000000243 solution Substances 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 206010010741 Conjunctivitis Diseases 0.000 claims 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 2
- 235000011054 acetic acid Nutrition 0.000 claims 2
- 208000026935 allergic disease Diseases 0.000 claims 2
- HWXBTNAVRSUOJR-UHFFFAOYSA-N alpha-hydroxyglutaric acid Natural products OC(=O)C(O)CCC(O)=O HWXBTNAVRSUOJR-UHFFFAOYSA-N 0.000 claims 2
- 229940009533 alpha-ketoglutaric acid Drugs 0.000 claims 2
- 239000013078 crystal Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 235000019260 propionic acid Nutrition 0.000 claims 2
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims 2
- 239000002002 slurry Substances 0.000 claims 2
- 239000011975 tartaric acid Substances 0.000 claims 2
- 235000002906 tartaric acid Nutrition 0.000 claims 2
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 208000024780 Urticaria Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 206010039083 rhinitis Diseases 0.000 claims 1
- 239000012047 saturated solution Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15382574.0 | 2015-11-20 | ||
| EP15382574.0A EP3170816A1 (en) | 2015-11-20 | 2015-11-20 | Supersaturated compositions of benzimidazole compounds |
| PCT/EP2016/078154 WO2017085265A1 (en) | 2015-11-20 | 2016-11-18 | Supersaturated compositions of benzimidazole compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018538267A JP2018538267A (ja) | 2018-12-27 |
| JP2018538267A5 true JP2018538267A5 (https=) | 2019-07-11 |
Family
ID=54707730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018526144A Withdrawn JP2018538267A (ja) | 2015-11-20 | 2016-11-18 | ベンズイミダゾール化合物の過飽和組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20180344854A1 (https=) |
| EP (2) | EP3170816A1 (https=) |
| JP (1) | JP2018538267A (https=) |
| ES (1) | ES2778434T3 (https=) |
| PT (1) | PT3377479T (https=) |
| WO (1) | WO2017085265A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200125923A (ko) | 2017-10-16 | 2020-11-05 | 파에스 파마, 에스.에이. | 빌라스틴 및 모메타손을 포함하는 수성 조성물 |
| CN116211795B (zh) * | 2022-12-26 | 2025-09-26 | 深圳市贝美药业有限公司 | 一种比拉斯汀口服液体制剂及其制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US818454A (en) * | 1904-04-06 | 1906-04-24 | Andrew Krus | Lathe-dog. |
| ES2048109B1 (es) | 1992-07-20 | 1994-12-16 | Espanola Prod Quimicos | Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol. |
| ES2124167B1 (es) | 1996-06-04 | 1999-09-16 | Espanola Prod Quimicos | Nuevos derivados del bencimidazol con actividad antihistaminica. |
| EP1505066B1 (en) * | 2002-04-19 | 2006-12-06 | Faes Farma, S.A. | Polymorph of acid 4-[2-[4-[1-(2-ethoxyethyl)-1h-benzimidazole-2-il]-1-piperidinyl]ethyl]-alpha, alpha-dimethyl-benzeneacetic |
| US20080132419A1 (en) * | 2006-10-04 | 2008-06-05 | Nair Rodriguez-Hornedo | Dissolution and precipitation of cocrystals with ionizable components |
| CN103351380B (zh) * | 2013-06-30 | 2019-01-22 | 北京万全德众医药生物技术有限公司 | 一种制备比拉斯汀的方法 |
-
2015
- 2015-11-20 EP EP15382574.0A patent/EP3170816A1/en not_active Withdrawn
-
2016
- 2016-11-18 US US15/777,132 patent/US20180344854A1/en not_active Abandoned
- 2016-11-18 JP JP2018526144A patent/JP2018538267A/ja not_active Withdrawn
- 2016-11-18 ES ES16797944T patent/ES2778434T3/es active Active
- 2016-11-18 WO PCT/EP2016/078154 patent/WO2017085265A1/en not_active Ceased
- 2016-11-18 PT PT167979442T patent/PT3377479T/pt unknown
- 2016-11-18 EP EP16797944.2A patent/EP3377479B1/en active Active
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