JP2018538267A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018538267A5 JP2018538267A5 JP2018526144A JP2018526144A JP2018538267A5 JP 2018538267 A5 JP2018538267 A5 JP 2018538267A5 JP 2018526144 A JP2018526144 A JP 2018526144A JP 2018526144 A JP2018526144 A JP 2018526144A JP 2018538267 A5 JP2018538267 A5 JP 2018538267A5
- Authority
- JP
- Japan
- Prior art keywords
- aqueous solution
- acid
- bilastin
- concentration
- organic carboxylic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000007864 aqueous solution Substances 0.000 claims 11
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 6
- 150000001735 carboxylic acids Chemical class 0.000 claims 5
- KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 claims 4
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 4
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 claims 3
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000000243 solution Substances 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 206010010741 Conjunctivitis Diseases 0.000 claims 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 2
- 235000011054 acetic acid Nutrition 0.000 claims 2
- 208000026935 allergic disease Diseases 0.000 claims 2
- HWXBTNAVRSUOJR-UHFFFAOYSA-N alpha-hydroxyglutaric acid Natural products OC(=O)C(O)CCC(O)=O HWXBTNAVRSUOJR-UHFFFAOYSA-N 0.000 claims 2
- 229940009533 alpha-ketoglutaric acid Drugs 0.000 claims 2
- 239000013078 crystal Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 235000019260 propionic acid Nutrition 0.000 claims 2
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims 2
- 239000002002 slurry Substances 0.000 claims 2
- 239000011975 tartaric acid Substances 0.000 claims 2
- 235000002906 tartaric acid Nutrition 0.000 claims 2
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 208000024780 Urticaria Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 206010039083 rhinitis Diseases 0.000 claims 1
- 239000012047 saturated solution Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15382574.0 | 2015-11-20 | ||
| EP15382574.0A EP3170816A1 (en) | 2015-11-20 | 2015-11-20 | Supersaturated compositions of benzimidazole compounds |
| PCT/EP2016/078154 WO2017085265A1 (en) | 2015-11-20 | 2016-11-18 | Supersaturated compositions of benzimidazole compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018538267A JP2018538267A (ja) | 2018-12-27 |
| JP2018538267A5 true JP2018538267A5 (https=) | 2019-07-11 |
Family
ID=54707730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018526144A Withdrawn JP2018538267A (ja) | 2015-11-20 | 2016-11-18 | ベンズイミダゾール化合物の過飽和組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20180344854A1 (https=) |
| EP (2) | EP3170816A1 (https=) |
| JP (1) | JP2018538267A (https=) |
| ES (1) | ES2778434T3 (https=) |
| PT (1) | PT3377479T (https=) |
| WO (1) | WO2017085265A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112020007569A2 (pt) | 2017-10-16 | 2020-09-24 | Faes Farma, S.A. | composições aquosas de bilastina |
| CN116211795B (zh) * | 2022-12-26 | 2025-09-26 | 深圳市贝美药业有限公司 | 一种比拉斯汀口服液体制剂及其制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US818454A (en) * | 1904-04-06 | 1906-04-24 | Andrew Krus | Lathe-dog. |
| ES2048109B1 (es) | 1992-07-20 | 1994-12-16 | Espanola Prod Quimicos | Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol. |
| ES2124167B1 (es) | 1996-06-04 | 1999-09-16 | Espanola Prod Quimicos | Nuevos derivados del bencimidazol con actividad antihistaminica. |
| NZ536551A (en) * | 2002-04-19 | 2006-08-31 | Faes Farma S | Preparation of polymorphous cyrstalline form, known as bilastine, and its antihistaminic and antiallergenic use |
| US20080132419A1 (en) * | 2006-10-04 | 2008-06-05 | Nair Rodriguez-Hornedo | Dissolution and precipitation of cocrystals with ionizable components |
| CN103351380B (zh) * | 2013-06-30 | 2019-01-22 | 北京万全德众医药生物技术有限公司 | 一种制备比拉斯汀的方法 |
-
2015
- 2015-11-20 EP EP15382574.0A patent/EP3170816A1/en not_active Withdrawn
-
2016
- 2016-11-18 EP EP16797944.2A patent/EP3377479B1/en active Active
- 2016-11-18 JP JP2018526144A patent/JP2018538267A/ja not_active Withdrawn
- 2016-11-18 US US15/777,132 patent/US20180344854A1/en not_active Abandoned
- 2016-11-18 WO PCT/EP2016/078154 patent/WO2017085265A1/en not_active Ceased
- 2016-11-18 ES ES16797944T patent/ES2778434T3/es active Active
- 2016-11-18 PT PT167979442T patent/PT3377479T/pt unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015517595A5 (https=) | ||
| JP6843103B2 (ja) | グルタルイミド誘導体、その使用、それに基づいた医薬組成物及びグルタルイミド誘導体を製造するための方法 | |
| JP2018516883A5 (https=) | ||
| JP2017524733A5 (https=) | ||
| JP2016503010A5 (https=) | ||
| NO20051726L (no) | Pyrimidinonderivaer som terapeutiske midler ovenfor akutte og kroniske inflammasjons-, iskemiske og remodeleringsprosesser | |
| FI3406609T3 (fi) | Bisyklisiä atsayhdisteitä muskariinireseptorin agonisteina | |
| NO20072193L (no) | 5-sulfonyl-1-piperidinylsubstituerte indolderivater som 5-HT6 reseptorantagonister for behandling av CNS lidelser | |
| JP2014525470A5 (https=) | ||
| NZ629323A (en) | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof | |
| JP2016530210A (ja) | ヘテロ環式ビニルオートタキシン阻害剤化合物 | |
| JP2016539157A5 (https=) | ||
| JP2017519015A5 (https=) | ||
| TW200529854A (en) | Salt forms of 4-(4-methylpiperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide | |
| JP2018538267A5 (https=) | ||
| JP2018520188A (ja) | 呼吸器合胞体ウイルス（ｒｓｖ）感染症の処置のためのｎ−［（３−アミノ−３−オキセタニル）メチル］−２−（２，３−ジヒドロ−１，１−ジオキシド−１，４−ベンゾチアゼピン−４（５ｈ）−イル）−６−メチル−４−キナゾリンアミンの結晶形 | |
| JP2018509426A5 (https=) | ||
| NO20064659L (no) | Nye kvarterniserte quinuklidin-estere | |
| JP2005529084A5 (https=) | ||
| JP2019516791A5 (https=) | ||
| CN103923168A (zh) | 一种阿加曲班一水合物的制备方法 | |
| JP2016523943A5 (https=) | ||
| PH12016500197A1 (en) | Novel biphenyl derivative and method for preparing same | |
| JP2010540440A5 (https=) | ||
| JP2016533367A5 (https=) |