JP2018537408A5 - - Google Patents
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- Publication number
- JP2018537408A5 JP2018537408A5 JP2018516713A JP2018516713A JP2018537408A5 JP 2018537408 A5 JP2018537408 A5 JP 2018537408A5 JP 2018516713 A JP2018516713 A JP 2018516713A JP 2018516713 A JP2018516713 A JP 2018516713A JP 2018537408 A5 JP2018537408 A5 JP 2018537408A5
- Authority
- JP
- Japan
- Prior art keywords
- oxy
- amine
- amino
- methyl
- dimethylpentyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3170DE2015 | 2015-10-01 | ||
| IN3170/DEL/2015 | 2015-10-01 | ||
| PCT/US2016/054471 WO2017059085A1 (en) | 2015-10-01 | 2016-09-29 | Biaryl kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018537408A JP2018537408A (ja) | 2018-12-20 |
| JP2018537408A5 true JP2018537408A5 (enExample) | 2019-11-07 |
| JP6785302B2 JP6785302B2 (ja) | 2020-11-18 |
Family
ID=57190217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018516713A Active JP6785302B2 (ja) | 2015-10-01 | 2016-09-29 | ビアリールキナーゼ阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10544120B2 (enExample) |
| EP (1) | EP3356340B1 (enExample) |
| JP (1) | JP6785302B2 (enExample) |
| KR (1) | KR102704295B1 (enExample) |
| CN (2) | CN108368084B (enExample) |
| ES (1) | ES2765730T3 (enExample) |
| WO (1) | WO2017059085A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2944466C (en) | 2014-04-02 | 2020-06-09 | Bristol-Myers Squibb Company | Biaryl kinase inhibitors |
| EP3356330B1 (en) | 2015-10-01 | 2019-11-20 | Bristol-Myers Squibb Company | Biaryl kinase inhibitors |
| CN108368084B (zh) | 2015-10-01 | 2020-10-16 | 百时美施贵宝公司 | 联芳基激酶抑制剂 |
| ES2891527T3 (es) | 2016-12-19 | 2022-01-28 | Novartis Ag | Nuevos derivados de ácido picolínico y su uso como intermedios |
| WO2021216441A1 (en) * | 2020-04-21 | 2021-10-28 | Lexicon Pharmaceuticals, Inc. | Aak1 inhibitors for use in treating viral infections |
| CN111995583A (zh) * | 2020-08-18 | 2020-11-27 | 上海毕得医药科技有限公司 | 一种1,5-二甲基嘧啶-2(1h)-酮的合成方法 |
| WO2023284838A1 (zh) * | 2021-07-15 | 2023-01-19 | 四川海思科制药有限公司 | Aak1抑制剂及其用途 |
| JP2025508781A (ja) * | 2022-03-01 | 2025-04-10 | レクシコン ファーマシューティカルズ インコーポレイテッド | Ａａｋ１阻害剤の合成に有用な方法及び化合物 |
| WO2023167807A1 (en) | 2022-03-01 | 2023-09-07 | Lexicon Pharmaceuticals, Inc. | Solid forms of (s)-l-((2',6-bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine and salts thereof |
| WO2024099430A1 (zh) * | 2022-11-10 | 2024-05-16 | 西藏海思科制药有限公司 | 一种含aak1抑制剂的药物组合物 |
| CN120641406A (zh) * | 2023-01-16 | 2025-09-12 | 上海海雁医药科技有限公司 | 杂环取代的含氮杂环衍生物、其药物组合物及应用与制备方法 |
| CN118772152B (zh) * | 2023-04-07 | 2026-01-02 | 艾立康药业股份有限公司 | 作为aak1抑制剂的氮杂环类化合物 |
| AU2024253688A1 (en) * | 2023-04-07 | 2025-10-23 | Alicorn Pharmaceutical Co., Ltd. | Nitrogen-containing heterocyclic compound as aak1 inhibitor |
| WO2025092928A1 (zh) * | 2023-11-02 | 2025-05-08 | 西藏海思科制药有限公司 | 一种可抑制连接蛋白相关激酶1的化合物、制备及其用途 |
| WO2025230262A1 (ko) | 2024-04-29 | 2025-11-06 | 심플렉스 주식회사 | 신규한 헤테로아릴 유도체 및 이의 aak1 억제 용도 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7348335B2 (en) * | 2002-11-05 | 2008-03-25 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of JAK and other protein kinases |
| CN112244015B (zh) * | 2012-02-29 | 2022-05-17 | 株式会社Mmag | 包括新型亚氨基吡啶衍生物的有害物防治组合物 |
| US8703953B2 (en) * | 2012-03-09 | 2014-04-22 | Bristol-Myers Squibb Company | Aryl ether-base kinase inhibitors |
| DK2822555T3 (en) | 2012-03-09 | 2018-02-05 | Lexicon Pharmaceuticals Inc | Inhibition of adapter-associated kinase 1 for the treatment of pain |
| US8901305B2 (en) * | 2012-07-31 | 2014-12-02 | Bristol-Myers Squibb Company | Aryl lactam kinase inhibitors |
| US9708337B2 (en) | 2013-02-22 | 2017-07-18 | Bristol-Myers Squibb Company | Aryl amide-based kinase inhibitors |
| US10253027B2 (en) | 2013-07-08 | 2019-04-09 | Bristol-Myers Squibb Company | Aryl lactam kinase inhibitors |
| EP3044226B1 (en) | 2013-09-11 | 2017-09-06 | Bristol-Myers Squibb Company | Aryl ether-base kinase inhibitors |
| US10206397B2 (en) * | 2013-09-19 | 2019-02-19 | Basf Se | N-acylimino heterocyclic compounds |
| CN106132414A (zh) | 2014-01-29 | 2016-11-16 | 百时美施贵宝公司 | 芳基内酰胺激酶抑制剂 |
| ES2701903T3 (es) | 2014-01-31 | 2019-02-26 | Bristol Myers Squibb Co | Inhibidores de cinasa a base de quinolina |
| CA2944466C (en) * | 2014-04-02 | 2020-06-09 | Bristol-Myers Squibb Company | Biaryl kinase inhibitors |
| EP3200797A1 (en) | 2014-09-30 | 2017-08-09 | Bristol-Myers Squibb Company | Quinazoline-based kinase inhibitors |
| EP3292124B1 (en) | 2015-04-10 | 2019-05-22 | Bristol-Myers Squibb Company | 6h-isochromeno[3,4-c]pyridines and benzo[c][1,7]naphthyridin-6-(5h)-ones as adaptor associated kinase 1 (aak1) inhibitors |
| EP3356330B1 (en) | 2015-10-01 | 2019-11-20 | Bristol-Myers Squibb Company | Biaryl kinase inhibitors |
| CN108368084B (zh) | 2015-10-01 | 2020-10-16 | 百时美施贵宝公司 | 联芳基激酶抑制剂 |
-
2016
- 2016-09-29 CN CN201680070440.1A patent/CN108368084B/zh active Active
- 2016-09-29 EP EP16785279.7A patent/EP3356340B1/en active Active
- 2016-09-29 WO PCT/US2016/054471 patent/WO2017059085A1/en not_active Ceased
- 2016-09-29 CN CN202010986635.9A patent/CN112142655A/zh active Pending
- 2016-09-29 US US15/763,280 patent/US10544120B2/en active Active
- 2016-09-29 KR KR1020187011874A patent/KR102704295B1/ko active Active
- 2016-09-29 JP JP2018516713A patent/JP6785302B2/ja active Active
- 2016-09-29 ES ES16785279T patent/ES2765730T3/es active Active
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