JP2018537408A5 - - Google Patents
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- Publication number
- JP2018537408A5 JP2018537408A5 JP2018516713A JP2018516713A JP2018537408A5 JP 2018537408 A5 JP2018537408 A5 JP 2018537408A5 JP 2018516713 A JP2018516713 A JP 2018516713A JP 2018516713 A JP2018516713 A JP 2018516713A JP 2018537408 A5 JP2018537408 A5 JP 2018537408A5
- Authority
- JP
- Japan
- Prior art keywords
- oxy
- amine
- amino
- methyl
- dimethylpentyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3170/DEL/2015 | 2015-10-01 | ||
| IN3170DE2015 | 2015-10-01 | ||
| PCT/US2016/054471 WO2017059085A1 (en) | 2015-10-01 | 2016-09-29 | Biaryl kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018537408A JP2018537408A (ja) | 2018-12-20 |
| JP2018537408A5 true JP2018537408A5 (enExample) | 2019-11-07 |
| JP6785302B2 JP6785302B2 (ja) | 2020-11-18 |
Family
ID=57190217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018516713A Active JP6785302B2 (ja) | 2015-10-01 | 2016-09-29 | ビアリールキナーゼ阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10544120B2 (enExample) |
| EP (1) | EP3356340B1 (enExample) |
| JP (1) | JP6785302B2 (enExample) |
| KR (1) | KR102704295B1 (enExample) |
| CN (2) | CN108368084B (enExample) |
| ES (1) | ES2765730T3 (enExample) |
| WO (1) | WO2017059085A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA028942B1 (ru) | 2014-04-02 | 2018-01-31 | Бристол-Майерс Сквибб Компани | Биарильные ингибиторы киназы |
| ES2765730T3 (es) | 2015-10-01 | 2020-06-10 | Bristol Myers Squibb Co | Inhibidores de biaril cinasa |
| CN108290843B (zh) | 2015-10-01 | 2021-08-24 | 百时美施贵宝公司 | 联芳基激酶抑制剂 |
| PL3555048T3 (pl) | 2016-12-19 | 2021-12-06 | Novartis Ag | Nowe pochodne kwasu pikolinowego i ich zastosowanie jako związki pośrednie |
| US11730723B2 (en) * | 2020-04-21 | 2023-08-22 | Lexicon Pharmaceuticals, Inc. | Compounds and methods for treating viral infections |
| CN111995583A (zh) * | 2020-08-18 | 2020-11-27 | 上海毕得医药科技有限公司 | 一种1,5-二甲基嘧啶-2(1h)-酮的合成方法 |
| MX2024000807A (es) | 2021-07-15 | 2024-02-06 | Xizang Haisco Pharmaceutical Co Ltd | Inhibidor de aak1 y uso de este. |
| WO2023167806A1 (en) * | 2022-03-01 | 2023-09-07 | Lexicon Pharmaceuticals, Inc. | Methods and compounds useful in the sythesis of an aak1 inhibitor |
| US12344596B2 (en) | 2022-03-01 | 2025-07-01 | Lexicon Pharmaceuticals, Inc. | Solid forms of (S)-1-((2′,6-bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine and salts thereof |
| CN120202001A (zh) * | 2022-11-10 | 2025-06-24 | 西藏海思科制药有限公司 | 一种含aak1抑制剂的药物组合物 |
| CN120641406A (zh) * | 2023-01-16 | 2025-09-12 | 上海海雁医药科技有限公司 | 杂环取代的含氮杂环衍生物、其药物组合物及应用与制备方法 |
| CN118772152B (zh) * | 2023-04-07 | 2026-01-02 | 艾立康药业股份有限公司 | 作为aak1抑制剂的氮杂环类化合物 |
| KR20250167096A (ko) | 2023-04-07 | 2025-11-28 | 앨리콘 파머슈티컬 컴퍼니 리미티드 | Aak1 억제제인 질소 함유 헤테로고리계 화합물 |
| WO2025092928A1 (zh) * | 2023-11-02 | 2025-05-08 | 西藏海思科制药有限公司 | 一种可抑制连接蛋白相关激酶1的化合物、制备及其用途 |
| WO2025230262A1 (ko) | 2024-04-29 | 2025-11-06 | 심플렉스 주식회사 | 신규한 헤테로아릴 유도체 및 이의 aak1 억제 용도 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7348335B2 (en) * | 2002-11-05 | 2008-03-25 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of JAK and other protein kinases |
| UA115326C2 (uk) * | 2012-02-29 | 2017-10-25 | Мейдзі Сейка Фарма Ко., Лтд. | Композиція для боротьби зі шкідниками, яка включає нове похідне імінопіридину |
| US8703953B2 (en) * | 2012-03-09 | 2014-04-22 | Bristol-Myers Squibb Company | Aryl ether-base kinase inhibitors |
| HUE036040T2 (hu) | 2012-03-09 | 2018-06-28 | Lexicon Pharmaceuticals Inc | Adaptor-asszociált kináz 1 gátlása fájdalom kezelésére |
| US8901305B2 (en) | 2012-07-31 | 2014-12-02 | Bristol-Myers Squibb Company | Aryl lactam kinase inhibitors |
| WO2014130258A1 (en) | 2013-02-22 | 2014-08-28 | Bristol-Myers Squibb Company | 5h-chromeno[3,4-c]pyridines as inhibitors of adaptor associated kinase 1 (aak1) |
| EP3019475A1 (en) | 2013-07-08 | 2016-05-18 | Bristol-Myers Squibb Company | Aryl amide kinase inhibitors |
| CN105683196B (zh) | 2013-09-11 | 2018-12-21 | 百时美施贵宝公司 | 基于芳基醚的激酶抑制剂 |
| CA2922506A1 (en) * | 2013-09-19 | 2015-03-26 | Basf Se | N-acylimino heterocyclic compounds |
| JP6276865B2 (ja) | 2014-01-29 | 2018-02-07 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | アリールラクタムキナーゼ阻害剤 |
| EA201691397A1 (ru) | 2014-01-31 | 2016-11-30 | Бристол-Майерс Сквибб Компани | Хинолиновые ингибиторы киназы |
| EA028942B1 (ru) * | 2014-04-02 | 2018-01-31 | Бристол-Майерс Сквибб Компани | Биарильные ингибиторы киназы |
| US20170239249A1 (en) | 2014-09-30 | 2017-08-24 | Bristol-Myers Squibb Company | Quinazoline-based kinase inhibitors |
| US10174044B2 (en) | 2015-04-10 | 2019-01-08 | Bristol-Myers Squibb Company | Fused pyridines as kinase inhibitors |
| ES2765730T3 (es) | 2015-10-01 | 2020-06-10 | Bristol Myers Squibb Co | Inhibidores de biaril cinasa |
| CN108290843B (zh) | 2015-10-01 | 2021-08-24 | 百时美施贵宝公司 | 联芳基激酶抑制剂 |
-
2016
- 2016-09-29 ES ES16785279T patent/ES2765730T3/es active Active
- 2016-09-29 EP EP16785279.7A patent/EP3356340B1/en active Active
- 2016-09-29 CN CN201680070440.1A patent/CN108368084B/zh active Active
- 2016-09-29 JP JP2018516713A patent/JP6785302B2/ja active Active
- 2016-09-29 KR KR1020187011874A patent/KR102704295B1/ko active Active
- 2016-09-29 CN CN202010986635.9A patent/CN112142655A/zh active Pending
- 2016-09-29 WO PCT/US2016/054471 patent/WO2017059085A1/en not_active Ceased
- 2016-09-29 US US15/763,280 patent/US10544120B2/en active Active
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