JP2018528949A - Ｐｉ３ｋ阻害剤およびｍｄｍ２阻害剤を使用する組み合わせ療法 - Google Patents

Ｐｉ３ｋ阻害剤およびｍｄｍ２阻害剤を使用する組み合わせ療法 Download PDF

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Publication number
JP2018528949A
JP2018528949A JP2018510878A JP2018510878A JP2018528949A JP 2018528949 A JP2018528949 A JP 2018528949A JP 2018510878 A JP2018510878 A JP 2018510878A JP 2018510878 A JP2018510878 A JP 2018510878A JP 2018528949 A JP2018528949 A JP 2018528949A
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Japan
Prior art keywords
cancer
compound
inhibitor
formula
pharmaceutical combination
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JP2018510878A
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English (en)
Japanese (ja)
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JP2018528949A5 (OSRAM
Inventor
キャポニグロ，ジョルダーノ
ホーン−スピローン，トーマス
レハール，ジョゼフ
Original Assignee
ノバルティス アーゲー
ノバルティス アーゲー
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Application filed by ノバルティス アーゲー, ノバルティス アーゲー filed Critical ノバルティス アーゲー
Publication of JP2018528949A publication Critical patent/JP2018528949A/ja
Publication of JP2018528949A5 publication Critical patent/JP2018528949A5/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2018510878A 2015-08-28 2016-08-25 Ｐｉ３ｋ阻害剤およびｍｄｍ２阻害剤を使用する組み合わせ療法 Pending JP2018528949A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562211016P 2015-08-28 2015-08-28
US62/211,016 2015-08-28
PCT/IB2016/055075 WO2017037586A1 (en) 2015-08-28 2016-08-25 Combination therapy using pi3k inhbitor and mdm2 inhibitor

Publications (2)

Publication Number Publication Date
JP2018528949A true JP2018528949A (ja) 2018-10-04
JP2018528949A5 JP2018528949A5 (OSRAM) 2019-10-03

Family

ID=56896742

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018510878A Pending JP2018528949A (ja) 2015-08-28 2016-08-25 Ｐｉ３ｋ阻害剤およびｍｄｍ２阻害剤を使用する組み合わせ療法

Country Status (5)

Country Link
US (1) US20180318275A1 (OSRAM)
EP (1) EP3341023A1 (OSRAM)
JP (1) JP2018528949A (OSRAM)
CN (1) CN108348611A (OSRAM)
WO (1) WO2017037586A1 (OSRAM)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112018000496A2 (pt) * 2015-08-14 2018-09-11 Novartis Ag combinações farmacêuticas e seu uso
EP3687981A4 (en) * 2017-09-26 2021-03-31 The Regents of the University of California COMPOSITIONS AND METHODS OF TREATMENT OF CANCER
CN108486041A (zh) * 2018-03-28 2018-09-04 华南农业大学 PI3K/Akt信号通路在鸡胚成纤维细胞内对马立克氏病毒增殖的应用及其检测方法
TW202123941A (zh) * 2019-09-16 2021-07-01 瑞士商諾華公司 Ｍｄｍ２抑制劑用於治療骨髓纖維化之用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015070224A2 (en) * 2013-11-11 2015-05-14 Amgen Inc. Combination therapy including an mdm2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8168784B2 (en) 2008-06-20 2012-05-01 Abbott Laboratories Processes to make apoptosis promoters
UA104147C2 (uk) 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
CU24130B1 (es) * 2009-12-22 2015-09-29 Novartis Ag Isoquinolinonas y quinazolinonas sustituidas
US8440693B2 (en) 2009-12-22 2013-05-14 Novartis Ag Substituted isoquinolinones and quinazolinones
US8815926B2 (en) * 2012-01-26 2014-08-26 Novartis Ag Substituted pyrrolo[3,4-D]imidazoles for the treatment of MDM2/4 mediated diseases
WO2015097622A1 (en) * 2013-12-23 2015-07-02 Novartis Ag Pharmaceutical combinations

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015070224A2 (en) * 2013-11-11 2015-05-14 Amgen Inc. Combination therapy including an mdm2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PAREJA, FRESIA ET AL.: "PI3K and BCL2 Inhibition Primes Glioblastoma Cells to Apoptosis through Downregulation of Mcl-1 and", MOLECULAR CANCER RESEARCH, vol. 12, no. 7, JPN6020023548, 2014, pages 987 - 1001, ISSN: 0004298311 *
SANJEEV SHANGARY ET AL.: "Targeting the MDM2-p53 Interaction for Cancer Therapy", CLINICAL CANCER RESEARCH, vol. 14, no. 17, JPN6020023551, 2008, pages 5318 - 5324, ISSN: 0004298312 *

Also Published As

Publication number Publication date
EP3341023A1 (en) 2018-07-04
CN108348611A (zh) 2018-07-31
US20180318275A1 (en) 2018-11-08
WO2017037586A1 (en) 2017-03-09

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