JP2018527324A5 - - Google Patents

Info

Publication number

JP2018527324A5

JP2018527324A5 JP2018503213A JP2018503213A JP2018527324A5 JP 2018527324 A5 JP2018527324 A5 JP 2018527324A5 JP 2018503213 A JP2018503213 A JP 2018503213A JP 2018503213 A JP2018503213 A JP 2018503213A JP 2018527324 A5 JP2018527324 A5 JP 2018527324A5

Authority

JP

Japan

Prior art keywords

alkyl

phenyl

aryl

thiazole

acetamide

Prior art date

2016-07-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 150000001875 compounds Chemical class 0.000 claims description 12
• 206010028980 Neoplasm Diseases 0.000 claims description 4
• 201000011510 cancer Diseases 0.000 claims description 4
• 230000000155 isotopic effect Effects 0.000 claims description 4
• 150000003839 salts Chemical class 0.000 claims description 4
• 239000012453 solvate Substances 0.000 claims description 4
• DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 28
• 125000000217 alkyl group Chemical group 0.000 claims 21
• -1 octa-1-ynyl Chemical group 0.000 claims 19
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 15
• 125000003118 aryl group Chemical group 0.000 claims 13
• 125000000304 alkynyl group Chemical group 0.000 claims 7
• 125000003342 alkenyl group Chemical group 0.000 claims 6
• 229910052736 halogen Inorganic materials 0.000 claims 6
• 150000002367 halogens Chemical class 0.000 claims 6
• 125000004432 carbon atom Chemical group C* 0.000 claims 5
• KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims 4
• 150000002430 hydrocarbons Chemical group 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 229940124530 sulfonamide Drugs 0.000 claims 3
• RGICCULPCWNRAB-UHFFFAOYSA-N 2-[2-(2-hexoxyethoxy)ethoxy]ethanol Chemical compound CCCCCCOCCOCCOCCO RGICCULPCWNRAB-UHFFFAOYSA-N 0.000 claims 2
• 125000000266 alpha-aminoacyl group Chemical group 0.000 claims 2
• 125000004122 cyclic group Chemical group 0.000 claims 2
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
• PQNFLJBBNBOBRQ-UHFFFAOYSA-N indane Chemical compound C1=CC=C2CCCC2=C1 PQNFLJBBNBOBRQ-UHFFFAOYSA-N 0.000 claims 2
• 241000894007 species Species 0.000 claims 2
• 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 1
• WGEWFHNQCHZZMF-UHFFFAOYSA-N 3-ethynylbenzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC(C#C)=C1 WGEWFHNQCHZZMF-UHFFFAOYSA-N 0.000 claims 1
• ZZLCFHIKESPLTH-UHFFFAOYSA-N 4-Methylbiphenyl Chemical compound C1=CC(C)=CC=C1C1=CC=CC=C1 ZZLCFHIKESPLTH-UHFFFAOYSA-N 0.000 claims 1
• 241001465754 Metazoa Species 0.000 claims 1
• 229910052799 carbon Inorganic materials 0.000 claims 1
• 125000000753 cycloalkyl group Chemical group 0.000 claims 1
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
• 201000001441 melanoma Diseases 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 150000003456 sulfonamides Chemical class 0.000 claims 1
• 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
• 208000024891 symptom Diseases 0.000 claims 1