JP2018526443A - 全身性エリテマトーデスを治療するためのｌｇａｌｓ３ｂｐの調節方法 - Google Patents

全身性エリテマトーデスを治療するためのｌｇａｌｓ３ｂｐの調節方法 Download PDF

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Publication number
JP2018526443A
JP2018526443A JP2018530651A JP2018530651A JP2018526443A JP 2018526443 A JP2018526443 A JP 2018526443A JP 2018530651 A JP2018530651 A JP 2018530651A JP 2018530651 A JP2018530651 A JP 2018530651A JP 2018526443 A JP2018526443 A JP 2018526443A
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JP
Japan
Prior art keywords
lgals3bp
patient
cells
antibody
cell
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JP2018530651A
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English (en)
Japanese (ja)
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JP2018526443A5 (https=
Inventor
デマルティノ ジュリー
デマルティノ ジュリー
デリー ジョナサン
デリー ジョナサン
ブラフ ヤロミール
ブラフ ヤロミール
ルイス ヌルデン
ルイス ヌルデン
ジェネスト メリンダ
ジェネスト メリンダ
オキツ シンジ
オキツ シンジ
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Merck Patent GmbH
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Merck Patent GmbH
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Publication of JP2018526443A publication Critical patent/JP2018526443A/ja
Publication of JP2018526443A5 publication Critical patent/JP2018526443A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2018530651A 2015-08-31 2016-08-30 全身性エリテマトーデスを治療するためのｌｇａｌｓ３ｂｐの調節方法 Pending JP2018526443A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562212163P 2015-08-31 2015-08-31
US62/212,163 2015-08-31
PCT/US2016/049378 WO2017040464A1 (en) 2015-08-31 2016-08-30 Methods for the modulation of lgals3bp to treat systemic lupus erythematosus

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020199985A Division JP2021050217A (ja) 2015-08-31 2020-12-02 全身性エリテマトーデスを治療するためのｌｇａｌｓ３ｂｐの調節方法

Publications (2)

Publication Number Publication Date
JP2018526443A true JP2018526443A (ja) 2018-09-13
JP2018526443A5 JP2018526443A5 (https=) 2019-08-15

Family

ID=56883878

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2018530651A Pending JP2018526443A (ja) 2015-08-31 2016-08-30 全身性エリテマトーデスを治療するためのｌｇａｌｓ３ｂｐの調節方法
JP2020199985A Pending JP2021050217A (ja) 2015-08-31 2020-12-02 全身性エリテマトーデスを治療するためのｌｇａｌｓ３ｂｐの調節方法

Family Applications After (1)

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JP2020199985A Pending JP2021050217A (ja) 2015-08-31 2020-12-02 全身性エリテマトーデスを治療するためのｌｇａｌｓ３ｂｐの調節方法

Country Status (9)

Country Link
US (1) US20180251559A1 (https=)
EP (1) EP3344283A1 (https=)
JP (2) JP2018526443A (https=)
CN (1) CN107921112A (https=)
AU (1) AU2016317768A1 (https=)
CA (1) CA2994180A1 (https=)
HK (1) HK1252815A1 (https=)
IL (1) IL257755A (https=)
WO (1) WO2017040464A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022005068A1 (ko) * 2020-06-30 2022-01-06 재단법인 아산사회복지재단 Lgals3bp에 특이적으로 결합하는 항체 및 이의 용도
JP2024516019A (ja) * 2021-05-04 2024-04-11 ノバルティス アーゲー 抗ｂａｆｆｒ抗体を使用する全身性エリテマトーデスのための治療
WO2025075163A1 (ja) * 2023-10-04 2025-04-10 国立大学法人東北大学 自己反応性ｄｎ２ｂ細胞が産生する自己抗体およびその使用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018156448A1 (en) * 2017-02-21 2018-08-30 The Board Of Regents Of The Uiversity Of Texas System Prediction and treatment of immunotherapeutic toxicity
KR101946884B1 (ko) * 2017-04-25 2019-02-13 고려대학교 산학협력단 대사체 분석을 이용한 베체트병의 진단방법
KR102704018B1 (ko) * 2020-06-30 2024-09-06 재단법인 아산사회복지재단 Lgals3bp에 특이적으로 결합하는 항체 및 이의 용도
EP4318629A4 (en) 2021-03-24 2025-11-12 Agc Inc Primer for energy storage device electrodes, primer layer formation composition, electrode for energy storage devices, and secondary battery

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013527834A (ja) * 2010-03-29 2013-07-04 マサチューセッツ インスティテュート オブ テクノロジー 抗炎症因子

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CN1247472A (zh) * 1997-01-10 2000-03-15 拜奥根有限公司 用抗cd40l化合物治疗狼疮性肾炎
EP1455813B1 (en) * 2001-12-18 2015-07-15 mondoBIOTECH AG Interferon gamma in combination with a diagnostic array for use in the improved treatment of idiopathic pulmonary fibrosis
US8163896B1 (en) * 2002-11-14 2012-04-24 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory genes and uses thereof
ES2244270A1 (es) * 2003-01-31 2005-12-01 Pilar Universidad Autonoma De Madrid Nueva estrategia de regulacion inmune fundamentada en la molecula inducible durante la activacion leucocitaria cd69.
WO2004076682A2 (en) * 2003-02-26 2004-09-10 Surromed, Inc. Targets for controlling cellular growth and for diagnostic methods
WO2011119185A1 (en) * 2010-03-26 2011-09-29 La Jolla Institute For Allergy And Immunology Methods of inhibiting inflammation and inflammatory diseases using gal-3bp (btbd17b, lgals3bp, galectin-3 binding protein, mac-2 binding protein)
WO2012074396A1 (en) * 2010-11-30 2012-06-07 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg Method for prognosticating the clinical response of a patient to b-lymphocyte inhibiting or depleting therapy in interferon driven diseases such as sle

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013527834A (ja) * 2010-03-29 2013-07-04 マサチューセッツ インスティテュート オブ テクノロジー 抗炎症因子

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022005068A1 (ko) * 2020-06-30 2022-01-06 재단법인 아산사회복지재단 Lgals3bp에 특이적으로 결합하는 항체 및 이의 용도
JP2024516019A (ja) * 2021-05-04 2024-04-11 ノバルティス アーゲー 抗ｂａｆｆｒ抗体を使用する全身性エリテマトーデスのための治療
WO2025075163A1 (ja) * 2023-10-04 2025-04-10 国立大学法人東北大学 自己反応性ｄｎ２ｂ細胞が産生する自己抗体およびその使用

Also Published As

Publication number Publication date
CA2994180A1 (en) 2017-03-09
EP3344283A1 (en) 2018-07-11
IL257755A (en) 2018-04-30
WO2017040464A1 (en) 2017-03-09
HK1252815A1 (zh) 2019-06-06
AU2016317768A1 (en) 2018-02-22
JP2021050217A (ja) 2021-04-01
US20180251559A1 (en) 2018-09-06
CN107921112A (zh) 2018-04-17

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