JP2018521056A5 - - Google Patents
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- Publication number
- JP2018521056A5 JP2018521056A5 JP2017568056A JP2017568056A JP2018521056A5 JP 2018521056 A5 JP2018521056 A5 JP 2018521056A5 JP 2017568056 A JP2017568056 A JP 2017568056A JP 2017568056 A JP2017568056 A JP 2017568056A JP 2018521056 A5 JP2018521056 A5 JP 2018521056A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- pharmaceutically acceptable
- acceptable salt
- prevention
- hiv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims description 15
- 239000011780 sodium chloride Substances 0.000 claims description 15
- 230000002265 prevention Effects 0.000 claims description 4
- 241000580858 Simian-Human immunodeficiency virus Species 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000001629 suppression Effects 0.000 claims 1
- 0 **CNc1n[o]nc1C(*NO)Nc(cc1Br)ccc1F Chemical compound **CNc1n[o]nc1C(*NO)Nc(cc1Br)ccc1F 0.000 description 10
- ASKFAJSXYFJELQ-UHFFFAOYSA-N C=[Br]c1cc(NC(c2n[o]nc2NCCNC(c(cc2)cc3c2C=COB3O)=O)NO)ccc1F Chemical compound C=[Br]c1cc(NC(c2n[o]nc2NCCNC(c(cc2)cc3c2C=COB3O)=O)NO)ccc1F ASKFAJSXYFJELQ-UHFFFAOYSA-N 0.000 description 2
- RIYRBWHNQTZMBR-UHFFFAOYSA-N CC(C)C(C1=CC=C(CCOB2O)C2C1)=O Chemical compound CC(C)C(C1=CC=C(CCOB2O)C2C1)=O RIYRBWHNQTZMBR-UHFFFAOYSA-N 0.000 description 2
- DNXAZITYJYNQPQ-UHFFFAOYSA-N CC(C)C(c1cccc2c1B(O)OC2)=O Chemical compound CC(C)C(c1cccc2c1B(O)OC2)=O DNXAZITYJYNQPQ-UHFFFAOYSA-N 0.000 description 2
- IZBNWPJOYYKSFJ-UHFFFAOYSA-N CC(C)C(c1cccc2c1B(O)OC=C2)=C Chemical compound CC(C)C(c1cccc2c1B(O)OC=C2)=C IZBNWPJOYYKSFJ-UHFFFAOYSA-N 0.000 description 2
- KAACQIWZUMBEBJ-UHFFFAOYSA-N CC(C)Cc1c(COB2O)c2ccc1 Chemical compound CC(C)Cc1c(COB2O)c2ccc1 KAACQIWZUMBEBJ-UHFFFAOYSA-N 0.000 description 2
- NGCVQDIQHBKURP-UHFFFAOYSA-N OB1OC=Cc2cccc(C(NCCNc3n[o]nc3C(Nc(cc3Br)ccc3F)NO)=O)c12 Chemical compound OB1OC=Cc2cccc(C(NCCNc3n[o]nc3C(Nc(cc3Br)ccc3F)NO)=O)c12 NGCVQDIQHBKURP-UHFFFAOYSA-N 0.000 description 2
- OYXGRSQLNLZJRZ-UHFFFAOYSA-N OB1OCCc2c1c(C=O)ccc2 Chemical compound OB1OCCc2c1c(C=O)ccc2 OYXGRSQLNLZJRZ-UHFFFAOYSA-N 0.000 description 2
- QWIUWMGHWXDMAA-UHFFFAOYSA-N OB1OCCc2cccc(C(NCCNc3n[o]nc3C(CNO)Nc(cc3Br)ccc3F)=O)c12 Chemical compound OB1OCCc2cccc(C(NCCNc3n[o]nc3C(CNO)Nc(cc3Br)ccc3F)=O)c12 QWIUWMGHWXDMAA-UHFFFAOYSA-N 0.000 description 2
- 206010000565 Acquired immunodeficiency syndrome Diseases 0.000 description 1
- 206010062016 Immunosuppression Diseases 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001506 immunosuppresive Effects 0.000 description 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562187937P | 2015-07-02 | 2015-07-02 | |
US62/187,937 | 2015-07-02 | ||
PCT/IB2016/053947 WO2017002078A1 (en) | 2015-07-02 | 2016-06-30 | Inhibitors of indoleamine 2,3-dioxygenase |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2018521056A JP2018521056A (ja) | 2018-08-02 |
JP2018521056A5 true JP2018521056A5 (US07794700-20100914-C00152.png) | 2019-05-09 |
JP6654208B2 JP6654208B2 (ja) | 2020-02-26 |
Family
ID=56363880
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017568056A Expired - Fee Related JP6654208B2 (ja) | 2015-07-02 | 2016-06-30 | インドールアミン2,3−ジオキシゲナーゼの阻害剤 |
Country Status (11)
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108530444B (zh) * | 2018-06-11 | 2021-08-24 | 药康众拓(江苏)医药科技有限公司 | 一种新型nampt和ido双重抑制剂及其制备方法和医药用途 |
WO2020092528A1 (en) | 2018-10-31 | 2020-05-07 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity |
JP7460644B2 (ja) | 2018-10-31 | 2024-04-02 | ギリアード サイエンシーズ, インコーポレイテッド | Hpk1阻害剤としての置換6-アザベンゾイミダゾール化合物 |
TWI826690B (zh) | 2019-05-23 | 2023-12-21 | 美商基利科學股份有限公司 | 經取代之烯吲哚酮化物及其用途 |
CN110156629A (zh) * | 2019-05-30 | 2019-08-23 | 广州药本君安医药科技股份有限公司 | 丙卡巴肼的合成方法 |
EP4052705A1 (en) | 2021-03-05 | 2022-09-07 | Universität Basel Vizerektorat Forschung | Compositions for the treatment of ebv associated diseases or conditions |
KR20230152715A (ko) | 2021-03-05 | 2023-11-03 | 유니버시타트 바셀 | Ebv 관련 질환 또는 질병의 치료용 조성물 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB427857A (en) | 1934-08-02 | 1935-05-01 | Newsum Sons & Company Ltd H | A new or improved system of construction for skeleton structures, particularly vehicle body frames and door frames |
US4107288A (en) | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
EP1378509A4 (en) | 2001-03-19 | 2009-03-25 | Ono Pharmaceutical Co | DRUGS WITH TRIAZASPIRO ç5.5] UNDECANDERIVATES AS ACTIVE SUBSTANCE |
DK2559690T3 (en) * | 2005-05-10 | 2016-04-25 | Incyte Holdings Corp | Modulators of indoleamine 2,3-dioxygenase and methods of use thereof |
CA2620085C (en) | 2005-08-31 | 2016-07-12 | Celgene Corporation | Isoindole-imide compounds and compositions comprising and methods of using the same |
BRPI0915692B8 (pt) * | 2008-07-08 | 2021-05-25 | Incyte Corp | compostos derivados de 1,2,5-oxadiazóis, sua forma sólida, sua composição, bem como seus usos |
TW201221131A (en) * | 2010-11-18 | 2012-06-01 | Glaxo Group Ltd | Compounds |
CA2889182A1 (en) * | 2012-10-26 | 2014-05-01 | The University Of Chicago | Synergistic combination of immunologic inhibitors for the treatment of cancer |
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2016
- 2016-06-30 CA CA2990335A patent/CA2990335A1/en not_active Abandoned
- 2016-06-30 US US15/578,861 patent/US10239894B2/en not_active Expired - Fee Related
- 2016-06-30 RU RU2018101431A patent/RU2018101431A/ru not_active Application Discontinuation
- 2016-06-30 BR BR112017028456A patent/BR112017028456A2/pt not_active Application Discontinuation
- 2016-06-30 WO PCT/IB2016/053947 patent/WO2017002078A1/en active Application Filing
- 2016-06-30 AU AU2016285483A patent/AU2016285483B2/en not_active Ceased
- 2016-06-30 EP EP16735943.9A patent/EP3317287B1/en active Active
- 2016-06-30 KR KR1020187003254A patent/KR20180022988A/ko unknown
- 2016-06-30 CN CN201680039221.7A patent/CN107709338A/zh active Pending
- 2016-06-30 JP JP2017568056A patent/JP6654208B2/ja not_active Expired - Fee Related
- 2016-06-30 ES ES16735943T patent/ES2752455T3/es active Active