JP2018520644A5 - - Google Patents
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- JP2018520644A5 JP2018520644A5 JP2017557212A JP2017557212A JP2018520644A5 JP 2018520644 A5 JP2018520644 A5 JP 2018520644A5 JP 2017557212 A JP2017557212 A JP 2017557212A JP 2017557212 A JP2017557212 A JP 2017557212A JP 2018520644 A5 JP2018520644 A5 JP 2018520644A5
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- JP
- Japan
- Prior art keywords
- seq
- peptide
- cell
- cancer
- variant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 58
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 18
- 210000004027 cell Anatomy 0.000 claims description 17
- 238000000338 in vitro Methods 0.000 claims description 8
- 239000000427 antigen Substances 0.000 claims description 7
- 108091007433 antigens Proteins 0.000 claims description 7
- 102000036639 antigens Human genes 0.000 claims description 7
- 230000005847 immunogenicity Effects 0.000 claims description 6
- 238000010186 staining Methods 0.000 claims description 3
- 206010028980 Neoplasm Diseases 0.000 claims 18
- 238000000034 method Methods 0.000 claims 18
- 108020004707 nucleic acids Proteins 0.000 claims 13
- 102000039446 nucleic acids Human genes 0.000 claims 13
- 150000007523 nucleic acids Chemical class 0.000 claims 13
- 210000001519 tissue Anatomy 0.000 claims 13
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 11
- 239000013604 expression vector Substances 0.000 claims 11
- 108091008874 T cell receptors Proteins 0.000 claims 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 239000003446 ligand Substances 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 238000010195 expression analysis Methods 0.000 claims 4
- 230000014509 gene expression Effects 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 3
- 238000003556 assay Methods 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000003053 toxin Substances 0.000 claims 3
- 231100000765 toxin Toxicity 0.000 claims 3
- 108091023037 Aptamer Proteins 0.000 claims 2
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 2
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 2
- 102000043129 MHC class I family Human genes 0.000 claims 2
- 108091054437 MHC class I family Proteins 0.000 claims 2
- 230000005867 T cell response Effects 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000012636 effector Substances 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 230000003308 immunostimulating effect Effects 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 108010028930 invariant chain Proteins 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 230000003211 malignant effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 238000002493 microarray Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000002018 overexpression Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 229920002477 rna polymer Polymers 0.000 claims 2
- 238000012163 sequencing technique Methods 0.000 claims 2
- 238000003860 storage Methods 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 238000011510 Elispot assay Methods 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 102000018713 Histocompatibility Antigens Class II Human genes 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 108091054438 MHC class II family Proteins 0.000 claims 1
- 108700018351 Major Histocompatibility Complex Proteins 0.000 claims 1
- 208000002030 Merkel cell carcinoma Diseases 0.000 claims 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 229940022399 cancer vaccine Drugs 0.000 claims 1
- 238000002659 cell therapy Methods 0.000 claims 1
- 208000017763 cutaneous neuroendocrine carcinoma Diseases 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000003114 enzyme-linked immunosorbent spot assay Methods 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 238000011502 immune monitoring Methods 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 229940038309 personalized vaccine Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 238000012070 whole genome sequencing analysis Methods 0.000 claims 1
- 230000000638 stimulation Effects 0.000 description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- 239000011324 bead Substances 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021059554A JP7513561B2 (ja) | 2015-05-06 | 2021-03-31 | 結腸直腸がん（ｃｒｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチドとそのスキャフォールドとの組み合わせ |
| JP2024102557A JP2024125363A (ja) | 2015-05-06 | 2024-06-26 | 結腸直腸がん（ｃｒｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチドとそのスキャフォールドとの組み合わせ |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562157684P | 2015-05-06 | 2015-05-06 | |
| GBGB1507719.1A GB201507719D0 (en) | 2015-05-06 | 2015-05-06 | Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (CRC) and other cancers |
| GB1507719.1 | 2015-05-06 | ||
| US62/157,684 | 2015-05-06 | ||
| PCT/EP2016/060007 WO2016177784A1 (en) | 2015-05-06 | 2016-05-04 | Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (crc) and other cancers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021059554A Division JP7513561B2 (ja) | 2015-05-06 | 2021-03-31 | 結腸直腸がん（ｃｒｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチドとそのスキャフォールドとの組み合わせ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018520644A JP2018520644A (ja) | 2018-08-02 |
| JP2018520644A5 true JP2018520644A5 (enrdf_load_stackoverflow) | 2019-04-18 |
| JP6985153B2 JP6985153B2 (ja) | 2021-12-22 |
Family
ID=56026813
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017557212A Active JP6985153B2 (ja) | 2015-05-06 | 2016-05-04 | 結腸直腸がん（ｃｒｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチドとそのスキャフォールドとの組み合わせ |
| JP2024102557A Withdrawn JP2024125363A (ja) | 2015-05-06 | 2024-06-26 | 結腸直腸がん（ｃｒｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチドとそのスキャフォールドとの組み合わせ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024102557A Withdrawn JP2024125363A (ja) | 2015-05-06 | 2024-06-26 | 結腸直腸がん（ｃｒｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチドとそのスキャフォールドとの組み合わせ |
Country Status (14)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20210528T1 (hr) | 2015-05-06 | 2021-08-06 | Immatics Biotechnologies Gmbh | Novi peptidi i kombinacija peptida i njihovih skela za uporabu u imunoterapiji protiv kolorektalnog karcinoma i drugih karcinoma |
| MY198087A (en) | 2015-10-05 | 2023-07-31 | Immatics Biotechnologies Gmbh | Peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers |
| GB201603987D0 (en) | 2016-03-08 | 2016-04-20 | Immatics Biotechnologies Gmbh | Uterine cancer treatments |
| CN112816682B (zh) * | 2021-01-28 | 2024-03-26 | 浙江省农业科学院 | 三螺旋dna分子开关探针及其在ota比色快速检测中的应用 |
| JP2022186461A (ja) * | 2021-06-04 | 2022-12-15 | 地方独立行政法人東京都健康長寿医療センター | 前立腺がん治療用医薬組成物 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2677653A1 (fr) | 1991-06-17 | 1992-12-18 | Inst Nat Sante Rech Med | Fragments peptidiques issus du cytochrome humain p450 iid6, anticorps anti-fragments peptidiques et leurs applications dans le diagnostic de l'hepatite auto-immune. |
| US5891857A (en) | 1996-02-20 | 1999-04-06 | Vanderbilt University | Characterized BRCA1 and BRCA2 proteins and screening and therapeutic methods based on characterized BRCA1 and BRCA2 proteins |
| US6773878B1 (en) | 1999-11-09 | 2004-08-10 | Eos Biotechnology, Inc. | Methods of diagnosing of colorectal cancer, compositions, and methods of screening for colorectal cancer modulators |
| WO2001057252A2 (en) | 2000-02-04 | 2001-08-09 | Aeomica, Inc. | Methods and apparatus for high-throughput detection and characterization of alternatively spliced genes |
| SE0203137D0 (sv) | 2002-10-24 | 2002-10-24 | Karolinska Innovations Ab | Drug target in cancer therapy |
| JP2006526405A (ja) | 2003-06-04 | 2006-11-24 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | 示差的調節された肝細胞癌遺伝子およびその利用 |
| JP2006166789A (ja) * | 2004-12-15 | 2006-06-29 | Hiroshima Univ | 癌の新規診断方法 |
| CN101168566A (zh) * | 2006-10-26 | 2008-04-30 | 北京市肿瘤防治研究所 | 抗肿瘤特异性标志蛋白ts/medp的抗体制备及用途 |
| EP2565204B1 (en) * | 2007-07-27 | 2015-10-07 | immatics biotechnologies GmbH | Novel immunogenic epitopes for immunotherapy |
| WO2009052415A1 (en) * | 2007-10-17 | 2009-04-23 | The Regents Of The University Of California | Peptide for the induction of immune tolerance as treatment for systemic lupus erythematosus |
| DK2172211T3 (en) * | 2008-10-01 | 2015-02-16 | Immatics Biotechnologies Gmbh | Composition of tumor-associated peptides and related anti-cancer vaccine for the treatment of glioblastoma (GBM) and other cancers |
| WO2013040142A2 (en) | 2011-09-16 | 2013-03-21 | Iogenetics, Llc | Bioinformatic processes for determination of peptide binding |
| EP2956544B1 (en) * | 2013-02-14 | 2017-11-01 | Immunocellular Therapeutics Ltd. | Cancer vaccines and vaccination methods |
| TWI714869B (zh) | 2013-08-05 | 2021-01-01 | 德商伊瑪提克斯生物科技有限公司 | 新穎肽類，細胞及其用於治療多種腫瘤的用途，其製造方法及包含其等之醫藥組成物 |
| GB201319446D0 (en) | 2013-11-04 | 2013-12-18 | Immatics Biotechnologies Gmbh | Personalized immunotherapy against several neuronal and brain tumors |
| GB201505305D0 (en) | 2015-03-27 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel Peptides and combination of peptides for use in immunotherapy against various tumors |
| HRP20210528T1 (hr) | 2015-05-06 | 2021-08-06 | Immatics Biotechnologies Gmbh | Novi peptidi i kombinacija peptida i njihovih skela za uporabu u imunoterapiji protiv kolorektalnog karcinoma i drugih karcinoma |
| CL2022002182A1 (es) | 2022-08-11 | 2023-02-24 | Immatics Biotechnologies Gmbh | Péptidos, combinaciones y soportes para inmunoterapia contra carcinoma colorrectal y otros tipos de cáncer |
| CL2022002183A1 (es) | 2022-08-11 | 2023-02-24 | Immatics Biotechnologies Gmbh | Péptidos, combinaciones y soportes para inmunoterapia contra carcinoma colorrectal y otros tipos de cáncer |
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2016
- 2016-05-04 HR HRP20210528TT patent/HRP20210528T1/hr unknown
- 2016-05-04 CN CN201680025708.XA patent/CN107810193B/zh active Active
- 2016-05-04 MY MYPI2017704127A patent/MY185616A/en unknown
- 2016-05-04 KR KR1020247036001A patent/KR20240161207A/ko active Pending
- 2016-05-04 PH PH1/2021/550910A patent/PH12021550910A1/en unknown
- 2016-05-04 CR CR20230131A patent/CR20230131A/es unknown
- 2016-05-04 IL IL308202A patent/IL308202A/en unknown
- 2016-05-04 JP JP2017557212A patent/JP6985153B2/ja active Active
- 2016-05-06 TW TW112111135A patent/TW202330590A/zh unknown
- 2016-05-06 TW TW109141683A patent/TWI800770B/zh not_active IP Right Cessation
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2017
- 2017-10-18 IL IL255126A patent/IL255126A0/en unknown
- 2017-10-25 CO CONC2017/0010830A patent/CO2017010830A2/es unknown
- 2017-10-31 MX MX2022002263A patent/MX2022002263A/es unknown
- 2017-11-02 PH PH12017501994A patent/PH12017501994A1/en unknown
- 2017-11-02 CL CL2017002766A patent/CL2017002766A1/es unknown
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2021
- 2021-04-15 CY CY20211100329T patent/CY1124038T1/el unknown
- 2021-06-11 US US17/345,457 patent/US12150979B2/en active Active
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2022
- 2022-11-18 US US18/056,887 patent/US20230086855A1/en active Pending
- 2022-11-18 US US18/056,858 patent/US20230088845A1/en active Pending
- 2022-12-08 US US18/063,396 patent/US20230203113A1/en active Pending
- 2022-12-08 US US18/063,430 patent/US20230203114A1/en active Pending
- 2022-12-08 US US18/063,418 patent/US20230212244A1/en active Pending
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2024
- 2024-06-26 JP JP2024102557A patent/JP2024125363A/ja not_active Withdrawn