JP2018518201A5 - - Google Patents
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- Publication number
- JP2018518201A5 JP2018518201A5 JP2018518771A JP2018518771A JP2018518201A5 JP 2018518201 A5 JP2018518201 A5 JP 2018518201A5 JP 2018518771 A JP2018518771 A JP 2018518771A JP 2018518771 A JP2018518771 A JP 2018518771A JP 2018518201 A5 JP2018518201 A5 JP 2018518201A5
- Authority
- JP
- Japan
- Prior art keywords
- sirna
- amine
- containing compound
- pharmaceutically acceptable
- cholesterol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510364229.8 | 2015-06-26 | ||
| CN201510364229 | 2015-06-26 | ||
| PCT/CN2016/087034 WO2016206626A1 (zh) | 2015-06-26 | 2016-06-24 | 一种siRNA、含有该siRNA的药物组合物和缀合物及它们的应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018518201A JP2018518201A (ja) | 2018-07-12 |
| JP2018518201A5 true JP2018518201A5 (cg-RX-API-DMAC7.html) | 2019-06-13 |
| JP6715325B2 JP6715325B2 (ja) | 2020-07-01 |
Family
ID=57584730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018518771A Active JP6715325B2 (ja) | 2015-06-26 | 2016-06-24 | ｓｉＲＮＡ、ｓｉＲＮＡを含む医薬組成物及び結合体、並びにそれらの応用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20190062749A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3315608B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6715325B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN107849567B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016206626A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3073851A1 (en) * | 2017-08-31 | 2019-03-07 | Life Technologies Corporation | Cationic lipid compositions for tissue-specific delivery |
| JP7365052B2 (ja) | 2017-12-01 | 2023-10-19 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用 |
| CN111050807B (zh) * | 2017-12-01 | 2024-05-28 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| US11414661B2 (en) | 2017-12-01 | 2022-08-16 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate containing nucleic acid, preparation method therefor and use thereof |
| JP7273417B2 (ja) * | 2017-12-01 | 2023-05-15 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、当該核酸を含む組成物および複合体ならびに調製方法と使用 |
| JP7727308B2 (ja) * | 2017-12-01 | 2025-08-21 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 二本鎖オリゴヌクレオチド、二本鎖オリゴヌクレオチドを含む組成物および複合体ならびに調製方法と使用 |
| US12083142B2 (en) * | 2017-12-01 | 2024-09-10 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate comprising the same, and preparation method and use thereof |
| CN110945131B (zh) * | 2017-12-01 | 2024-05-28 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| DK3732185T3 (da) | 2017-12-29 | 2025-03-31 | Suzhou Ribo Life Science Co Ltd | Konjugater og fremstilling og anvendelse heraf |
| US11918600B2 (en) | 2018-08-21 | 2024-03-05 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition and conjugate containing nucleic acid, and use thereof |
| CN111655297A (zh) * | 2018-09-30 | 2020-09-11 | 苏州瑞博生物技术有限公司 | 一种siRNA缀合物及其制备方法和用途 |
| EP3903830A4 (en) | 2018-12-28 | 2023-04-26 | Suzhou Ribo Life Science Co., Ltd. | NUCLEIC ACID, COMPOSITION AND CONJUGATE WITH NUCLEIC ACID, PROCESS FOR THEIR PREPARATION AND ITS USE |
| CN112423795A (zh) * | 2018-12-28 | 2021-02-26 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| CN111377985B (zh) * | 2018-12-29 | 2023-11-10 | 苏州瑞博生物技术股份有限公司 | 化合物和缀合物及其制备方法和用途 |
| CN113330117B (zh) * | 2019-01-18 | 2024-05-28 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| AU2020280438B2 (en) * | 2019-05-22 | 2025-03-06 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use |
| CN111979237A (zh) * | 2019-05-22 | 2020-11-24 | 苏州瑞博生物技术股份有限公司 | 核酸、含有该核酸的药物组合物与siRNA缀合物及制备方法和用途 |
| CN111973617A (zh) * | 2019-05-23 | 2020-11-24 | 苏州瑞博生物技术股份有限公司 | 核酸、药物组合物与缀合物及制备方法和用途 |
| CN111973618B (zh) * | 2019-05-23 | 2024-02-02 | 苏州瑞博生物技术股份有限公司 | 核酸、药物组合物与siRNA缀合物及制备方法和用途 |
| US20230076803A1 (en) * | 2019-08-29 | 2023-03-09 | Suzhou Ribo Life Science Co., Ltd. | Compound and drug conjugate, and preparation method and use thereof |
| WO2021110148A1 (zh) * | 2019-12-06 | 2021-06-10 | 南京明德新药研发有限公司 | siRNA缀合物、双链siRNA缀合物及其盐和应用 |
| CN111110866B (zh) * | 2019-12-30 | 2023-04-11 | 福州大学 | 还原性聚谷氨酸/聚乙烯亚胺/siRNA复合纳米粒及制备与应用 |
| CN115702006B (zh) * | 2020-06-10 | 2025-12-23 | 南京明德新药研发有限公司 | 缀合基团及其缀合物 |
| CN113663089B (zh) * | 2021-06-25 | 2022-10-28 | 北京理工大学 | 可电离脂质纳米颗粒组合物、制备方法及应用 |
| WO2023116764A1 (zh) * | 2021-12-23 | 2023-06-29 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及其用途 |
| CN114634984A (zh) * | 2022-02-02 | 2022-06-17 | 复旦大学 | 一种脑胶质瘤生物标记物mlkl基因及其应用 |
| CN115487308B (zh) * | 2022-09-29 | 2024-09-27 | 北京大学 | 反义核酸糖基缀合物及其制备方法和在肝癌治疗中的应用 |
| CN120676949A (zh) * | 2022-12-08 | 2025-09-19 | 强新科技国际研究院 | 反义RNA（asRNA）技术及其应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2365077B1 (en) * | 2004-03-12 | 2013-05-08 | Alnylam Pharmaceuticals, Inc. | iRNA agents targeting VEGF |
| KR101147147B1 (ko) * | 2004-04-01 | 2012-05-25 | 머크 샤프 앤드 돔 코포레이션 | Ｒｎａ 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드 |
| CN101142316A (zh) * | 2005-03-09 | 2008-03-12 | 牧岩生命工学研究所 | 小干扰rna和包含它的用于治疗乙型肝炎的药物组合物 |
| CN101426912A (zh) * | 2005-08-17 | 2009-05-06 | 瑟纳治疗公司 | 介导rna干扰的化学修饰短干扰核酸分子 |
| CN102140461B (zh) * | 2010-01-29 | 2012-12-05 | 苏州瑞博生物技术有限公司 | 小干扰核酸和药物组合物及其制药应用 |
| CN102140458B (zh) * | 2010-01-29 | 2013-05-22 | 苏州瑞博生物技术有限公司 | 小干扰核酸和药物组合物及其制药应用 |
| WO2012068176A1 (en) * | 2010-11-15 | 2012-05-24 | Life Technologies Corporation | Amine-containing transfection reagents and methods for making and using same |
| BR112014010134A2 (pt) * | 2011-10-28 | 2019-09-24 | Goethe-University | inibição da expressão genética viral |
| IL284530B (en) * | 2011-11-18 | 2022-07-01 | Alnylam Pharmaceuticals Inc | rnai factors, preparations and methods of using them for the treatment of transthyretin-related diseases |
| CA2879693A1 (en) * | 2012-08-06 | 2014-02-13 | Alnylam Pharmaceuticals, Inc. | Carbohydrate conjugated rna agents and process for their preparation |
| KR20150095763A (ko) * | 2012-12-14 | 2015-08-21 | 다이서나 파마수이티컬, 인크. | 이중쇄 rna에 의한 ckap5의 특이적 저해를 위한 방법 및 조성물 |
| SMT201700552T1 (it) * | 2013-03-14 | 2018-01-11 | Alnylam Pharmaceuticals Inc | COMPOSIZIONI DI iRNA DEL COMPONENTE DEL COMPLEMENTO C5 E LORO METODI DI USO |
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2016
- 2016-06-24 US US15/738,006 patent/US20190062749A1/en not_active Abandoned
- 2016-06-24 EP EP16813742.0A patent/EP3315608B1/en active Active
- 2016-06-24 JP JP2018518771A patent/JP6715325B2/ja active Active
- 2016-06-24 WO PCT/CN2016/087034 patent/WO2016206626A1/zh not_active Ceased
- 2016-06-24 CN CN201680036513.5A patent/CN107849567B/zh active Active