JP2018515762A5 - - Google Patents
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- Publication number
- JP2018515762A5 JP2018515762A5 JP2017556249A JP2017556249A JP2018515762A5 JP 2018515762 A5 JP2018515762 A5 JP 2018515762A5 JP 2017556249 A JP2017556249 A JP 2017556249A JP 2017556249 A JP2017556249 A JP 2017556249A JP 2018515762 A5 JP2018515762 A5 JP 2018515762A5
- Authority
- JP
- Japan
- Prior art keywords
- clusterin
- specific
- renal
- kidney
- specifically bind
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000003780 Clusterin Human genes 0.000 claims description 85
- 108090000197 Clusterin Proteins 0.000 claims description 85
- 150000001720 carbohydrates Chemical class 0.000 claims description 39
- 108090001090 Lectins Proteins 0.000 claims description 36
- 102000004856 Lectins Human genes 0.000 claims description 36
- 239000002523 lectin Substances 0.000 claims description 36
- 238000000034 method Methods 0.000 claims description 29
- 108010029485 Protein Isoforms Proteins 0.000 claims description 28
- 102000001708 Protein Isoforms Human genes 0.000 claims description 28
- 210000003734 kidney Anatomy 0.000 claims description 27
- 230000027455 binding Effects 0.000 claims description 22
- 210000004369 blood Anatomy 0.000 claims description 16
- 239000008280 blood Substances 0.000 claims description 16
- 239000012634 fragment Substances 0.000 claims description 16
- 239000000427 antigen Substances 0.000 claims description 15
- 102000036639 antigens Human genes 0.000 claims description 15
- 108091007433 antigens Proteins 0.000 claims description 15
- 244000046052 Phaseolus vulgaris Species 0.000 claims description 9
- 108010046516 Wheat Germ Agglutinins Proteins 0.000 claims description 6
- 210000002966 serum Anatomy 0.000 claims description 6
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 claims description 4
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims description 4
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 claims description 4
- 101000690735 Triticum aestivum Agglutinin isolectin 2 Proteins 0.000 claims description 4
- 229950006780 n-acetylglucosamine Drugs 0.000 claims description 4
- 101710186708 Agglutinin Proteins 0.000 claims description 3
- 101710154606 Hemagglutinin Proteins 0.000 claims description 3
- 101710146024 Horcolin Proteins 0.000 claims description 3
- 101710189395 Lectin Proteins 0.000 claims description 3
- 101710179758 Mannose-specific lectin Proteins 0.000 claims description 3
- 101710150763 Mannose-specific lectin 1 Proteins 0.000 claims description 3
- 101710150745 Mannose-specific lectin 2 Proteins 0.000 claims description 3
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims description 3
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims description 3
- 235000010627 Phaseolus vulgaris Nutrition 0.000 claims description 3
- 101710176177 Protein A56 Proteins 0.000 claims description 3
- 101000690736 Triticum aestivum Agglutinin isolectin 1 Proteins 0.000 claims description 3
- 101000690738 Triticum aestivum Agglutinin isolectin 3 Proteins 0.000 claims description 3
- 239000000910 agglutinin Substances 0.000 claims description 3
- 108010014507 erythroagglutinating phytohemagglutinin Proteins 0.000 claims description 3
- 239000000185 hemagglutinin Substances 0.000 claims description 3
- 108010014765 tomato lectin Proteins 0.000 claims description 3
- 244000068988 Glycine max Species 0.000 claims description 2
- 235000010469 Glycine max Nutrition 0.000 claims description 2
- 244000061456 Solanum tuberosum Species 0.000 claims description 2
- 235000002595 Solanum tuberosum Nutrition 0.000 claims description 2
- 230000009870 specific binding Effects 0.000 claims description 2
- 238000003556 assay Methods 0.000 claims 9
- 241000124008 Mammalia Species 0.000 claims 5
- 208000017169 kidney disease Diseases 0.000 claims 5
- 206010061481 Renal injury Diseases 0.000 claims 4
- 241000282414 Homo sapiens Species 0.000 claims 3
- 238000002965 ELISA Methods 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 241000282326 Felis catus Species 0.000 claims 2
- 241000282465 Canis Species 0.000 claims 1
- 241000282324 Felis Species 0.000 claims 1
- 108010044467 Isoenzymes Proteins 0.000 claims 1
- 108010039491 Ricin Proteins 0.000 claims 1
- 240000008042 Zea mays Species 0.000 claims 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims 1
- 238000007818 agglutination assay Methods 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 235000005822 corn Nutrition 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 238000001502 gel electrophoresis Methods 0.000 claims 1
- 238000003018 immunoassay Methods 0.000 claims 1
- 238000003364 immunohistochemistry Methods 0.000 claims 1
- 239000006249 magnetic particle Substances 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 208000019206 urinary tract infection Diseases 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 102000009112 Mannose-Binding Lectin Human genes 0.000 description 1
- 108010087870 Mannose-Binding Lectin Proteins 0.000 description 1
- OVRNDRQMDRJTHS-RTRLPJTCSA-N N-acetyl-D-glucosamine Chemical class CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-RTRLPJTCSA-N 0.000 description 1
- 244000042324 Trifolium repens Species 0.000 description 1
- 235000013540 Trifolium repens var repens Nutrition 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- -1 sWGA Proteins 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021012877A JP2021099342A (ja) | 2015-04-30 | 2021-01-29 | クラステリンアイソフォームの特異的検出 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562155175P | 2015-04-30 | 2015-04-30 | |
| US62/155,175 | 2015-04-30 | ||
| PCT/US2016/030075 WO2016176565A1 (en) | 2015-04-30 | 2016-04-29 | Specific detection of clusterin isoforms |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021012877A Division JP2021099342A (ja) | 2015-04-30 | 2021-01-29 | クラステリンアイソフォームの特異的検出 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018515762A JP2018515762A (ja) | 2018-06-14 |
| JP2018515762A5 true JP2018515762A5 (enExample) | 2019-05-16 |
| JP6948265B2 JP6948265B2 (ja) | 2021-10-13 |
Family
ID=56069221
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017556249A Active JP6948265B2 (ja) | 2015-04-30 | 2016-04-29 | クラステリンアイソフォームの特異的検出 |
| JP2021012877A Pending JP2021099342A (ja) | 2015-04-30 | 2021-01-29 | クラステリンアイソフォームの特異的検出 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021012877A Pending JP2021099342A (ja) | 2015-04-30 | 2021-01-29 | クラステリンアイソフォームの特異的検出 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20180142009A1 (enExample) |
| EP (2) | EP4019976A1 (enExample) |
| JP (2) | JP6948265B2 (enExample) |
| KR (1) | KR102462056B1 (enExample) |
| CN (1) | CN108093648B (enExample) |
| AU (1) | AU2016254150B2 (enExample) |
| CA (1) | CA2983828A1 (enExample) |
| DK (1) | DK3289363T3 (enExample) |
| ES (1) | ES2907068T3 (enExample) |
| MX (1) | MX388832B (enExample) |
| WO (1) | WO2016176565A1 (enExample) |
| ZA (1) | ZA201707313B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3289363T3 (da) * | 2015-04-30 | 2022-02-28 | Idexx Lab Inc | Specifik påvisning af clusterin isoformer |
| EP3232200A1 (en) | 2016-04-12 | 2017-10-18 | Institut Catalá De Ciencies Cardiovasculars (ICCC) | Methods and kits for the diagnosis and risk stratification of patients with ischemia |
| FR3069156B1 (fr) | 2017-07-21 | 2019-08-09 | Universite de Bordeaux | Clusterine pour son utilisation dans le traitement des micro-angiopathies thrombotiques |
| CN109239362B (zh) * | 2018-10-22 | 2021-05-07 | 西北大学 | 一种凝集素探针组合在基于尿蛋白糖型鉴别秦岭川金丝猴妊娠方面的应用 |
| CN110045127A (zh) * | 2019-04-03 | 2019-07-23 | 中国医学科学院北京协和医院 | 一种IgG4相关性疾病多器官受累的生物标志物及其用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5202238A (en) | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
| JP2714664B2 (ja) * | 1988-04-13 | 1998-02-16 | 塩野義製薬株式会社 | マイコプラズマ由来マクロファージ活性化因子 |
| US5726010A (en) | 1991-07-31 | 1998-03-10 | Idexx Laboratories, Inc. | Reversible flow chromatographic binding assay |
| WO2004005934A2 (en) * | 2002-07-04 | 2004-01-15 | Oxford Glycosciences (Uk) Ltd | Toxicity markers |
| ITRM20040098A1 (it) * | 2004-02-25 | 2004-05-25 | Univ Roma | Anticorpi oligoclonali anticlasterina per la diagnosi di neoplasie e la predizione del loro grado di malignita', metodo diagnostico e kit relativi. |
| EP1877796A2 (en) * | 2005-05-05 | 2008-01-16 | Philadelphia Health & Education Corporation d/b/a | Diagnosis of liver pathology through assessment of protein glycosylation |
| EP2913676A1 (en) * | 2008-11-10 | 2015-09-02 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US8168396B2 (en) * | 2009-05-11 | 2012-05-01 | Diabetomics, Llc | Methods for detecting pre-diabetes and diabetes using differential protein glycosylation |
| US9551720B2 (en) * | 2011-01-26 | 2017-01-24 | University of Pittsburgh—Of the Commonwaelth System of Higher Education | Urine biomarkers for prediction of recovery after acute kidney injury: proteomics |
| US20160146832A1 (en) * | 2013-06-05 | 2016-05-26 | Lakhmir S. Chawla | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CN104267187A (zh) * | 2014-10-15 | 2015-01-07 | 吉林大学 | 检测尿液Clusterin含量试纸条的制备及应用 |
| DK3289363T3 (da) * | 2015-04-30 | 2022-02-28 | Idexx Lab Inc | Specifik påvisning af clusterin isoformer |
-
2016
- 2016-04-29 DK DK16724520.8T patent/DK3289363T3/da active
- 2016-04-29 US US15/568,653 patent/US20180142009A1/en active Pending
- 2016-04-29 EP EP21206365.5A patent/EP4019976A1/en active Pending
- 2016-04-29 EP EP16724520.8A patent/EP3289363B1/en active Active
- 2016-04-29 ES ES16724520T patent/ES2907068T3/es active Active
- 2016-04-29 WO PCT/US2016/030075 patent/WO2016176565A1/en not_active Ceased
- 2016-04-29 AU AU2016254150A patent/AU2016254150B2/en active Active
- 2016-04-29 CN CN201680038724.2A patent/CN108093648B/zh active Active
- 2016-04-29 MX MX2017013729A patent/MX388832B/es unknown
- 2016-04-29 JP JP2017556249A patent/JP6948265B2/ja active Active
- 2016-04-29 CA CA2983828A patent/CA2983828A1/en active Pending
- 2016-04-29 KR KR1020177031499A patent/KR102462056B1/ko active Active
-
2017
- 2017-10-27 ZA ZA2017/07313A patent/ZA201707313B/en unknown
-
2021
- 2021-01-29 JP JP2021012877A patent/JP2021099342A/ja active Pending
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