JP2018512061A5 - - Google Patents
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- JP2018512061A5 JP2018512061A5 JP2017544322A JP2017544322A JP2018512061A5 JP 2018512061 A5 JP2018512061 A5 JP 2018512061A5 JP 2017544322 A JP2017544322 A JP 2017544322A JP 2017544322 A JP2017544322 A JP 2017544322A JP 2018512061 A5 JP2018512061 A5 JP 2018512061A5
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- msc
- cultured
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- 206010021143 Hypoxia Diseases 0.000 claims description 23
- 230000001146 hypoxic Effects 0.000 claims description 23
- 210000004271 bone marrow stromal cells Anatomy 0.000 claims description 22
- 238000002347 injection Methods 0.000 claims description 12
- 239000007924 injection Substances 0.000 claims description 12
- 229910052760 oxygen Inorganic materials 0.000 claims description 11
- 210000000845 Cartilage Anatomy 0.000 claims description 8
- 239000001301 oxygen Substances 0.000 claims description 7
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims description 7
- 206010048592 Musculoskeletal disease Diseases 0.000 claims description 6
- 229920002674 hyaluronan Polymers 0.000 claims description 6
- 229960003160 hyaluronic acid Drugs 0.000 claims description 6
- MAKUBRYLFHZREJ-JWBQXVCJSA-M sodium;(2S,3S,4R,5R,6R)-3-[(2S,3R,5S,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylate Chemical group [Na+].CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@H](O)[C@H]1O MAKUBRYLFHZREJ-JWBQXVCJSA-M 0.000 claims description 6
- 210000002435 Tendons Anatomy 0.000 claims description 5
- 208000008035 Back Pain Diseases 0.000 claims description 4
- 102000008186 Collagen Human genes 0.000 claims description 4
- 108010035532 Collagen Proteins 0.000 claims description 4
- 210000003041 Ligaments Anatomy 0.000 claims description 4
- 210000003205 Muscles Anatomy 0.000 claims description 4
- 206010043255 Tendonitis Diseases 0.000 claims description 4
- 230000003592 biomimetic Effects 0.000 claims description 4
- 210000004027 cells Anatomy 0.000 claims description 4
- 229920001436 collagen Polymers 0.000 claims description 4
- 229960005188 collagen Drugs 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 229920001684 low density polyethylene Polymers 0.000 claims description 4
- 239000004702 low-density polyethylene Substances 0.000 claims description 4
- 210000004962 mammalian cells Anatomy 0.000 claims description 4
- 229920005615 natural polymer Polymers 0.000 claims description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- 229920002493 poly(chlorotrifluoroethylene) Polymers 0.000 claims description 4
- 239000005023 polychlorotrifluoroethylene (PCTFE) polymer Substances 0.000 claims description 4
- -1 polytetrafluoroethylene Polymers 0.000 claims description 4
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 4
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 4
- 201000010874 syndrome Diseases 0.000 claims description 4
- 229920001059 synthetic polymer Polymers 0.000 claims description 4
- 238000002513 implantation Methods 0.000 claims description 3
- 201000008482 osteoarthritis Diseases 0.000 claims description 3
- XJKJWTWGDGIQRH-BFIDDRIFSA-N Alginic acid Chemical compound O1[C@@H](C(O)=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](C)[C@@H](O)[C@H]1O XJKJWTWGDGIQRH-BFIDDRIFSA-N 0.000 claims description 2
- 206010006811 Bursitis Diseases 0.000 claims description 2
- 208000003295 Carpal Tunnel Syndrome Diseases 0.000 claims description 2
- 229920001661 Chitosan Polymers 0.000 claims description 2
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 claims description 2
- 208000001640 Fibromyalgia Diseases 0.000 claims description 2
- 102000016359 Fibronectins Human genes 0.000 claims description 2
- 108010067306 Fibronectins Proteins 0.000 claims description 2
- 208000003098 Ganglion Cysts Diseases 0.000 claims description 2
- 102000007547 Laminin Human genes 0.000 claims description 2
- 108010085895 Laminin Proteins 0.000 claims description 2
- 206010024453 Ligament sprain Diseases 0.000 claims description 2
- 206010031243 Osteogenesis imperfecta Diseases 0.000 claims description 2
- 208000001132 Osteoporosis Diseases 0.000 claims description 2
- 239000004952 Polyamide Substances 0.000 claims description 2
- 239000004698 Polyethylene (PE) Substances 0.000 claims description 2
- 208000007048 Polymyalgia Rheumatica Diseases 0.000 claims description 2
- 239000004793 Polystyrene Substances 0.000 claims description 2
- 229920001021 Polysulfide Polymers 0.000 claims description 2
- 206010039073 Rheumatoid arthritis Diseases 0.000 claims description 2
- 210000000513 Rotator Cuff Anatomy 0.000 claims description 2
- 208000005400 Synovial Cyst Diseases 0.000 claims description 2
- 210000001138 Tears Anatomy 0.000 claims description 2
- 208000002240 Tennis Elbow Diseases 0.000 claims description 2
- 229920000615 alginic acid Polymers 0.000 claims description 2
- 229960001126 alginic acid Drugs 0.000 claims description 2
- 235000010443 alginic acid Nutrition 0.000 claims description 2
- 239000000783 alginic acid Substances 0.000 claims description 2
- 229920001222 biopolymer Polymers 0.000 claims description 2
- 201000011275 epicondylitis Diseases 0.000 claims description 2
- 230000037320 fibronectin Effects 0.000 claims description 2
- 239000004700 high-density polyethylene Substances 0.000 claims description 2
- 238000010255 intramuscular injection Methods 0.000 claims description 2
- 239000007927 intramuscular injection Substances 0.000 claims description 2
- 238000010253 intravenous injection Methods 0.000 claims description 2
- 201000002273 mucopolysaccharidosis II Diseases 0.000 claims description 2
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- 229920001888 polyacrylic acid Polymers 0.000 claims description 2
- 239000004584 polyacrylic acid Substances 0.000 claims description 2
- 229920002647 polyamide Polymers 0.000 claims description 2
- 239000011528 polyamide (building material) Substances 0.000 claims description 2
- 229920000515 polycarbonate Polymers 0.000 claims description 2
- 239000004417 polycarbonate Substances 0.000 claims description 2
- 229920000728 polyester Polymers 0.000 claims description 2
- 229920000573 polyethylene Polymers 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 229920002223 polystyrene Polymers 0.000 claims description 2
- 239000005077 polysulfide Substances 0.000 claims description 2
- 150000008117 polysulfides Polymers 0.000 claims description 2
- 229920002635 polyurethane Polymers 0.000 claims description 2
- 239000004814 polyurethane Substances 0.000 claims description 2
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 2
- 239000004800 polyvinyl chloride Substances 0.000 claims description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 2
- 239000011593 sulfur Substances 0.000 claims description 2
- 229910052717 sulfur Inorganic materials 0.000 claims description 2
- 201000004415 tendinitis Diseases 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 22
- 210000002901 Mesenchymal Stem Cells Anatomy 0.000 claims 10
- 239000006285 cell suspension Substances 0.000 claims 2
- 239000002609 media Substances 0.000 claims 2
- 210000001185 Bone Marrow Anatomy 0.000 claims 1
- 239000001963 growth media Substances 0.000 claims 1
- 239000007928 intraperitoneal injection Substances 0.000 claims 1
- 238000010254 subcutaneous injection Methods 0.000 claims 1
- 239000007929 subcutaneous injection Substances 0.000 claims 1
- 210000000988 Bone and Bones Anatomy 0.000 description 3
- 210000003414 Extremities Anatomy 0.000 description 2
- 210000001503 Joints Anatomy 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 230000036407 pain Effects 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 102000000503 Collagen Type II Human genes 0.000 description 1
- 108010041390 Collagen Type II Proteins 0.000 description 1
- 102000028959 Collagen Type X Human genes 0.000 description 1
- 108010022510 Collagen Type X Proteins 0.000 description 1
- 206010053643 Neurodegenerative disease Diseases 0.000 description 1
- 208000008558 Osteophyte Diseases 0.000 description 1
- 102000016611 Proteoglycans Human genes 0.000 description 1
- 108010067787 Proteoglycans Proteins 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000003247 decreasing Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 201000010934 exostosis Diseases 0.000 description 1
- 238000005755 formation reaction Methods 0.000 description 1
- 230000004968 inflammatory condition Effects 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562118827P | 2015-02-20 | 2015-02-20 | |
| US62/118,827 | 2015-02-20 | ||
| PCT/CN2016/074290 WO2016131430A1 (en) | 2015-02-20 | 2016-02-22 | Use of mesenchymal stem cells in treating osteoarthritis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018512061A JP2018512061A (ja) | 2018-05-10 |
| JP2018512061A5 true JP2018512061A5 (hu) | 2019-04-18 |
Family
ID=56691981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017544322A Pending JP2018512061A (ja) | 2015-02-20 | 2016-02-22 | 骨関節炎処置のための間葉幹細胞の使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10780129B2 (hu) |
| EP (1) | EP3300506A4 (hu) |
| JP (1) | JP2018512061A (hu) |
| CN (1) | CN107849533A (hu) |
| HK (1) | HK1254588A1 (hu) |
| TW (1) | TWI723977B (hu) |
| WO (1) | WO2016131430A1 (hu) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018101481A1 (ja) * | 2016-12-02 | 2018-06-07 | 株式会社日本触媒 | 細胞製剤 |
| SG11202003507QA (en) * | 2017-10-17 | 2020-05-28 | Univ Hiroshima | Pluripotent stem cells inducing osteochondral repair |
| CN110935010A (zh) * | 2019-11-22 | 2020-03-31 | 丛秀丽 | 一种干细胞制剂和生长因子组合物及其制备方法和应用 |
| CN114515336B (zh) * | 2022-02-16 | 2023-04-07 | 天津长和生物技术有限公司 | 低氧培养的hUCMSC联合OMgP抗体在脊髓损伤治疗中的应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070053963A1 (en) * | 2004-01-13 | 2007-03-08 | Hotchkiss Robert N | Drug delivery to a joint |
| CN1676603A (zh) * | 2004-03-30 | 2005-10-05 | 中国人民解放军军事医学科学院基础医学研究所 | 一种人骨髓间充质干细胞体外扩增的新方法 |
| US9173975B2 (en) * | 2009-04-24 | 2015-11-03 | Ingeneron, Inc. | Reparative cell delivery via hyaluronic acid vehicles |
| EP2446024A1 (en) * | 2009-06-26 | 2012-05-02 | Life&Light Limited | Mesenchymal stem cells grown under hypoxic conditions: compositions, methods and uses therefor |
| US8900860B2 (en) * | 2009-11-30 | 2014-12-02 | National Yang-Ming University | Method for expanding mesenchymal stem cells in low-density and hypoxic culture |
| JP6607675B2 (ja) * | 2011-07-06 | 2019-11-20 | セル セラピー リミテッド | 中胚葉系列の前駆細胞 |
| EP2612907A1 (en) * | 2012-01-05 | 2013-07-10 | Taipei Veterans General Hospital | Preparation of cell transplant |
| KR101532556B1 (ko) * | 2012-09-03 | 2015-06-30 | 메디포스트(주) | 간엽줄기세포의 배양 방법 |
-
2016
- 2016-02-22 WO PCT/CN2016/074290 patent/WO2016131430A1/en active Application Filing
- 2016-02-22 US US15/552,410 patent/US10780129B2/en active Active
- 2016-02-22 TW TW105105187A patent/TWI723977B/zh active
- 2016-02-22 JP JP2017544322A patent/JP2018512061A/ja active Pending
- 2016-02-22 CN CN201680016519.6A patent/CN107849533A/zh active Pending
- 2016-02-22 EP EP16751961.0A patent/EP3300506A4/en not_active Ceased
-
2018
- 2018-09-26 HK HK18112312.6A patent/HK1254588A1/zh unknown
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