JP2018509415A5 - - Google Patents

Info

Publication number

JP2018509415A5

JP2018509415A5 JP2017547980A JP2017547980A JP2018509415A5 JP 2018509415 A5 JP2018509415 A5 JP 2018509415A5 JP 2017547980 A JP2017547980 A JP 2017547980A JP 2017547980 A JP2017547980 A JP 2017547980A JP 2018509415 A5 JP2018509415 A5 JP 2018509415A5

Authority

JP

Japan

Prior art keywords

group

seq

kit according

cell wall

agent

Prior art date

2016-03-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000003899 bactericide agent Substances 0.000 claims 6
• 210000004027 cell Anatomy 0.000 claims 6
• 210000002421 cell wall Anatomy 0.000 claims 6
• 230000003834 intracellular effect Effects 0.000 claims 6
• 230000000844 anti-bacterial effect Effects 0.000 claims 5
• 102000044503 Antimicrobial Peptides Human genes 0.000 claims 4
• 108700042778 Antimicrobial Peptides Proteins 0.000 claims 4
• 239000003795 chemical substances by application Substances 0.000 claims 4
• 239000003910 polypeptide antibiotic agent Substances 0.000 claims 4
• 208000035143 Bacterial infection Diseases 0.000 claims 3
• 101000925662 Enterobacteria phage PRD1 Endolysin Proteins 0.000 claims 3
• 108090000790 Enzymes Proteins 0.000 claims 3
• 102000004190 Enzymes Human genes 0.000 claims 3
• 208000022362 bacterial infectious disease Diseases 0.000 claims 3
• 229920001184 polypeptide Polymers 0.000 claims 3
• 108090000765 processed proteins & peptides Proteins 0.000 claims 3
• 102000004196 processed proteins & peptides Human genes 0.000 claims 3
• 108090000623 proteins and genes Proteins 0.000 claims 3
• 102000004169 proteins and genes Human genes 0.000 claims 3
• 230000026683 transduction Effects 0.000 claims 3
• 238000010361 transduction Methods 0.000 claims 3
• NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims 2
• 230000003113 alkalizing effect Effects 0.000 claims 2
• 230000001580 bacterial effect Effects 0.000 claims 2
• 230000003115 biocidal effect Effects 0.000 claims 2
• WHTVZRBIWZFKQO-AWEZNQCLSA-N (S)-chloroquine Chemical compound ClC1=CC=C2C(N[C@@H](C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-AWEZNQCLSA-N 0.000 claims 1
• WZRJTRPJURQBRM-UHFFFAOYSA-N 4-amino-n-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide;5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1.COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 WZRJTRPJURQBRM-UHFFFAOYSA-N 0.000 claims 1
• 108010062877 Bacteriocins Proteins 0.000 claims 1
• 229930186147 Cephalosporin Natural products 0.000 claims 1
• 108010013198 Daptomycin Proteins 0.000 claims 1
• UIOFUWFRIANQPC-JKIFEVAISA-N Floxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=C(F)C=CC=C1Cl UIOFUWFRIANQPC-JKIFEVAISA-N 0.000 claims 1
• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
• 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims 1
• 206010041925 Staphylococcal infections Diseases 0.000 claims 1
• 108010059993 Vancomycin Proteins 0.000 claims 1
• 229940126574 aminoglycoside antibiotic Drugs 0.000 claims 1
• 239000002647 aminoglycoside antibiotic agent Substances 0.000 claims 1
• 235000019270 ammonium chloride Nutrition 0.000 claims 1
• 239000003242 anti bacterial agent Substances 0.000 claims 1
• WZPBZJONDBGPKJ-VEHQQRBSSA-N aztreonam Chemical compound O=C1N(S([O-])(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=CSC([NH3+])=N1 WZPBZJONDBGPKJ-VEHQQRBSSA-N 0.000 claims 1
• 229960003644 aztreonam Drugs 0.000 claims 1
• XDHNQDDQEHDUTM-JQWOJBOSSA-N bafilomycin A1 Chemical compound CO[C@H]1\C=C\C=C(C)\C[C@H](C)[C@H](O)[C@H](C)\C=C(/C)\C=C(OC)\C(=O)O[C@@H]1[C@@H](C)[C@@H](O)[C@H](C)[C@]1(O)O[C@H](C(C)C)[C@@H](C)[C@H](O)C1 XDHNQDDQEHDUTM-JQWOJBOSSA-N 0.000 claims 1
• XDHNQDDQEHDUTM-ZGOPVUMHSA-N bafilomycin A1 Natural products CO[C@H]1C=CC=C(C)C[C@H](C)[C@H](O)[C@H](C)C=C(C)C=C(OC)C(=O)O[C@@H]1[C@@H](C)[C@@H](O)[C@H](C)[C@]1(O)O[C@H](C(C)C)[C@@H](C)[C@H](O)C1 XDHNQDDQEHDUTM-ZGOPVUMHSA-N 0.000 claims 1
• XDHNQDDQEHDUTM-UHFFFAOYSA-N bafliomycin A1 Natural products COC1C=CC=C(C)CC(C)C(O)C(C)C=C(C)C=C(OC)C(=O)OC1C(C)C(O)C(C)C1(O)OC(C(C)C)C(C)C(O)C1 XDHNQDDQEHDUTM-UHFFFAOYSA-N 0.000 claims 1
• 239000003782 beta lactam antibiotic agent Substances 0.000 claims 1
• YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 claims 1
• 230000001413 cellular effect Effects 0.000 claims 1
• 229940124587 cephalosporin Drugs 0.000 claims 1
• 150000001780 cephalosporins Chemical class 0.000 claims 1
• 229960003677 chloroquine Drugs 0.000 claims 1
• WHTVZRBIWZFKQO-UHFFFAOYSA-N chloroquine Natural products ClC1=CC=C2C(NC(C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-UHFFFAOYSA-N 0.000 claims 1
• 229940047766 co-trimoxazole Drugs 0.000 claims 1
• DOAKLVKFURWEDJ-QCMAZARJSA-N daptomycin Chemical compound C([C@H]1C(=O)O[C@H](C)[C@@H](C(NCC(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@H](C(=O)N1)[C@H](C)CC(O)=O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CCCCCCCCC)C(=O)C1=CC=CC=C1N DOAKLVKFURWEDJ-QCMAZARJSA-N 0.000 claims 1
• 229960005484 daptomycin Drugs 0.000 claims 1
• 229960004273 floxacillin Drugs 0.000 claims 1
• 229940124307 fluoroquinolone Drugs 0.000 claims 1
• 239000000417 fungicide Substances 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 230000002132 lysosomal effect Effects 0.000 claims 1
• VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims 1
• 229960000282 metronidazole Drugs 0.000 claims 1
• 239000002855 microbicide agent Substances 0.000 claims 1
• NXFQHRVNIOXGAQ-YCRREMRBSA-N nitrofurantoin Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)NC(=O)C1 NXFQHRVNIOXGAQ-YCRREMRBSA-N 0.000 claims 1
• 229960000564 nitrofurantoin Drugs 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 150000002960 penicillins Chemical class 0.000 claims 1
• 230000002085 persistent effect Effects 0.000 claims 1
• 210000000680 phagosome Anatomy 0.000 claims 1
• 239000002157 polynucleotide Substances 0.000 claims 1
• 102000040430 polynucleotide Human genes 0.000 claims 1
• 108091033319 polynucleotide Proteins 0.000 claims 1
• 229960003250 telithromycin Drugs 0.000 claims 1
• LJVAJPDWBABPEJ-PNUFFHFMSA-N telithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]([C@]2(OC(=O)N(CCCCN3C=C(N=C3)C=3C=NC=CC=3)[C@@H]2[C@@H](C)C(=O)[C@H](C)C[C@@]1(C)OC)C)CC)[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O LJVAJPDWBABPEJ-PNUFFHFMSA-N 0.000 claims 1
• 241001515965 unidentified phage Species 0.000 claims 1
• 229960003165 vancomycin Drugs 0.000 claims 1
• MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 claims 1
• MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims 1
• 239000002132 β-lactam antibiotic Substances 0.000 claims 1
• 229940124586 β-lactam antibiotics Drugs 0.000 claims 1